Gut T1R3 sweet taste receptors do not mediate sucrose-conditioned flavor preferences in mice

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 299, Issue 6, 2010, Pages

  Sclafani, Anthony ^a   Glass, Damien S ^a   Margolskee, Robert F ^b   Glendinning, John I ^c  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b MONELL CHEMICAL SENSES CENTER   (United States)

^c Barnard College of Columbia University   (United States)

Author keywords

Flavor learning; Gastric infusions; Sucralose; T1R3 knockout mouse

Indexed keywords

PROTEIN T 1 R 3; RECEPTOR; SUCRALOSE; SUCROSE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SWEETNESS; TASTE BUD; TASTE PREFERENCE; TRAINING; WILD TYPE;

ANALYSIS OF VARIANCE; ANIMALS; CHOICE BEHAVIOR; CONDITIONING (PSYCHOLOGY); FOOD PREFERENCES; MICE; MICE, KNOCKOUT; RECEPTORS, G-PROTEIN-COUPLED; STOMACH; SUCROSE; TASTE;

EID: 78649891153     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00495.2010     Document Type: Article

References (46)

1. Ackroff K, Dym C, Yiin YM, Sclafani A. Rapid acquisition of conditioned flavor preferences in rats. Physiol Behav 97: 406-413, 2009.
2. Ackroff K, Yiin YM, Sclafani A. Post-oral infusion sites that support glucose-conditioned flavor preferences in rats. Physiol Behav 99: 402-411, 2010.
3. Bachmanov AA, Beauchamp GK. Taste receptor genes. Annu Rev Nutr 27: 389-414, 2007.
4. Bachmanov AA, Tordoff MG, Beauchamp GK. Sweetener preference of C57BL/6ByJ and 129P3/J mice. Chem Senses 26: 905-913, 2001.
5. Bezençon C, le Coutre J, Damak S. Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells. Chem Senses 32: 41-49, 2006. (Pubitemid 46017873)
6. Damak S, Rong M, Yasumatsu K, Kokrashvili Z, Perez CA, Shigemura N, Yoshida R, Mosinger B Jr, Glendinning JI, Ninomiya Y, Margolskee RF. Trpm5 null mice respond to bitter, sweet, and umami compounds. Chem Senses 31: 253-264, 2006.
7. Damak S, Rong M, Yasumatsu K, Kokrashvili Z, Varadarajan V, Zou S, Jiang P, Ninomiya Y, Margolskee RF. Detection of sweet and umami taste in the absence of taste receptor T1r3. Science 301: 850-853, 2003.
8. De Araujo IE, Oliveira-Maia AJ, Sotnikova TD, Gainetdinov RR, Caron MG, Nicolelis MAL, Simon SA. Food reward in the absence of taste receptor signaling. Neuron 57: 930-941, 2008.
9. Drucker DB, Sclafani A. The role of gastric and postgastric sites in glucose-conditioned flavor preferences in rats. Physiol Behav 61: 351-358, 1997.
10. Dyer J, Salmon KS, Zibrik L, Shirazi-Beechey SP. Expression of sweet taste receptors of the T1R family in the intestinal tract and enteroendocrine cells. Biochem Soc Trans 33: 302-305, 2005.
11. Fujita Y, Wideman RD, Speck M, Asadi A, King DS, Webber TD, Haneda M, Kieffer TJ. Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo. Am J Physiol Endocrinol Metab 296: E473-E479, 2009.
12. Glass DS, Margolskee RF, Sclafani A. Glucose-conditioned preferences in taste-impaired TRPM5 knockout mice (Abstract). Appetite 52: 833, 2009.
13. Glendinning JI, Beltran F, Benton L, Cheng S, Gieseke J, Gillman J, Spain HN. Taste does not determine daily intake of dilute sugar solutions in mice. Am J Physiol Regul Integr Comp Physiol 299: R1333-R1341, 2010.
14. Glendinning JI, Yiin YM, Ackroff K, Sclafani A. Intragastric infusion of denatonium conditions flavor aversions and delays gastric emptying in rodents. Physiol Behav 93: 757-765, 2008.
15. Hass N, Schwarzenbacher K, Breer H. T1R3 is expressed in brush cells and ghrelin-producing cells of murine stomach. Cell Tissue Res 339: 493-504, 2010.
16. Höfer D, Püschel B, Drenckhahn D. Taste receptor-like cells in the rat gut identified by expression of alpha-gustducin. Proc Natl Acad Sci USA 93: 6631-6634, 1996.
17. Kokrashvili Z, Jiang P, Mosinger B, Margolskee RF. Roles of taste signaling molecules in endocrine cells in pancreas and tongue (Abstract). Chem Senses 35: A12, 2010.
18. Kokrashvili Z, Mosinger B, Margolskee RF. T1r3 and alpha-gustducin in gut regulate secretion of glucagon-like peptide-1. Ann NY Acad Sci 1170: 91-94, 2009.
19. Le Gall M, Tobin V, Stolarczyk E, Dalet V, Leturque A, Brot-Laroche E. Sugar sensing by enterocytes combines polarity, membrane bound detectors and sugar metabolism. J Cell Physiol 213: 834-843, 2007.
20. Li X, Staszewski L, Xu H, Durick K, Zoller M, Adler E. Human receptors for sweet and umami taste. Proc Natl Acad Sci USA 99: 4692-4696, 2002.
