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Volumn 116, Issue 25, 2010, Pages 5679-5687

Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin

Author keywords

[No Author keywords available]

Indexed keywords

CD71 ANTIGEN; HEMOJUVELIN; HEPCIDIN; HEREDITARY HEMOCHROMATOSIS PROTEIN; MEMBRANE PROTEIN; MUTANT PROTEIN; TRANSFERRIN RECEPTOR 2; UNCLASSIFIED DRUG;

EID: 78650423863     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-04-277954     Document Type: Article
Times cited : (20)

References (53)
  • 1
    • 47649126246 scopus 로고    scopus 로고
    • Forging a field: The golden age of iron biology
    • Andrews NC. Forging a field: the golden age of iron biology. Blood. 2008;112(2):219-230.
    • (2008) Blood , vol.112 , Issue.2 , pp. 219-230
    • Andrews, N.C.1
  • 2
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • DOI 10.1126/science.1104742
    • Nemeth E, Tuttle MS, Powelson J, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306(5704):2090-2093. (Pubitemid 40007660)
    • (2004) Science , vol.306 , Issue.5704 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3    Vaughn, M.D.4    Donovan, A.5    Ward, D.M.6    Ganz, T.7    Kaplan, J.8
  • 4
    • 21144435281 scopus 로고    scopus 로고
    • The molecular basis of ferroportin-linked hemochromatosis
    • De Domenico I, Ward DM, Nemeth E, et al. The molecular basis of ferroportin-linked hemochromatosis. Proc Natl Acad Sci U S A. 2005;102(25):8955-8960.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.25 , pp. 8955-8960
    • De Domenico, I.1    Ward, D.M.2    Nemeth, E.3
  • 6
  • 7
    • 9144252017 scopus 로고    scopus 로고
    • Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis
    • Papanikolaou G, Samuels ME, Ludwig EH, et al. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet. 2004;36(1):77-82.
    • (2004) Nat Genet , vol.36 , Issue.1 , pp. 77-82
    • Papanikolaou, G.1    Samuels, M.E.2    Ludwig, E.H.3
  • 8
    • 0037460697 scopus 로고    scopus 로고
    • Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis
    • Bridle KR, Frazer DM, Wilkins SJ, et al. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet. 2003;361(9358):669-673.
    • (2003) Lancet , vol.361 , Issue.9358 , pp. 669-673
    • Bridle, K.R.1    Frazer, D.M.2    Wilkins, S.J.3
  • 9
    • 9344224529 scopus 로고    scopus 로고
    • A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
    • Feder JN, Gnirke A, Thomas W, et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet. 1996; 13(4):399-408.
    • (1996) Nat Genet , vol.13 , Issue.4 , pp. 399-408
    • Feder, J.N.1    Gnirke, A.2    Thomas, W.3
  • 12
    • 0035914480 scopus 로고    scopus 로고
    • Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites
    • West AP, Jr., Giannetti AM, Herr AB, et al. Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites. J Mol Biol. 2001;313(2):385-397.
    • (2001) J Mol Biol , vol.313 , Issue.2 , pp. 385-397
    • West Jr., A.P.1    Giannetti, A.M.2    Herr, A.B.3
  • 13
    • 0033082699 scopus 로고    scopus 로고
    • The cytoplasmic and the transmembrane domains are not sufficient for class I MHC signal transduction
    • DOI 10.1006/cimm.1998.1417
    • Gur H, Geppert TD, Wacholtz MC, Lipsky PE. The cytoplasmic and the transmembrane domains are not sufficient for class I MHC signal transduction. Cell Immunol. 1999;191(2):105-116. (Pubitemid 29091844)
    • (1999) Cellular Immunology , vol.191 , Issue.2 , pp. 105-116
    • Gur, H.1    Geppert, T.D.2    Wacholtz, M.C.3    Lipsky, P.E.4
  • 14
    • 0034634505 scopus 로고    scopus 로고
    • Interactions of the ectodomain of HFE with the transferrin receptor are critical for iron homeostasis in cells
    • Roy CN, Carlson EJ, Anderson EL, et al. Interactions of the ectodomain of HFE with the transferrin receptor are critical for iron homeostasis in cells. FEBS Lett. 2000;484(3):271-274.
