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Volumn 11, Issue 1, 2011, Pages 91-100

Tumor-associated macrophages in breast cancer as potential biomarkers for new treatments and diagnostics

Author keywords

alternative activation; breast cancer; leukocyte infiltrate; tumor associated macrophage

Indexed keywords

BIOLOGICAL MARKER; PLASTIC;

EID: 78650547508     PISSN: 14737159     EISSN: 17448352     Source Type: Journal    
DOI: 10.1586/erm.10.97     Document Type: Review
Times cited : (118)

References (113)
  • 1
    • 40049088602 scopus 로고    scopus 로고
    • The inflammatory micro-environment in tumor progression: The role of tumor-associated macrophages
    • Allavena P, Sica A, Solinas G, Porta C, Mantovani A. The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages. Crit. Rev. Oncol. Hematol. 66(1), 1-9 (2008).
    • (2008) Crit. Rev. Oncol. Hematol. , vol.66 , Issue.1 , pp. 1-9
    • Allavena, P.1    Sica, A.2    Solinas, G.3    Porta, C.4    Mantovani, A.5
  • 2
    • 70249113748 scopus 로고    scopus 로고
    • Chronic inflammation and breast cancer recurrence
    • Cole SW. Chronic inflammation and breast cancer recurrence. J. Clin. Oncol. 27(21), 3418-3419 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.21 , pp. 3418-3419
    • Cole, S.W.1
  • 3
    • 19344365408 scopus 로고    scopus 로고
    • De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent
    • de Visser KE, Korets LV, Coussens LM. De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent. Cancer Cell 7(5), 411-423 (2005).
    • (2005) Cancer Cell , vol.7 , Issue.5 , pp. 411-423
    • De Visser, K.E.1    Korets, L.V.2    Coussens, L.M.3
  • 4
    • 77949872871 scopus 로고    scopus 로고
    • Cancer and inflammation: Implications for pharmacology and therapeutics
    • Balkwill F, Mantovani A. Cancer and inflammation: implications for pharmacology and therapeutics. Clin. Pharmacol. Ther. 87(4), 401-406 (2010).
    • (2010) Clin. Pharmacol. Ther. , vol.87 , Issue.4 , pp. 401-406
    • Balkwill, F.1    Mantovani, A.2
  • 5
    • 70249127607 scopus 로고    scopus 로고
    • Elevated biomarkers of inflammation are associated with reduced survival among breast cancer patients
    • Pierce BL, Ballard-Barbash R, Bernstein L et al. Elevated biomarkers of inflammation are associated with reduced survival among breast cancer patients. J. Clin. Oncol. 27(21), 3437-3444 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.21 , pp. 3437-3444
    • Pierce, B.L.1    Ballard-Barbash, R.2    Bernstein, L.3
  • 6
    • 2442662761 scopus 로고    scopus 로고
    • Association of frequency and duration of aspirin use and hormone receptor status with breast cancer risk
    • Terry MB, Gammon MD, Zhang FF et al. Association of frequency and duration of aspirin use and hormone receptor status with breast cancer risk. JAMA 291(20), 2433-2440 (2004).
    • (2004) JAMA , vol.291 , Issue.20 , pp. 2433-2440
    • Terry, M.B.1    Gammon, M.D.2    Zhang, F.F.3
  • 7
    • 0141842615 scopus 로고    scopus 로고
    • Breast cancer and nonsteroidal anti-inflammatory drugs: Prospective results from the Womens Health Initiative
    • Harris RE, Chlebowski RT, Jackson RD et al. Breast cancer and nonsteroidal anti-inflammatory drugs: prospective results from the Womens Health Initiative. Cancer Res. 63(18), 6096-6101 (2003).
    • (2003) Cancer Res. , vol.63 , Issue.18 , pp. 6096-6101
    • Harris, R.E.1    Chlebowski, R.T.2    Jackson, R.D.3
  • 8
    • 4644324186 scopus 로고    scopus 로고
    • NF-kB functions as a tumour promoter in inflammation-associated cancer
    • Pikarsky E, Porat RM, Stein I et al. NF-kB functions as a tumour promoter in inflammation-associated cancer. Nature 431(7007), 461-466 (2004).
    • (2004) Nature , vol.431 , Issue.7007 , pp. 461-466
    • Pikarsky, E.1    Porat, R.M.2    Stein, I.3
  • 9
    • 4043088499 scopus 로고    scopus 로고
    • IKKb links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    • Greten FR, Eckmann L, Greten TF et al. IKKb links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118(3), 285-296 (2004).
    • (2004) Cell , vol.118 , Issue.3 , pp. 285-296
    • Greten, F.R.1    Eckmann, L.2    Greten, T.F.3
  • 10
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-kB in cancer development and progression
    • Karin M. Nuclear factor-kB in cancer development and progression. Nature 441(7092), 431-436 (2006).
    • (2006) Nature , vol.441 , Issue.7092 , pp. 431-436
    • Karin, M.1
  • 11
    • 67349168435 scopus 로고    scopus 로고
    • Role of macrophages in tumour progression
    • Siveen KS, Kuttan G. Role of macrophages in tumour progression. Immunol. Lett. 123(2), 97-102 (2009).
    • (2009) Immunol. Lett. , vol.123 , Issue.2 , pp. 97-102
    • Siveen, K.S.1    Kuttan, G.2
  • 12
    • 48349102876 scopus 로고    scopus 로고
    • Macrophage polarization in tumour progression
    • Sica A, Larghi P, Mancino A et al. Macrophage polarization in tumour progression. Semin. Cancer Biol. 18(5), 349-355 (2008).
    • (2008) Semin. Cancer Biol. , vol.18 , Issue.5 , pp. 349-355
    • Sica, A.1    Larghi, P.2    Mancino, A.3
  • 13
    • 68349121579 scopus 로고    scopus 로고
    • Cellular and molecular pathways linking inflammation and cancer
    • Porta C, Larghi P, Rimoldi M et al. Cellular and molecular pathways linking inflammation and cancer. Immunobiology 214(9-10), 761-777 (2009).
    • (2009) Immunobiology , vol.214 , Issue.9-10 , pp. 761-777
    • Porta, C.1    Larghi, P.2    Rimoldi, M.3
  • 14
    • 63849307580 scopus 로고    scopus 로고
    • IL-17 expression by breast-cancerassociated macrophages: IL-17 promotes invasiveness of breast cancer cell lines
    • Zhu X, Mulcahy LA, Mohammed RA et al. IL-17 expression by breast-cancerassociated macrophages: IL-17 promotes invasiveness of breast cancer cell lines. Breast Cancer Res. 10(6), R95 (2008).
