-
1
-
-
14944385553
-
Global cancer statistics, 2002
-
10.3322/canjclin.55.2.74, 15761078
-
Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005, 55:74-108. 10.3322/canjclin.55.2.74, 15761078.
-
(2005)
CA Cancer J Clin
, vol.55
, pp. 74-108
-
-
Parkin, D.M.1
Bray, F.2
Ferlay, J.3
Pisani, P.4
-
2
-
-
44449085884
-
Design and endpoints of clinical trials in hepatocellular carcinoma
-
10.1093/jnci/djn134, 18477802
-
Llovet JM, Di Bisceglie AM, Bruix J, Kramer BS, Lencioni R, Zhu AX, Sherman M, Schwartz M, Lotze M, Talwalkar J, Gores GJ. Design and endpoints of clinical trials in hepatocellular carcinoma. J Natl Cancer Inst 2008, 100:698-711. 10.1093/jnci/djn134, 18477802.
-
(2008)
J Natl Cancer Inst
, vol.100
, pp. 698-711
-
-
Llovet, J.M.1
Di Bisceglie, A.M.2
Bruix, J.3
Kramer, B.S.4
Lencioni, R.5
Zhu, A.X.6
Sherman, M.7
Schwartz, M.8
Lotze, M.9
Talwalkar, J.10
Gores, G.J.11
-
3
-
-
0033998334
-
The PPARs: from orphan receptors to drug discovery
-
10.1021/jm990554g, 10691680
-
Willson TM, Brown PJ, Sternbach DD, Henke BR. The PPARs: from orphan receptors to drug discovery. J Med Chem 2000, 43:527-550. 10.1021/jm990554g, 10691680.
-
(2000)
J Med Chem
, vol.43
, pp. 527-550
-
-
Willson, T.M.1
Brown, P.J.2
Sternbach, D.D.3
Henke, B.R.4
-
4
-
-
0035851187
-
PPARgamma : a nuclear regulator of metabolism, differentiation, and cell growth
-
10.1074/jbc.M106424200, 11459852
-
Rosen ED, Spiegelman BM. PPARgamma : a nuclear regulator of metabolism, differentiation, and cell growth. J Biol Chem 2001, 276:37731-37734. 10.1074/jbc.M106424200, 11459852.
-
(2001)
J Biol Chem
, vol.276
, pp. 37731-37734
-
-
Rosen, E.D.1
Spiegelman, B.M.2
-
5
-
-
0036189407
-
PPARadigms and PPARadoxes: expanding roles for PPARgamma in the control of lipid metabolism
-
Walczak R, Tontonoz P. PPARadigms and PPARadoxes: expanding roles for PPARgamma in the control of lipid metabolism. J Lipid Res 2002, 43:177-186.
-
(2002)
J Lipid Res
, vol.43
, pp. 177-186
-
-
Walczak, R.1
Tontonoz, P.2
-
6
-
-
0028972025
-
15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma
-
10.1016/0092-8674(95)90193-0, 8521497
-
Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell 1995, 83:803-812. 10.1016/0092-8674(95)90193-0, 8521497.
-
(1995)
Cell
, vol.83
, pp. 803-812
-
-
Forman, B.M.1
Tontonoz, P.2
Chen, J.3
Brun, R.P.4
Spiegelman, B.M.5
Evans, R.M.6
-
7
-
-
0029016829
-
An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)
-
10.1074/jbc.270.50.30221, 7768881
-
Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer SA. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J Biol Chem 1995, 270:12953-12956. 10.1074/jbc.270.50.30221, 7768881.
-
(1995)
J Biol Chem
, vol.270
, pp. 12953-12956
-
-
Lehmann, J.M.1
Moore, L.B.2
Smith-Oliver, T.A.3
Wilkison, W.O.4
Willson, T.M.5
Kliewer, S.A.6
-
8
-
-
0027983920
-
Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone
-
10.1056/NEJM199411033311803, 7935656
-
Nolan JJ, Ludvik B, Beerdsen P, Joyce M, Olefsky J. Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. N Engl J Med 1994, 331:1188-1193. 10.1056/NEJM199411033311803, 7935656.
-
(1994)
N Engl J Med
, vol.331
, pp. 1188-1193
-
-
Nolan, J.J.1
Ludvik, B.2
Beerdsen, P.3
Joyce, M.4
Olefsky, J.5
-
9
-
-
50649097541
-
Fat and Beyond: The Diverse Biology of PPARgamma
-
10.1146/annurev.biochem.77.061307.091829, 18518822
-
Tontonoz P, Spiegelman BM. Fat and Beyond: The Diverse Biology of PPARgamma. Annu Rev Biochem 2008, 77:289-312. 10.1146/annurev.biochem.77.061307.091829, 18518822.
