메뉴 건너뛰기




Volumn 5, Issue 1, 2010, Pages

Neuroprotective effects and mechanism of cognitive-enhancing choline analogs JWB 1-84-1 and JAY 2-22-33 in neuronal culture and Caenorhabditis elegans

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CHOLINE DERIVATIVE; JAY 2 22 33; JWB 1 84 1; NICOTINE DERIVATIVE; PRESENILIN 1; UNCLASSIFIED DRUG;

EID: 78650102379     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/1750-1326-5-59     Document Type: Article
Times cited : (16)

References (52)
  • 1
    • 3943092621 scopus 로고    scopus 로고
    • Pathways towards and away from Alzheimer's disease
    • 10.1038/nature02621. 15295589
    • Pathways towards and away from Alzheimer's disease. MP Mattson, Nature 2004 430 7000 631 9 10.1038/nature02621 15295589
    • (2004) Nature , vol.430 , Issue.7000 , pp. 631-9
    • Mattson, M.P.1
  • 2
    • 33746310315 scopus 로고    scopus 로고
    • Alzheimer's disease
    • 10.1016/S0140-6736(06)69113-7. 16876668
    • Alzheimer's disease. K Blennow MJ de Leon H Zetterberg, Lancet 2006 368 9533 387 403 10.1016/S0140-6736(06)69113-7 16876668
    • (2006) Lancet , vol.368 , Issue.9533 , pp. 387-403
    • Blennow, K.1    De Leon, M.J.2    Zetterberg, H.3
  • 3
    • 3042857903 scopus 로고    scopus 로고
    • Alzheimer's disease
    • 10.1056/NEJMra040223. 15229308
    • Alzheimer's disease. JL Cummings, N Engl J Med 2004 351 1 56 67 10.1056/NEJMra040223 15229308
    • (2004) N Engl J Med , vol.351 , Issue.1 , pp. 56-67
    • Cummings, J.L.1
  • 4
    • 75449102536 scopus 로고    scopus 로고
    • Alzheimer's disease
    • 10.1056/NEJMra0909142. 20107219
    • Alzheimer's disease. HW Querfurth FM LaFerla, N Engl J Med 2010 362 4 329 44 10.1056/NEJMra0909142 20107219
    • (2010) N Engl J Med , vol.362 , Issue.4 , pp. 329-44
    • Querfurth, H.W.1    Laferla, F.M.2
  • 5
    • 0035251680 scopus 로고    scopus 로고
    • Cognitive effects of nicotine
    • 10.1016/S0006-3223(00)01094-5. 11230877
    • Cognitive effects of nicotine. AH Rezvani ED Levin, Biol Psychiatry 2001 49 3 258 67 10.1016/S0006-3223(00)01094-5 11230877
    • (2001) Biol Psychiatry , vol.49 , Issue.3 , pp. 258-67
    • Rezvani, A.H.1    Levin, E.D.2
  • 6
    • 33846029827 scopus 로고    scopus 로고
    • Dissecting the signaling pathway of nicotine-mediated neuroprotection in a mouse Alzheimer disease model
    • 10.1096/fj.06-5841com. 17135361
    • Dissecting the signaling pathway of nicotine-mediated neuroprotection in a mouse Alzheimer disease model. Q Liu J Zhang H Zhu C Qin Q Chen B Zhao, FASEB J 2007 21 1 61 73 10.1096/fj.06-5841com 17135361
    • (2007) FASEB J , vol.21 , Issue.1 , pp. 61-73
    • Liu, Q.1    Zhang, J.2    Zhu, H.3    Qin, C.4    Chen, Q.5    Zhao, B.6
  • 7
    • 77953480973 scopus 로고    scopus 로고
    • Chronic nicotine restores normal Abeta levels and prevents short-term memory and E-LTP impairment in Abeta rat model of Alzheimer's disease
    • Chronic nicotine restores normal Abeta levels and prevents short-term memory and E-LTP impairment in Abeta rat model of Alzheimer's disease. M Srivareerat TT Tran S Salim AM Aleisa KA Alkadhi, Neurobiol Aging 2009 4 15
    • (2009) Neurobiol Aging , vol.4 , pp. 15