    • (2008) Breast Cancer Res. , vol.10 , Issue.6
    • Zhu, X.1    Mulcahy, L.A.2    Mohammed, R.A.3
  • 15
    • 33745078300 scopus 로고    scopus 로고
    • Tumour-associated macrophages are related to progression in patients with metastatic melanoma following interleukin-2 based immunotherapy
    • Hansen BD, Schmidt H, von der Maase H, Sjoegren P, Agger R, Hokland M. Tumour-associated macrophages are related to progression in patients with metastatic melanoma following interleukin-2 based immunotherapy. Acta Oncol. 45(4), 400-405 (2006).
    • (2006) Acta Oncol. , vol.45 , Issue.4 , pp. 400-405
    • Hansen, B.D.1    Schmidt, H.2    Von Der Maase, H.3    Sjoegren, P.4    Agger, R.5    Hokland, M.6
  • 16
    • 77949345555 scopus 로고    scopus 로고
    • Tumorassociated macrophages and survival in classic Hodgkins lymphoma
    • Steidl C, Lee T, Shah SP et al. Tumorassociated macrophages and survival in classic Hodgkins lymphoma. N. Engl. J. Med. 362(10), 875-885 (2010).
    • (2010) N. Engl. J. Med. , vol.362 , Issue.10 , pp. 875-885
    • Steidl, C.1    Lee, T.2    Shah, S.P.3
  • 17
    • 70350728931 scopus 로고    scopus 로고
    • Tumor-associated macrophages (TAM) as major players of the cancerrelated inflammation
    • Solinas G, Germano G, Mantovani A, Allavena P. Tumor-associated macrophages (TAM) as major players of the cancerrelated inflammation. J. Leukoc. Biol. 86(5), 1065-1073 (2009).
    • (2009) J. Leukoc. Biol. , vol.86 , Issue.5 , pp. 1065-1073
    • Solinas, G.1    Germano, G.2    Mantovani, A.3    Allavena, P.4
  • 18
    • 19944422061 scopus 로고    scopus 로고
    • A multigene assay to predict recurrence of tamoxifentreated, node-negative breast cancer
    • Paik S, Shak S, Tang G et al. A multigene assay to predict recurrence of tamoxifentreated, node-negative breast cancer. N. Engl. J. Med. 351(27), 2817-2826 (2004).
    • (2004) N. Engl. J. Med. , vol.351 , Issue.27 , pp. 2817-2826
    • Paik, S.1    Shak, S.2    Tang, G.3
  • 19
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat. Rev. Immunol. 8(12), 958-969 (2008).
    • (2008) Nat. Rev. Immunol. , vol.8 , Issue.12 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 20
    • 0037310024 scopus 로고    scopus 로고
    • The many faces of macrophage activation
    • Mosser DM. The many faces of macrophage activation. J. Leukoc. Biol. 73(2), 209-212 (2003).
    • (2003) J. Leukoc. Biol. , vol.73 , Issue.2 , pp. 209-212
    • Mosser, D.M.1
  • 21
    • 77949681013 scopus 로고    scopus 로고
    • Macrophage dysfunction impairs resolution of inflammation in the wounds of diabetic mice
    • Khanna S, Biswas S, Shang Y et al. Macrophage dysfunction impairs resolution of inflammation in the wounds of diabetic mice. PLoS ONE 5(3), e9539 (2010).
    • (2010) PLoS ONE , vol.5 , Issue.3
    • Khanna, S.1    Biswas, S.2    Shang, Y.3
  • 22
    • 77951631929 scopus 로고    scopus 로고
    • Differential roles of macrophages in diverse phases of skin repair
    • Lucas T, Waisman A, Ranjan R et al. Differential roles of macrophages in diverse phases of skin repair. J. Immunol. 184(7), 3964-3977 (2010).
    • (2010) J. Immunol. , vol.184 , Issue.7 , pp. 3964-3977
    • Lucas, T.1    Waisman, A.2    Ranjan, R.3
  • 24
    • 77952027489 scopus 로고    scopus 로고
    • Multi-tasking of helper T cells
    • Wan YY. Multi-tasking of helper T cells. Immunology 130(2), 166-171 (2010).
    • (2010) Immunology , vol.130 , Issue.2 , pp. 166-171
    • Wan, Y.Y.1
  • 25
    • 33747345981 scopus 로고    scopus 로고
    • Classical and alternative activation of mononuclear phagocytes: Picking the best of both worlds for tumor promotion
    • Van Ginderachter JA, Movahedi K, Hassanzadeh Ghassabeh G et al. Classical and alternative activation of mononuclear phagocytes: picking the best of both worlds for tumor promotion. Immunobiology 211(6-8), 487-501 (2006).
    • (2006) Immunobiology , vol.211 , Issue.6-8 , pp. 487-501
    • Van Ginderachter, J.A.1    Movahedi, K.2    Hassanzadeh Ghassabeh, G.3
  • 26
    • 26644452073 scopus 로고    scopus 로고
    • Macrophage polarization comes of age
    • Mantovani A, Sica A, Locati M. Macrophage polarization comes of age. Immunity 23(4), 344-346 (2005).
    • (2005) Immunity , vol.23 , Issue.4 , pp. 344-346
    • Mantovani, A.1    Sica, A.2    Locati, M.3
  • 27
    • 64849106667 scopus 로고    scopus 로고
    • Tumor-specific bacteriophages induce tumor destruction through activation of tumor-associated macrophages
    • Eriksson F, Tsagozis P, Lundberg K et al. Tumor-specific bacteriophages induce tumor destruction through activation of tumor-associated macrophages. J. Immunol. 182(5), 3105-3111 (2009).
    • (2009) J. Immunol. , vol.182 , Issue.5 , pp. 3105-3111
    • Eriksson, F.1    Tsagozis, P.2    Lundberg, K.3
  • 28
    • 19344363035 scopus 로고    scopus 로고
    • Gene expression signature of fibroblast serum response predicts human cancer progression: Similarities between tumors and wounds
    • Chang HY, Sneddon JB, Alizadeh AA et al. Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds. PLoS Biol. 2(2), E7 (2004).
    • (2004) PLoS Biol. , vol.2 , Issue.2
    • Chang, H.Y.1    Sneddon, J.B.2    Alizadeh, A.A.3
  • 29
    • 72549085332 scopus 로고    scopus 로고
    • Activation of host wound responses in breast cancer microenvironment
    • Troester MA, Lee MH, Carter M et al. Activation of host wound responses in breast cancer microenvironment. Clin. Cancer Res. 15(22), 7020-7028 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.22 , pp. 7020-7028
    • Troester, M.A.1    Lee, M.H.2    Carter, M.3
  • 30
    • 73649122504 scopus 로고    scopus 로고
    • Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor
    • Patsialou A, Wyckoff J, Wang Y, Goswami S, Stanley ER, Condeelis JS. Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor. Cancer Res. 69(24), 9498-9506 (2009).
