Functional dissection of the N-terminal degron of human thymidylate synthase

Biochemical Journal

Volumn 432, Issue 1, 2010, Pages 217-226

  Melo, Sandra P ^a,b   Yoshida, Asami ^c   Berger, Franklin G ^a  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NAGASAKI UNIVERSITY   (Japan)

Author keywords

Degron; Human thymidylate synthase (hTS); Intrinsically disordered region; Proteasome; Protein degradation; Ubiquitin independent

Indexed keywords

DEGRON; INTRINSICALLY DISORDERED REGION; PROTEASOMES; PROTEIN DEGRADATION; THYMIDYLATE SYNTHASE; UBIQUITIN;

AMINO ACIDS; MAMMALS; PROTEINS;

DEGRADATION;

ARGININE; POLYPEPTIDE; PROTEASOME; THYMIDYLATE SYNTHASE; UBIQUITIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; GENE DELETION; GENE MUTATION; HUMAN; IMMUNOBLOTTING; MOUSE; MUTANT; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN MOTIF; RNA INTERFERENCE; SITE DIRECTED MUTAGENESIS; UBIQUITINATION; WILD TYPE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; ARGININE; BLOTTING, WESTERN; CELL LINE; DIPEPTIDES; ENZYME STABILITY; HCT116 CELLS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEASOME ENDOPEPTIDASE COMPLEX; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; SPECIES SPECIFICITY; THYMIDYLATE SYNTHASE; TRANSFECTION;

MAMMALIA;

EID: 78649747459     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20101027     Document Type: Article

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