The ubiquitin ligase E6-AP is induced and recruited to aggresomes in response to proteasome inhibition and may be involved in the ubiquitination of Hsp70-bound misfolded proteins

Journal of Biological Chemistry

Volumn 284, Issue 16, 2009, Pages 10537-10545

  Mishra, Amit ^a   Godavarthi, Swetha K ^a   Maheshwari, Megha ^a   Goswami, Anand ^a   Jana, Nihar Ranjan ^a  

^a NATIONAL BRAIN RESEARCH CENTRE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRESOMES; CELLULAR QUALITY CONTROL; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATORS; ENDOPLASMIC RETICULUM STRESS; FOLDED PROTEINS; MICROTUBULE; MISFOLDED PROTEINS; MOLECULAR CHAPERONES; NEURODEGENERATIVE DISORDERS; OVER-EXPRESSION; POLYGLUTAMINE PROTEINS; PROTEASOME; PROTEIN AGGREGATION; SUBCELLULAR STRUCTURE; SUBSTRATE BINDING DOMAIN; UBIQUITIN LIGASE; UBIQUITIN-PROTEASOME SYSTEM; UBIQUITINATION; UNFOLDED PROTEINS;

CELL DEATH; DEGRADATION; ENZYMES; MACHINERY; QUALITY ASSURANCE; QUALITY CONTROL; QUALITY FUNCTION DEPLOYMENT; SUBSTRATES; TOTAL QUALITY MANAGEMENT;

PROTEINS;

CHAPERONE; HEAT SHOCK PROTEIN 70; LUCIFERASE; PROTEASOME; TRANSMEMBRANE CONDUCTANCE REGULATOR; UBIQUITIN PROTEIN LIGASE E3; BENZYLOXYCARBONYLLEUCYL LEUCYL LEUCINE ALDEHYDE; BENZYLOXYCARBONYLLEUCYL-LEUCYL-LEUCINE ALDEHYDE; CYSTEINE PROTEINASE INHIBITOR; HYBRID PROTEIN; LEUPEPTIN; PEPTIDE; POLYGLUTAMINE; UBE3A PROTEIN, HUMAN; UBIQUITIN; UBIQUITIN PROTEIN LIGASE;

AGGRESOME; ANIMAL CELL; ARTICLE; CELL DEATH; CELL PROTECTION; CELL STRAIN COS7; CELL STRESS; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INDUCTION; ENZYME LOCALIZATION; ENZYME SUBSTRATE; GENE OVEREXPRESSION; HAPPY PUPPET SYNDROME; MICROTUBULE ORGANIZING CENTER; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN INTERACTION; QUALITY CONTROL; UBIQUITINATION; ANIMAL; CELL LINE; DRUG ANTAGONISM; GENETICS; HEAT; HUMAN; METABOLISM; PHYSIOLOGY;

ANGELMAN SYNDROME; ANIMALS; CELL DEATH; CELL LINE; CYSTEINE PROTEINASE INHIBITORS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; HOT TEMPERATURE; HSP70 HEAT-SHOCK PROTEINS; HUMANS; LEUPEPTINS; LUCIFERASES; PEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN FOLDING; RECOMBINANT FUSION PROTEINS; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 67449107793     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M806804200     Document Type: Article

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