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Volumn 69, Issue 2, 2011, Pages 146-156

Epigenetic studies of psychosis: Current findings, methodological approaches, and implications for postmortem research

Author keywords

Bipolar disorder; brain; DNA methylation; epigenetics; histone modification; postmortem; schizophrenia

Indexed keywords

DNA METHYLTRANSFERASE; HISTONE DEACETYLASE;

EID: 78650429158     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2010.03.029     Document Type: Review
Times cited : (99)

References (129)
  • 1
    • 30344447674 scopus 로고    scopus 로고
    • Genes for schizophrenia and bipolar disorder?: Implications for psychiatric nosology
    • N. Craddock, M.C. O'Donovan, and M.J. Owen Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology Schizophr Bull 32 2006 9 16
    • (2006) Schizophr Bull , vol.32 , pp. 9-16
    • Craddock, N.1    O'Donovan, M.C.2    Owen, M.J.3
  • 4
    • 0344305525 scopus 로고    scopus 로고
    • Schizophrenia as a complex trait: Evidence from a meta-analysis of twin studies
    • P.F. Sullivan, K.S. Kendler, and M.C. Neale Schizophrenia as a complex trait: Evidence from a meta-analysis of twin studies Arch Gen Psychiatry 60 2003 1187 1192
    • (2003) Arch Gen Psychiatry , vol.60 , pp. 1187-1192
    • Sullivan, P.F.1    Kendler, K.S.2    Neale, M.C.3
  • 5
    • 0031939076 scopus 로고    scopus 로고
    • The genetic epidemiology of schizophrenia in a Finnish twin cohort: A population-based modeling study
    • T.D. Cannon, J. Kaprio, J. Lonnqvist, M. Huttunen, and M. Koskenvuo The genetic epidemiology of schizophrenia in a Finnish twin cohort A population-based modeling study Arch Gen Psychiatry 55 1998 67 74
    • (1998) Arch Gen Psychiatry , vol.55 , pp. 67-74
    • Cannon, T.D.1    Kaprio, J.2    Lonnqvist, J.3    Huttunen, M.4    Koskenvuo, M.5
  • 6
    • 0037629099 scopus 로고    scopus 로고
    • The heritability of bipolar affective disorder and the genetic relationship to unipolar depression
    • P. McGuffin, F. Rijsdijk, M. Andrew, P. Sham, R. Katz, and A. Cardno The heritability of bipolar affective disorder and the genetic relationship to unipolar depression Arch Gen Psychiatry 60 2003 497 502
    • (2003) Arch Gen Psychiatry , vol.60 , pp. 497-502
    • McGuffin, P.1    Rijsdijk, F.2    Andrew, M.3    Sham, P.4    Katz, R.5    Cardno, A.6
  • 7
    • 4744342062 scopus 로고    scopus 로고
    • High concordance of bipolar i disorder in a nationwide sample of twins
    • T. Kieseppa, T. Partonen, J. Haukka, J. Kaprio, and J. Lonnqvist High concordance of bipolar I disorder in a nationwide sample of twins Am J Psychiatry 161 2004 1814 1821
    • (2004) Am J Psychiatry , vol.161 , pp. 1814-1821
    • Kieseppa, T.1    Partonen, T.2    Haukka, J.3    Kaprio, J.4    Lonnqvist, J.5
  • 8
    • 0041884746 scopus 로고    scopus 로고
    • Catechol O-methyltransferase (COMT) mRNA expression in the dorsolateral prefrontal cortex of patients with schizophrenia
    • M. Matsumoto, C.S. Weickert, S. Beltaifa, B. Kolachana, J. Chen, and T.M. Hyde Catechol O-methyltransferase (COMT) mRNA expression in the dorsolateral prefrontal cortex of patients with schizophrenia Neuropsychopharmacology 28 2003 1521 1530
    • (2003) Neuropsychopharmacology , vol.28 , pp. 1521-1530
    • Matsumoto, M.1    Weickert, C.S.2    Beltaifa, S.3    Kolachana, B.4    Chen, J.5    Hyde, T.M.6
  • 9
    • 0036347948 scopus 로고    scopus 로고
    • Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus: Brain-derived neurotrophic factor
    • P. Sklar, S.B. Gabriel, M.G. McInnis, P. Bennett, Y.M. Lim, and G. Tsan Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus Brain-derived neurotrophic factor Mol Psychiatry 7 2002 579 593
    • (2002) Mol Psychiatry , vol.7 , pp. 579-593
    • Sklar, P.1    Gabriel, S.B.2    McInnis, M.G.3    Bennett, P.4    Lim, Y.M.5    Tsan, G.6
  • 10
    • 0036724341 scopus 로고    scopus 로고
    • The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: Evidence from a family-based association study
    • M. Neves-Pereira, E. Mundo, P. Muglia, N. King, F. Macciardi, and J.L. Kennedy The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: Evidence from a family-based association study Am J Hum Genet 71 2002 651 655
    • (2002) Am J Hum Genet , vol.71 , pp. 651-655
    • Neves-Pereira, M.1    Mundo, E.2    Muglia, P.3    King, N.4    MacCiardi, F.5    Kennedy, J.L.6
  • 11
    • 33750208670 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor (BDNF) gene and rapid-cycling bipolar disorder: Family-based association study
    • D.J. Muller, V. de Luca, T. Sicard, N. King, J. Strauss, and J.L. Kennedy Brain-derived neurotrophic factor (BDNF) gene and rapid-cycling bipolar disorder: Family-based association study Br J Psychiatry 189 2006 317 323
    • (2006) Br J Psychiatry , vol.189 , pp. 317-323
    • Muller, D.J.1    De Luca, V.2    Sicard, T.3    King, N.4    Strauss, J.5    Kennedy, J.L.6
  • 12
    • 77953292719 scopus 로고    scopus 로고
    • An association study of DRD2 gene polymorphisms with schizophrenia in a Chinese Han population [published online ahead of print November 12]
    • H. Fan, F. Zhang, Y. Xu, X. Huang, G. Sun, and Y. Song An association study of DRD2 gene polymorphisms with schizophrenia in a Chinese Han population [published online ahead of print November 12] Neurosci Lett 2009 10.1016/j.neulet.2009.11.017