    • (2000) FEBS Lett , vol.484 , Issue.3 , pp. 271-274
    • Roy, C.N.1    Carlson, E.J.2    Anderson, E.L.3
  • 15
    • 14644390830 scopus 로고    scopus 로고
    • Tails of wonder: Endocytic-sorting motifs key for exogenous antigen presentation
    • DOI 10.1016/j.it.2005.01.005
    • Lizee G, Basha G, Jefferies WA. Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation. Trends Immunol. 2005;26(3): 141-149. (Pubitemid 40312521)
    • (2005) Trends in Immunology , vol.26 , Issue.3 , pp. 141-149
    • Lizee, G.1    Basha, G.2    Jefferies, W.A.3
  • 16
    • 0025014580 scopus 로고
    • Role of the human transferrin receptor cytoplasmic domain in endocytosis: Localization of a specific signal sequence for internalization
    • Jing SQ, Spencer T, Miller K, Hopkins C, Trowbridge IS. Role of the human transferrin receptor cytoplasmic domain in endocytosis: localization of a specific signal sequence for internalization. J Cell Biol. 1990;110(2):283-294. (Pubitemid 20067573)
    • (1990) Journal of Cell Biology , vol.110 , Issue.2 , pp. 283-294
    • Jing, S.1    Spencer, T.2    Miller, K.3    Hopkins, C.4    Trowbridge, I.S.5
  • 17
    • 60649103774 scopus 로고    scopus 로고
    • Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression
    • Gao J, Chen J, Kramer M, Tsukamoto H, Zhang AS, Enns CA. Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression. Cell Metab. 2009;9(3):217-227.
    • (2009) Cell Metab , vol.9 , Issue.3 , pp. 217-227
    • Gao, J.1    Chen, J.2    Kramer, M.3    Tsukamoto, H.4    Zhang, A.S.5    Enns, C.A.6
  • 19
    • 77953883546 scopus 로고    scopus 로고
    • Hepcidin expression does not rescue the iron-poor phenotype of Kupffer cells in Hfe-null mice after liver transplantation
    • Garuti C, Tian Y, Montosi G, et al. Hepcidin expression does not rescue the iron-poor phenotype of Kupffer cells in Hfe-null mice after liver transplantation. Gastroenterology. 2010;139(1): 315-322.e311.
    • (2010) Gastroenterology , vol.139 , Issue.1
    • Garuti, C.1    Tian, Y.2    Montosi, G.3
  • 20
    • 39649115776 scopus 로고    scopus 로고
    • The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression
    • Schmidt PJ, Toran PT, Giannetti AM, Bjorkman PJ, Andrews NC. The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression. Cell Metab. 2008;7(3):205-214.
    • (2008) Cell Metab , vol.7 , Issue.3 , pp. 205-214
    • Schmidt, P.J.1    Toran, P.T.2    Giannetti, A.M.3    Bjorkman, P.J.4    Andrews, N.C.5
  • 21
    • 33749393565 scopus 로고    scopus 로고
    • Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing
    • DOI 10.1074/jbc.C600197200
    • Goswami T, Andrews NC. Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing. J Biol Chem. 2006; 281(39):28494-28498. (Pubitemid 44506991)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.39 , pp. 28494-28498
    • Goswami, T.1    Andrews, N.C.2
  • 23
    • 73149083742 scopus 로고    scopus 로고
    • Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload
    • Wallace DF, Summerville L, Crampton EM, Frazer DM, Anderson GJ, Subramaniam VN. Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload. Hepatology. 2009;50(6): 1992-2000.
