A residue close to α1 loop F disrupts modulation of GABAA receptors by benzodiazepines while their binding is maintained

Journal of Neurochemistry

Volumn 115, Issue 6, 2010, Pages 1478-1485

  Baur, Roland ^a   Lüscher, Benjamin P ^a   Richter, Lars ^b   Sigel, Erwin ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

benzodiazepine binding; benzodiazepine modulation; channel gating; F loop; GABA; GABAA receptor

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE DERIVATIVE; FLUMAZENIL; FLUNITRAZEPAM; NEUROSTEROID; PENTOBARBITAL; PHENYLALANINE; TYROSINE; ZOLPIDEM;

ARTICLE; BINDING AFFINITY; BINDING ASSAY; BINDING SITE; CELL CULTURE; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; LIGAND BINDING; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION;

ANIMALS; BENZODIAZEPINES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GAMMA-AMINOBUTYRIC ACID; HEK293 CELLS; HUMANS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, GABA-A; XENOPUS LAEVIS;

EID: 78650000833     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2010.07052.x     Document Type: Article

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