-
(2008)
Annu Rev Biochem
, vol.77
, pp. 289-312
-
-
Tontonoz, P.1
Spiegelman, B.M.2
-
10
-
-
12644265334
-
Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor
-
10.1073/pnas.94.1.237, 19300, 8990192
-
Tontonoz P, Singer S, Forman BM, Sarraf P, Fletcher JA, Fletcher CD, Brun RP, Mueller E, Altiok S, Oppenheim H, et al. Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor. Proc Natl Acad Sci USA 1997, 94:237-241. 10.1073/pnas.94.1.237, 19300, 8990192.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 237-241
-
-
Tontonoz, P.1
Singer, S.2
Forman, B.M.3
Sarraf, P.4
Fletcher, J.A.5
Fletcher, C.D.6
Brun, R.P.7
Mueller, E.8
Altiok, S.9
Oppenheim, H.10
-
11
-
-
17844395188
-
Peroxisome proliferator-activated receptor gamma ligand-induced growth inhibition of human hepatocellular carcinoma
-
10.1054/bjoc.2001.1821, 2363681, 11401318
-
Rumi MA, Sato H, Ishihara S, Kawashima K, Hamamoto S, Kazumori H, Okuyama T, Fukuda R, Nagasue N, Kinoshita Y. Peroxisome proliferator-activated receptor gamma ligand-induced growth inhibition of human hepatocellular carcinoma. Br J Cancer 2001, 84:1640-1647. 10.1054/bjoc.2001.1821, 2363681, 11401318.
-
(2001)
Br J Cancer
, vol.84
, pp. 1640-1647
-
-
Rumi, M.A.1
Sato, H.2
Ishihara, S.3
Kawashima, K.4
Hamamoto, S.5
Kazumori, H.6
Okuyama, T.7
Fukuda, R.8
Nagasue, N.9
Kinoshita, Y.10
-
12
-
-
0343855442
-
Effects of ligand activation of peroxisome proliferator-activated receptor gamma in human prostate cancer
-
10.1073/pnas.180329197, 27136, 10984506
-
Mueller E, Smith M, Sarraf P, Kroll T, Aiyer A, Kaufman DS, Oh W, Demetri G, Figg WD, Zhou XP, et al. Effects of ligand activation of peroxisome proliferator-activated receptor gamma in human prostate cancer. Proc Natl Acad Sci USA 2000, 97:10990-10995. 10.1073/pnas.180329197, 27136, 10984506.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 10990-10995
-
-
Mueller, E.1
Smith, M.2
Sarraf, P.3
Kroll, T.4
Aiyer, A.5
Kaufman, D.S.6
Oh, W.7
Demetri, G.8
Figg, W.D.9
Zhou, X.P.10
-
13
-
-
0031595670
-
Activation of PPARgamma leads to inhibition of anchorage-independent growth of human colorectal cancer cells
-
10.1016/S0016-5085(98)70072-1, 9797355
-
Brockman JA, Gupta RA, Dubois RN. Activation of PPARgamma leads to inhibition of anchorage-independent growth of human colorectal cancer cells. Gastroenterology 1998, 115:1049-1055. 10.1016/S0016-5085(98)70072-1, 9797355.
-
(1998)
Gastroenterology
, vol.115
, pp. 1049-1055
-
-
Brockman, J.A.1
Gupta, R.A.2
Dubois, R.N.3
-
14
-
-
0031671246
-
Differentiation and reversal of malignant changes in colon cancer through PPARgamma
-
10.1038/2030, 9734398
-
Sarraf P, Mueller E, Jones D, King FJ, DeAngelo DJ, Partridge JB, Holden SA, Chen LB, Singer S, Fletcher C, Spiegelman BM. Differentiation and reversal of malignant changes in colon cancer through PPARgamma. Nat Med 1998, 4:1046-1052. 10.1038/2030, 9734398.