    • (2009) Hepatology , vol.50 , Issue.6 , pp. 1992-2000
    • Wallace, D.F.1    Summerville, L.2    Crampton, E.M.3    Frazer, D.M.4    Anderson, G.J.5    Subramaniam, V.N.6
  • 24
    • 33646370235 scopus 로고    scopus 로고
    • Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
    • Babitt JL, Huang FW, Wrighting DM, et al. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet. 2006; 38(5):531-539.
    • (2006) Nat Genet , vol.38 , Issue.5 , pp. 531-539
    • Babitt, J.L.1    Huang, F.W.2    Wrighting, D.M.3
  • 26
    • 23644444316 scopus 로고    scopus 로고
    • Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload
    • DOI 10.1172/JCI25683
    • Niederkofler V, Salie R, Arber S. Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. J Clin Invest. 2005; 115(8):2180-2186. (Pubitemid 41134159)
    • (2005) Journal of Clinical Investigation , vol.115 , Issue.8 , pp. 2180-2186
    • Niederkofler, V.1    Salie, R.2    Arber, S.3
  • 27
    • 33644876815 scopus 로고    scopus 로고
    • A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression
    • Wang RH, Li C, Xu X, et al. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab. 2005;2(6):399-409.
    • (2005) Cell Metab , vol.2 , Issue.6 , pp. 399-409
    • Wang, R.H.1    Li, C.2    Xu, X.3
  • 29
    • 63449103712 scopus 로고    scopus 로고
    • BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
    • Andriopoulos B, Jr., Corradini E, Xia Y, et al. BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat Genet. 2009;41(4):482-487.
    • (2009) Nat Genet , vol.41 , Issue.4 , pp. 482-487
    • Andriopoulos Jr., B.1    Corradini, E.2    Xia, Y.3
  • 30
    • 70349494083 scopus 로고    scopus 로고
    • Bone morphogenetic protein signaling is impaired in an Hfe knockout mouse model of hemochromatosis
    • Corradini E, Garuti C, Montosi G, et al. Bone morphogenetic protein signaling is impaired in an Hfe knockout mouse model of hemochromatosis. Gastroenterology. 2009;137(4):1489-1497.
    • (2009) Gastroenterology , vol.137 , Issue.4 , pp. 1489-1497
    • Corradini, E.1    Garuti, C.2    Montosi, G.3
  • 31
    • 70350494274 scopus 로고    scopus 로고
    • BMP/Smad signaling is not enhanced in Hfe-deficient mice despite increased Bmp6 expression
    • Kautz L, Meynard D, Besson-Fournier C, et al. BMP/Smad signaling is not enhanced in Hfe-deficient mice despite increased Bmp6 expression. Blood. 2009;114(12):2515-2520.
    • (2009) Blood , vol.114 , Issue.12 , pp. 2515-2520
    • Kautz, L.1    Meynard, D.2    Besson-Fournier, C.3
  • 32
    • 0023676242 scopus 로고
    • Topogenic signals in integral membrane proteins
    • von Heijne G, Gavel Y. Topogenic signals in integral membrane proteins. Eur J Biochem. 1988; 174(4):671-678.
    • (1988) Eur J Biochem , vol.174 , Issue.4 , pp. 671-678
    • Von Heijne, G.1    Gavel, Y.2
  • 33
    • 0002413872 scopus 로고
    • Tissue iron stores
    • Cook JD, ed. New York: Churchill Livingstone Press
    • Torrance JD, Bothwell TH. Tissue iron stores. In: Cook JD, ed. Methods in Hematology. Vol. 1. New York: Churchill Livingstone Press; 1980:104-109.
    • (1980) Methods in Hematology , vol.1 , pp. 104-109
    • Torrance, J.D.1    Bothwell, T.H.2
  • 34
    • 51649096725 scopus 로고    scopus 로고
    • Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver
    • Kautz L, Meynard D, Monnier A, et al. Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver. Blood. 2008;112(4):1503-1509.