    • (2009) Cancer Res. , vol.69 , Issue.24 , pp. 9498-9506
    • Patsialou, A.1    Wyckoff, J.2    Wang, Y.3    Goswami, S.4    Stanley, E.R.5    Condeelis, J.S.6
  • 31
    • 33645991795 scopus 로고    scopus 로고
    • Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: Potential targets of anti-cancer therapy
    • Sica A, Schioppa T, Mantovani A, Allavena P. Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy. Eur. J. Cancer 42(6), 717-727 (2006).
    • (2006) Eur. J. Cancer , vol.42 , Issue.6 , pp. 717-727
    • Sica, A.1    Schioppa, T.2    Mantovani, A.3    Allavena, P.4
  • 32
    • 68249142896 scopus 로고    scopus 로고
    • Stromal MCP-1 in mammary tumors induces tumor-associated macrophage infiltration and contributes to tumor progression
    • Fujimoto H, Sangai T, Ishii G et al. Stromal MCP-1 in mammary tumors induces tumor-associated macrophage infiltration and contributes to tumor progression. Int. J. Cancer 125(6), 1276-1284 (2009).
    • (2009) Int. J. Cancer , vol.125 , Issue.6 , pp. 1276-1284
    • Fujimoto, H.1    Sangai, T.2    Ishii, G.3
  • 33
    • 20444436815 scopus 로고    scopus 로고
    • Macrophages promote the invasion of breast carcinoma cells via a colonystimulating factor-1/epidermal growth factor paracrine loop
    • Goswami S, Sahai E, Wyckoff JB et al. Macrophages promote the invasion of breast carcinoma cells via a colonystimulating factor-1/epidermal growth factor paracrine loop. Cancer Res. 65(12), 5278-5283 (2005).
    • (2005) Cancer Res. , vol.65 , Issue.12 , pp. 5278-5283
    • Goswami, S.1    Sahai, E.2    Wyckoff, J.B.3
  • 34
    • 67349245430 scopus 로고    scopus 로고
    • Phosphatidylinostitol-3 kinase and phospholipase C enhance CSF-1-dependent macrophage survival by controlling glucose uptake
    • Chang M, Hamilton JA, Scholz GM, Masendycz P, Macaulay SL, Elsegood CL. Phosphatidylinostitol-3 kinase and phospholipase C enhance CSF-1-dependent macrophage survival by controlling glucose uptake. Cell Signal. 21, 1361-1369 (2009).
    • (2009) Cell Signal. , vol.21 , pp. 1361-1369
    • Chang, M.1    Hamilton, J.A.2    Scholz, G.M.3    Masendycz, P.4    MacAulay, S.L.5    Elsegood, C.L.6
  • 35
    • 0035911221 scopus 로고    scopus 로고
    • Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy
    • Lin EY, Nguyen AV, Russell RG, Pollard JW. Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J. Exp. Med. 193(6), 727-740 (2001).
    • (2001) J. Exp. Med. , vol.193 , Issue.6 , pp. 727-740
    • Lin, E.Y.1    Nguyen, A.V.2    Russell, R.G.3    Pollard, J.W.4
  • 36
    • 73649093148 scopus 로고    scopus 로고
    • Folate receptor b is expressed by tumor-associated macrophages and constitutes a marker for M2 anti-inflammatory/regulatory macrophages
    • Puig-Kroger A, Sierra-Filardi E, Dominguez-Soto A et al. Folate receptor b is expressed by tumor-associated macrophages and constitutes a marker for M2 anti-inflammatory/regulatory macrophages. Cancer Res. 69(24), 9395-9403 (2009).
    • (2009) Cancer Res. , vol.69 , Issue.24 , pp. 9395-9403
    • Puig-Kroger, A.1    Sierra-Filardi, E.2    Dominguez-Soto, A.3
  • 37
    • 0041929158 scopus 로고    scopus 로고
    • M-CSF induces vascular endothelial growth factor production and angiogenic activity from human monocytes
    • Eubank TD, Galloway M, Montague CM, Waldman WJ, Marsh CB. M-CSF induces vascular endothelial growth factor production and angiogenic activity from human monocytes. J. Immunol. 171(5), 2637-2643 (2003).
    • (2003) J. Immunol. , vol.171 , Issue.5 , pp. 2637-2643
    • Eubank, T.D.1    Galloway, M.2    Montague, C.M.3    Waldman, W.J.4    Marsh, C.B.5
  • 38
    • 0029001004 scopus 로고
    • Cytokine regulation of angiogenesis in breast cancer: The role of tumor-associated macrophages
    • Lewis CE, Leek R, Harris A, McGee JO. Cytokine regulation of angiogenesis in breast cancer: the role of tumor-associated macrophages. J. Leukoc. Biol. 57(5), 747-751 (1995).
    • (1995) J. Leukoc. Biol. , vol.57 , Issue.5 , pp. 747-751
    • Lewis, C.E.1    Leek, R.2    Harris, A.3    McGee, J.O.4
  • 39
    • 34347226359 scopus 로고    scopus 로고
    • Tumor-associated macrophages press the angiogenic switch in breast cancer
    • Lin EY, Pollard JW. Tumor-associated macrophages press the angiogenic switch in breast cancer. Cancer Res. 67(11), 5064-5066 (2007).
    • (2007) Cancer Res. , vol.67 , Issue.11 , pp. 5064-5066
    • Lin, E.Y.1    Pollard, J.W.2
  • 40
    • 33845767868 scopus 로고    scopus 로고
    • Macrophages regulate the angiogenic switch in a mouse model of breast cancer
    • Lin EY, Li JF, Gnatovskiy L et al. Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Cancer Res. 66(23), 11238-11246 (2006).
    • (2006) Cancer Res. , vol.66 , Issue.23 , pp. 11238-11246
    • Lin, E.Y.1    Li, J.F.2    Gnatovskiy, L.3
  • 41
    • 30644464801 scopus 로고    scopus 로고
    • Elevated serum levels of vascular endothelial growth factor are associated with tumor-associated macrophages in primary breast cancer
    • Vicioso L, Gonzalez FJ, Alvarez M et al. Elevated serum levels of vascular endothelial growth factor are associated with tumor-associated macrophages in primary breast cancer. Am. J. Clin. Pathol. 125(1), 111-118 (2006).
    • (2006) Am. J. Clin. Pathol. , vol.125 , Issue.1 , pp. 111-118
    • Vicioso, L.1    Gonzalez, F.J.2    Alvarez, M.3
  • 42
    • 68749109536 scopus 로고    scopus 로고
    • A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth
    • Qian B, Deng Y, Im JH et al. A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth. PLoS ONE 4(8), e6562 (2009).