-
(1998)
Nat Med
, vol.4
, pp. 1046-1052
-
-
Sarraf, P.1
Mueller, E.2
Jones, D.3
King, F.J.4
DeAngelo, D.J.5
Partridge, J.B.6
Holden, S.A.7
Chen, L.B.8
Singer, S.9
Fletcher, C.10
Spiegelman, B.M.11
-
15
-
-
0031694577
-
Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice
-
10.1038/2036, 9734399
-
Lefebvre AM, Chen I, Desreumaux P, Najib J, Fruchart JC, Geboes K, Briggs M, Heyman R, Auwerx J. Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice. Nat Med 1998, 4:1053-1057. 10.1038/2036, 9734399.
-
(1998)
Nat Med
, vol.4
, pp. 1053-1057
-
-
Lefebvre, A.M.1
Chen, I.2
Desreumaux, P.3
Najib, J.4
Fruchart, J.C.5
Geboes, K.6
Briggs, M.7
Heyman, R.8
Auwerx, J.9
-
16
-
-
0031667938
-
Activators of the nuclear receptor PPARgamma enhance colon polyp formation
-
10.1038/2042, 9734400
-
Saez E, Tontonoz P, Nelson MC, Alvarez JG, Ming UT, Baird SM, Thomazy VA, Evans RM. Activators of the nuclear receptor PPARgamma enhance colon polyp formation. Nat Med 1998, 4:1058-1061. 10.1038/2042, 9734400.
-
(1998)
Nat Med
, vol.4
, pp. 1058-1061
-
-
Saez, E.1
Tontonoz, P.2
Nelson, M.C.3
Alvarez, J.G.4
Ming, U.T.5
Baird, S.M.6
Thomazy, V.A.7
Evans, R.M.8
-
17
-
-
33747164536
-
RS5444, a novel PPARgamma agonist, regulates aspects of the differentiated phenotype in nontransformed intestinal epithelial cells
-
10.1016/j.mce.2006.02.006, 16574311
-
Chen L, Bush CR, Necela BM, Su W, Yanagisawa M, Anastasiadis PZ, Fields AP, Thompson EA. RS5444, a novel PPARgamma agonist, regulates aspects of the differentiated phenotype in nontransformed intestinal epithelial cells. Mol Cell Endocrinol 2006, 251:17-32. 10.1016/j.mce.2006.02.006, 16574311.
-
(2006)
Mol Cell Endocrinol
, vol.251
, pp. 17-32
-
-
Chen, L.1
Bush, C.R.2
Necela, B.M.3
Su, W.4
Yanagisawa, M.5
Anastasiadis, P.Z.6
Fields, A.P.7
Thompson, E.A.8
-
18
-
-
43049165453
-
The epithelial-mesenchymal transition generates cells with properties of stem cells
-
10.1016/j.cell.2008.03.027, 2728032, 18485877
-
Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008, 133:704-715. 10.1016/j.cell.2008.03.027, 2728032, 18485877.
-
(2008)
Cell
, vol.133
, pp. 704-715
-
-
Mani, S.A.1
Guo, W.2
Liao, M.J.3
Eaton, E.N.4
Ayyanan, A.5
Zhou, A.Y.6
Brooks, M.7
Reinhard, F.8
Zhang, C.C.9
Shipitsin, M.10
-
19
-
-
12144287188
-
PPAR gamma signaling exacerbates mammary gland tumor development
-
10.1101/gad.1167804, 374235, 15037548
-
Saez E, Rosenfeld J, Livolsi A, Olson P, Lombardo E, Nelson M, Banayo E, Cardiff RD, Izpisua-Belmonte JC, Evans RM. PPAR gamma signaling exacerbates mammary gland tumor development. Genes Dev 2004, 18:528-540. 10.1101/gad.1167804, 374235, 15037548.
-
(2004)
Genes Dev
, vol.18
, pp. 528-540
-
-
Saez, E.1
Rosenfeld, J.2
Livolsi, A.3
Olson, P.4
Lombardo, E.5
Nelson, M.6
Banayo, E.7
Cardiff, R.D.8
Izpisua-Belmonte, J.C.9
Evans, R.M.10
-
20
-
-
0037109043
-
APC-dependent suppression of colon carcinogenesis by PPARgamma
-
10.1073/pnas.162480299, 129773, 12370429
-
Girnun GD, Smith WM, Drori S, Sarraf P, Mueller E, Eng C, Nambiar P, Rosenberg DW, Bronson RT, Edelmann W, et al. APC-dependent suppression of colon carcinogenesis by PPARgamma. Proc Natl Acad Sci USA 2002, 99:13771-13776. 10.1073/pnas.162480299, 129773, 12370429.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 13771-13776
-
-
Girnun, G.D.1
Smith, W.M.2
Drori, S.3
Sarraf, P.4
Mueller, E.5
Eng, C.6
Nambiar, P.7
Rosenberg, D.W.8
Bronson, R.T.9
Edelmann, W.10
-
21
-
-
0037124098
-
Loss of the peroxisome proliferation-activated receptor gamma (PPARgamma) does not affect mammary development and propensity for tumor formation but leads to reduced fertility
-
10.1074/jbc.M200186200, 11884400
-
Cui Y, Miyoshi K, Claudio E, Siebenlist UK, Gonzalez FJ, Flaws J, Wagner KU, Hennighausen L. Loss of the peroxisome proliferation-activated receptor gamma (PPARgamma) does not affect mammary development and propensity for tumor formation but leads to reduced fertility. J Biol Chem 2002, 277:17830-17835. 10.1074/jbc.M200186200, 11884400.