    • Srivareerat, M.1    Tran, T.T.2    Salim, S.3    Aleisa, A.M.4    Alkadhi, K.A.5
  • 8
    • 63849213473 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptor signalling: Roles in Alzheimer's disease and amyloid neuroprotection
    • 10.1124/pr.108.000562. 19293145
    • Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. SD Buckingham AK Jones LA Brown DB Sattelle, Pharmacol Rev 2009 61 1 39 61 10.1124/pr.108.000562 19293145
    • (2009) Pharmacol Rev , vol.61 , Issue.1 , pp. 39-61
    • Buckingham, S.D.1    Jones, A.K.2    Brown, L.A.3    Sattelle, D.B.4
  • 9
    • 77249153190 scopus 로고    scopus 로고
    • Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease
    • 10.1523/JNEUROSCI.5038-09.2010. 20164328
    • Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease. CM Hernandez R Kayed H Zheng JD Sweatt KT Dineley, J Neurosci 2010 30 7 2442 53 10.1523/JNEUROSCI.5038-09. 2010 20164328
    • (2010) J Neurosci , vol.30 , Issue.7 , pp. 2442-53
    • Hernandez, C.M.1    Kayed, R.2    Zheng, H.3    Sweatt, J.D.4    Dineley, K.T.5
  • 10
    • 0030576581 scopus 로고    scopus 로고
    • An evaluation of neuronal nicotinic acetylcholine receptor activation by quaternary nitrogen compounds indicates that choline is selective for the alpha 7 subtype
    • 8873149
    • An evaluation of neuronal nicotinic acetylcholine receptor activation by quaternary nitrogen compounds indicates that choline is selective for the alpha 7 subtype. RL Papke M Bencherif P Lippiello, Neurosci Lett 1996 213 3 201 4 8873149
    • (1996) Neurosci Lett , vol.213 , Issue.3 , pp. 201-4
    • Papke, R.L.1    Bencherif, M.2    Lippiello, P.3
  • 11
    • 0031410384 scopus 로고    scopus 로고
    • Choline is a selective agonist of alpha7 nicotinic acetylcholine receptors in the rat brain neurons
    • 10.1111/j.1460-9568.1997.tb01702.x. 9517478
    • Choline is a selective agonist of alpha7 nicotinic acetylcholine receptors in the rat brain neurons. M Alkondon EF Pereira WS Cortes A Maelicke EX Albuquerque, Eur J Neurosci 1997 9 12 2734 42 10.1111/j.1460-9568.1997. tb01702.x 9517478
    • (1997) Eur J Neurosci , vol.9 , Issue.12 , pp. 2734-42
    • Alkondon, M.1    Pereira, E.F.2    Cortes, W.S.3    Maelicke, A.4    Albuquerque, E.X.5
  • 12
    • 0037444897 scopus 로고    scopus 로고
    • Relative levels of cytoprotection produced by analogs of choline and the role of alpha7-nicotinic acetylcholine receptors
    • 10.1002/syn.10176. 12539199
    • Relative levels of cytoprotection produced by analogs of choline and the role of alpha7-nicotinic acetylcholine receptors. RR Jonnala JH Graham AV Terry Jr. JW Beach JA Young JJ Buccafusco, Synapse 2003 47 4 262 9 10.1002/syn.10176 12539199
    • (2003) Synapse , vol.47 , Issue.4 , pp. 262-9
    • Jonnala, R.R.1    Graham, J.H.2    Terry Jr., A.V.3    Beach, J.W.4    Young, J.A.5    Buccafusco, J.J.6
  • 13
    • 7244242447 scopus 로고    scopus 로고
    • Neuronal nicotinic receptor subtypes: Defining therapeutic targets
    • 10.1124/mi.4.5.8. 15471911
    • Neuronal nicotinic receptor subtypes: defining therapeutic targets. JJ Buccafusco, Mol Interv 2004 4 5 285 95 10.1124/mi.4.5.8 15471911
    • (2004) Mol Interv , vol.4 , Issue.5 , pp. 285-95
