Claudin-10 exists in six alternatively spliced isoforms that exhibit distinct localization and function

Journal of Cell Science

Volumn 122, Issue 10, 2009, Pages 1507-1517

  Günzel, Dorothee ^a   Stuiver, Marchel ^a   Kausalya, P Jaya ^b   Haisch, Lee ^a   Krug, Susanne M ^a   Rosenthal, Rita ^a   Meij, Iwan C ^c   Hunziker, Walter ^b   Fromm, Michael ^a   Müller, Dominik ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Alternative splicing; Eisenman sequence; Epithelial transport; Ion permeability; Kidney; Renal cell lines; Subcellular localization; Tight junction

Indexed keywords

CATION; CLAUDIN; CLAUDIN 10; NUCLEOTIDE; UNCLASSIFIED DRUG; ISOPROTEIN; MEMBRANE PROTEIN; PHOSPHOPROTEIN; ZONULA OCCLUDENS 1 PROTEIN; ZONULA OCCLUDENS-1 PROTEIN;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL STRAIN; CONTROLLED STUDY; ELECTROPHYSIOLOGY; ENDOPLASMIC RETICULUM; EXON; GENE DELETION; GENETIC TRANSFECTION; HUMAN; IMMUNOCYTOCHEMISTRY; MALE; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIGHT JUNCTION; ANIMAL; BINDING SITE; CELL LINE; CELL MEMBRANE POTENTIAL; CHEMISTRY; DOG; GENETICS; IMPEDANCE; ION TRANSPORT; KIDNEY; METABOLISM; PERMEABILITY; PROTEIN CONFORMATION; PROTEIN TRANSPORT; RNA SPLICING;

ALTERNATIVE SPLICING; ANIMALS; BINDING SITES; CELL LINE; DOGS; ELECTRIC IMPEDANCE; ENDOPLASMIC RETICULUM; EXONS; HUMANS; ION TRANSPORT; KIDNEY; MEMBRANE POTENTIALS; MEMBRANE PROTEINS; MICE; PERMEABILITY; PHOSPHOPROTEINS; PROTEIN CONFORMATION; PROTEIN ISOFORMS; PROTEIN TRANSPORT; RNA SPLICE SITES; TIGHT JUNCTIONS; TRANSFECTION;

EID: 67249117191     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.040113     Document Type: Article

References (29)

