ADAM Is an Effective Tool for in Vivo Study of Serotonergic Function: Validation in Rat Models

Synapse

Volumn 52, Issue 2, 2004, Pages 136-142

  Chalon, Sylvie ^a   Bronquard, Cécile ^a   Vercouillie, Johnny ^a   Kodas, Ercem ^a   Garreau, Lucette ^a   Bodard, Sylvie ^a   Emond, Patrick ^a   Besnard, Jean Claude ^a   Guilloteau, Denis ^a  

^a INSERM   (France)

Author keywords

5,7 Dihydroxytryptamine; Imaging; Monoamine; Serotonin transporter; SPECT

Indexed keywords

2 [[2 [(DIMETHYLAMINO)METHYL]PHENYL]THIO] 5 IODOPHENYLAMINE; 5,7 DIHYDROXYTRYPTAMINE; FENCLONINE; IODINATED CONTRAST MEDIUM; IODINE 125; MONOAMINE; NISOXETINE; PAROXETINE; RADIOLIGAND; SEROTONIN; SEROTONIN TRANSPORTER; TRACER; UNCLASSIFIED DRUG; VANOXERINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CELL LOSS; CONTROLLED STUDY; CORPUS STRIATUM; FRONTAL CORTEX; HIPPOCAMPUS; HYPOTHALAMUS; IN VIVO STUDY; MALE; NEUROIMAGING; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONIN BRAIN LEVEL; SEROTONINERGIC NERVE CELL; SEROTONINERGIC TRANSMISSION; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; THALAMUS; VALIDATION PROCESS;

ANIMALS; BRAIN; CARRIER PROTEINS; CINANSERIN; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; RADIOACTIVE TRACERS; RATS; RATS, WISTAR; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 1842562959     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/syn.20012     Document Type: Article

References (33)