-
(2002)
J Biol Chem
, vol.277
, pp. 17830-17835
-
-
Cui, Y.1
Miyoshi, K.2
Claudio, E.3
Siebenlist, U.K.4
Gonzalez, F.J.5
Flaws, J.6
Wagner, K.U.7
Hennighausen, L.8
-
22
-
-
33644792520
-
Troglitazone inhibits tumor growth in hepatocellular carcinoma in vitro and in vivo
-
10.1002/hep.20994, 16374840
-
Yu J, Qiao L, Zimmermann L, Ebert MP, Zhang H, Lin W, Rocken C, Malfertheiner P, Farrell GC. Troglitazone inhibits tumor growth in hepatocellular carcinoma in vitro and in vivo. Hepatology 2006, 43:134-143. 10.1002/hep.20994, 16374840.
-
(2006)
Hepatology
, vol.43
, pp. 134-143
-
-
Yu, J.1
Qiao, L.2
Zimmermann, L.3
Ebert, M.P.4
Zhang, H.5
Lin, W.6
Rocken, C.7
Malfertheiner, P.8
Farrell, G.C.9
-
23
-
-
0033616795
-
Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma
-
10.1073/pnas.96.7.3951, 22401, 10097144
-
Demetri GD, Fletcher CD, Mueller E, Sarraf P, Naujoks R, Campbell N, Spiegelman BM, Singer S. Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma. Proc Natl Acad Sci USA 1999, 96:3951-3956. 10.1073/pnas.96.7.3951, 22401, 10097144.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 3951-3956
-
-
Demetri, G.D.1
Fletcher, C.D.2
Mueller, E.3
Sarraf, P.4
Naujoks, R.5
Campbell, N.6
Spiegelman, B.M.7
Singer, S.8
-
24
-
-
28644435769
-
Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer
-
10.1038/sj.bjc.6602862, 2361529, 16288304
-
Lin HJ, Hsieh FC, Song H, Lin J. Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer. Br J Cancer 2005, 93:1372-1381. 10.1038/sj.bjc.6602862, 2361529, 16288304.
-
(2005)
Br J Cancer
, vol.93
, pp. 1372-1381
-
-
Lin, H.J.1
Hsieh, F.C.2
Song, H.3
Lin, J.4
-
25
-
-
26044443105
-
AKT activation predicts outcome in breast cancer patients treated with tamoxifen
-
10.1002/path.1829, 16088978
-
Kirkegaard T, Witton CJ, McGlynn LM, Tovey SM, Dunne B, Lyon A, Bartlett JM. AKT activation predicts outcome in breast cancer patients treated with tamoxifen. J Pathol 2005, 207:139-146. 10.1002/path.1829, 16088978.
-
(2005)
J Pathol
, vol.207
, pp. 139-146
-
-
Kirkegaard, T.1
Witton, C.J.2
McGlynn, L.M.3
Tovey, S.M.4
Dunne, B.5
Lyon, A.6
Bartlett, J.M.7
-
26
-
-
0036632368
-
The phosphatidylinositol 3-Kinase AKT pathway in human cancer
-
10.1038/nrc839, 12094235
-
Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002, 2:489-501. 10.1038/nrc839, 12094235.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
27
-
-
43749120732
-
The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications
-
10.2174/156800908784293659, 18473732
-
Carnero A, Blanco-Aparicio C, Renner O, Link W, Leal JF. The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications. Curr Cancer Drug Targets 2008, 8:187-198. 10.2174/156800908784293659, 18473732.