    • (2009) PLoS ONE , vol.4 , Issue.8
    • Qian, B.1    Deng, Y.2    Im, J.H.3
  • 43
    • 25844503817 scopus 로고    scopus 로고
    • Tumor immunity: A balancing act between T cell activation, macrophage activation and tumorinduced immune suppression
    • Sinha P, Clements VK, Miller S, Ostrand-Rosenberg S. Tumor immunity: a balancing act between T cell activation, macrophage activation and tumorinduced immune suppression. Cancer Immunol. Immunother. 54(11), 1137-1142 (2005).
    • (2005) Cancer Immunol. Immunother. , vol.54 , Issue.11 , pp. 1137-1142
    • Sinha, P.1    Clements, V.K.2    Miller, S.3    Ostrand-Rosenberg, S.4
  • 44
    • 77949668375 scopus 로고    scopus 로고
    • Shigella mediated depletion of macrophages in a murine breast cancer model is associated with tumor regression
    • Galmbacher K, Heisig M, Hotz C et al. Shigella mediated depletion of macrophages in a murine breast cancer model is associated with tumor regression. PLoS ONE 5(3), e9572 (2010).
    • (2010) PLoS ONE , vol.5 , Issue.3
    • Galmbacher, K.1    Heisig, M.2    Hotz, C.3
  • 45
    • 70350381008 scopus 로고    scopus 로고
    • Chemokine (C-C motif ) ligand 2 engages CCR2+ stromal cells of monocytic origin to promote breast cancer metastasis to lung and bone
    • Lu X, Kang Y. Chemokine (C-C motif ) ligand 2 engages CCR2+ stromal cells of monocytic origin to promote breast cancer metastasis to lung and bone. J. Biol. Chem. 284(42), 29087-29096 (2009).
    • (2009) J. Biol. Chem. , vol.284 , Issue.42 , pp. 29087-29096
    • Lu, X.1    Kang, Y.2
  • 46
    • 3442901908 scopus 로고    scopus 로고
    • Colony-stimulating factor-1 blockade by antisense oligonucleotides and small interfering RNAs suppresses growth of human mammary tumor xenografts in mice
    • Aharinejad S, Paulus P, Sioud M et al. Colony-stimulating factor-1 blockade by antisense oligonucleotides and small interfering RNAs suppresses growth of human mammary tumor xenografts in mice. Cancer Res. 64(15), 5378-5384 (2004).
    • (2004) Cancer Res. , vol.64 , Issue.15 , pp. 5378-5384
    • Aharinejad, S.1    Paulus, P.2    Sioud, M.3
  • 47
    • 0033903714 scopus 로고    scopus 로고
    • Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer
    • Ueno T, Toi M, Saji H et al. Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer. Clin. Cancer Res. 6(8), 3282-3289 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , Issue.8 , pp. 3282-3289
    • Ueno, T.1    Toi, M.2    Saji, H.3
  • 48
    • 70249125819 scopus 로고    scopus 로고
    • Rapid release of cytoplasmic IL-15 from tumor-associated macrophages is an initial and critical event in IL-12-initiated tumor regression
    • Watkins SK, Li B, Richardson KS et al. Rapid release of cytoplasmic IL-15 from tumor-associated macrophages is an initial and critical event in IL-12-initiated tumor regression. Eur. J. Immunol. 39(8), 2126-2135 (2009).
    • (2009) Eur. J. Immunol. , vol.39 , Issue.8 , pp. 2126-2135
    • Watkins, S.K.1    Li, B.2    Richardson, K.S.3
  • 49
    • 36148960830 scopus 로고    scopus 로고
    • Inflammatory cell infiltration of tumors: Jekyll or Hyde
    • Talmadge JE, Donkor M, Scholar E. Inflammatory cell infiltration of tumors: Jekyll or Hyde. Cancer Metastasis Rev. 26(3-4), 373-400 (2007).
    • (2007) Cancer Metastasis Rev. , vol.26 , Issue.3-4 , pp. 373-400
    • Talmadge, J.E.1    Donkor, M.2    Scholar, E.3
  • 50
    • 34548545297 scopus 로고    scopus 로고
    • Inflammation and breast cancer. Microenvironmental factors regulating macrophage function in breast tumours: Hypoxia and angiopoietin-2
    • Lewis CE, Hughes R. Inflammation and breast cancer. Microenvironmental factors regulating macrophage function in breast tumours: hypoxia and angiopoietin-2. Breast Cancer Res. 9(3), 209 (2007).
    • (2007) Breast Cancer Res. , vol.9 , Issue.3 , pp. 209
    • Lewis, C.E.1    Hughes, R.2
  • 51
    • 45149134605 scopus 로고    scopus 로고
    • Re-educating tumor-associated macrophages by targeting NF-kB
    • Hagemann T, Lawrence T, McNeish I et al. Re-educating tumor-associated macrophages by targeting NF-kB. J. Exp. Med. 205(6), 1261-1268 (2008).
    • (2008) J. Exp. Med. , vol.205 , Issue.6 , pp. 1261-1268
    • Hagemann, T.1    Lawrence, T.2    McNeish, I.3
  • 52
    • 2142644409 scopus 로고    scopus 로고
    • Macrophage infiltration and angiogenesis in human malignancy
    • Knowles H, Leek R, Harris AL. Macrophage infiltration and angiogenesis in human malignancy. Novartis Found Symp. 256, 189-200 (2004).
    • (2004) Novartis Found Symp. , vol.256 , pp. 189-200
    • Knowles, H.1    Leek, R.2    Harris, A.L.3
  • 53
    • 0035863521 scopus 로고    scopus 로고
    • Absence of endothelial cells, central necrosis, and fibrosis are associated with aggressive inflammatory breast cancer
    • Shirakawa K, Tsuda H, Heike Y et al. Absence of endothelial cells, central necrosis, and fibrosis are associated with aggressive inflammatory breast cancer. Cancer Res. 61(2), 445-451 (2001).
    • (2001) Cancer Res. , vol.61 , Issue.2 , pp. 445-451
    • Shirakawa, K.1    Tsuda, H.2    Heike, Y.3
  • 54
    • 62449179631 scopus 로고    scopus 로고
    • Granulocyte macrophage colonystimulating factor inhibits breast cancer growth and metastasis by invoking an anti-angiogenic program in tumoreducated macrophages
    • Eubank TD, Roberts RD, Khan M et al. Granulocyte macrophage colonystimulating factor inhibits breast cancer growth and metastasis by invoking an anti-angiogenic program in tumoreducated macrophages. Cancer Res. 69(5), 2133-2140 (2009).
    • (2009) Cancer Res. , vol.69 , Issue.5 , pp. 2133-2140
    • Eubank, T.D.1    Roberts, R.D.2    Khan, M.3
  • 55
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: A leading role for STAT3
    • Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat. Rev. Cancer 9(11), 798-809 (2009).