    • (2009) Neurosci Lett
    • Fan, H.1    Zhang, F.2    Xu, Y.3    Huang, X.4    Sun, G.5    Song, Y.6
  • 13
    • 18244407076 scopus 로고    scopus 로고
    • Positive association of dopamine D2 receptor polymorphism with bipolar affective disorder in a European Multicenter Association Study of affective disorders
    • I. Massat, D. Souery, J. Del-Favero, S. Van Gestel, A. Serretti, and F. Macciardi Positive association of dopamine D2 receptor polymorphism with bipolar affective disorder in a European Multicenter Association Study of affective disorders Am J Med Genet 114 2002 177 185
    • (2002) Am J Med Genet , vol.114 , pp. 177-185
    • Massat, I.1    Souery, D.2    Del-Favero, J.3    Van Gestel, S.4    Serretti, A.5    MacCiardi, F.6
  • 14
    • 20944446077 scopus 로고    scopus 로고
    • Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: Longitudinal evidence of a gene × environment interaction
    • A. Caspi, T.E. Moffitt, M. Cannon, J. McClay, R. Murray, and H. Harrington Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: Longitudinal evidence of a gene × environment interaction Biol Psychiatry 57 2005 1117 1127
    • (2005) Biol Psychiatry , vol.57 , pp. 1117-1127
    • Caspi, A.1    Moffitt, T.E.2    Cannon, M.3    McClay, J.4    Murray, R.5    Harrington, H.6
  • 16
    • 50449089356 scopus 로고    scopus 로고
    • Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
    • M.A. Ferreira, M.C. O'Donovan, Y.A. Meng, I.R. Jones, D.M. Ruderfer, and L. Jones Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder Nat Genet 40 2008 1056 1058
    • (2008) Nat Genet , vol.40 , pp. 1056-1058
    • Ferreira, M.A.1    O'Donovan, M.C.2    Meng, Y.A.3    Jones, I.R.4    Ruderfer, D.M.5    Jones, L.6
  • 18
    • 33744458952 scopus 로고    scopus 로고
    • Molecular genetic studies of schizophrenia
    • B. Riley, and K.S. Kendler Molecular genetic studies of schizophrenia Eur J Hum Genet 14 2006 669 680
    • (2006) Eur J Hum Genet , vol.14 , pp. 669-680
    • Riley, B.1    Kendler, K.S.2
  • 19
    • 33846160926 scopus 로고    scopus 로고
    • Molecular genetics of bipolar disorder and depression
    • T. Kato Molecular genetics of bipolar disorder and depression Psychiatry Clin Neurosci 61 2007 3 19
    • (2007) Psychiatry Clin Neurosci , vol.61 , pp. 3-19
    • Kato, T.1
  • 20
    • 67651108762 scopus 로고    scopus 로고
    • Genetics of psychosis; Insights from views across the genome
    • M.C. O'Donovan, N.J. Craddock, and M.J. Owen Genetics of psychosis; insights from views across the genome Hum Genet 126 2009 3 12
    • (2009) Hum Genet , vol.126 , pp. 3-12
    • O'Donovan, M.C.1    Craddock, N.J.2    Owen, M.J.3
  • 21
    • 70449724778 scopus 로고    scopus 로고
    • Copy-number variants in neurodevelopmental disorders: Promises and challenges
    • A.K. Merikangas, A.P. Corvin, and L. Gallagher Copy-number variants in neurodevelopmental disorders: Promises and challenges Trends Genet 25 2009 536 544
    • (2009) Trends Genet , vol.25 , pp. 536-544
    • Merikangas, A.K.1    Corvin, A.P.2    Gallagher, L.3
  • 22
    • 84870892855 scopus 로고    scopus 로고
    • The relevance of epigenetics to Major psychosis
    • J. Mill, and A. Petronis The relevance of epigenetics to Major psychosis A.C. Ferguson-Smith, J.M. Greally, R.A. Meartienssen, Epigenomics 2009 Springer Amsterdam
    • (2009) Epigenomics
    • Mill, J.1    Petronis, A.2
  • 23
    • 0242322769 scopus 로고    scopus 로고
    • Epigenetics and bipolar disorder: New opportunities and challenges
    • A. Petronis Epigenetics and bipolar disorder: New opportunities and challenges Am J Med Genet C Semin Med Genet 123C 2003 65 75
    • (2003) Am J Med Genet C Semin Med Genet , vol.123 , pp. 65-75
    • Petronis, A.1
  • 24
    • 0031201685 scopus 로고    scopus 로고
    • Exploring and explaining epigenetic effects
    • S. Henikoff, and M.A. Matzke Exploring and explaining epigenetic effects Trends Genet 13 1997 293 295
    • (1997) Trends Genet , vol.13 , pp. 293-295
    • Henikoff, S.1    Matzke, M.A.2
  • 25
    • 0036733675 scopus 로고    scopus 로고
    • Chromatin modification and epigenetic reprogramming in mammalian development
    • E. Li Chromatin modification and epigenetic reprogramming in mammalian development Nat Rev Genet 3 2002 662 673
    • (2002) Nat Rev Genet , vol.3 , pp. 662-673
    • Li, E.1
  • 26
    • 33947310031 scopus 로고    scopus 로고
    • Environmental epigenomics and disease susceptibility
    • R.L. Jirtle, and M.K. Skinner Environmental epigenomics and disease susceptibility Nat Rev Genet 8 2007 253 262
    • (2007) Nat Rev Genet , vol.8 , pp. 253-262
    • Jirtle, R.L.1    Skinner, M.K.2
  • 27
    • 78650509719 scopus 로고    scopus 로고
    • Brain weight in males is correlated with DNA methylation at IGF2 [published online ahead of print December 15]
    • R. Pidsley, E.L. Dempster, and J. Mill Brain weight in males is correlated with DNA methylation at IGF2 [published online ahead of print December 15] Mol Psychiatry 2009
    • (2009) Mol Psychiatry
    • Pidsley, R.1    Dempster, E.L.2    Mill, J.3
  • 28
    • 57649239938 scopus 로고    scopus 로고
    • Decoding the epigenetic language of neuronal plasticity