-
(2008)
Curr Cancer Drug Targets
, vol.8
, pp. 187-198
-
-
Carnero, A.1
Blanco-Aparicio, C.2
Renner, O.3
Link, W.4
Leal, J.F.5
-
28
-
-
0032555196
-
Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice
-
10.1073/pnas.95.15.8806, 21158, 9671760
-
Elstner E, Muller C, Koshizuka K, Williamson EA, Park D, Asou H, Shintaku P, Said JW, Heber D, Koeffler HP. Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice. Proc Natl Acad Sci USA 1998, 95:8806-8811. 10.1073/pnas.95.15.8806, 21158, 9671760.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 8806-8811
-
-
Elstner, E.1
Muller, C.2
Koshizuka, K.3
Williamson, E.A.4
Park, D.5
Asou, H.6
Shintaku, P.7
Said, J.W.8
Heber, D.9
Koeffler, H.P.10
-
29
-
-
35448982383
-
Biology of PPAR gamma in cancer: a critical review on existing lacunae
-
10.2174/156652407781695765, 17896990
-
Krishnan A, Nair SA, Pillai MR. Biology of PPAR gamma in cancer: a critical review on existing lacunae. Curr Mol Med 2007, 7:532-540. 10.2174/156652407781695765, 17896990.
-
(2007)
Curr Mol Med
, vol.7
, pp. 532-540
-
-
Krishnan, A.1
Nair, S.A.2
Pillai, M.R.3
-
30
-
-
3042630489
-
Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells
-
10.1038/sj.onc.1207598, 15064713
-
Yin F, Bruemmer D, Blaschke F, Hsueh WA, Law RE, Herle AJ. Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells. Oncogene 2004, 23:4614-4623. 10.1038/sj.onc.1207598, 15064713.
-
(2004)
Oncogene
, vol.23
, pp. 4614-4623
-
-
Yin, F.1
Bruemmer, D.2
Blaschke, F.3
Hsueh, W.A.4
Law, R.E.5
Herle, A.J.6
-
31
-
-
14844350942
-
Antidiabetic thiazolidinediones induce ductal differentiation but not apoptosis in pancreatic cancer cells
-
Ceni E, Mello T, Tarocchi M, Crabb DW, Caldini A, Invernizzi P, Surrenti C, Milani S, Galli A. Antidiabetic thiazolidinediones induce ductal differentiation but not apoptosis in pancreatic cancer cells. World J Gastroenterol 2005, 11:1122-1130.
-
(2005)
World J Gastroenterol
, vol.11
, pp. 1122-1130
-
-
Ceni, E.1
Mello, T.2
Tarocchi, M.3
Crabb, D.W.4
Caldini, A.5
Invernizzi, P.6
Surrenti, C.7
Milani, S.8
Galli, A.9
-
32
-
-
2342418256
-
Peroxisome proliferator-activated receptor gamma activation modulates cyclin D1 transcription via beta-catenin-independent and cAMP-response element-binding protein-dependent pathways in mouse hepatocytes
-
10.1074/jbc.M309045200, 14764597
-
Sharma C, Pradeep A, Pestell RG, Rana B. Peroxisome proliferator-activated receptor gamma activation modulates cyclin D1 transcription via beta-catenin-independent and cAMP-response element-binding protein-dependent pathways in mouse hepatocytes. J Biol Chem 2004, 279:16927-16938. 10.1074/jbc.M309045200, 14764597.
-
(2004)
J Biol Chem
, vol.279
, pp. 16927-16938
-
-
Sharma, C.1
Pradeep, A.2
Pestell, R.G.3
Rana, B.4
-
33
-
-
13044305289
-
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway
-
10.1073/pnas.96.11.6199, 26859, 10339565
-
Sun H, Lesche R, Li DM, Liliental J, Zhang H, Gao J, Gavrilova N, Mueller B, Liu X, Wu H. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci USA 1999, 96:6199-6204. 10.1073/pnas.96.11.6199, 26859, 10339565.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 6199-6204
-
-
Sun, H.1
Lesche, R.2
Li, D.M.3
Liliental, J.4
Zhang, H.5
Gao, J.6
Gavrilova, N.7
Mueller, B.8
Liu, X.9
Wu, H.10
-
34
-
-
0032571084
-
Phosphatidylinositol 3-kinase inhibitors block aortic smooth muscle cell proliferation in mid-late G1 phase: effect on cyclin-dependent kinase 2 and the inhibitory protein p27KIP1
-
10.1006/bbrc.1997.7885, 9535716
-
Bacqueville D, Casagrande F, Perret B, Chap H, Darbon JM, Breton-Douillon M. Phosphatidylinositol 3-kinase inhibitors block aortic smooth muscle cell proliferation in mid-late G1 phase: effect on cyclin-dependent kinase 2 and the inhibitory protein p27KIP1. Biochem Biophys Res Commun 1998, 244:630-636. 10.1006/bbrc.1997.7885, 9535716.
