An approach for serotonin depletion in pigs: Effects on serotonin receptor binding

Synapse

Volumn 65, Issue 2, 2011, Pages 136-145

  Ettrup, Anders ^a   Kornum, Birgitte R ^a   Weikop, Pia ^b   Knudsen, Gitte M ^a  

^a University of Copenhagen   (Denmark)

^b NEUROSEARCH A S   (Denmark)

Author keywords

5 HT, autoradiography; para chlorophenylalanine; Porcine models; Serotonin receptors

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; 5 HYDROXYINDOLEACETIC ACID; DOPAMINE; FENCLONINE; HOMOVANILLIC ACID; SEROTONIN; SEROTONIN 2A RECEPTOR; SEROTONIN 4 RECEPTOR; SEROTONIN TRANSPORTER;

ANIMAL EXPERIMENT; ARTICLE; AUTORADIOGRAPHY; BRAIN STEM; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; FEMALE; FRONTAL CORTEX; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; NONHUMAN; NUCLEUS ACCUMBENS; OCCIPITAL CORTEX; PRIORITY JOURNAL; RECEPTOR BINDING; SEROTONIN RELEASE; SWINE; TISSUE LEVEL; UPREGULATION;

ANALYSIS OF VARIANCE; ANIMALS; AUTORADIOGRAPHY; BIOGENIC MONOAMINES; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CITALOPRAM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FEMALE; FENCLONINE; FUNCTIONAL LATERALITY; PROTEIN BINDING; RECEPTORS, SEROTONIN, 5-HT4; SEROTONIN; SEROTONIN ANTAGONISTS; SEROTONIN UPTAKE INHIBITORS; SWINE; TISSUE DISTRIBUTION; TRITIUM;

EID: 78650031732     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.20827     Document Type: Article

References (40)