1. 123I]IDAM. Eur J Nucl Med 26:1359-1362.
2. 123I]ODAM. Eur J Nucl Med 26:1359-1362.
3. 123I]ADAM and SPECT. J Nucl Med 42:1556-1562.
4. Baumgarten HG, Bjorklund A, Lachenmeyer L, Nobin A. 1973. Evaluation of the effects of 5,7-dihydroxytryptamine on serotonin and catecholamine neurons in the rat CNS. Acta Physiol Scan (Suppl) 391:1-19.
5. Bonvento G, Borredon J, Seylaz J, Lacombe P. 1997. Cerebrovascular consequences of altering serotonergic transmission in conscious rat. Brain Res 767:208-213.
6. 123I]β-CIT. Binding kinetics in the human brain. J Neural Transm [Gen Sect] 94:137-146.
7. Carli M, Reader TA. 1997. Regulation of central serotonin transporters by chronic lithium: an autoradiographic study. Synapse 27:83-89.
8. 3H]]citalopram. Neuroscience 54:691-699.
9. 125I]ADAM to serotonin transporters in rat brain. Synapse 38:403-412.
10. Compan V, Dusticier N, Nieoullon A, Daszuta A. 1996. Opposites changes in striatal neuropeptide Y immunoreactivity after partial and complete serotonergic depletion in the rat. Synapse 24:87-96.
11. Cortés R, Mengod G, Celada P, Artigas F. 1993. p-chlorophenylalanine increases tryptophan-5-hydroxylase mRNA levels in the rat dorsal raphe: a time course study using in situ hybridization. J Neurochem 60:761-764.
12. Dugar A, Keck BJ, Maines LW, Miller S, Njai R, Laroski JM. 2001. Hippocampal serotonergic system following neurodegenerative injury with 5,7-dihydroxytryptamine. Synapse 39:109-121.
13. Ferris RM, Brieaddy L, Mehta N, Hollingsworth E, Rigdon G, Wang C, Soroko F, Wastila W, Cooper B. 1995. Pharmacological properties of 403U76, a new chemical class of 5-hydroxytryptamine- and noradrenaline-reuptake inhibitor. J Pharm Pharmacol 47:775-781.
14. Ginovart N, Hassoun W, Le Bars D, Weissmann D, Leviel V. 2000. In vivo characterization of p-[(18)F]MPPF, a fluoro analog of WAY-100635 for visualization of 5-HT(1a) receptors. Synapse 35:192-200.
15. Hébert C, Habimana A, Elie R, Reader TA. 2001. Effects of chronic antidepressant treatments on 5-HT and NA transporters in rat brain: an autoradiographic study. Neurochem Int 38:63-74.
16. Hiltunen J, Akerman KK, Kuikka JT, Bergström KA, Halldin C, Nikula T, Räsänen P, Tiihonen J, Vauhkonen M, Karhu J, Kupila J, Länsimies E, Farde L. 1998. Iodine-123 labeled nor-β-CIT as a potential tracer for serotonin transporter imaging in the human brain with single-photon emission tomography. Eur J Nucl Med 25:19-23.
17. 3H]imipramine localization and relationship to serotonin transporter. J Pharmacol Exp Ther 252:410-418.
18. Jéquier E, Lovenberg W, Sjoerdsma A. 1967. Tryptophan hydroxylase inhibition: the mechanism by which p-chlorophenylalanine depletes rat brain serotonin. Mol Pharmacol 3:274-278.
19. 123I]IDAM as a novel single-photon emission tomography tracer for serotonin transporters. Eur J Nucl Med 26:844-853.
20. Laruelle M. 2000. Imaging neurotransmission with in vivo binding competition techniques: a critical review. J Cereb Blood Flow Metab 20:423-451.
21. Leake A, Fairbairn AF, McKeith IG, Ferrier IN. 1991. Studies on the serotonin uptake binding site in major depressive disorder and control post-mortem brain: neurochemical and clinical correlates. Psychiatry Res 39:155-165.
22. 123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane and single photon emission computed tomography. Biol Psychiatry 44:1090-1098.
23. Mann JJ. 1998. The role of in vivo neurotransmitter system imaging studies in understanding major depression. Biol Psychiatry 44:1077-1078.
24. Mash DC, Staley JK, Izenwasser S, Basile M, Ruttenber AJ. 2000. Serotonin transporters upregulate with chronic cocaine use. J Chem Neuroanat 20:271-280.
25. McCann UD, Szabo Z, Scheffel U, Dannals RF, Ricaurte GA. 1998. Positron emission tomographic evidence of toxic effect of MDMA ("ecstasy") on brain serotonin neurons in human beings. Lancet 352:1433-1437.
26. Meltzer H. 1990. Role of serotonin in depression. Ann NY Acad Sci 487:486-500.
27. Oya S, Choi S-R, Hou C, Mu M, Kung M-P, Acton PD, Siciliano M, Kung HF. 2000. 2-((2-(Dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM): an improved serotonin transporter ligand. Nucl Med Biol 27:249-254.
28. Paxinos G, Watson C. 1982. The rat brain in stereotaxic coordinates. Nex York: Academoc Press.
29. Semple DM, Ebmeier KP, Glabus MF, O'Carroll RE, Johnstone EC. 1999. Reduced in vivo binding to serotonin transporters in the cerebral cortex of MDMA ("ecstasy") users. Br J Psychiatry 175:63-69.
30. Staley JK, Malison RT, Innis RB. 1998. Imaging of the serotonergic systems: interactions of neuroanatomical and functional abnormalities of depression. Biol Psychiatry 44:534-549.
31. 3H]imipramine binding sites are decreased in the frontal cortex of suicides. Science 216:1337-1339.
32. Tejani-Butt SM, Yang J, Pawlyk AC. 1995. Altered serotonin transporter sites in Alzheimer's disease raphe and hippocampus. NeuroReport 6:1207-1210.
33. 18F-MPPF in the rat hippocampus: kinetic β measurements combined with microdialysis. J Neurochem 80:278-286.