    • (2009) Nat. Rev. Cancer , vol.9 , Issue.11 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 56
    • 17144398046 scopus 로고    scopus 로고
    • Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection
    • Guiducci C, Vicari AP, Sangaletti S, Trinchieri G, Colombo MP. Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection. Cancer Res. 65(8), 3437-3446 (2005).
    • (2005) Cancer Res. , vol.65 , Issue.8 , pp. 3437-3446
    • Guiducci, C.1    Vicari, A.P.2    Sangaletti, S.3    Trinchieri, G.4    Colombo, M.P.5
  • 57
    • 70349334303 scopus 로고    scopus 로고
    • SHIP represses the generation of IL-3-induced M2 macrophages by inhibiting IL-4 production from basophils
    • Kuroda E, Ho V, Ruschmann J et al. SHIP represses the generation of IL-3-induced M2 macrophages by inhibiting IL-4 production from basophils. J. Immunol. 183(6), 3652-3660 (2009).
    • (2009) J. Immunol. , vol.183 , Issue.6 , pp. 3652-3660
    • Kuroda, E.1    Ho, V.2    Ruschmann, J.3
  • 58
    • 63149160727 scopus 로고    scopus 로고
    • Regulation of macrophage function in tumors: The multifaceted role of NF-kB
    • Hagemann T, Biswas SK, Lawrence T, Sica A, Lewis CE. Regulation of macrophage function in tumors: the multifaceted role of NF-kB. Blood 113(14), 3139-3146 (2009).
    • (2009) Blood , vol.113 , Issue.14 , pp. 3139-3146
    • Hagemann, T.1    Biswas, S.K.2    Lawrence, T.3    Sica, A.4    Lewis, C.E.5
  • 59
    • 0034650833 scopus 로고    scopus 로고
    • Autocrine production of IL-10 mediates defective IL-12 production and NF-kB activation in tumor-associated macrophages
    • Sica A, Saccani A, Bottazzi B et al. Autocrine production of IL-10 mediates defective IL-12 production and NF-kB activation in tumor-associated macrophages. J. Immunol. 164(2), 762-767 (2000).
    • (2000) J. Immunol. , vol.164 , Issue.2 , pp. 762-767
    • Sica, A.1    Saccani, A.2    Bottazzi, B.3
  • 60
    • 70349275277 scopus 로고    scopus 로고
    • Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kB
    • Porta C, Rimoldi M, Raes G et al. Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kB. Proc. Natl Acad. Sci. USA 106(35), 14978-14983 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , Issue.35 , pp. 14978-14983
    • Porta, C.1    Rimoldi, M.2    Raes, G.3
  • 61
    • 33845752914 scopus 로고    scopus 로고
    • P50 nuclear factor-kB overexpression in tumor-associated macrophages inhibits M1 inflammatory responses and antitumor resistance
    • Saccani A, Schioppa T, Porta C et al. p50 nuclear factor-kB overexpression in tumor-associated macrophages inhibits M1 inflammatory responses and antitumor resistance. Cancer Res. 66(23), 11432-11440 (2006).
    • (2006) Cancer Res. , vol.66 , Issue.23 , pp. 11432-11440
    • Saccani, A.1    Schioppa, T.2    Porta, C.3
  • 62
    • 33344460032 scopus 로고    scopus 로고
    • A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kB and enhanced IRF-3/STAT1 activation)
    • Biswas SK, Gangi L, Paul S et al. A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kB and enhanced IRF-3/STAT1 activation). Blood 107(5), 2112-2122 (2006).
    • (2006) Blood , vol.107 , Issue.5 , pp. 2112-2122
    • Biswas, S.K.1    Gangi, L.2    Paul, S.3
  • 63
    • 34548805636 scopus 로고    scopus 로고
    • Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response
    • Sinha P, Clements VK, Bunt SK, Albelda SM, Ostrand-Rosenberg S. Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response. J. Immunol. 179(2), 977-983 (2007).
    • (2007) J. Immunol. , vol.179 , Issue.2 , pp. 977-983
    • Sinha, P.1    Clements, V.K.2    Bunt, S.K.3    Albelda, S.M.4    Ostrand-Rosenberg, S.5
  • 64
    • 3142644996 scopus 로고    scopus 로고
    • Tumour-associated macrophages as a prototypic type II polarised phagocyte population: Role in tumour progression
    • Mantovani A, Allavena P, Sica A. Tumour-associated macrophages as a prototypic type II polarised phagocyte population: role in tumour progression. Eur. J. Cancer 40(11), 1660-1667 (2004).
    • (2004) Eur. J. Cancer , vol.40 , Issue.11 , pp. 1660-1667
    • Mantovani, A.1    Allavena, P.2    Sica, A.3
  • 65
    • 67651160649 scopus 로고    scopus 로고
    • CD4+ T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages
    • DeNardo DG, Barreto JB, Andreu P et al. CD4+ T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell. 16(2), 91-102 (2009).
    • (2009) Cancer Cell. , vol.16 , Issue.2 , pp. 91-102
    • Denardo, D.G.1    Barreto, J.B.2    Andreu, P.3
  • 66
    • 33746718151 scopus 로고    scopus 로고
    • Targeting tumor-associated macrophages as a novel strategy against breast cancer
    • Luo Y, Zhou H, Krueger J et al. Targeting tumor-associated macrophages as a novel strategy against breast cancer. J. Clin. Invest. 116(8), 2132-2141 (2006).
    • (2006) J. Clin. Invest. , vol.116 , Issue.8 , pp. 2132-2141
    • Luo, Y.1    Zhou, H.2    Krueger, J.3
  • 67
    • 78049367774 scopus 로고    scopus 로고
    • Alternatively activated macrophages inhibit T cell proliferation by STAT6-dependent expression of PD-L2
    • Huber S, Hoffmann R, Muskens F, Voehringer D. Alternatively activated macrophages inhibit T cell proliferation by STAT6-dependent expression of PD-L2. Blood 116(17), 3311-3320 (2010).
    • (2010) Blood , vol.116 , Issue.17 , pp. 3311-3320
    • Huber, S.1    Hoffmann, R.2    Muskens, F.3    Voehringer, D.4
  • 68
    • 77956114905 scopus 로고    scopus 로고
    • Macrophage polarization to a unique phenotype driven by B cells
    • Wong SC, Puaux AL, Chittezhath M et al. Macrophage polarization to a unique phenotype driven by B cells. Eur. J. Immunol. 40(8), 2296-2307 (2010).
    • (2010) Eur. J. Immunol. , vol.40 , Issue.8 , pp. 2296-2307
    • Wong, S.C.1    Puaux, A.L.2    Chittezhath, M.3
  • 69
    • 0034796870 scopus 로고    scopus 로고
    • Development of tumor-infiltrating lymphocytes in breast cancer after neoadjuvant paclitaxel chemotherapy
    • Demaria S, Volm MD, Shapiro RL et al. Development of tumor-infiltrating lymphocytes in breast cancer after neoadjuvant paclitaxel chemotherapy. Clin. Cancer Res. 7(10), 3025-3030 (2001).