21. Lucas F, Sclafani A. Capsaicin attenuates feeding suppression but not reinforcement by intestinal nutrients. Am J Physiol Regul Integr Comp Physiol 270: R1059-R1064, 1996.
22. Ma J, Bellon M, Wishart JM, Young RL, Blackshaw LA, Jones KL, Horowitz M, Rayner CK. Effect of the artificial sweetener, sucralose, on gastric emptying and incretin hormone release in healthy subjects. Am J Physiol Gastrointest Liver Physiol 296: G735-G739, 2009.
23. Mace OJ, Affleck JA, Patel N, Kellett GL. Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2. J Physiol 582: 379-392, 2007.
24. Maljaars PWJ, Peters HPF, Mela DJ, Masclee AAM. Ileal brake: A sensible food target for appetite control. A review. Physiol Behav 95: 271-281, 2008.
25. +-glucose cotransporter 1. Proc Natl Acad Sci USA 104: 15075-15080, 2007.
26. +/glucose co-transporter 1 (SGLT1) is enhanced by supplementation of the diet of weaning piglets with artificial sweeteners. Brit J Nutr 1-10, 2010.
27. Nie Y, Vigues S, Hobbs JR, Conn GL, Munger SD. Distinct contributions of T1R2 and T1R3 taste receptor subunits to the detection of sweet stimuli. Curr Biol 15: 1948-1952, 2005.
28. Parker HE, Habib AM, Rogers GJ, Gribble FM, Reimann F. Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells. Diabetologia 52: 289-298, 2009.
29. Ramirez I. Why do sugars taste good? Neurosci Biobehav Rev 14: 125-134, 1990. (Pubitemid 20159549)
30. Rozengurt E. Bitter taste receptors and alpha-gustducin in the mammalian gut. Am J Physiol Gastrointest Liver Physiol 291: G171-G177, 2006.
31. Schiffman SS, Booth BJ, Losee ML, Pecore SD, Warwick ZS. Bitterness of sweeteners as a function of concentration. Brain Res Bull 36: 505-513, 1995.
32. Sclafani A. Oral and postoral determinants of food reward. Physiol Behav 81: 773-779, 2004.
33. Sclafani A. Sucrose motivation in sweet "sensitive" (C57BL/6J) and "subsensitive" (129P3/J) mice measured by progressive ratio licking. Physiol Behav 87: 734-744, 2006.
34. Sclafani A, Ackroff K, Schwartz GJ. Selective effects of vagal deafferentation and celiac-superior mesenteric ganglionectomy on the reinforcing and satiating action of intestinal nutrients. Physiol Behav 78: 285-294, 2003.
35. Sclafani A, Cardieri C, Tucker K, Blusk D, Ackroff K. Intragastric glucose but not fructose conditions robust flavor preferences in rats. Am J Physiol Regul Integr Comp Physiol 265: R320-R325, 1993.
36. Sclafani A, Glendinning JI. Flavor preferences conditioned in C57BL/6 mice by intragastric carbohydrate self-infusion. Physiol Behav 79: 783-788, 2003. (Pubitemid 37087975)
37. Sclafani A, Glendinning JI. Sugar and fat conditioned flavor preferences in C57BL/6J and 129 mice: Oral and postoral interactions. Am J Physiol Regul Integr Comp Physiol 289: R712-R720, 2005.
38. Smith JC, Fisher EM, Maleszewski V, McClain B. Orosensory factors in the ingestion of corn oil/sucrose mixtures by the rat. Physiol Behav 69: 135-146, 2000.
39. Stearns AT, Balakrishnan A, Rhoads DB, Tavakkolizadeh A. Rapid upregulation of sodium-glucose transporter SGLT1 in response to intestinal sweet taste stimulation. Ann Surg 251: 865-871, 2010.
40. Touzani K, Bodnar RJ, Sclafani A. Activation of dopamine D1 receptors in the nucleus accumbens is critical for the acquisition, but not the expression, of flavor preference conditioned by intragastric glucose in rats. Eur J Neurosci 27: 1525-1533, 2008.
41. Treesukosol Y, Blonde G, Spector AC. The T1R2 and T1R3 subunits are individually unnecessary for normal affective licking responses to Polycose: Implications for saccharide taste receptors in mice. Am J Physiol Regul Integr Comp Physiol 296: R855-R865, 2009.
42. Wong GT, Gannon KS, Margolskee RF. Transduction of bitter and sweet taste by gustducin. Nature 381: 796-800, 1996.
43. Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJP. Coding of sweet, bitter, and umami tastes: Different receptor cells sharing similar signaling pathways. Cell 112: 293-301, 2003.
44. Zhao GQ, Zhang Y, Hoon MA, Chandrashekar J, Erlenbach I, Ryba NJP, Zuker CS. The receptors for mammalian sweet and umami taste. Cell 115: 255-266, 2003.
45. Zukerman S, Glendinning JI, Margolskee RF, Sclafani A. T1R3 taste receptor is critical for sucrose but not Polycose taste. Am J Physiol Regul Integr Comp Physiol 296: R866-R876, 2009.
46. Zukerman S, Touzani K, Margolskee RF, Sclafani A. Role of olfaction in the conditioned sucrose preference of sweet-ageusic T1R3 knockout mice. Chem Senses 34: 685-694, 2009.