    • E. Borrelli, E.J. Nestler, C.D. Allis, and P. Sassone-Corsi Decoding the epigenetic language of neuronal plasticity Neuron 60 2008 961 974
    • (2008) Neuron , vol.60 , pp. 961-974
    • Borrelli, E.1    Nestler, E.J.2    Allis, C.D.3    Sassone-Corsi, P.4
  • 29
    • 68649088591 scopus 로고    scopus 로고
    • Regulation of chromatin structure in memory formation
    • T.L. Roth, and J.D. Sweatt Regulation of chromatin structure in memory formation Curr Opin Neurobiol 19 2009 336 342
    • (2009) Curr Opin Neurobiol , vol.19 , pp. 336-342
    • Roth, T.L.1    Sweatt, J.D.2
  • 30
    • 48149096013 scopus 로고    scopus 로고
    • Epigenetic mechanisms in drug addiction
    • W. Renthal, and E.J. Nestler Epigenetic mechanisms in drug addiction Trends Mol Med 14 2008 341 350
    • (2008) Trends Mol Med , vol.14 , pp. 341-350
    • Renthal, W.1    Nestler, E.J.2
  • 31
    • 67649185049 scopus 로고    scopus 로고
    • Genetics, environmental factors and the emerging role of epigenetics in neurodegenerative diseases
    • L. Migliore, and F. Coppede Genetics, environmental factors and the emerging role of epigenetics in neurodegenerative diseases Mutat Res 667 2009 82 97
    • (2009) Mutat Res , vol.667 , pp. 82-97
    • Migliore, L.1    Coppede, F.2
  • 34
    • 77950627166 scopus 로고    scopus 로고
    • Histone modifications, DNA methylation, and schizophrenia
    • D.P. Gavin, and R.P. Sharma Histone modifications, DNA methylation, and schizophrenia Neurosci Biobehav Rev 34 2010 882 888
    • (2010) Neurosci Biobehav Rev , vol.34 , pp. 882-888
    • Gavin, D.P.1    Sharma, R.P.2
  • 35
    • 68549111206 scopus 로고    scopus 로고
    • Epigenetic profiling in schizophrenia and major mental disorders
    • K. Iwamoto, and T. Kato Epigenetic profiling in schizophrenia and major mental disorders Neuropsychobiology 60 2009 5 11
    • (2009) Neuropsychobiology , vol.60 , pp. 5-11
    • Iwamoto, K.1    Kato, T.2
  • 36
    • 32344450824 scopus 로고    scopus 로고
    • Genomic DNA methylation: The mark and its mediators
    • R.J. Klose, and A.P. Bird Genomic DNA methylation: The mark and its mediators Trends Biochem Sci 31 2006 89 97
    • (2006) Trends Biochem Sci , vol.31 , pp. 89-97
    • Klose, R.J.1    Bird, A.P.2
  • 37
    • 0022540321 scopus 로고
    • CpG-rich islands and the function of DNA methylation
    • A.P. Bird CpG-rich islands and the function of DNA methylation Nature 321 1986 209 213
    • (1986) Nature , vol.321 , pp. 209-213
    • Bird, A.P.1
  • 38
    • 0037372003 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals
    • R. Jaenisch, and A. Bird Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals Nat Genet 33 suppl 2003 245 254
    • (2003) Nat Genet , vol.33 , Issue.SUPPL. , pp. 245-254
    • Jaenisch, R.1    Bird, A.2
  • 39
    • 33747879037 scopus 로고    scopus 로고
    • Abnormal CpG island methylation occurs during in vitro differentiation of human embryonic stem cells
    • Y. Shen, J. Chow, Z. Wang, and G. Fan Abnormal CpG island methylation occurs during in vitro differentiation of human embryonic stem cells Hum Mol Genet 15 2006 2623 2635
    • (2006) Hum Mol Genet , vol.15 , pp. 2623-2635
    • Shen, Y.1    Chow, J.2    Wang, Z.3    Fan, G.4
  • 40
    • 0032702598 scopus 로고    scopus 로고
    • Role of covalent modifications of histones in regulating gene expression
    • V.A. Spencer, and J.R. Davie Role of covalent modifications of histones in regulating gene expression Gene 240 1999 1 12
    • (1999) Gene , vol.240 , pp. 1-12
    • Spencer, V.A.1    Davie, J.R.2
  • 41
    • 34249299791 scopus 로고    scopus 로고
    • The complex language of chromatin regulation during transcription
    • S.L. Berger The complex language of chromatin regulation during transcription Nature 447 2007 407 412
    • (2007) Nature , vol.447 , pp. 407-412
    • Berger, S.L.1
  • 42
    • 33845755946 scopus 로고    scopus 로고
    • Heterochromatin revisited
    • S.I. Grewal, and S. Jia Heterochromatin revisited Nat Rev Genet 8 2007 35 46
    • (2007) Nat Rev Genet , vol.8 , pp. 35-46
    • Grewal, S.I.1    Jia, S.2
  • 43
    • 58149316420 scopus 로고    scopus 로고
    • Epigenetic regulation in human brain-focus on histone lysine methylation
    • S. Akbarian, and H.S. Huang Epigenetic regulation in human brain-focus on histone lysine methylation Biol Psychiatry 65 2009 198 203
    • (2009) Biol Psychiatry , vol.65 , pp. 198-203
    • Akbarian, S.1    Huang, H.S.2
  • 44
    • 33644946604 scopus 로고    scopus 로고
    • HATs and HDACs in neurodegeneration: A tale of disconcerted acetylation homeostasis
    • R.N. Saha, and K. Pahan HATs and HDACs in neurodegeneration: A tale of disconcerted acetylation homeostasis Cell Death Differ 13 2006 539 550
    • (2006) Cell Death Differ , vol.13 , pp. 539-550
    • Saha, R.N.1    Pahan, K.2
  • 45
    • 0034060459 scopus 로고    scopus 로고
    • Twin studies of schizophrenia: From bow-and-arrow concordances to star wars Mx and functional genomics
    • A.G. Cardno, and I.I. Gottesman Twin studies of schizophrenia: From bow-and-arrow concordances to star wars Mx and functional genomics Am J Med Genet 97 2000 12 17
    • (2000) Am J Med Genet , vol.97 , pp. 12-17
    • Cardno, A.G.1    Gottesman, I.I.2
  • 46
    • 0012114353 scopus 로고    scopus 로고