    • Buccafusco, J.J.1
  • 14
    • 34848914887 scopus 로고    scopus 로고
    • The effects of JWB1-84-1 on memory-related task performance by amyloid Abeta transgenic mice and by young and aged monkeys
    • 10.1016/j.neuropharm.2007.06.028. 17698153
    • The effects of JWB1-84-1 on memory-related task performance by amyloid Abeta transgenic mice and by young and aged monkeys. A Sood J Warren Beach SJ Webster AV Terry JJ Buccafusco, Neuropharmacology 2007 53 5 588 600 10.1016/j.neuropharm.2007.06.028 17698153
    • (2007) Neuropharmacology , vol.53 , Issue.5 , pp. 588-600
    • Sood, A.1    Warren Beach, J.2    Webster, S.J.3    Terry, A.V.4    Buccafusco, J.J.5
  • 15
    • 70350370787 scopus 로고    scopus 로고
    • What have worm models told us about the mechanisms of neuronal dysfunction in human neurodegenerative diseases?
    • 10.1186/1750-1326-4-38. 19785750
    • What have worm models told us about the mechanisms of neuronal dysfunction in human neurodegenerative diseases? D Teschendorf CD Link, Mol Neurodegener 2009 4 38 10.1186/1750-1326-4-38 19785750
    • (2009) Mol Neurodegener , vol.4 , pp. 38
    • Teschendorf, D.1    Link, C.D.2
  • 16
    • 45749151056 scopus 로고    scopus 로고
    • Animal models of Alzheimer's disease and frontotemporal dementia
    • 10.1038/nrn2420. 18568014
    • Animal models of Alzheimer's disease and frontotemporal dementia. J Gotz LM Ittner, Nat Rev Neurosci 2008 9 7 532 44 10.1038/nrn2420 18568014
    • (2008) Nat Rev Neurosci , vol.9 , Issue.7 , pp. 532-44
    • Gotz, J.1    Ittner, L.M.2
  • 17
    • 0037971209 scopus 로고    scopus 로고
    • Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein
    • 10.1046/j.1471-4159.2003.01809.x. 12807436
    • Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein. M Lakso S Vartiainen AM Moilanen J Sirvio JH Thomas R Nass RD Blakely G Wong, J Neurochem 2003 86 1 165 72 10.1046/j.1471-4159.2003.01809.x 12807436
    • (2003) J Neurochem , vol.86 , Issue.1 , pp. 165-72
    • Lakso, M.1    Vartiainen, S.2    Moilanen, A.M.3    Sirvio, J.4    Thomas, J.H.5    Nass, R.6    Blakely, R.D.7    Wong, G.8
  • 18
    • 0033524413 scopus 로고    scopus 로고
    • Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron
    • 10.1073/pnas.96.1.179. 9874792
    • Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron. PW Faber JR Alter ME MacDonald AC Hart, Proc Natl Acad Sci USA 1999 96 1 179 84 10.1073/pnas.96.1.179 9874792
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.1 , pp. 179-84
    • Faber, P.W.1    Alter, J.R.2    MacDonald, M.E.3    Hart, A.C.4
  • 19
    • 33751397131 scopus 로고    scopus 로고
    • C. elegans models of age-associated neurodegenerative diseases: Lessons from transgenic worm models of Alzheimer's disease
    • 10.1016/j.exger.2006.06.059. 16930903
    • C. elegans models of age-associated neurodegenerative diseases: lessons from transgenic worm models of Alzheimer's disease. CD Link, Exp Gerontol 2006 41 10 1007 13 10.1016/j.exger.2006.06.059 16930903
    • (2006) Exp Gerontol , vol.41 , Issue.10 , pp. 1007-13
    • Link, C.D.1
  • 20
    • 69249153430 scopus 로고    scopus 로고
    • The Caenorhabditis elegans A beta 1-42 model of Alzheimer disease predominantly expresses A beta 3-42