1. Barnes NM, Sharp T. 1999. A review of central 5-HT receptors and their function. Neuropharmacology 38: 1083-1152.
2. Burnet PW, Eastwood SL, Harrison PJ. 1997. [3H]WAY-100635 for 5-HT1A receptor autoradiography in human brain: A comparison with [3H]8-OH-DPAT and demonstration of increased binding in the frontal cortex in schizophrenia. Neurochem Int 30: 565-574.
3. Cahir M, Ardis T, Reynolds GP, Cooper SJ. 2007. Acute and chronic tryptophan depletion differentially regulate central 5-HT1A and 5-HT 2A receptor binding in the rat. Psychopharmacology (Berl) 190: 497-506.
4. Chalon S, Bronquard C, Vercouillie J, Kodas E, Garreau L, Bodard S, Emond P, Besnard JC, Guilloteau D. 2004. ADAM is an effective tool for in vivo study of serotonergic function: Validation in rat models. Synapse 52: 136-142.
5. Compan V, Daszuta A, Salin P, Sebben M, Bockaert J, Dumuis A. 1996. Lesion study of the distribution of serotonin 5-HT4 receptors in rat basal ganglia and hippocampus. Eur J Neurosci 8: 2591-2598.
6. Compan V, Segu L, Buhot MC, Daszuta A. 1998. Differential effects of serotonin (5-HT) lesions and synthesis blockade on neuropeptide-Y immunoreactivity and 5-HT1A, 5-HT1B/1D and 5-HT2A/2C receptor binding sites in the rat cerebral cortex. Brain Res 795: 264-276.
7. Cumming P, Kretzschmar M, Brust P, Smith DF. 2001. Quantitative radioluminography of serotonin uptake sites in the porcine brain. Synapse 39: 351-355.
8. Cumming P, Moller M, Benda K, Minuzzi L, Jakobsen S, Jensen SB, Pakkenberg B, Stark AK, Gramsbergen JB, Andreasen MF, Olsen AK. 2007. A PET study of effects of chronic 3, 4-methylenedioxymethamphetamine (MDMA, "ecstasy") on serotonin markers in Gottingen minipig brain. Synapse 61: 478-487.
9. Datla KP, Curzon G. 1996. Effect of p-chlorophenylalanine at moderate dosage on 5-HT and 5-HIAA concentrations in brain regions of control and p-chloroamphetamine treated rats. Neuropharmacology 35: 315-320.
10. Delgado PL, Charney DS, Price LH, Aghajanian GK, Landis H, Heninger GR. 1990. Serotonin function and the mechanism of antidepressant action. Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan. Arch Gen Psychiatry 47: 411-418.
11. Felix B, Leger ME, Albe-Fessard D, Marcilloux JC, Rampin O, Laplace JP. 1999. Stereotaxic atlas of the pig brain. Brain Res Bull 49: 1-137.
12. Fischette CT, Nock B, Renner K. 1987. Effects of 5, 7-dihydroxytryptamine on serotonin1 and serotonin2 receptors throughout the rat central nervous system using quantitative autoradiography. Brain Res 421: 263-279.
13. Fusar-Poli P, Allen P, McGuire P, Placentino A, Cortesi M, Perez J. 2006. Neuroimaging and electrophysiological studies of the effects of acute tryptophan depletion: A systematic review of the literature. Psychopharmacology (Berl) 188: 131-143.
14. Gobbi M, Regondi MC, Pompeiano M, Palacios JM, Mennini T. 1994. Differential effects of 5, 7-dihydroxytryptamine-induced serotoninergic degeneration of 5-HT1A receptors and 5-HT uptake sites in the rat brain. J Chem Neuroanat 7: 65-73.
15. Gradwell PB, Everitt BJ, Herbert J. 1975. 5-Hydroxytryptamine in the central nervous system and sexual receptivity of female rhesus monkeys. Brain Res 88: 281-293.
16. Hall H, Lundkvist C, Halldin C, Farde L, Pike VW, McCarron JA, Fletcher A, Cliffe IA, Barf T, Wikstrom H, Sedvall G. 1997. Autoradiographic localization of 5-HT1A receptors in the post-mortem human brain using [3H]WAY-100635 and [11C]way-100635. Brain Res 745: 96-108.
17. Hall H, Farde L, Halldin C, Lundkvist C, Sedvall G. 2000. Autoradiographic localization of 5-HT(2A) receptors in the human brain using [(3)H]M100907 and [(11)C]M100907. Synapse 38: 421-431.
18. Jans LA, Riedel WJ, Markus CR, Blokland A. 2007. Serotonergic vulnerability and depression: Assumptions, experimental evidence and implications. Mol Psychiatry 12: 522-543.
19. King MV, Marsden CA, Fone KC. 2008. A role for the 5-HT(1A), 5-HT4 and 5-HT6 receptors in learning and memory. Trends Pharmacol Sci 29: 482-492.
20. Koe BK, Weissman A. 1966. p-Chlorophenylalanine: A specific depletor of brain serotonin. J Pharmacol Exp Ther 154: 499-516.
21. Kornum BR, Licht CL, Weikop P, Knudsen GM, Aznar S. 2006. Central serotonin depletion affects rat brain areas differently: A qualitative and quantitative comparison between different treatment schemes. Neurosci Lett 392: 129-134.