    • (2001) Clin. Cancer Res. , vol.7 , Issue.10 , pp. 3025-3030
    • Demaria, S.1    Volm, M.D.2    Shapiro, R.L.3
  • 70
    • 0021281497 scopus 로고
    • A high macrophage content in human breast cancer is not associated with favourable prognostic factors
    • Steele RJ, Eremin O, Brown M, Hawkins RA. A high macrophage content in human breast cancer is not associated with favourable prognostic factors. Br. J. Surg. 71(6), 456-458 (1984).
    • (1984) Br. J. Surg. , vol.71 , Issue.6 , pp. 456-458
    • Steele, R.J.1    Eremin, O.2    Brown, M.3    Hawkins, R.A.4
  • 71
    • 0021992964 scopus 로고
    • Characterisation of macrophages infiltrating human mammary carcinomas
    • Steele RJ, Brown M, Eremin O. Characterisation of macrophages infiltrating human mammary carcinomas. Br. J. Cancer 51(1), 135-138 (1985).
    • (1985) Br. J. Cancer , vol.51 , Issue.1 , pp. 135-138
    • Steele, R.J.1    Brown, M.2    Eremin, O.3
  • 72
    • 0031799041 scopus 로고    scopus 로고
    • Tumourassociated macrophages in breast cancer and their prognostic correlations
    • Volodko N, Rudas M, Jakesz R. Tumourassociated macrophages in breast cancer and their prognostic correlations. Breast 7(2), 99-105 (1998).
    • (1998) Breast , vol.7 , Issue.2 , pp. 99-105
    • Volodko, N.1    Rudas, M.2    Jakesz, R.3
  • 74
    • 0033067163 scopus 로고    scopus 로고
    • Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast
    • Leek RD, Landers RJ, Harris AL, Lewis CE. Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast. Br. J. Cancer 79(5-6), 991-995 (1999).
    • (1999) Br. J. Cancer , vol.79 , Issue.5-6 , pp. 991-995
    • Leek, R.D.1    Landers, R.J.2    Harris, A.L.3    Lewis, C.E.4
  • 75
    • 0029816609 scopus 로고    scopus 로고
    • Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma
    • Leek RD, Lewis CE, Whitehouse R, Greenall M, Clarke J, Harris AL. Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma. Cancer Res. 56(20), 4625-4629 (1996).
    • (1996) Cancer Res. , vol.56 , Issue.20 , pp. 4625-4629
    • Leek, R.D.1    Lewis, C.E.2    Whitehouse, R.3    Greenall, M.4    Clarke, J.5    Harris, A.L.6
  • 76
    • 0034021278 scopus 로고    scopus 로고
    • Macrophage infiltration is associated with VEGF and EGFR expression in breast cancer
    • Leek RD, Hunt NC, Landers RJ, Lewis CE, Royds JA, Harris AL. Macrophage infiltration is associated with VEGF and EGFR expression in breast cancer. J. Pathol. 190(4), 430-436 (2000).
    • (2000) J. Pathol. , vol.190 , Issue.4 , pp. 430-436
    • Leek, R.D.1    Hunt, N.C.2    Landers, R.J.3    Lewis, C.E.4    Royds, J.A.5    Harris, A.L.6
  • 77
    • 53049083445 scopus 로고    scopus 로고
    • The relationship between the systemic inflammatory response, tumour proliferative activity, T-lymphocytic and macrophage infiltration, microvessel density and survival in patients with primary operable breast cancer
    • Murri AM, Hilmy M, Bell J et al. The relationship between the systemic inflammatory response, tumour proliferative activity, T-lymphocytic and macrophage infiltration, microvessel density and survival in patients with primary operable breast cancer. Br. J. Cancer 99(7), 1013-1019 (2008).
    • (2008) Br. J. Cancer , vol.99 , Issue.7 , pp. 1013-1019
    • Murri, A.M.1    Hilmy, M.2    Bell, J.3
  • 78
    • 0029598463 scopus 로고
    • Clinicopathologic analysis of macrophage infiltrates in breast carcinoma
    • Visscher DW, Tabaczka P, Long D, Crissman JD. Clinicopathologic analysis of macrophage infiltrates in breast carcinoma. Pathol. Res. Pract. 191(11), 1133-1139 (1995).
    • (1995) Pathol. Res. Pract. , vol.191 , Issue.11 , pp. 1133-1139
    • Visscher, D.W.1    Tabaczka, P.2    Long, D.3    Crissman, J.D.4
  • 79
    • 33751098783 scopus 로고    scopus 로고
    • Microvessel density, VEGF expression, and tumor-associated macrophages in breast tumors: Correlations with prognostic parameters
    • Bolat F, Kayaselcuk F, Nursal TZ, Yagmurdur MC, Bal N, Demirhan B. Microvessel density, VEGF expression, and tumor-associated macrophages in breast tumors: correlations with prognostic parameters. J. Exp. Clin. Cancer Res. 25(3), 365-372 (2006).
    • (2006) J. Exp. Clin. Cancer Res. , vol.25 , Issue.3 , pp. 365-372
    • Bolat, F.1    Kayaselcuk, F.2    Nursal, T.Z.3    Yagmurdur, M.C.4    Bal, N.5    Demirhan, B.6
  • 81
    • 33750587397 scopus 로고    scopus 로고
    • Magnetic resonance imaging captures the biology of ductal carcinoma in situ
    • Esserman LJ, Kumar AS, Herrera AF et al. Magnetic resonance imaging captures the biology of ductal carcinoma in situ. J. Clin. Oncol. 24(28), 4603-4610 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , Issue.28 , pp. 4603-4610
    • Esserman, L.J.1    Kumar, A.S.2    Herrera, A.F.3
  • 82
    • 0026520603 scopus 로고
    • PCNA and Ki67 expression in breast carcinoma: Correlations with clinical and biological variables
    • Leonardi E, Girlando S, Serio G et al. PCNA and Ki67 expression in breast carcinoma: correlations with clinical and biological variables. J. Clin. Pathol. 45(5), 416-419 (1992).
    • (1992) J. Clin. Pathol. , vol.45 , Issue.5 , pp. 416-419
    • Leonardi, E.1    Girlando, S.2    Serio, G.3
  • 83
    • 0034865355 scopus 로고    scopus 로고
    • Local macrophage proliferation correlates with increased renal M-CSF expression in human glomerulonephritis
    • Isbel NM, Nikolic-Paterson DJ, Hill PA, Dowling J, Atkins RC. Local macrophage proliferation correlates with increased renal M-CSF expression in human glomerulonephritis. Nephrol. Dial. Transplant. 16(8), 1638-1647 (2001).