    • 10.1074/jbc.C109.028514. 19574211
    • The Caenorhabditis elegans A beta 1-42 model of Alzheimer disease predominantly expresses A beta 3-42. G McColl BR Roberts AP Gunn KA Perez DJ Tew CL Masters KJ Barnham RA Cherny AI Bush, J Biol Chem 2009 284 34 22697 702 10.1074/jbc.C109.028514 19574211
    • (2009) J Biol Chem , vol.284 , Issue.34 , pp. 22697-702
    • McColl, G.1    Roberts, B.R.2    Gunn, A.P.3    Perez, K.A.4    Tew, D.J.5    Masters, C.L.6    Barnham, K.J.7    Cherny, R.A.8    Bush, A.I.9
  • 21
    • 33748792821 scopus 로고    scopus 로고
    • Opposing activities protect against age-onset proteotoxicity
    • 10.1126/science.1124646. 16902091
    • Opposing activities protect against age-onset proteotoxicity. E Cohen J Bieschke RM Perciavalle JW Kelly A Dillin, Science 2006 313 5793 1604 10 10.1126/science.1124646 16902091
    • (2006) Science , vol.313 , Issue.5793 , pp. 1604-10
    • Cohen, E.1    Bieschke, J.2    Perciavalle, R.M.3    Kelly, J.W.4    Dillin, A.5
  • 22
    • 77955923792 scopus 로고    scopus 로고
    • Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans
    • 10.1016/j.neuropharm.2010.04.008. 20420844
    • Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans. R Keowkase M Aboukhatwa Y Luo, Neuropharmacology 2010 59 4-5 358 65 10.1016/j.neuropharm. 2010.04.008 20420844
    • (2010) Neuropharmacology , vol.59 , Issue.4-5 , pp. 358-65
    • Keowkase, R.1    Aboukhatwa, M.2    Luo, Y.3
  • 23
    • 44049102976 scopus 로고    scopus 로고
    • Current and future therapy in Alzheimer's disease
    • 10.1111/j.1472-8206.2008.00578.x. 18485144
    • Current and future therapy in Alzheimer's disease. RJ van Marum, Fundam Clin Pharmacol 2008 22 3 265 74 10.1111/j.1472-8206.2008.00578.x 18485144
    • (2008) Fundam Clin Pharmacol , vol.22 , Issue.3 , pp. 265-74
    • Van Marum, R.J.1
  • 24
    • 52449086907 scopus 로고    scopus 로고
    • The insulin paradox: Aging, proteotoxicity and neurodegeneration
    • 10.1038/nrn2474. 18769445
    • The insulin paradox: aging, proteotoxicity and neurodegeneration. E Cohen A Dillin, Nat Rev Neurosci 2008 9 10 759 67 10.1038/nrn2474 18769445
    • (2008) Nat Rev Neurosci , vol.9 , Issue.10 , pp. 759-67
    • Cohen, E.1    Dillin, A.2
  • 25
    • 33846681436 scopus 로고    scopus 로고
    • Worming pathways to and from DAF-16/FOXO
    • 10.1016/j.exger.2006.05.020. 16839734
    • Worming pathways to and from DAF-16/FOXO. A Mukhopadhyay SW Oh HA Tissenbaum, Exp Gerontol 2006 41 10 928 34 10.1016/j.exger.2006.05.020 16839734
    • (2006) Exp Gerontol , vol.41 , Issue.10 , pp. 928-34
    • Mukhopadhyay, A.1    Oh, S.W.2    Tissenbaum, H.A.3
  • 26
    • 33751430460 scopus 로고    scopus 로고
    • The search for DAF-16/FOXO transcriptional targets: Approaches and discoveries
    • 10.1016/j.exger.2006.06.040. 16934425
    • The search for DAF-16/FOXO transcriptional targets: approaches and discoveries. CT Murphy, Exp Gerontol 2006 41 10 910 21 10.1016/j.exger.2006.06. 040 16934425
    • (2006) Exp Gerontol , vol.41 , Issue.10 , pp. 910-21
    • Murphy, C.T.1
  • 27
    • 33745114656 scopus 로고    scopus 로고
    • Recent aging research in Caenorhabditis elegans