    • Genetics of affective disorders
    • I. Jones, L. Kent, and N. Craddock Genetics of affective disorders P. McGuffin, M.J. Owen, I.I. Gottesman, Psychiatric Genetics and Genomics 2002 Oxford University Press Oxford 211 246
    • (2002) Psychiatric Genetics and Genomics , pp. 211-246
    • Jones, I.1    Kent, L.2    Craddock, N.3
  • 49
    • 33745039815 scopus 로고    scopus 로고
    • Evidence for monozygotic twin (MZ) discordance in methylation level at two CpG sites in the promoter region of the catechol-O-methyltransferase (COMT) gene
    • J. Mill, E. Dempster, A. Caspi, B. Williams, T. Moffitt, and I. Craig Evidence for monozygotic twin (MZ) discordance in methylation level at two CpG sites in the promoter region of the catechol-O-methyltransferase (COMT) gene Am J Med Genet B Neuropsychiatr Genet 141 2006 421 425
    • (2006) Am J Med Genet B Neuropsychiatr Genet , vol.141 , pp. 421-425
    • Mill, J.1    Dempster, E.2    Caspi, A.3    Williams, B.4    Moffitt, T.5    Craig, I.6
  • 50
    • 17444403604 scopus 로고    scopus 로고
    • Phenotypic differences in genetically identical organisms: The epigenetic perspective
    • A.H. Wong, and I.I. Gottesman PA Phenotypic differences in genetically identical organisms: The epigenetic perspective Hum Mol Genet 14 2005 R11 R18
    • (2005) Hum Mol Genet , vol.14
    • Wong, A.H.1    Gottesman, P.A.I.I.2
  • 51
    • 84870892855 scopus 로고    scopus 로고
    • The relevance of epigenetics to major psychosis
    • J Mill, and A Petronis The relevance of epigenetics to major psychosis A. Ferguson-Smith, J. Greally, R. Martienssen, Epigenomics 2009 Springer Dordrecht, The Netherlands 411 434
    • (2009) Epigenomics , pp. 411-434
    • Mill, J.1    Petronis, A.2
  • 52
    • 33847095134 scopus 로고    scopus 로고
    • Complex disease, gender and epigenetics
    • Z. Kaminsky, S.C. Wang, and A. Petronis Complex disease, gender and epigenetics Ann Med 38 2006 530 544
    • (2006) Ann Med , vol.38 , pp. 530-544
    • Kaminsky, Z.1    Wang, S.C.2    Petronis, A.3
  • 53
    • 0037376939 scopus 로고    scopus 로고
    • Gender differences in schizophrenia
    • H. Hafner Gender differences in schizophrenia Psychoneuroendocrinology 28 suppl 2 2003 17 54
    • (2003) Psychoneuroendocrinology , vol.28 , Issue.SUPPL. 2 , pp. 17-54
    • Hafner, H.1
  • 54
    • 54249166128 scopus 로고    scopus 로고
    • Gene-environment interactions in schizophrenia: Review of epidemiological findings and future directions
    • J. van Os, B.P. Rutten, and R. Poulton Gene-environment interactions in schizophrenia: Review of epidemiological findings and future directions Schizophr Bull 34 2008 1066 1082
    • (2008) Schizophr Bull , vol.34 , pp. 1066-1082
    • Van Os, J.1    Rutten, B.P.2    Poulton, R.3
  • 56
    • 0037354521 scopus 로고    scopus 로고
    • Epigenetics and the environment
    • J.E. Sutherland, and M. Costa Epigenetics and the environment Ann NY Acad Sci 983 2003 151 160
    • (2003) Ann NY Acad Sci , vol.983 , pp. 151-160
    • Sutherland, J.E.1    Costa, M.2
  • 57
    • 34247109637 scopus 로고    scopus 로고
    • Epigenetic gene regulation: Linking early developmental environment to adult disease
    • D.C. Dolinoy, J.R. Weidman, and R.L. Jirtle Epigenetic gene regulation: Linking early developmental environment to adult disease Reprod Toxicol 23 2007 297 307
    • (2007) Reprod Toxicol , vol.23 , pp. 297-307
    • Dolinoy, D.C.1    Weidman, J.R.2    Jirtle, R.L.3
  • 58
    • 73949103869 scopus 로고    scopus 로고
    • Epigenetic mediation of environmental influences in major psychotic disorders
    • B.P. Rutten, and J. Mill Epigenetic mediation of environmental influences in major psychotic disorders Schizophr Bull 35 2009 1045 1056
    • (2009) Schizophr Bull , vol.35 , pp. 1045-1056
    • Rutten, B.P.1    Mill, J.2
  • 59
    • 34547768323 scopus 로고    scopus 로고
    • The role of one-carbon metabolism in schizophrenia and depression
    • F.R. Frankenburg The role of one-carbon metabolism in schizophrenia and depression Harv Rev Psychiatry 15 2007 146 160
    • (2007) Harv Rev Psychiatry , vol.15 , pp. 146-160
    • Frankenburg, F.R.1
  • 65
    • 0025863475 scopus 로고
    • Prevention of neural tube defects: Results of the Medical Research Council Vitamin study
    • MRC Vitamin Study Research Group
    • MRC Vitamin Study Research Group Prevention of neural tube defects: Results of the Medical Research Council Vitamin study Lancet 338 1991 131 137
    • (1991) Lancet , vol.338 , pp. 131-137
  • 66
    • 34547683246 scopus 로고    scopus 로고
    • Schizophrenia and neural tube defects: Comparisons from an epidemiological perspective
    • S. Zammit, S. Lewis, D. Gunnell, and G.D. Smith Schizophrenia and neural tube defects: Comparisons from an epidemiological perspective Schizophr Bull 33 2007 853 858
    • (2007) Schizophr Bull , vol.33 , pp. 853-858
    • Zammit, S.1    Lewis, S.2    Gunnell, D.3    Smith, G.D.4
  • 67
    • 70949085092 scopus 로고    scopus 로고
    • One-carbon metabolism and schizophrenia: Current challenges and future directions
    • M.O. Krebs, A. Bellon, G. Mainguy, T.M. Jay, and H. Frieling One-carbon metabolism and schizophrenia: Current challenges and future directions Trends Mol Med 15 2009 562 570