    • (2008) Blood , vol.112 , Issue.4 , pp. 1503-1509
    • Kautz, L.1    Meynard, D.2    Monnier, A.3
  • 35
    • 56149110150 scopus 로고    scopus 로고
    • Transthyretin and amyloid in the islets of Langerhans in type-2 diabetes
    • Westermark GT, Westermark P. Transthyretin and amyloid in the islets of Langerhans in type-2 diabetes. Exp Diabetes Res. 2008;2008:429274.
    • (2008) Exp Diabetes Res , vol.2008 , pp. 429274
    • Westermark, G.T.1    Westermark, P.2
  • 37
    • 34247366783 scopus 로고    scopus 로고
    • Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation
    • DOI 10.1182/blood-2006-10-051755
    • Roy CN, Mak HH, Akpan I, Losyev G, Zurakowski D, Andrews NC. Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation. Blood. 2007;109(9):4038-4044. (Pubitemid 46641759)
    • (2007) Blood , vol.109 , Issue.9 , pp. 4038-4044
    • Roy, C.N.1    Mak, H.H.2    Akpan, I.3    Losyev, G.4    Zurakowski, D.5    Andrews, N.C.6
  • 38
    • 68949220321 scopus 로고    scopus 로고
    • ER stress controls iron metabolism through induction of hepcidin
    • Vecchi C, Montosi G, Zhang K, et al. ER stress controls iron metabolism through induction of hepcidin. Science. 2009;325(5942):877-880.
    • (2009) Science , vol.325 , Issue.5942 , pp. 877-880
    • Vecchi, C.1    Montosi, G.2    Zhang, K.3
  • 39
    • 68949162173 scopus 로고    scopus 로고
    • ER stress-inducible factor CHOP affects the expression of hepcidin by modulating C/EBPalpha activity
    • Oliveira SJ, Pinto JP, Picarote G, et al. ER stress-inducible factor CHOP affects the expression of hepcidin by modulating C/EBPalpha activity. PLoS ONE. 2009;4(8):e6618.
    • (2009) PLoS ONE , vol.4 , Issue.8
    • Oliveira, S.J.1    Pinto, J.P.2    Picarote, G.3
  • 41
    • 0035966269 scopus 로고    scopus 로고
    • XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
    • DOI 10.1016/S0092-8674(01)00611-0
    • Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K. XBP1 mRNAis induced byATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell. 2001;107(7):881-891. (Pubitemid 34084979)
    • (2001) Cell , vol.107 , Issue.7 , pp. 881-891
    • Yoshida, H.1    Matsui, T.2    Yamamoto, A.3    Okada, T.4    Mori, K.5
  • 42
    • 2942755868 scopus 로고    scopus 로고
    • Signaling the unfolded protein response from the endoplasmic reticulum
    • DOI 10.1074/jbc.R400008200
    • Zhang K, Kaufman RJ. Signaling the unfolded protein response from the endoplasmic reticulum. J Biol Chem. 2004;279(25):25935-25938. (Pubitemid 38798732)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.25 , pp. 25935-25938
    • Zhang, K.1    Kaufman, R.J.2
  • 43
    • 37549055467 scopus 로고    scopus 로고
    • HFE Modulates Transferrin Receptor 2 Levels in Hepatoma Cells via Interactions That Differ from Transferrin Receptor 1-HFE Interactions
    • Chen J, Chloupkova M, Gao J, Chapman-Arvedson TL, Enns CA. HFE Modulates Transferrin Receptor 2 Levels in Hepatoma Cells via Interactions That Differ from Transferrin Receptor 1-HFE Interactions. J Biol Chem. 2007;282(51): 36862-36870.
