Gyrase B inhibitor impairs HIV-1 replication by targeting Hsp90 and the capsid protein

Journal of Biological Chemistry

Volumn 285, Issue 50, 2010, Pages 39314-39328

  Vozzolo, Luciano ^a   Loh, Belinda ^a   Gane, Paul J ^b   Tribak, Maryame ^a   Zhou, Lihong ^a   Anderson, Ian ^a   Nyakatura, Elisabeth ^a   Jenner, Richard G ^a   Selwood, David ^b   Fassati, Ariberto ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRAL DRUGS; ANTIRETROVIRALS; C TERMINUS; C-TERMINAL DOMAINS; CAPSID PROTEINS; CHEMICAL GENETICS; CHROMATIN IMMUNOPRECIPITATION; CYCLOPHILIN; DIMER FORMATION; DNA MOTORS; GENETIC APPROACH; HOST-PATHOGEN INTERACTIONS; INFECTED CELLS; MAMMALIAN CELLS; MOLECULAR DOCKING; POINT MUTATIONS; SMALL MOLECULES; VIRAL PROMOTERS;

CHROMOSOMES; DIMERS; DISEASES; GENE EXPRESSION REGULATION; MAMMALS; VIRUSES;

GENE EXPRESSION;

BETA LAPACHONE; CAPSID PROTEIN; CIPROFLOXACIN; COUMAMYCIN A1; CYCLOPHILIN A; DAUNORUBICIN; DOXORUBICIN; ETOPOSIDE; HEAT SHOCK PROTEIN 90; NOVOBIOCIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DIMERIZATION; DRUG STRUCTURE; DRUG TARGETING; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; VIRUS DNA CELL DNA INTERACTION; VIRUS INHIBITION; VIRUS REPLICATION;

AMINOCOUMARINS; CAPSID PROTEINS; CYCLOPHILIN A; DIMERIZATION; DNA GYRASE; HELA CELLS; HIV-1; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY;

HUMAN IMMUNODEFICIENCY VIRUS 1; MAMMALIA; MIRIDAE;

EID: 78649867001     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.155275     Document Type: Article

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