Identification of the interferon-inducible double-stranded RNA-dependent protein kinase as a regulator of cellular response to bulky adducts

Cancer Research

Volumn 60, Issue 24, 2000, Pages 6800-6804

  Bergeron, Josȳe ^a   Benlimame, Naciba ^a   Zeng Rong, Nie ^c   Xiao, Dingzhang ^c   Scrivens, P James ^b   Koromilas, Antonis E ^a,b   Alaoui Jamali, Moulay A ^a,b,c  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; DNA; DOUBLE STRANDED RNA; DOXORUBICIN; INTERFERON; MELPHALAN; PROTEIN KINASE; PROTEIN P53; STAT1 PROTEIN;

APOPTOSIS; ARTICLE; DNA ADDUCT; DNA DAMAGE; DNA REPAIR; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE MICROSCOPY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, ALKYLATING; APOPTOSIS; CISPLATIN; DNA; DNA ADDUCTS; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; EIF-2 KINASE; FIBROBLASTS; GENOTYPE; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INTERFERONS; KINETICS; MELPHALAN; MICE; MICROSCOPY, FLUORESCENCE; RETROVIRIDAE; RNA, DOUBLE-STRANDED; SIGNAL TRANSDUCTION; TIME FACTORS; TUMOR CELLS, CULTURED; ULTRAVIOLET RAYS;

EID: 0034671744     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

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3. Mutants of the RNA-dependent protein kinase (PKR) lacking double-stranded RNA binding domain I can act as transdominant inhibitors and induce malignant transformation
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