    • (2009) Trends Mol Med , vol.15 , pp. 562-570
    • Krebs, M.O.1    Bellon, A.2    Mainguy, G.3    Jay, T.M.4    Frieling, H.5
  • 68
    • 36848999415 scopus 로고    scopus 로고
    • Contribution of methylenetetrahydrofolate reductase (MTHFR) polymorphisms to negative symptoms in schizophrenia
    • J.L. Roffman, A.P. Weiss, S. Purcell, C.A. Caffalette, O. Freudenreich, and D.C. Henderson Contribution of methylenetetrahydrofolate reductase (MTHFR) polymorphisms to negative symptoms in schizophrenia Biol Psychiatry 63 2008 42 48
    • (2008) Biol Psychiatry , vol.63 , pp. 42-48
    • Roffman, J.L.1    Weiss, A.P.2    Purcell, S.3    Caffalette, C.A.4    Freudenreich, O.5    Henderson, D.C.6
  • 70
    • 46249104490 scopus 로고    scopus 로고
    • Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: The SzGene database
    • N.C. Allen, S. Bagade, M.B. McQueen, J.P. Ioannidis, F.K. Kavvoura, and M.J. Khoury Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: The SzGene database Nat Genet 40 2008 827 834
    • (2008) Nat Genet , vol.40 , pp. 827-834
    • Allen, N.C.1    Bagade, S.2    McQueen, M.B.3    Ioannidis, J.P.4    Kavvoura, F.K.5    Khoury, M.J.6
  • 72
    • 67349198048 scopus 로고    scopus 로고
    • An upregulation of DNA-methyltransferase one and 3a expressed in telencephalic GABAergic neurons of schizophrenia patients is also detected in peripheral blood lymphocytes
    • A. Zhubi, M. Veldic, N.V. Puri, B. Kadriu, H. Caruncho, and I. Loza An upregulation of DNA-methyltransferase one and 3a expressed in telencephalic GABAergic neurons of schizophrenia patients is also detected in peripheral blood lymphocytes Schizophr Res 111 2009 115 122
    • (2009) Schizophr Res , vol.111 , pp. 115-122
    • Zhubi, A.1    Veldic, M.2    Puri, N.V.3    Kadriu, B.4    Caruncho, H.5    Loza, I.6
  • 73
    • 47249107242 scopus 로고    scopus 로고
    • Reduced baseline acetylated histone three levels, and a blunted response to HDAC inhibition in lymphocyte cultures from schizophrenia subjects
    • D.P. Gavin, S. Kartan, K. Chase, D.R. Grayson, and R.P. Sharma Reduced baseline acetylated histone three levels, and a blunted response to HDAC inhibition in lymphocyte cultures from schizophrenia subjects Schizophr Res 103 2008 330 332
    • (2008) Schizophr Res , vol.103 , pp. 330-332
    • Gavin, D.P.1    Kartan, S.2    Chase, K.3    Grayson, D.R.4    Sharma, R.P.5
  • 75
    • 33750626746 scopus 로고    scopus 로고
    • Valproic acid and chromatin remodeling in schizophrenia and bipolar disorder: Preliminary results from a clinical population
    • R.P. Sharma, C. Rosen, S. Kartan, A. Guidotti, E. Costa, D.R. Grayson, and K. Chase Valproic acid and chromatin remodeling in schizophrenia and bipolar disorder: Preliminary results from a clinical population Schizophr Res 88 2006 227 231
    • (2006) Schizophr Res , vol.88 , pp. 227-231
    • Sharma, R.P.1    Rosen, C.2    Kartan, S.3    Guidotti, A.4    Costa, E.5    Grayson, D.R.6    Chase, K.7
  • 76
    • 62349095315 scopus 로고    scopus 로고
    • Recent advances in postmortem pathology and neurochemistry in schizophrenia
    • B. Dean, S. Boer, A. Gibbons, T. Money, and E. Scarr Recent advances in postmortem pathology and neurochemistry in schizophrenia Curr Opin Psychiatry 22 2009 154 160
    • (2009) Curr Opin Psychiatry , vol.22 , pp. 154-160
    • Dean, B.1    Boer, S.2    Gibbons, A.3    Money, T.4    Scarr, E.5
  • 77
    • 77953543930 scopus 로고    scopus 로고
    • The molecular pathology of schizophrenia-focus on histone and DNA modifications [published online ahead of print September 1]
    • S. Akbarian The molecular pathology of schizophrenia-focus on histone and DNA modifications [published online ahead of print September 1] Brain Res Bull 2009
    • (2009) Brain Res Bull
    • Akbarian, S.1
  • 78
    • 33750244045 scopus 로고    scopus 로고
    • Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder
    • H.M. Abdolmaleky, K.H. Cheng, S.V. Faraone, M. Wilcox, S.J. Glatt, and F. Gao Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder Hum Mol Genet 15 2006 3132 3145
    • (2006) Hum Mol Genet , vol.15 , pp. 3132-3145
    • Abdolmaleky, H.M.1    Cheng, K.H.2    Faraone, S.V.3    Wilcox, M.4    Glatt, S.J.5    Gao, F.6
  • 80
    • 20044389866 scopus 로고    scopus 로고
    • DNA methylation status of SOX10 correlates with its downregulation and oligodendrocyte dysfunction in schizophrenia
    • K. Iwamoto, M. Bundo, K. Yamada, H. Takao, Y. Iwayama-Shigeno, T. Yoshikawa, and T. Kato DNA methylation status of SOX10 correlates with its downregulation and oligodendrocyte dysfunction in schizophrenia J Neurosci 25 2005 5376 5381
    • (2005) J Neurosci , vol.25 , pp. 5376-5381
    • Iwamoto, K.1    Bundo, M.2    Yamada, K.3    Takao, H.4    Iwayama-Shigeno, Y.5    Yoshikawa, T.6    Kato, T.7
  • 81
    • 33646247628 scopus 로고    scopus 로고
    • The quantification of COMT mRNA in post mortem cerebellum tissue: Diagnosis, genotype, methylation and expression
    • E.L. Dempster, J. Mill, I.W. Craig, and D.A. Collier The quantification of COMT mRNA in post mortem cerebellum tissue: Diagnosis, genotype, methylation and expression BMC Med Genet 7 2006 10
    • (2006) BMC Med Genet , vol.7 , pp. 10
    • Dempster, E.L.1    Mill, J.2    Craig, I.W.3    Collier, D.A.4
