A Novel Linear Amphipathic β-Sheet Cationic Antimicrobial Peptide with Enhanced Selectivity for Bacterial Lipids

Journal of Biological Chemistry

Volumn 276, Issue 30, 2001, Pages 27899-27906

  Blazyk, Jack ^a,b   Wiegand, Russell ^b   Klein, Jason ^b   Hammer, Janet ^a   Epand, Richard M ^c   Epand, Raquel F ^c   Maloy, W Lee ^d   Kari, U Prasad ^d  

^a OHIO UNIVERSITY   (United States)

^b OHIO UNIVERSITY   (United States)

^c MCMASTER UNIVERSITY MEDICAL CENTRE   (Canada)

^d Genaera Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BIOLOGICAL MEMBRANES; FLUORESCENCE; FOURIER TRANSFORM INFRARED SPECTROSCOPY;

ANTIMICROBIAL AGENTS;

LIPIDS;

ANTIINFECTIVE AGENT; CATION; LIPID; LYSYLISOLEUCYLALANYLGLYCYLLYSYLISOLEUCYLALANINE; LYSYLISOLEUCYLGLYCYLALANYLLYSYLISOLEUCINE; LYSYLLEUCYLALANYLGLYCYLLEUCYLALANYLLYSINE; PEPTIDE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLGLYCEROL; TRYPTOPHAN; UNCLASSIFIED DRUG; CALCEIN; FLUORESCEIN DERIVATIVE;

ANTIMICROBIAL ACTIVITY; ARTICLE; BETA SHEET; CELL MEMBRANE PERMEABILITY; CIRCULAR DICHROISM; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; FLUORESCENCE; INFRARED SPECTROSCOPY; LIPID VESICLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN LIPID INTERACTION; AMINO ACID SEQUENCE; ANIMAL; BACTERIUM; CHEMISTRY; DIFFERENTIAL SCANNING CALORIMETRY; HEMOLYSIS; LIPID METABOLISM; METABOLISM; MOLECULAR GENETICS; PROTEIN SECONDARY STRUCTURE; SPECTROFLUOROMETRY;

BACTERIA (MICROORGANISMS); MAMMALIA;

AMINO ACID SEQUENCE; ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIA; CALORIMETRY, DIFFERENTIAL SCANNING; CIRCULAR DICHROISM; FLUORESCEINS; HEMOLYSIS; LIPID METABOLISM; MOLECULAR SEQUENCE DATA; PEPTIDES; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLGLYCEROLS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SPECTROMETRY, FLUORESCENCE; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TRYPTOPHAN;

EID: 0035958848     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M102865200     Document Type: Article

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