    • 10.1016/j.exger.2006.02.008. 16584861
    • Recent aging research in Caenorhabditis elegans. E Schaffitzel M Hertweck, Exp Gerontol 2006 41 6 557 63 10.1016/j.exger.2006.02.008 16584861
    • (2006) Exp Gerontol , vol.41 , Issue.6 , pp. 557-63
    • Schaffitzel, E.1    Hertweck, M.2
  • 29
    • 60949111629 scopus 로고    scopus 로고
    • Nicotinic receptor agonists and antagonists increase sAPPalpha secretion and decrease Abeta levels in vitro
    • 10.1016/j.neuint.2008.12.001. 19111588
    • Nicotinic receptor agonists and antagonists increase sAPPalpha secretion and decrease Abeta levels in vitro. M Mousavi E Hellstrom-Lindahl, Neurochem Int 2009 54 3-4 237 44 10.1016/j.neuint.2008.12.001 19111588
    • (2009) Neurochem Int , vol.54 , Issue.3-4 , pp. 237-44
    • Mousavi, M.1    Hellstrom-Lindahl, E.2
  • 31
    • 1042300330 scopus 로고    scopus 로고
    • Chronic transdermal nicotine patch treatment effects on cognitive performance in age-associated memory impairment
    • 10.1007/s00213-003-1614-8. 14534771
    • Chronic transdermal nicotine patch treatment effects on cognitive performance in age-associated memory impairment. HK White ED Levin, Psychopharmacology (Berl) 2004 171 4 465 71 10.1007/s00213-003-1614-8 14534771
    • (2004) Psychopharmacology (Berl) , vol.171 , Issue.4 , pp. 465-71
    • White, H.K.1    Levin, E.D.2
  • 32
    • 56049112088 scopus 로고    scopus 로고
    • Absence of effect of chronic nicotine administration on amyloid beta peptide levels in transgenic mice overexpressing mutated human APP (Sw, Ind)
    • 18926877
    • Absence of effect of chronic nicotine administration on amyloid beta peptide levels in transgenic mice overexpressing mutated human APP (Sw, Ind). MN Sabbagh DG Walker RT Reid T Stadnick K Anand LF Lue, Neurosci Lett 2008 448 2 217 20 18926877
    • (2008) Neurosci Lett , vol.448 , Issue.2 , pp. 217-20
    • Sabbagh, M.N.1    Walker, D.G.2    Reid, R.T.3    Stadnick, T.4    Anand, K.5    Lue, L.F.6
  • 33
    • 33745223646 scopus 로고    scopus 로고
    • Finding function in novel targets: C. elegans as a model organism
    • 10.1038/nrd2031. 16672925
    • Finding function in novel targets: C. elegans as a model organism. T Kaletta MO Hengartner, Nat Rev Drug Discov 2006 5 5 387 98 10.1038/nrd2031 16672925
    • (2006) Nat Rev Drug Discov , vol.5 , Issue.5 , pp. 387-98
    • Kaletta, T.1    Hengartner, M.O.2
  • 34
    • 68149172794 scopus 로고    scopus 로고
    • Insulin signaling in sporadic Alzheimer's disease
    • 10.1126/scisignal.274pe36. 19509405
    • Insulin signaling in sporadic Alzheimer's disease. FF Liao H Xu, Sci Signal 2009 2 74 e36 10.1126/scisignal.274pe36 19509405
    • (2009) Sci Signal , vol.2 , Issue.74
    • Liao, F.F.1    Xu, H.2
  • 35
    • 36348935683 scopus 로고    scopus 로고
    • Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway
    • 10.1074/jbc.M610390200. 17855343
    • Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway. M Townsend T Mehta DJ Selkoe, J Biol Chem 2007 282 46 33305 12 10.1074/jbc.M610390200 17855343
    • (2007) J Biol Chem , vol.282 , Issue.46 , pp. 33305-12
    • Townsend, M.1    Mehta, T.2    Selkoe, D.J.3
  • 36
    • 67650544970 scopus 로고    scopus 로고
    • Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}
    • 10.1074/jbc.M109.011015. 19406747
    • Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}. WQ Zhao PN Lacor H Chen MP Lambert MJ Quon GA Krafft WL Klein, J Biol Chem 2009 284 28 18742 53 10.1074/jbc.M109.011015 19406747
    • (2009) J Biol Chem , vol.284 , Issue.28 , pp. 18742-53
    • Zhao, W.Q.1    Lacor, P.N.2    Chen, H.3    Lambert, M.P.4    Quon, M.J.5    Krafft, G.A.6    Klein, W.L.7
  • 37
    • 67649690124 scopus 로고    scopus 로고
    • The model Caenorhabditis elegans in diabetes mellitus and Alzheimer's disease
    • 19387121
    • The model Caenorhabditis elegans in diabetes mellitus and Alzheimer's disease. M Morcos H Hutter, J Alzheimers Dis 2009 16 4 897 908 19387121
    • (2009) J Alzheimers Dis , vol.16 , Issue.4 , pp. 897-908
    • Morcos, M.1    Hutter, H.2
  • 38
    • 0038701745 scopus 로고    scopus 로고
    • Regulation of aging and age-related disease by DAF-16 and heat-shock factor
    • 10.1126/science.1083701. 12750521
    • Regulation of aging and age-related disease by DAF-16 and heat-shock factor. AL Hsu CT Murphy C Kenyon, Science 2003 300 5622 1142 5 10.1126/science.1083701 12750521
    • (2003) Science , vol.300 , Issue.5622 , pp. 1142-5
    • Hsu, A.L.1    Murphy, C.T.2    Kenyon, C.3
  • 39
    • 0742323000 scopus 로고    scopus 로고
    • Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones
    • 10.1091/mbc.E03-07-0532. 14668486
    • Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. JF Morley RI Morimoto, Mol Biol Cell 2004 15 2 657 64 10.1091/mbc.E03-07-0532 14668486
    • (2004) Mol Biol Cell , vol.15 , Issue.2 , pp. 657-64
    • Morley, J.F.1    Morimoto, R.I.2
  • 40
    • 43449138491 scopus 로고    scopus 로고
    • Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans
    • 10.1111/j.1474-9726.2008.00385.x. 18331616
    • Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans. KA Steinkraus ED Smith C Davis D Carr WR Pendergrass GL Sutphin BK Kennedy M Kaeberlein, Aging Cell 2008 7 3 394 404 10.1111/j.1474-9726.2008.00385.x 18331616
    • (2008) Aging Cell , vol.7 , Issue.3 , pp. 394-404
    • Steinkraus, K.A.1    Smith, E.D.2    Davis, C.3    Carr, D.4    Pendergrass, W.R.5    Sutphin, G.L.6    Kennedy, B.K.7    Kaeberlein, M.8
  • 41
    • 22844452091 scopus 로고    scopus 로고
    • Acr-16 encodes an essential subunit of the levamisole-resistant nicotinic receptor at the Caenorhabditis elegans neuromuscular junction
    • 10.1074/jbc.M502818200. 15917232
    • acr-16 encodes an essential subunit of the levamisole-resistant nicotinic receptor at the Caenorhabditis elegans neuromuscular junction. D Touroutine RM Fox SE Von Stetina A Burdina DM Miller JE Richmond, J Biol Chem 2005 280 29 27013 21 10.1074/jbc.M502818200 15917232
    • (2005) J Biol Chem , vol.280 , Issue.29 , pp. 27013-21
    • Touroutine, D.1    Fox, R.M.2    Von Stetina, S.E.3    Burdina, A.4    Miller, D.M.5    Richmond, J.E.6
  • 42
    • 0342716455 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptors in the nematode Caenorhabditis elegans
    • 10.1006/jmbi.1996.0248. 8627624