  • 82
    • 38949150121 scopus 로고    scopus 로고
    • Methylation status of the reelin promoter region in the brain of schizophrenic patients
    • M. Tochigi, K. Iwamoto, M. Bundo, A. Komori, T. Sasaki, N. Kato, and T. Kato Methylation status of the reelin promoter region in the brain of schizophrenic patients Biol Psychiatry 63 2008 530 533
    • (2008) Biol Psychiatry , vol.63 , pp. 530-533
    • Tochigi, M.1    Iwamoto, K.2    Bundo, M.3    Komori, A.4    Sasaki, T.5    Kato, N.6    Kato, T.7
  • 83
    • 41149140859 scopus 로고    scopus 로고
    • Epigenomic profiling reveals DNA-methylation changes associated with major psychosis
    • J. Mill, T. Tang, Z. Kaminsky, T. Khare, S. Yazdanpanah, and L. Bouchard Epigenomic profiling reveals DNA-methylation changes associated with major psychosis Am J Hum Genet 82 2008 696 711
    • (2008) Am J Hum Genet , vol.82 , pp. 696-711
    • Mill, J.1    Tang, T.2    Kaminsky, Z.3    Khare, T.4    Yazdanpanah, S.5    Bouchard, L.6
  • 84
    • 45149127401 scopus 로고    scopus 로고
    • Differential methylation of the X-chromosome is a possible source of discordance for bipolar disorder female monozygotic twins
    • A. Rosa, M.M. Picchioni, S. Kalidindi, C.S. Loat, J. Knight, and T. Toulopoulou Differential methylation of the X-chromosome is a possible source of discordance for bipolar disorder female monozygotic twins Am J Med Genet B Neuropsychiatr Genet 147B 2008 459 462
    • (2008) Am J Med Genet B Neuropsychiatr Genet , vol.147 , pp. 459-462
    • Rosa, A.1    Picchioni, M.M.2    Kalidindi, S.3    Loat, C.S.4    Knight, J.5    Toulopoulou, T.6
  • 85
    • 40849116456 scopus 로고    scopus 로고
    • Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins
    • G. Kuratomi, K. Iwamoto, M. Bundo, I. Kusumi, N. Kato, and N. Iwata Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins Mol Psychiatry 13 2008 429 441
    • (2008) Mol Psychiatry , vol.13 , pp. 429-441
    • Kuratomi, G.1    Iwamoto, K.2    Bundo, M.3    Kusumi, I.4    Kato, N.5    Iwata, N.6
  • 86
    • 0035007327 scopus 로고    scopus 로고
    • GABAergic interneurons: Implications for understanding schizophrenia and bipolar disorder
    • F.M. Benes, and S. Berretta GABAergic interneurons: Implications for understanding schizophrenia and bipolar disorder Neuropsychopharmacology 25 2001 1 27
    • (2001) Neuropsychopharmacology , vol.25 , pp. 1-27
    • Benes, F.M.1    Berretta, S.2
  • 87
    • 0028948389 scopus 로고
    • Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics
    • S. Akbarian, J.J. Kim, S.G. Potkin, J.O. Hagman, A. Tafazzoli, W.E. Bunney Jr, and E.G. Jones Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics Arch Gen Psychiatry 52 1995 258 266
    • (1995) Arch Gen Psychiatry , vol.52 , pp. 258-266
    • Akbarian, S.1    Kim, J.J.2    Potkin, S.G.3    Hagman, J.O.4    Tafazzoli, A.5    Bunney Jr., W.E.6    Jones, E.G.7
  • 88
    • 0033759439 scopus 로고    scopus 로고
    • Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: A postmortem brain study
    • A. Guidotti, J. Auta, J.M. Davis, V. Di-Giorgi-Gerevini, Y. Dwivedi, and D.R. Grayson Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: A postmortem brain study Arch Gen Psychiatry 57 2000 1061 1069
    • (2000) Arch Gen Psychiatry , vol.57 , pp. 1061-1069
    • Guidotti, A.1    Auta, J.2    Davis, J.M.3    Di-Giorgi-Gerevini, V.4    Dwivedi, Y.5    Grayson, D.R.6
  • 89
    • 38649094308 scopus 로고    scopus 로고
    • GAD1 mRNA expression and DNA methylation in prefrontal cortex of subjects with schizophrenia
    • H.S. Huang, and S. Akbarian GAD1 mRNA expression and DNA methylation in prefrontal cortex of subjects with schizophrenia PLoS ONE 2 2007 e809
    • (2007) PLoS ONE , vol.2 , pp. 809
    • Huang, H.S.1    Akbarian, S.2
  • 90
    • 67749120074 scopus 로고    scopus 로고
    • Dimethylated lysine nine of histone three is elevated in schizophrenia and exhibits a divergent response to histone deacetylase inhibitors in lymphocyte cultures
    • D.P. Gavin, C. Rosen, K. Chase, D.R. Grayson, N. Tun, and R.P. Sharma Dimethylated lysine nine of histone three is elevated in schizophrenia and exhibits a divergent response to histone deacetylase inhibitors in lymphocyte cultures J Psychiatry Neurosci 34 2009 232 237
    • (2009) J Psychiatry Neurosci , vol.34 , pp. 232-237
    • Gavin, D.P.1    Rosen, C.2    Chase, K.3    Grayson, D.R.4    Tun, N.5    Sharma, R.P.6
  • 91
    • 23744449082 scopus 로고    scopus 로고
    • Chromatin alterations associated with down-regulated metabolic gene expression in the prefrontal cortex of subjects with schizophrenia
    • S. Akbarian, M.G. Ruehl, E. Bliven, L.A. Luiz, A.C. Peranelli, and S.P. Baker Chromatin alterations associated with down-regulated metabolic gene expression in the prefrontal cortex of subjects with schizophrenia Arch Gen Psychiatry 62 2005 829 840
    • (2005) Arch Gen Psychiatry , vol.62 , pp. 829-840
    • Akbarian, S.1    Ruehl, M.G.2    Bliven, E.3    Luiz, L.A.4    Peranelli, A.C.5    Baker, S.P.6
  • 92
    • 42649089780 scopus 로고    scopus 로고
    • The methylome: Approaches for global DNA methylation profiling
    • S. Beck, and V.K. Rakyan The methylome: Approaches for global DNA methylation profiling Trends Genet 24 2008 231 237