-
(1998)
Biochem Biophys Res Commun
, vol.244
, pp. 630-636
-
-
Bacqueville, D.1
Casagrande, F.2
Perret, B.3
Chap, H.4
Darbon, J.M.5
Breton-Douillon, M.6
-
35
-
-
0034745353
-
Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells
-
10.1038/35060032, 11231573
-
Zhou BP, Liao Y, Xia W, Spohn B, Lee MH, Hung MC. Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol 2001, 3:245-252. 10.1038/35060032, 11231573.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 245-252
-
-
Zhou, B.P.1
Liao, Y.2
Xia, W.3
Spohn, B.4
Lee, M.H.5
Hung, M.C.6
-
36
-
-
2142662252
-
Reciprocal control of Forkhead box O 3a and c-Myc via the phosphatidylinositol 3-kinase pathway coordinately regulates p27Kip1 levels
-
Chandramohan V, Jeay S, Pianetti S, Sonenshein GE. Reciprocal control of Forkhead box O 3a and c-Myc via the phosphatidylinositol 3-kinase pathway coordinately regulates p27Kip1 levels. J Immunol 2004, 172:5522-5527.
-
(2004)
J Immunol
, vol.172
, pp. 5522-5527
-
-
Chandramohan, V.1
Jeay, S.2
Pianetti, S.3
Sonenshein, G.E.4
-
37
-
-
51549110734
-
LY294002 inhibits glucocorticoid-induced COX-2 gene expression in cardiomyocytes through a phosphatidylinositol 3 kinase-independent mechanism
-
10.1016/j.taap.2008.05.024, 18657281
-
Sun H, Xu B, Sheveleva E, Chen QM. LY294002 inhibits glucocorticoid-induced COX-2 gene expression in cardiomyocytes through a phosphatidylinositol 3 kinase-independent mechanism. Toxicol Appl Pharmacol 2008, 232:25-32. 10.1016/j.taap.2008.05.024, 18657281.
-
(2008)
Toxicol Appl Pharmacol
, vol.232
, pp. 25-32
-
-
Sun, H.1
Xu, B.2
Sheveleva, E.3
Chen, Q.M.4
-
38
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
10.1126/science.1106148, 15718470
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005, 307:1098-1101. 10.1126/science.1106148, 15718470.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
39
-
-
38949200283
-
Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes
-
10.1016/j.yjmcc.2007.10.016, 2278035, 18054038
-
Mao K, Kobayashi S, Jaffer ZM, Huang Y, Volden P, Chernoff J, Liang Q. Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes. J Mol Cell Cardiol 2008, 44:429-434. 10.1016/j.yjmcc.2007.10.016, 2278035, 18054038.
-
(2008)
J Mol Cell Cardiol
, vol.44
, pp. 429-434
-
-
Mao, K.1
Kobayashi, S.2
Jaffer, Z.M.3
Huang, Y.4
Volden, P.5
Chernoff, J.6
Liang, Q.7
-
40
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
-
10.1016/j.molcel.2006.03.029, 16603397
-
Sarbassov DD, Ali SM, Sengupta S, Sheen JH, Hsu PP, Bagley AF, Markhard AL, Sabatini DM. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell 2006, 22:159-168. 10.1016/j.molcel.2006.03.029, 16603397.
-
(2006)
Mol Cell
, vol.22
, pp. 159-168
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sengupta, S.3
Sheen, J.H.4
Hsu, P.P.5
Bagley, A.F.6
Markhard, A.L.7
Sabatini, D.M.8
-
41
-
-
2942675416
-
PAK is essential for RAS-induced upregulation of cyclin D1 during the G1 to S transition
-
10.4161/cc.3.1.593, 14657670
-
Nheu T, He H, Hirokawa Y, Walker F, Wood J, Maruta H. PAK is essential for RAS-induced upregulation of cyclin D1 during the G1 to S transition. Cell Cycle 2004, 3:71-74. 10.4161/cc.3.1.593, 14657670.