22. Kornum BR, Lind NM, Gillings N, Marner L, Andersen F, Knudsen GM. 2009. Evaluation of the novel 5-HT4 receptor PET ligand [11C]SB207145 in the Gottingen minipig. J Cereb Blood Flow Metab 29: 186-196.
23. Kristiansen H, Elfving B, Plenge P, Pinborg LH, Gillings N, Knudsen GM. 2005. Binding characteristics of the 5-HT2A receptor antagonists altanserin and MDL 100907. Synapse 58: 249-257.
24. Licht CL, Marcussen AB, Wegener G, Overstreet DH, Aznar S, Knudsen GM. 2009. The brain 5-HT4 receptor binding is down-regulated in the flinders sensitive line depression model and in response to paroxetine administration. J Neurochem 109: 1363-1374.
25. Lind NM, Moustgaard A, Jelsing J, Vajta G, Cumming P, Hansen AK. 2007. The use of pigs in neuroscience: Modeling brain disorders. Neurosci Biobehav Rev 31: 728-751.
26. Lopez-Gimenez JF, Mengod G, Palacios JM, Vilaro MT. 1997. Selective visualization of rat brain 5-HT2A receptors by autoradiography with [3H]MDL 100, 907. Naunyn Schmiedebergs Arch Pharmacol 356: 446-454.
27. Lopez-Gimenez JF, Vilaro MT, Palacios JM, Mengod G. 1998. [3H]MDL 100, 907 labels 5-HT2A serotonin receptors selectively in primate brain. Neuropharmacology 37: 1147-1158.
28. Lopez-Gimenez JF, Vilaro MT, Palacios JM, Mengod G. 2001. Mapping of 5-HT2A receptors and their mRNA in monkey brain: [3H]MDL100, 907 autoradiography and in situ hybridization studies. J Comp Neurol 429: 571-589.
29. McGregor IS, Clemens KJ, Van der PG, Li KM, Hunt GE, Chen F, Lawrence AJ. 2003. Increased anxiety 3 months after brief exposure to MDMA ("Ecstasy") in rats: Association with altered 5-HT transporter and receptor density. Neuropsychopharmacology 28: 1472-1484.
30. Nielsen K, Brask D, Knudsen GM, Aznar S. 2006. Immunodetection of the serotonin transporter protein is a more valid marker for serotonergic fibers than serotonin. Synapse 59: 270-276.
31. O'Connell MT, Portas CM, Sarna GS, Curzon G. 1991. Effect of p-chlorophenylalanine on release of 5-hydroxytryptamine from the rat frontal cortex in vivo. Br J Pharmacol 102: 831-836.
32. O'Leary OF, Bechtholt AJ, Crowley JJ, Hill TE, Page ME, Lucki I. 2007. Depletion of serotonin and catecholamines block the acute behavioral response to different classes of antidepressant drugs in the mouse tail suspension test. Psychopharmacology (Berl) 192: 357-371.
33. Paxinos G, Burt J, Atrens DM, Jackson DM. 1977. 5-Hydroxytryptamine depletion with para-chlorophenylalanine: Effects on eating, drinking, irritability, muricide, and copulation. Pharmacol Biochem Behav 6: 439-447.
34. Pike VW, Halldin C, Nobuhara K, Hiltunen J, Mulligan RS, Swahn CG, Karlsson P, Olsson H, Hume SP, Hirani E, Whalley J, Pilowsky LS, Larsson S, Schnell PO, Ell PJ, Farde L. 2003. Radioiodinated SB 207710 as a radioligand in vivo: Imaging of brain 5-HT4 receptors with SPET. Eur J Nucl Med Mol Imaging 30: 1520-1528.
35. Rattray M, Baldessari S, Gobbi M, Mennini T, Samanin R, Bendotti C. 1996. p-Chlorphenylalanine changes serotonin transporter mRNA levels and expression of the gene product. J Neurochem 67: 463-472.
36. Reneman L, Endert E, de Bruin K, Lavalaye J, Feenstra MG, de Wolff FA, Booij J. 2002. The acute and chronic effects of MDMA ("ecstasy") on cortical 5-HT2A receptors in rat and human brain. Neuropsychopharmacology 26: 387-396.
37. Thomsen C, Helboe L. 2003. Regional pattern of binding and c-Fos induction by (R)- and (S)-citalopram in rat brain. Neuroreport 14: 2411-2414.
38. Varnäs K, Halldin C, Pike VW, Hall H. 2003. Distribution of 5-HT4 receptors in the postmortem human brain-an autoradiographic study using [125I]SB 207710. Eur Neuropsychopharmacol 13: 228-234.
39. Vodicka P, Smetana KJr, Dvorankova B, Emerick T, Xu YZ, Ourednik J, Ourednik V, Motlik J. 2005. The miniature pig as an animal model in biomedical research. Ann N Y Acad Sci 1049: 161-171.
40. Weikop P, Kehr J, Scheel-Kruger J. 2007. Reciprocal effects of combined administration of serotonin, noradrenaline and dopamine reuptake inhibitors on serotonin and dopamine levels in the rat prefrontal cortex: The role of 5-HT1A receptors. J Psychopharmacol 21: 795-804.