A residue in loop 9 of the β2-subunit stabilizes the closed state of the GABAA receptor

Journal of Biological Chemistry

Volumn 285, Issue 10, 2010, Pages 7281-7287

  Williams, Carrie A ^a   Bell, Shannon V ^a   Jenkins, Andrew ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

293 CELLS; AMINOBUTYRIC ACIDS; CHANNEL OPENING; DIRECT ACTIVATION; GATING EFFICIENCY; HUMAN EMBRYONIC KIDNEYS; HYDROPHILIC INTERACTION; LIGAND BINDING; PROPOFOL; RECEPTOR ACTIVATION; SITE DIRECTED MUTAGENESIS; STRONG CORRELATION; STRUCTURAL ELEMENTS; WHOLE CELL; WILD TYPES;

AMINO ACIDS; ANESTHETICS; BINDING ENERGY; ELECTRIC CONDUCTIVITY MEASUREMENT; ORGANIC ACIDS;

HYDROPHILICITY;

4 AMINOBUTYRIC ACID A RECEPTOR BETA2; ALANINE; ASPARAGINE; ASPARTIC ACID; ELTANOLONE; GLUTAMINE; GLYCINE; ISOLEUCINE; LEUCINE; PICROTOXIN; PROLINE; PROPOFOL; THREONINE; VALINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; CELL STRAIN HEK293; CHEMICAL INTERACTION; CONTROLLED STUDY; EMBRYO; GENE MUTATION; HUMAN; HUMAN CELL; HYDROPHILICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; RAT; RECEPTOR UPREGULATION; SITE DIRECTED MUTAGENESIS; WHOLE CELL; WILD TYPE;

ALANINE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANESTHETICS; ANIMALS; CELL LINE; GAMMA-AMINOBUTYRIC ACID; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PATCH-CLAMP TECHNIQUES; PREGNANOLONE; PROPOFOL; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RATS; RECEPTORS, GABA-A; SEQUENCE ALIGNMENT;

EID: 77951237621     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.050294     Document Type: Article

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