-
(2004)
Cell Cycle
, vol.3
, pp. 71-74
-
-
Nheu, T.1
He, H.2
Hirokawa, Y.3
Walker, F.4
Wood, J.5
Maruta, H.6
-
42
-
-
0041845231
-
Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actions
-
10.1074/jbc.M302094200, 12734182
-
Katome T, Obata T, Matsushima R, Masuyama N, Cantley LC, Gotoh Y, Kishi K, Shiota H, Ebina Y. Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actions. J Biol Chem 2003, 278:28312-28323. 10.1074/jbc.M302094200, 12734182.
-
(2003)
J Biol Chem
, vol.278
, pp. 28312-28323
-
-
Katome, T.1
Obata, T.2
Matsushima, R.3
Masuyama, N.4
Cantley, L.C.5
Gotoh, Y.6
Kishi, K.7
Shiota, H.8
Ebina, Y.9
-
43
-
-
0034847431
-
Prospects for prevention and treatment of cancer with selective PPARgamma modulators (SPARMs)
-
10.1016/S1471-4914(01)02100-1, 11530334
-
Sporn MB, Suh N, Mangelsdorf DJ. Prospects for prevention and treatment of cancer with selective PPARgamma modulators (SPARMs). Trends Mol Med 2001, 7:395-400. 10.1016/S1471-4914(01)02100-1, 11530334.
-
(2001)
Trends Mol Med
, vol.7
, pp. 395-400
-
-
Sporn, M.B.1
Suh, N.2
Mangelsdorf, D.J.3
-
44
-
-
33747682898
-
Peroxisome proliferator-activated receptor gamma promotes epithelial to mesenchymal transformation by Rho GTPase-dependent activation of ERK1/2
-
10.1074/jbc.M604147200, 16815847
-
Chen L, Necela BM, Su W, Yanagisawa M, Anastasiadis PZ, Fields AP, Thompson EA. Peroxisome proliferator-activated receptor gamma promotes epithelial to mesenchymal transformation by Rho GTPase-dependent activation of ERK1/2. J Biol Chem 2006, 281:24575-24587. 10.1074/jbc.M604147200, 16815847.
-
(2006)
J Biol Chem
, vol.281
, pp. 24575-24587
-
-
Chen, L.1
Necela, B.M.2
Su, W.3
Yanagisawa, M.4
Anastasiadis, P.Z.5
Fields, A.P.6
Thompson, E.A.7
-
45
-
-
34248531653
-
P21-activated protein kinase is overexpressed in hepatocellular carcinoma and enhances cancer metastasis involving c-Jun NH2-terminal kinase activation and paxillin phosphorylation
-
10.1158/0008-5472.CAN-06-3994, 17440071
-
Ching YP, Leong VY, Lee MF, Xu HT, Jin DY, Ng IO. P21-activated protein kinase is overexpressed in hepatocellular carcinoma and enhances cancer metastasis involving c-Jun NH2-terminal kinase activation and paxillin phosphorylation. Cancer Res 2007, 67:3601-3608. 10.1158/0008-5472.CAN-06-3994, 17440071.
-
(2007)
Cancer Res
, vol.67
, pp. 3601-3608
-
-
Ching, Y.P.1
Leong, V.Y.2
Lee, M.F.3
Xu, H.T.4
Jin, D.Y.5
Ng, I.O.6
-
46
-
-
41649085584
-
P21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer
-
2288538, 18392133
-
Li Q, Mullins SR, Sloane BF, Mattingly RR. p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer. Neoplasia 2008, 10:314-329. 2288538, 18392133.
-
(2008)
Neoplasia
, vol.10
, pp. 314-329
-
-
Li, Q.1
Mullins, S.R.2
Sloane, B.F.3
Mattingly, R.R.4
-
47
-
-
78049337472
-
A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells
-
10.1038/onc.2010.318, 20711231
-
Arias-Romero LE, Villamar-Cruz O, Pacheco A, Kosoff R, Huang M, Muthuswamy SK, Chernoff J. A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells. Oncogene 29:5839-5849. 10.1038/onc.2010.318, 20711231.
-
Oncogene
, vol.29
, pp. 5839-5849
-
-
Arias-Romero, L.E.1
Villamar-Cruz, O.2
Pacheco, A.3
Kosoff, R.4
Huang, M.5
Muthuswamy, S.K.6
Chernoff, J.7
-
48
-
-
0026597465
-
Production of infectious hepatitis delta virus in vitro and neutralization with antibodies directed against hepatitis B virus pre-S antigens
-
240836, 1309901
-
Sureau C, Moriarty AM, Thornton GB, Lanford RE. Production of infectious hepatitis delta virus in vitro and neutralization with antibodies directed against hepatitis B virus pre-S antigens. J Virol 1992, 66:1241-1245. 240836, 1309901.