    • (2007) J Biol Chem , vol.282 , Issue.51 , pp. 36862-36870
    • Chen, J.1    Chloupkova, M.2    Gao, J.3    Chapman-Arvedson, T.L.4    Enns, C.A.5
  • 44
    • 33947111426 scopus 로고    scopus 로고
    • Transferrin receptor 2: Evidence for ligand-induced stabilization and redirection to a recycling pathway
    • DOI 10.1091/mbc.E06-09-0798
    • Johnson MB, Chen J, Murchison N, Green FA, Enns CA. Transferrin receptor 2: evidence for ligand-induced stabilization and redirection to a recycling pathway. Mol Biol Cell. 2007;18(3):743-754. (Pubitemid 46399482)
    • (2007) Molecular Biology of the Cell , vol.18 , Issue.3 , pp. 743-754
    • Johnson, M.B.1    Chen, J.2    Murchison, N.3    Green, F.A.4    Enns, C.A.5
  • 45
    • 19544386871 scopus 로고    scopus 로고
    • Hepcidin in iron overload disorders
    • Papanikolaou G, Tzilianos M, Christakis JI, et al. Hepcidin in iron overload disorders. Blood. 2005; 105(10):4103-4105.
    • (2005) Blood , vol.105 , Issue.10 , pp. 4103-4105
    • Papanikolaou, G.1    Tzilianos, M.2    Christakis, J.I.3
  • 49
    • 26644471267 scopus 로고    scopus 로고
    • Interaction of hemojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells
    • DOI 10.1074/jbc.M506207200
    • Zhang AS,WestAP, Jr.,WymanAE, Bjorkman PJ, Enns CA. Interaction of hemojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells. J Biol Chem. 2005;280(40):33885-33894. (Pubitemid 41443108)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.40 , pp. 33885-33894
    • Zhang, A.-S.1    West Jr., A.P.2    Wyman, A.E.3    Bjorkman, P.J.4    Enns, C.A.5
  • 50
    • 41849096388 scopus 로고    scopus 로고
    • Neogenin interacts with hemojuvelin through its two membrane-proximal fibronectin type III domains
    • DOI 10.1021/bi800036h
    • Yang F, West AP, Jr., Allendorph GP, Choe S, Bjorkman PJ. Neogenin interacts with hemojuvelin through its two membrane-proximal fibronectin type III domains. Biochemistry. 2008;47(14): 4237-4245. (Pubitemid 351499880)
    • (2008) Biochemistry , vol.47 , Issue.14 , pp. 4237-4245
    • Yang, F.1    West Jr., A.P.2    Allendorph, G.P.3    Choe, S.4    Bjorkman, P.J.5
  • 51
    • 77951086900 scopus 로고    scopus 로고
    • Neogenin inhibits HJV secretion and regulates BMP induced hepcidin expression and iron homeostasis
    • Lee DH, Zhou LJ, Zhou Z, et al. Neogenin inhibits HJV secretion and regulates BMP induced hepcidin expression and iron homeostasis. Blood. 2010;115(15):3136-3145.
    • (2010) Blood , vol.115 , Issue.15 , pp. 3136-3145
    • Lee, D.H.1    Zhou, L.J.2    Zhou, Z.3
  • 52
    • 2942537827 scopus 로고    scopus 로고
    • Expression of the hereditary hemochromatosis protein HFE increases ferritin levels by inhibiting iron export in HT29 cells
    • Davies PS, Enns CA. Expression of the hereditary hemochromatosis protein HFE increases ferritin levels by inhibiting iron export in HT29 cells. J Biol Chem. 2004;279(24):25085-25092.
    • (2004) J Biol Chem , vol.279 , Issue.24 , pp. 25085-25092
    • Davies, P.S.1    Enns, C.A.2
  • 53
    • 52049125740 scopus 로고    scopus 로고
    • The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 cells
    • Gao J, Zhao N, Knutson MD, Enns CA. The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 cells. J Biol Chem. 2008;283(31):21462-21468.
    • (2008) J Biol Chem , vol.283 , Issue.31 , pp. 21462-21468
    • Gao, J.1    Zhao, N.2    Knutson, M.D.3    Enns, C.A.4


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