Designed β-boomerang antiendotoxic and antimicrobial peptides. Structures and activities in lipopolysaccharide

Journal of Biological Chemistry

Volumn 284, Issue 33, 2009, Pages 21991-22004

  Bhunia, Anirban ^a   Mohanram, Harini ^a   Domadia, Prerna ^a   Torres, Jaume ^a   Bhattacharjya, Surajit ^a,b  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b NONE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-MICROBIAL ACTIVITY; ANTIMICROBIAL PEPTIDE; AROMATIC RESIDUES; BI-LAYER; BINDING MOTIF; BIOLOGICAL PROCESS; DEPTH OF INSERTION; ENDOTOXICITY; ENDOTOXIN NEUTRALIZATION; GRAM-NEGATIVE BACTERIA; HEAD GROUPS; INTEGRAL PART; LIPOPOLYSACCHARIDES; MICELLE STRUCTURE; MODE OF ACTION; NMR STRUCTURES; OUTER MEMBRANE; OUTER MEMBRANE PROTEIN; SELECTIVE INTERACTION; SEPTIC SHOCKS; STRAND CONFORMATION; STRUCTURAL FEATURE; STRUCTURE-ACTIVITY; TRP-FLUORESCENCE;

AROMATIC COMPOUNDS; BACTERIA; CONFORMATIONS; FOURIER TRANSFORM INFRARED SPECTROSCOPY; PEPTIDES; POLYSACCHARIDES; PROTEIN FOLDING; SPECTROSCOPIC ANALYSIS; SPECTROSCOPY;

AMINES;

ALANINE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GLYCYLTRYPTOPHYLLYSYLARGINYLLYSYLARGINYLPHENYLALANYLGLYCINE; LEUCINE; OCTAPEPTIDE; POLYPEPTIDE ANTIBIOTIC AGENT; TYROSYLVALYLLEUCYLALANYLLYSYLARGINYLLYSYLARGINYLALANYLISOLEUCYLPHENYLALANYLISOLEUCINE; TYROSYLVALYLLEUCYLLEUCYLLYSYLARGINYLLYSYLARGINYLLEUCYLISOLEUCYLPHENYLALANYLISOLEUCINE; TYROSYLVALYLLEUCYLPHENYLALANYLLYSYLARGINYLLYSYLARGINYLPHENYLALANYLISOLEUCYLPHENYLALANYLISOLEUCINE; TYROSYLVALYLLEUCYLTRYPTOPHYLLYSYLARGINYLLYSYLARGINYLPHENYLALANYLISOLEUCYLPHENYLALANYLISOLEUCINE; TYROSYLVALYLLEUCYLTRYPTOPHYLLYSYLARGINYLLYSYLARGINYLTRYPTOPHYLISOLEUCYLPHENYLALANYLISOLEUCINE; TYROSYLVALYLLEUCYLTRYPTOPHYLLYSYLARGINYLLYSYLARGINYLTYROSYLISOLEUCYLPHENYLALANYLISOLEUCINE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERIAL OUTER MEMBRANE; BETA SHEET; CONTROLLED STUDY; DRUG DESIGN; INFRARED SPECTROSCOPY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN IMMOBILIZATION; PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS;

AMINO ACID MOTIFS; ANTI-INFECTIVE AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; CELL MEMBRANE; ENDOTOXINS; HEMAGGLUTININS; LIPID BILAYERS; LIPOPOLYSACCHARIDES; MICELLES; MICROBIAL SENSITIVITY TESTS; PEPTIDES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SPECTROMETRY, FLUORESCENCE; SPECTROPHOTOMETRY, INFRARED;

NEGIBACTERIA;

EID: 69249119005     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.013573     Document Type: Article

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