    • (2001) Nephrol. Dial. Transplant. , vol.16 , Issue.8 , pp. 1638-1647
    • Isbel, N.M.1    Nikolic-Paterson, D.J.2    Hill, P.A.3    Dowling, J.4    Atkins, R.C.5
  • 84
    • 0036792136 scopus 로고    scopus 로고
    • Injection of human primary effusion lymphoma cells or associated macrophages into severe combined immunodeficient mice causes murine lymphomas
    • Zenger E, Abbey NW, Weinstein MD et al. Injection of human primary effusion lymphoma cells or associated macrophages into severe combined immunodeficient mice causes murine lymphomas. Cancer Res. 62(19), 5536-5542 (2002).
    • (2002) Cancer Res. , vol.62 , Issue.19 , pp. 5536-5542
    • Zenger, E.1    Abbey, N.W.2    Weinstein, M.D.3
  • 85
    • 84887212459 scopus 로고    scopus 로고
    • Differences in the tumor microenvironment between African-American and European- American breast cancer patients
    • Martin DN, Boersma BJ, Yi M et al. Differences in the tumor microenvironment between African-American and European- American breast cancer patients. PLoS ONE 4(2), e4531 (2009).
    • (2009) PLoS ONE , vol.4 , Issue.2
    • Martin, D.N.1    Boersma, B.J.2    Yi, M.3
  • 86
    • 0031032895 scopus 로고    scopus 로고
    • Breast cancer stage at diagnosis: Caucasians versus Hispanics
    • Zaloznik AJ. Breast cancer stage at diagnosis: Caucasians versus Hispanics. Breast Cancer Res. Treat. 42(2), 121-124 (1997).
    • (1997) Breast Cancer Res. Treat. , vol.42 , Issue.2 , pp. 121-124
    • Zaloznik, A.J.1
  • 87
    • 77952633935 scopus 로고    scopus 로고
    • Breast cancer in Latinas: Gene expression, differential response to treatments, and differential toxicities in Latinas compared with other population groups
    • Patel TA, Colon-Otero G, Bueno Hume C, Copland JA 3rd, Perez EA. Breast cancer in Latinas: gene expression, differential response to treatments, and differential toxicities in Latinas compared with other population groups. Oncologist 15(5), 466-475 (2010).
    • (2010) Oncologist , vol.15 , Issue.5 , pp. 466-475
    • Patel, T.A.1    Colon-Otero, G.2    Bueno Hume, C.3    Copland III, J.A.4    Perez, E.A.5
  • 88
    • 78650545153 scopus 로고    scopus 로고
    • Evaluation of levels of proliferating macrophages in patients at a county hospital and those with early recurrences
    • Chicago, IL, USA, 4-8 June 2010.
    • Mukhtar R, Moore A, Nseyo O et al. Evaluation of levels of proliferating macrophages in patients at a county hospital and those with early recurrences. Presented at: ASCO Annual Meeting Proceedings. Chicago, IL, USA, 4-8 June 2010.
    • Presented At: ASCO Annual Meeting Proceedings
    • Mukhtar, R.1    Moore, A.2    Nseyo, O.3
  • 90
    • 77749264278 scopus 로고    scopus 로고
    • Alternatively activated macrophages and collagen remodeling characterize the postpartum involuting mammary gland across species
    • OBrien J, Lyons T, Monks J et al. Alternatively activated macrophages and collagen remodeling characterize the postpartum involuting mammary gland across species. Am. J. Pathol. 176(3), 1241-1255 (2010).
    • (2010) Am. J. Pathol. , vol.176 , Issue.3 , pp. 1241-1255
    • Obrien, J.1    Lyons, T.2    Monks, J.3
  • 91
    • 67649233612 scopus 로고    scopus 로고
    • Macrophages in breast cancer: Do involution macrophages account for the poor prognosis of pregnancy-associated breast cancer?
    • OBrien J, Schedin P. Macrophages in breast cancer: do involution macrophages account for the poor prognosis of pregnancy-associated breast cancer? J. Mammary Gland Biol. Neoplasia 14(2), 145-157 (2009).
    • (2009) J. Mammary Gland Biol. Neoplasia , vol.14 , Issue.2 , pp. 145-157
    • Obrien, J.1    Schedin, P.2
  • 92
    • 47049108919 scopus 로고    scopus 로고
    • Breast cancer expression of CD163, a macrophage scavenger receptor, is related to early distant recurrence and reduced patient survival
    • Shabo I, Stal O, Olsson H, Dore S, Svanvik J. Breast cancer expression of CD163, a macrophage scavenger receptor, is related to early distant recurrence and reduced patient survival. Int. J. Cancer 123(4), 780-786 (2008).
    • (2008) Int. J. Cancer , vol.123 , Issue.4 , pp. 780-786
    • Shabo, I.1    Stal, O.2    Olsson, H.3    Dore, S.4    Svanvik, J.5
  • 93
    • 20044387192 scopus 로고    scopus 로고
    • Macrophage galactose-type C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation
    • Raes G, Brys L, Dahal BK et al. Macrophage galactose-type C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation. J. Leukoc. Biol. 77(3), 321-327 (2005).
    • (2005) J. Leukoc. Biol. , vol.77 , Issue.3 , pp. 321-327
    • Raes, G.1    Brys, L.2    Dahal, B.K.3
  • 94
    • 33947416133 scopus 로고    scopus 로고
    • Squamous differentiation in primary urothelial carcinoma of the urinary tract as seen by MAC387 immunohistochemistry
    • Lopez-Beltran A, Requena MJ, Alvarez- Kindelan J, Quintero A, Blanca A, Montironi R. Squamous differentiation in primary urothelial carcinoma of the urinary tract as seen by MAC387 immunohistochemistry. J. Clin. Pathol. 60(3), 332-335 (2007).
    • (2007) J. Clin. Pathol. , vol.60 , Issue.3 , pp. 332-335
    • Lopez-Beltran, A.1    Requena, M.J.2    Alvarez- Kindelan, J.3    Quintero, A.4    Blanca, A.5    Montironi, R.6
  • 95
    • 1642576136 scopus 로고    scopus 로고
    • Macrophage colony-stimulating factor-1 receptor expression is associated with poor outcome in breast cancer by large cohort tissue microarray analysis
    • Kluger HM, Dolled-Filhart M, Rodov S, Kacinski BM, Camp RL, Rimm DL. Macrophage colony-stimulating factor-1 receptor expression is associated with poor outcome in breast cancer by large cohort tissue microarray analysis. Clin. Cancer Res. 10(1 Pt 1), 173-177 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , Issue.1 PART 1 , pp. 173-177
    • Kluger, H.M.1    Dolled-Filhart, M.2    Rodov, S.3    Kacinski, B.M.4    Camp, R.L.5    Rimm, D.L.6
  • 96
    • 76549119724 scopus 로고    scopus 로고
    • La mala educacin of tumor-associated macrophages: Diverse pathways and new players
    • Mantovani A. La mala educacin of tumor-associated macrophages: diverse pathways and new players. Cancer Cell 17(2), 111-112 (2010).