1. Amasheh, S., Meiri, N., Gitter, A. H., Schöneberg, T., Mankertz, J., Schulzke, J. D. and Fromm, M. (2002). Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells. J. Cell Sci. 115, 4969-4976.
2. Cereijido, M., Robbins, E. S., Dolan, W. J., Rotunno, C. A. and Sabatini, D. D. (1978). Polarized monolayers formed by epithelial cells on a permeable and translucent support. J. Cell Biol. 77, 853-880.
3. Diamond, F. M. and Wright, E. M. (1969). Biological membranes: the physical basis of ion and nonelectrolyte selectivity. Annu. Rev. Physiol. 31, 581-646.
4. Eisenman, G. (1962). Cation selective glass electrodes and their mode of operation. Biophys. J. 2, 259-323.
5. Gekle, M., Wunsch, S., Oberleithner, H. and Silbernagl, S. (1994). Characterization of two MDCK-cell subtypes as a model system to study principal cell and intercalated cell properties Pflügers Arch. 428, 157-162.
6. Greger, R. (1981). Cation selectivity of the isolated perfused cortical thick ascending limb of Henle's loop of rabbit kidney. Pflügers Arch. 390, 30-37.
7. Guan, X., Inai, T. and Shibata, Y. (2005). Segment-specific expression of tight junction proteins, claudin-2 and -10, in the rat epididymal epithelium. Arch. Histol. Cytol. 68, 213-225.
8. Hashizume, A., Ueno, T., Furuse, M., Tsukita, S., Nakanishi, Y. and Hieda, Y. (2004). Expression patterns of claudin family of tight junction membrane proteins in developing mouse submandibular gland. Dev. Dyn. 231, 425-431.
9. Holmes, J. L., Van Itallie, C. M., Rasmussen, J. E. and Anderson, J. M. (2006). Claudin profiling in the mouse during postnatal intestinal development and along the gastrointestinal tract reveals complex expression patterns. Gene Expr. Patterns 6, 581-588.
10. Hou, J., Paul, D. L. and Goodenough, D. A. (2005). Paracellin-1 and the modulation of ion selectivity of tight junctions. J. Cell Sci. 118, 5109-5118.
11. Hou, J., Renigunta, A., Konrad, M., Gomes, A. S., Schneeberger, E. E., Paul, D. L., Waldegger, S. and Goodenough, D. A. (2008). Claudin-16 and claudin-19 interact and form a cation-selective tight junction complex. J. Clin. Invest. 118, 619-628.
12. Inai, T., Sengoku, A., Guan, X., Hirose, E., Iida, H. and Shibata, Y. (2005). Heterogeneity in expression and subcellular localization of tight junction proteins, claudin-10 and -15, examined by RT-PCR and immunofluorescence microscopy. Arch. Histol. Cytol. 68, 349-360.
13. Itoh, M., Furuse, M., Morita, K., Kubota, K., Saitou, M. and Tsukita, S. (1999). Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J. Cell Biol. 147, 1351-1363.
14. Kausalya, P. J., Reichert, M. and Hunziker, W. (2001). Connexin45 directly binds to ZO-1 and localizes to the tight junction region in epithelial MDCK cells. FEBS Lett. 505, 92-96.
15. 2+ transport function of claudin-16. J. Clin. Invest. 116, 878-891.
16. Kikeri, D., Sun, A., Zeidel, M. L. and Hebert, S. C. (1989). Cell membranes impermeable to NH3. Nature 339, 478-480.
17. Kiuchi-Saishin, Y., Gotoh, S., Furuse, M., Takasuga, A., Tano, Y. and Tsukita, S. (2002). Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments. J. Am. Soc. Nephrol. 13, 875-886.
18. - secretion in epithelial monolayers of mucus-forming human colon cells (HT-29/B6). Am. J. Physiol. 261, C574-C582.
19. Lim, T. S., Vedula, S. R., Hui, S., Kausalya, P. J., Hunziker, W. and Lim, C. T. (2008). Probing effects of pH change on dynamic response of Claudin-2 mediated adhesion using single molecule force spectroscopy. Exp. Cell Res. 314, 2643-2651.
20. Meier, P. C. (1982). Two parameter Debye-Huckel approximation for the evaluation of mean activity coefficients of 109 electrolytes. Anal. Chim. Acta 136, 363-368.
21. Müller, D., Kausalya, P. J., Claverie-Martin, F., Meij, I. C., Eggert, P., Garcia-Nieto, V. and Hunziker, W. (2003). A novel claudin-16 mutation associated with childhood hypercalciuria abolishes binding to ZO-1 and results in lysosomal mistargeting. Am. J. Hum. Genet. 73, 1293-1301.
22. Ohta, H., Adachi, H., Takiguchi, M. and Inaba, M. (2006). Restricted localization of claudin-16 at the tight junction in the thick ascending limb of Henle's loop together with claudins 3, 4, and 10 in bovine nephrons. J. Vet. Med. Sci. 68, 453-463.
23. Smith, A. N., Jouret, F., Bord, S., Borthwick, K. J., Al-Lamki, R. S., Wagner, C. A., Ireland, D. C., Cormier-Daire, V., Frattini, A., Villa, A. et al. (2005). Vacuolar H+- ATPase d2 subunit: molecular characterization, developmental regulation, and localization to specialized proton pumps in kidney and bone. J. Am. Soc. Nephrol. 16, 1245-1256.
24. +-ATPase subunit defective in an inherited form of distal renal tubular acidosis. J. Am. Soc. Nephrol. 14, 3027-3038.
25. 2+ transport. Rev. Physiol. Biochem. Pharmacol. 158, 77-160.
26. Van Itallie, C. M. and Anderson, J. M. (2006). Claudins and epithelial paracellular transport. Annu. Rev. Physiol. 68, 403-429.
27. Van Itallie, C. M., Fanning, A. S. and Anderson, J. M. (2003). Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudins. Am. J. Physiol. Renal Physiol. 285, F1078-F1084.
28. Van Itallie, C. M., Rogan, S., Yu, A., Vidal, L. S., Holmes, J. and Anderson, J. M. (2006). Two splice variants of claudin-10 in the kidney create paracellular pores with different ion selectivities. Am. J. Physiol. Renal Physiol. 291, F1288-F1299.
29. Wen, H., Watry, D. D., Marcondes, M. C. and Fox, H. S. (2004). Selective decrease in paracellular conductance of tight junctions: role of the first extracellular domain of claudin-5. Mol. Cell. Biol. 24, 8408-8417.