    • (2008) Trends Genet , vol.24 , pp. 231-237
    • Beck, S.1    Rakyan, V.K.2
  • 93
    • 0030014751 scopus 로고    scopus 로고
    • Cytosine methylation: Quantitation by automated genomic sequencing and GeneScan analysis
    • C.L. Paul, and S.J. Clark Cytosine methylation: Quantitation by automated genomic sequencing and GeneScan analysis BioTechniques 21 1996 126 133
    • (1996) BioTechniques , vol.21 , pp. 126-133
    • Paul, C.L.1    Clark, S.J.2
  • 96
    • 38449113853 scopus 로고    scopus 로고
    • DNA methylation analysis by pyrosequencing
    • J. Tost, and I.G. Gut DNA methylation analysis by pyrosequencing Nat Protoc 2 2007 2265 2275
    • (2007) Nat Protoc , vol.2 , pp. 2265-2275
    • Tost, J.1    Gut, I.G.2
  • 97
    • 27644548948 scopus 로고    scopus 로고
    • Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry
    • M. Ehrich, M.R. Nelson, P. Stanssens, M. Zabeau, T. Liloglou, and G. Xinarianos Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry Proc Natl Acad Sci U S A 102 2005 15785 15790
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 15785-15790
    • Ehrich, M.1    Nelson, M.R.2    Stanssens, P.3    Zabeau, M.4    Liloglou, T.5    Xinarianos, G.6
  • 100
  • 101
    • 44849092317 scopus 로고    scopus 로고
    • Maternal cocaine administration in mice alters DNA methylation and gene expression in hippocampal neurons of neonatal and prepubertal offspring
    • S.I. Novikova, F. He, J. Bai, N.J. Cutrufello, M.S. Lidow, and A.S. Undieh Maternal cocaine administration in mice alters DNA methylation and gene expression in hippocampal neurons of neonatal and prepubertal offspring PLoS ONE 3 2008 e1919
    • (2008) PLoS ONE , vol.3 , pp. 1919
    • Novikova, S.I.1    He, F.2    Bai, J.3    Cutrufello, N.J.4    Lidow, M.S.5    Undieh, A.S.6
  • 102
    • 33744938449 scopus 로고    scopus 로고
    • LUMA (luminometric methylation assay)A high throughput method to the analysis of genomic DNA methylation
    • M. Karimi, S. Johansson, D. Stach, M. Corcoran, D. Grander, and M. Schalling LUMA (luminometric methylation assay)A high throughput method to the analysis of genomic DNA methylation Exp Cell Res 312 2006 1989 1995
    • (2006) Exp Cell Res , vol.312 , pp. 1989-1995
    • Karimi, M.1    Johansson, S.2    Stach, D.3    Corcoran, M.4    Grander, D.5    Schalling, M.6
  • 104
    • 33745549658 scopus 로고    scopus 로고
    • Epigenetic characterization of the early embryo with a chromatin immunoprecipitation protocol applicable to small cell populations
    • L.P. O'Neill, M.D. verMilyea, and B.M. Turner Epigenetic characterization of the early embryo with a chromatin immunoprecipitation protocol applicable to small cell populations Nat Genet 38 2006 835 841
    • (2006) Nat Genet , vol.38 , pp. 835-841
    • O'Neill, L.P.1    Vermilyea, M.D.2    Turner, B.M.3
  • 105
    • 35348935589 scopus 로고    scopus 로고
    • Analysis of transcription, chromatin dynamics and epigenetic changes in neural genes
    • N.J. Buckley Analysis of transcription, chromatin dynamics and epigenetic changes in neural genes Prog Neurobiol 83 2007 195 210
    • (2007) Prog Neurobiol , vol.83 , pp. 195-210
    • Buckley, N.J.1
  • 107
    • 57749200922 scopus 로고    scopus 로고
    • Brain banking: Opportunities, challenges and meaning for the future
    • H. Kretzschmar Brain banking: Opportunities, challenges and meaning for the future Nat Rev Neurosci 10 2009 70 78
    • (2009) Nat Rev Neurosci , vol.10 , pp. 70-78
    • Kretzschmar, H.1
  • 108
    • 70649095120 scopus 로고    scopus 로고
    • Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts
    • A. Doi, I.H. Park, B. Wen, P. Murakami, M.J. Aryee, and R. Irizarry Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts Nat Genet 41 2009 1350 1353
    • (2009) Nat Genet , vol.41 , pp. 1350-1353
    • Doi, A.1    Park, I.H.2    Wen, B.3    Murakami, P.4    Aryee, M.J.5    Irizarry, R.6
  • 109
    • 0037998074 scopus 로고    scopus 로고
    • Biochemical and molecular studies using human autopsy brain tissue
    • M.R. Hynd, J.M. Lewohl, H.L. Scott, and P.R. Dodd Biochemical and molecular studies using human autopsy brain tissue J Neurochem 85 2003 543 562
    • (2003) J Neurochem , vol.85 , pp. 543-562
    • Hynd, M.R.1    Lewohl, J.M.2    Scott, H.L.3    Dodd, P.R.4
  • 110
  • 112
    • 48449090669 scopus 로고    scopus 로고
    • Brain banks: Benefits, limitations and cautions concerning the use of post-mortem brain tissue for molecular studies
    • I. Ferrer, A. Martinez, S. Boluda, P. Parchi, and M. Barrachina Brain banks: Benefits, limitations and cautions concerning the use of post-mortem brain tissue for molecular studies Cell Tissue Bank 9 2008 181 194
    • (2008) Cell Tissue Bank , vol.9 , pp. 181-194
    • Ferrer, I.1    Martinez, A.2    Boluda, S.3    Parchi, P.4    Barrachina, M.5
  • 113
    • 34347249613 scopus 로고    scopus 로고
    • Effects of formalin fixation, paraffin embedding, and time of storage on DNA preservation in brain tissue: A BrainNet Europe study
    • I. Ferrer, J. Armstrong, S. Capellari, P. Parchi, T. Arzberger, and J. Bell Effects of formalin fixation, paraffin embedding, and time of storage on DNA preservation in brain tissue: A BrainNet Europe study Brain Pathol 17 2007 297 303
    • (2007) Brain Pathol , vol.17 , pp. 297-303