-
(1992)
J Virol
, vol.66
, pp. 1241-1245
-
-
Sureau, C.1
Moriarty, A.M.2
Thornton, G.B.3
Lanford, R.E.4
-
49
-
-
33749430399
-
Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner
-
10.1016/j.ccr.2006.08.022, 17045205
-
Skeen JE, Bhaskar PT, Chen CC, Chen WS, Peng XD, Nogueira V, Hahn-Windgassen A, Kiyokawa H, Hay N. Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner. Cancer Cell 2006, 10:269-280. 10.1016/j.ccr.2006.08.022, 17045205.
-
(2006)
Cancer Cell
, vol.10
, pp. 269-280
-
-
Skeen, J.E.1
Bhaskar, P.T.2
Chen, C.C.3
Chen, W.S.4
Peng, X.D.5
Nogueira, V.6
Hahn-Windgassen, A.7
Kiyokawa, H.8
Hay, N.9
-
50
-
-
67649403612
-
Caspase-mediated Cleavage of {beta}-Catenin Precedes Drug-induced Apoptosis in Resistant Cancer Cells
-
10.1074/jbc.M900248200, 2679459, 19289465
-
Senthivinayagam S, Mishra P, Paramasivam SK, Yallapragada S, Chatterjee M, Wong L, Rana A, Rana B. Caspase-mediated Cleavage of {beta}-Catenin Precedes Drug-induced Apoptosis in Resistant Cancer Cells. J Biol Chem 2009, 284:13577-13588. 10.1074/jbc.M900248200, 2679459, 19289465.
-
(2009)
J Biol Chem
, vol.284
, pp. 13577-13588
-
-
Senthivinayagam, S.1
Mishra, P.2
Paramasivam, S.K.3
Yallapragada, S.4
Chatterjee, M.5
Wong, L.6
Rana, A.7
Rana, B.8
-
51
-
-
33846928413
-
Somatostatin-receptor-targeted alpha-emitting 213Bi is therapeutically more effective than beta(-)-emitting 177Lu in human pancreatic adenocarcinoma cells
-
10.1016/j.nucmedbio.2006.11.006, 17307126
-
Nayak TK, Norenberg JP, Anderson TL, Prossnitz ER, Stabin MG, Atcher RW. Somatostatin-receptor-targeted alpha-emitting 213Bi is therapeutically more effective than beta(-)-emitting 177Lu in human pancreatic adenocarcinoma cells. Nucl Med Biol 2007, 34:185-193. 10.1016/j.nucmedbio.2006.11.006, 17307126.
-
(2007)
Nucl Med Biol
, vol.34
, pp. 185-193
-
-
Nayak, T.K.1
Norenberg, J.P.2
Anderson, T.L.3
Prossnitz, E.R.4
Stabin, M.G.5
Atcher, R.W.6
-
52
-
-
4143065010
-
Peroxisome proliferator-activated receptor gamma activation can regulate beta-catenin levels via a proteasome-mediated and adenomatous polyposis coli-independent pathway
-
10.1074/jbc.M403143200, 15190077
-
Sharma C, Pradeep A, Wong L, Rana A, Rana B. Peroxisome proliferator-activated receptor gamma activation can regulate beta-catenin levels via a proteasome-mediated and adenomatous polyposis coli-independent pathway. J Biol Chem 2004, 279:35583-35594. 10.1074/jbc.M403143200, 15190077.
-
(2004)
J Biol Chem
, vol.279
, pp. 35583-35594
-
-
Sharma, C.1
Pradeep, A.2
Wong, L.3
Rana, A.4
Rana, B.5
-
53
-
-
9444255249
-
Peroxisome proliferator-activated receptor gamma-dependent activation of p21 in Panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins
-
10.1210/en.2004-0686, 15345676
-
Hong J, Samudio I, Liu S, Abdelrahim M, Safe S. Peroxisome proliferator-activated receptor gamma-dependent activation of p21 in Panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins. Endocrinology 2004, 145:5774-5785. 10.1210/en.2004-0686, 15345676.
-
(2004)
Endocrinology
, vol.145
, pp. 5774-5785
-
-
Hong, J.1
Samudio, I.2
Liu, S.3
Abdelrahim, M.4
Safe, S.5
|