    • (2010) Cancer Cell , vol.17 , Issue.2 , pp. 111-112
    • Mantovani, A.1
  • 97
    • 17044403497 scopus 로고    scopus 로고
    • Macrophage colony-stimulating factor receptor c-Fms is a novel target of imatinib
    • Dewar AL, Cambareri AC, Zannettino AC et al. Macrophage colony-stimulating factor receptor c-Fms is a novel target of imatinib. Blood 105(8), 3127-3132 (2005).
    • (2005) Blood , vol.105 , Issue.8 , pp. 3127-3132
    • Dewar, A.L.1    Cambareri, A.C.2    Zannettino, A.C.3
  • 98
    • 58149395521 scopus 로고    scopus 로고
    • Imatinib mesylate suppresses bone metastases of breast cancer by inhibiting osteoclasts through the blockade of c-Fms signals
    • Hiraga T, Nakamura H. Imatinib mesylate suppresses bone metastases of breast cancer by inhibiting osteoclasts through the blockade of c-Fms signals. Int. J. Cancer 124(1), 215-222 (2009).
    • (2009) Int. J. Cancer , vol.124 , Issue.1 , pp. 215-222
    • Hiraga, T.1    Nakamura, H.2
  • 99
    • 33845214085 scopus 로고    scopus 로고
    • A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model
    • Ohno H, Kubo K, Murooka H et al. A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model. Mol. Cancer Ther. 5(11), 2634-2643 (2006).
    • (2006) Mol. Cancer Ther. , vol.5 , Issue.11 , pp. 2634-2643
    • Ohno, H.1    Kubo, K.2    Murooka, H.3
  • 100
    • 70949104409 scopus 로고    scopus 로고
    • JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/ FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia
    • Manthey CL, Johnson DL, Illig CR et al. JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/ FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia. Mol. Cancer Ther. 8(11), 3151-3161 (2009).
    • (2009) Mol. Cancer Ther. , vol.8 , Issue.11 , pp. 3151-3161
    • Manthey, C.L.1    Johnson, D.L.2    Illig, C.R.3
  • 102
    • 71049158817 scopus 로고    scopus 로고
    • Optical imaging of the peri-tumoral inflammatory response in breast cancer
    • Sista AK, Knebel RJ, Tavri S et al. Optical imaging of the peri-tumoral inflammatory response in breast cancer. J. Transl. Med. 7, 2009
    • (2009) J. Transl. Med. , vol.7
    • Sista, A.K.1    Knebel, R.J.2    Tavri, S.3
  • 104
    • 28544446111 scopus 로고    scopus 로고
    • Monocyte and macrophage heterogeneity
    • Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nat. Rev. Immunol. 5(12), 953-964 (2005).
    • (2005) Nat. Rev. Immunol. , vol.5 , Issue.12 , pp. 953-964
    • Gordon, S.1    Taylor, P.R.2
  • 105
    • 34248172324 scopus 로고    scopus 로고
    • Altered macrophage differentiation and immune dysfunction in tumor development
    • Sica A, Bronte V. Altered macrophage differentiation and immune dysfunction in tumor development. J. Clin. Invest. 117(5), 1155-1166 (2007).
    • (2007) J. Clin. Invest. , vol.117 , Issue.5 , pp. 1155-1166
    • Sica, A.1    Bronte, V.2
  • 106
    • 46749137580 scopus 로고    scopus 로고
    • Epigenetic control of MHC class II expression in tumor-associated macrophages by decoy receptor 3
    • Chang YC, Chen TC, Lee CT et al. Epigenetic control of MHC class II expression in tumor-associated macrophages by decoy receptor 3. Blood 111(10), 5054-5063 (2008).
    • (2008) Blood , vol.111 , Issue.10 , pp. 5054-5063
    • Chang, Y.C.1    Chen, T.C.2    Lee, C.T.3
  • 108
    • 0029745365 scopus 로고    scopus 로고
    • Interleukin-4-induced macrophage fusion is prevented by inhibitors of mannose receptor activity
    • McNally AK, DeFife KM, Anderson JM. Interleukin-4-induced macrophage fusion is prevented by inhibitors of mannose receptor activity. Am. J. Pathol. 149(3), 975-985 (1996).
    • (1996) Am. J. Pathol. , vol.149 , Issue.3 , pp. 975-985
    • McNally, A.K.1    Defife, K.M.2    Anderson, J.M.3
  • 109
    • 0842346188 scopus 로고    scopus 로고
    • Regulation of myeloid development and function by colony stimulating factors
    • Barreda DR, Hanington PC, Belosevic M. Regulation of myeloid development and function by colony stimulating factors. Dev. Comp. Immunol. 28(5), 509-554 (2004).
    • (2004) Dev. Comp. Immunol. , vol.28 , Issue.5 , pp. 509-554
    • Barreda, D.R.1    Hanington, P.C.2    Belosevic, M.3
  • 110
    • 0036839143 scopus 로고    scopus 로고
    • Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    • Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 23(11), 549-555 (2002).
    • (2002) Trends Immunol. , vol.23 , Issue.11 , pp. 549-555
    • Mantovani, A.1    Sozzani, S.2    Locati, M.3    Allavena, P.4    Sica, A.5
  • 111
    • 70350529527 scopus 로고    scopus 로고
    • Functional plasticity of macrophages: In situ reprogramming of tumor-associated macrophages
    • Stout RD, Watkins SK, Suttles J. Functional plasticity of macrophages: in situ reprogramming of tumor-associated macrophages. J. Leukoc. Biol. 86(5), 1105-109 (2009).
    • (2009) J. Leukoc. Biol. , vol.86 , Issue.5 , pp. 1105-109
    • Stout, R.D.1    Watkins, S.K.2    Suttles, J.3
  • 112
    • 7644231561 scopus 로고    scopus 로고
    • The chemokine system in diverse forms of macrophage activation and polarization
    • Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 25(12), 677-686 (2004).
    • (2004) Trends Immunol. , vol.25 , Issue.12 , pp. 677-686
    • Mantovani, A.1    Sica, A.2    Sozzani, S.3    Allavena, P.4    Vecchi, A.5    Locati, M.6
  • 113
    • 51349098155 scopus 로고    scopus 로고
    • Cytokines as a key component of cancerrelated inflammation
    • Germano G, Allavena P, Mantovani A. Cytokines as a key component of cancerrelated inflammation. Cytokine 43(3), 374-379 (2008)
    • (2008) Cytokine , vol.43 , Issue.3 , pp. 374-379
    • Germano, G.1    Allavena, P.2    Mantovani, A.3


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