Central serotonin depletion affects rat brain areas differently: A qualitative and quantitative comparison between different treatment schemes

Neuroscience Letters

Volumn 392, Issue 1-2, 2006, Pages 129-134

  Kornum, Birgitte Rahbek ^a   Licht, Cecilie Löe ^a   Weikop, Pia ^b   Knudsen, Gitte Moos ^a   Aznar, Susana ^a  

^a Rigshospitalet   (Denmark)

^b NEUROSEARCH A S   (Denmark)

Author keywords

5 HT depletion; Fenfluramine; HPLC; Immunohistochemistry; p Chlorophenylalanine

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; FENCLONINE; FENFLURAMINE; SEROTONIN; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN REGION; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; MALE; MEDIAL FOREBRAIN BUNDLE; NONHUMAN; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RAPHE NUCLEUS; RAT; SEROTONIN BRAIN LEVEL; SEROTONIN RELEASE; SEROTONINERGIC SYSTEM; THALAMUS; TISSUE DISTRIBUTION;

ANIMALS; BRAIN; BRAIN CHEMISTRY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG ADMINISTRATION SCHEDULE; DRUG INTERACTIONS; FENFLURAMINE; HYDROXYINDOLEACETIC ACID; MALE; P-CHLOROAMPHETAMINE; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SEROTONIN AGENTS; SEROTONIN UPTAKE INHIBITORS;

EID: 28744453389     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2005.09.013     Document Type: Article

References (21)

1. N.M. Appel, J.F. Contrera, and E.B. De Souza Fenfluramine selectively and differentially decreases the density of serotonergic nerve terminals in rat brain: evidence from immunocytochemical studies J. Pharmacol. Exp. Ther. 249 1989 928 943
2. M.H. Baumann, M.A. Ayestas, C.M. Dersch, J.S. Partilla, and R.B. Rothman Serotonin transporters, serotonin release, and the mechanism of fenfluramine neurotoxicity Ann. N.Y. Acad. Sci. 914 2000 172 186
3. M.H. Baumann, M.A. Ayestas, and R.B. Rothman Functional consequences of central serotonin depletion produced by repeated fenfluramine administration in rats J. Neurosci. 18 1998 9069 9077
4. 3H]paroxetine as an in vivo ligand for serotonin uptake sites: a quantitative autoradiographic study in the rat brain Synapse 13 1993 1 9
5. 3H-paroxetine binding sites in rat brain J. Pharmacol. Toxicol. Methods 27 1992 209 216
6. B.V. Clineschmidt, J.A. Totaro, J.C. McGuffin, and A.B. Pflueger Fenfluramine: long-term reduction in brain serotonin (5-hydroxytryptamine) Eur. J. Pharmacol. 35 1976 211 214
7. M.I. Colado, E. O'Shea, R. Granados, T.K. Murray, and A.R. Green In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA ('ecstasy') and p-chloroamphetamine but not the degeneration following fenfluramine Br. J. Pharmacol. 121 1997 889 900
8. J.F. Cryan, A. Harkin, M. Naughton, J.P. Kelly, and B.E. Leonard Characterization of d-fenfluramine-induced hypothermia: evidence for multiple sites of action Eur. J. Pharmacol. 390 2000 275 285
9. J.A. Harvey, S.E. McMaster, and L.M. Yunger p-Chloramphetamine: selective neurotoxic action in brain Science 187 1975 841 843
10. B.L. Jacobs, and E.C. Azmitia Structure and function of the brain serotonin system Physiol. Rev. 72 1992 165 229
11. B.K. Koe Tryptophan hydroxylase inhibitors Fed. Proc. 30 1971 886 896
12. L.A. Mamounas, C.A. Altar, M.E. Blue, D.R. Kaplan, L. Tessarollo, and W.E. Lyons BDNF promotes the regenerative sprouting, but not survival, of injured serotonergic axons in the adult rat brain J. Neurosci. 20 2000 771 782
13. L.A. Mamounas, C.A. Mullen, E. O'Hearn, and M.E. Molliver Dual serotoninergic projections to forebrain in the rat: morphologically distinct 5-HT axon terminals exhibit differential vulnerability to neurotoxic amphetamine derivatives J. Comp. Neurol. 314 1991 558 586
14. E.J. Manzana, W.J. Chen, and T.H. Champney Acute melatonin and para-chloroamphetamine interactions on pineal, brain and serum serotonin levels as well as stress hormone levels Brain Res. 909 2001 127 137
15. D. Muck-Seler, and M. Diksic d,l-Fenfluramine increases the 5-HT synthesis rate in the terminals while decreasing it in the cell bodies of the rat brain Brain Res. 737 1996 45 50
16. E.P. Prinssen, M.B. Assie, W. Koek, and M.S. Kleven Depletion of 5-HT disrupts prepulse inhibition in rats: dependence on the magnitude of depletion, and reversal by a 5-HT precursor Neuropsychopharmacology 26 2002 340 347
17. G. Rudnick, and S.C. Wall p-Chloroamphetamine induces serotonin release through serotonin transporters Biochemistry 31 1992 6710 6718
18. F. Shutoh, S. Hamada, M. Shibata, M. Narita, T. Shiga, E.C. Azmitia, and N. Okado Long term depletion of serotonin leads to selective changes in glutamate receptor subunits Neurosci. Res. 38 2000 365 371
19. F. Yamane, Y. Tohyama, and M. Diksic Acute and chronic d-fenfluramine treatments have different effects on serotonin synthesis rates in the rat brain: an autoradiographic study Neurochem. Res. 24 1999 1611 1620
20. R. Zaczek, G. Battaglia, S. Culp, N.M. Appel, J.F. Contrera, and E.B. De Souza Effects of repeated fenfluramine administration on indices of monoamine function in rat brain: pharmacokinetic, dose response, regional specificity and time course data J. Pharmacol. Exp. Ther. 253 1990 104 112
21. D. Zhou, M. Schreinert, J. Pilz, and G. Huether Rat strain differences in the vulnerability of serotonergic nerve endings to neurotoxic damage by p-chloroamphetamine J. Neural. Transm. 103 1996 1381 1395