    • Ferrer, I.1    Armstrong, J.2    Capellari, S.3    Parchi, P.4    Arzberger, T.5    Bell, J.6
  • 114
    • 0022491546 scopus 로고
    • Extensive postmortem stability of RNA from rat and human brain
    • S.A. Johnson, D.G. Morgan, and C.E. Finch Extensive postmortem stability of RNA from rat and human brain J Neurosci Res 16 1986 267 280
    • (1986) J Neurosci Res , vol.16 , pp. 267-280
    • Johnson, S.A.1    Morgan, D.G.2    Finch, C.E.3
  • 115
    • 34249026300 scopus 로고    scopus 로고
    • High-resolution profiling of histone methylations in the human genome
    • A. Barski, S. Cuddapah, K. Cui, T.Y. Roh, D.E. Schones, and Z. Wang High-resolution profiling of histone methylations in the human genome Cell 129 2007 823 837
    • (2007) Cell , vol.129 , pp. 823-837
    • Barski, A.1    Cuddapah, S.2    Cui, K.3    Roh, T.Y.4    Schones, D.E.5    Wang, Z.6
  • 116
    • 33846110316 scopus 로고    scopus 로고
    • Brain protein preservation largely depends on the postmortem storage temperature: Implications for study of proteins in human neurologic diseases and management of brain banks: A BrainNet Europe Study
    • I. Ferrer, G. Santpere, T. Arzberger, J. Bell, R. Blanco, and S. Boluda Brain protein preservation largely depends on the postmortem storage temperature: implications for study of proteins in human neurologic diseases and management of brain banks: a BrainNet Europe Study J Neuropathol Exp Neurol 66 2007 35 46
    • (2007) J Neuropathol Exp Neurol , vol.66 , pp. 35-46
    • Ferrer, I.1    Santpere, G.2    Arzberger, T.3    Bell, J.4    Blanco, R.5    Boluda, S.6
  • 117
    • 70349332644 scopus 로고    scopus 로고
    • Interplay between DNA methylation, histone modification and chromatin remodeling in stem cells and during development
    • K. Ikegami, J. Ohgane, S. Tanaka, S. Yagi, and K. Shiota Interplay between DNA methylation, histone modification and chromatin remodeling in stem cells and during development Int J Dev Biol 53 2009 203 214
    • (2009) Int J Dev Biol , vol.53 , pp. 203-214
    • Ikegami, K.1    Ohgane, J.2    Tanaka, S.3    Yagi, S.4    Shiota, K.5
  • 118
    • 23044514626 scopus 로고    scopus 로고
    • Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells
    • M. Weber, J.J. Davies, D. Wittig, E.J. Oakeley, M. Haase, W.L. Lam, and D. Schbeler Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells Nat Genet 37 2005 853 862
    • (2005) Nat Genet , vol.37 , pp. 853-862
    • Weber, M.1    Davies, J.J.2    Wittig, D.3    Oakeley, E.J.4    Haase, M.5    Lam, W.L.6    Schbeler, D.7
  • 120
    • 33749063646 scopus 로고    scopus 로고
    • Probing the transcriptome of neuronal cell types
    • S.B. Nelson, C. Hempel, and K. Sugino Probing the transcriptome of neuronal cell types Curr Opin Neurobiol 16 2006 571 576
    • (2006) Curr Opin Neurobiol , vol.16 , pp. 571-576
    • Nelson, S.B.1    Hempel, C.2    Sugino, K.3
  • 121
    • 33947671401 scopus 로고    scopus 로고
    • Selective epigenetic alteration of layer i GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection
    • W.B. Ruzicka, A. Zhubi, M. Veldic, D.R. Grayson, E. Costa, and A. Guidotti Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection Mol Psychiatry 12 2007 385 397
    • (2007) Mol Psychiatry , vol.12 , pp. 385-397
    • Ruzicka, W.B.1    Zhubi, A.2    Veldic, M.3    Grayson, D.R.4    Costa, E.5    Guidotti, A.6
  • 125
    • 2442424419 scopus 로고    scopus 로고
    • Germline epimutation of MLH1 in individuals with multiple cancers
    • C.M. Suter, D.I. Martin, and R.L. Ward Germline epimutation of MLH1 in individuals with multiple cancers Nat Genet 36 2004 497 501
    • (2004) Nat Genet , vol.36 , pp. 497-501
    • Suter, C.M.1    Martin, D.I.2    Ward, R.L.3
  • 126
    • 18444407168 scopus 로고    scopus 로고
    • Discordant KCNQ1OT1 imprinting in sets of monozygotic twins discordant for BeckwithWiedemann syndrome
    • R. Weksberg, C. Shuman, O. Caluseriu, A.C. Smith, Y.L. Fei, and J. Nishikawa Discordant KCNQ1OT1 imprinting in sets of monozygotic twins discordant for BeckwithWiedemann syndrome Hum Mol Genet 11 2002 1317 1325
    • (2002) Hum Mol Genet , vol.11 , pp. 1317-1325
    • Weksberg, R.1    Shuman, C.2    Caluseriu, O.3    Smith, A.C.4    Fei, Y.L.5    Nishikawa, J.6
  • 127
    • 34047170360 scopus 로고    scopus 로고
    • Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes
    • S. Milutinovic, A.C. D'Alessio, N. Detich, and M. Szyf Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes Carcinogenesis 28 2007 560 571
    • (2007) Carcinogenesis , vol.28 , pp. 560-571
    • Milutinovic, S.1    D'Alessio, A.C.2    Detich, N.3    Szyf, M.4
  • 128
    • 47149112211 scopus 로고    scopus 로고
    • DNA methylation changes in schizophrenia and bipolar disorder
    • C.M. Connor, and S. Akbarian DNA methylation changes in schizophrenia and bipolar disorder Epigenetics 3 2008 55 58
    • (2008) Epigenetics , vol.3 , pp. 55-58
    • Connor, C.M.1    Akbarian, S.2
  • 129
    • 84959317449 scopus 로고    scopus 로고
    • The NIH Common Fund, National Institutes of Health
    • The NIH Common Fund, National Institutes of Health Epigenomics http://nihroadmap.nih.gov/epigenomics
    • Epigenomics


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