    • Nicotinic acetylcholine receptors in the nematode Caenorhabditis elegans. M Ballivet C Alliod S Bertrand D Bertrand, J Mol Biol 1996 258 2 261 9 10.1006/jmbi.1996.0248 8627624
    • (1996) J Mol Biol , vol.258 , Issue.2 , pp. 261-9
    • Ballivet, M.1    Alliod, C.2    Bertrand, S.3    Bertrand, D.4
  • 44
    • 0027771804 scopus 로고
    • A C. elegans mutant that lives twice as long as wild type
    • 10.1038/366461a0. 8247153
    • A C. elegans mutant that lives twice as long as wild type. C Kenyon J Chang E Gensch A Rudner R Tabtiang, Nature 1993 366 6454 461 4 10.1038/366461a0 8247153
    • (1993) Nature , vol.366 , Issue.6454 , pp. 461-4
    • Kenyon, C.1    Chang, J.2    Gensch, E.3    Rudner, A.4    Tabtiang, R.5
  • 45
    • 0035815445 scopus 로고    scopus 로고
    • A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
    • 10.1126/science.1057987. 11292875
    • A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. M Tatar A Kopelman D Epstein MP Tu CM Yin RS Garofalo, Science 2001 292 5514 107 10 10.1126/science.1057987 11292875
    • (2001) Science , vol.292 , Issue.5514 , pp. 107-10
    • Tatar, M.1    Kopelman, A.2    Epstein, D.3    Tu, M.P.4    Yin, C.M.5    Garofalo, R.S.6
  • 46
    • 0347664057 scopus 로고    scopus 로고
    • IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
    • 10.1038/nature01298. 12483226
    • IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. M Holzenberger J Dupont B Ducos P Leneuve A Geloen PC Even P Cervera Y Le Bouc, Nature 2003 421 6919 182 7 10.1038/nature01298 12483226
    • (2003) Nature , vol.421 , Issue.6919 , pp. 182-7
    • Holzenberger, M.1    Dupont, J.2    Ducos, B.3    Leneuve, P.4    Geloen, A.5    Even, P.C.6    Cervera, P.7    Le Bouc, Y.8
  • 49
    • 42149141146 scopus 로고    scopus 로고
    • Functionally significant insulin-like growth factor i receptor mutations in centenarians
    • 10.1073/pnas.0705467105. 18316725
    • Functionally significant insulin-like growth factor I receptor mutations in centenarians. Y Suh G Atzmon MO Cho D Hwang B Liu DJ Leahy N Barzilai P Cohen, Proc Natl Acad Sci USA 2008 105 9 3438 42 10.1073/pnas.0705467105 18316725
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.9 , pp. 3438-42
    • Suh, Y.1    Atzmon, G.2    Cho, M.O.3    Hwang, D.4    Liu, B.5    Leahy, D.J.6    Barzilai, N.7    Cohen, P.8
  • 51
    • 0029942495 scopus 로고    scopus 로고
    • Metabolism of the "swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus
    • 10.1074/jbc.271.16.9390. 8621605
    • Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus. G Thinakaran DB Teplow R Siman B Greenberg SS Sisodia, J Biol Chem 1996 271 16 9390 7 10.1074/jbc.271.16.9390 8621605
    • (1996) J Biol Chem , vol.271 , Issue.16 , pp. 9390-7
    • Thinakaran, G.1    Teplow, D.B.2    Siman, R.3    Greenberg, B.4    Sisodia, S.S.5
  • 52
    • 0028981288 scopus 로고
    • Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans
    • 10.1073/pnas.92.20.9368. 7568134
    • Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans. CD Link, Proc Natl Acad Sci USA 1995 92 20 9368 72 10.1073/pnas.92.20. 9368 7568134
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.20 , pp. 9368-72
    • Link, C.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.