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Volumn 278, Issue 3, 2010, Pages 294-304

Gene-environmental interactions and organophosphate toxicity

Author keywords

CYP; Organophosphate; Paraoxonase; Sheep dip; Susceptibility

Indexed keywords

ARYLDIALKYLPHOSPHATASE 1; ARYLDIALKYLPHOSPHATASE 2; BROMOPHOS; CARBOFENOTION; CHLORPYRIFOS; CHOLINESTERASE; COUMAFOS; CYTOCHROME P450; DICHLOFENTHION; DIMPYLATE; DIOXATION; FENCLOFOS; IODOFEPHOS; ORGANOPHOSPHATE PESTICIDE; PYRIMITHATE; UNCLASSIFIED DRUG;

EID: 78649726020     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2010.02.007     Document Type: Review
Times cited : (35)

References (84)
  • 1
    • 0030779740 scopus 로고    scopus 로고
    • Chronic organophosphate exposure: toward the definition of a neuropsychiatric syndrome
    • Ahmed G.M., Davies D.R. Chronic organophosphate exposure: toward the definition of a neuropsychiatric syndrome. J. Nutr. Environ. Med. 1997, 7:169-176.
    • (1997) J. Nutr. Environ. Med. , vol.7 , pp. 169-176
    • Ahmed, G.M.1    Davies, D.R.2
  • 2
    • 33748437807 scopus 로고    scopus 로고
    • Appraisal Panel for Human Suspected Adverse Reactions to Veterinary and Medicines.
    • Appraisal Panel for Human Suspected Adverse Reactions to Veterinary and Medicines Annual Report for 2004 2004, http://www.vpc.gov.uk/Public/AR/vpcapar04.pdf.
    • (2004) Annual Report for 2004
  • 5
    • 0035873429 scopus 로고    scopus 로고
    • Commentary: facing the challenge of gene-environment interaction: the two-by-four table and beyond
    • Botto L.D., Khoury M.J. Commentary: facing the challenge of gene-environment interaction: the two-by-four table and beyond. Am. J. Epidemiol. 2001, 153:1016-1020.
    • (2001) Am. J. Epidemiol. , vol.153 , pp. 1016-1020
    • Botto, L.D.1    Khoury, M.J.2
  • 6
    • 84987049453 scopus 로고
    • A survey of sheep dip usage in Scotland in 1978
    • Bowen H.M., Cutler J.R., Craigie I.R. A survey of sheep dip usage in Scotland in 1978. Pestic. Sci. 1982, 13:563-574.
    • (1982) Pestic. Sci. , vol.13 , pp. 563-574
    • Bowen, H.M.1    Cutler, J.R.2    Craigie, I.R.3
  • 9
    • 0034771186 scopus 로고    scopus 로고
    • Estimation of cumulative exposure to organophosphate sheep dips in a study of chronic neurological health effects among United Kingdom sheep dippers
    • Buchanan D., Pilkington A., Sewell C., Tannahill S.N., Kidd M.W., Cherrie B., Hurley J.F. Estimation of cumulative exposure to organophosphate sheep dips in a study of chronic neurological health effects among United Kingdom sheep dippers. Occup. Environ. Med. 2001, 58:694-701.
    • (2001) Occup. Environ. Med. , vol.58 , pp. 694-701
    • Buchanan, D.1    Pilkington, A.2    Sewell, C.3    Tannahill, S.N.4    Kidd, M.W.5    Cherrie, B.6    Hurley, J.F.7
  • 10
    • 0037291881 scopus 로고    scopus 로고
    • CYP-specific bioactivation of four organophosphate pesticides by human liver microsomes
    • Buratti F.M., Volpe M.T., Meneguz A., Vittozzi L., Testai E. CYP-specific bioactivation of four organophosphate pesticides by human liver microsomes. Toxicol. Appl. Pharmacol. 2003, 186:143-154.
    • (2003) Toxicol. Appl. Pharmacol. , vol.186 , pp. 143-154
    • Buratti, F.M.1    Volpe, M.T.2    Meneguz, A.3    Vittozzi, L.4    Testai, E.5
  • 13
    • 0037025549 scopus 로고    scopus 로고
    • Biological monitoring of exposure to organophosphate pesticides
    • Cocker J., Mason H.J., Garfitt S.J., Jones K. Biological monitoring of exposure to organophosphate pesticides. Toxicol. Lett. 2002, 134:97-103.
    • (2002) Toxicol. Lett. , vol.134 , pp. 97-103
    • Cocker, J.1    Mason, H.J.2    Garfitt, S.J.3    Jones, K.4
  • 15
    • 0003916177 scopus 로고    scopus 로고
    • Department of Health, London, Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment
    • Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment Organophosphates 1999, Department of Health, London.
    • (1999) Organophosphates
  • 18
    • 84981576474 scopus 로고
    • A survey of sheep dip usage in Scotland in 1973
    • Cutler J.R. A survey of sheep dip usage in Scotland in 1973. Pestic. Sci. 1975, 6:617-627.
    • (1975) Pestic. Sci. , vol.6 , pp. 617-627
    • Cutler, J.R.1
  • 19
    • 0035197548 scopus 로고    scopus 로고
    • Identification of variants of CYP3A4 and characterisation of their abilities to metabolize testosterone and chlorpyrifos
    • Dai D., Tang J., Rose R., Hodgson E., Bienstock R.J., Mohrenweiser H.W., Goldstein J.A. Identification of variants of CYP3A4 and characterisation of their abilities to metabolize testosterone and chlorpyrifos. J. Pharmacol. Exp. Ther. 2001, 299:825-831.
    • (2001) J. Pharmacol. Exp. Ther. , vol.299 , pp. 825-831
    • Dai, D.1    Tang, J.2    Rose, R.3    Hodgson, E.4    Bienstock, R.J.5    Mohrenweiser, H.W.6    Goldstein, J.A.7
  • 20
    • 0030293198 scopus 로고    scopus 로고
    • The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin
    • Davies H.G., Richter R.J., Keifer M., Broomfield C.A., Sowalla J., Furlong C.E. The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin. Nat. Genet. 1996, 14:334-336.
    • (1996) Nat. Genet. , vol.14 , pp. 334-336
    • Davies, H.G.1    Richter, R.J.2    Keifer, M.3    Broomfield, C.A.4    Sowalla, J.5    Furlong, C.E.6
  • 23
    • 21244491480 scopus 로고    scopus 로고
    • Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities
    • Draganov D.I., Teiber J.F., Speelman A., Osawa Y., Sunahara R., La Du B. Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. J. Lipid Res. 2005, 46:1239-1247.
    • (2005) J. Lipid Res. , vol.46 , pp. 1239-1247
    • Draganov, D.I.1    Teiber, J.F.2    Speelman, A.3    Osawa, Y.4    Sunahara, R.5    La Du, B.6
  • 25
    • 34047106626 scopus 로고    scopus 로고
    • Sensitivity of butyrylcholinesterase knockout mice to (-)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission
    • Duysen E.G., Li B., Darvesh S., Lockridge O. Sensitivity of butyrylcholinesterase knockout mice to (-)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission. Toxicology 2007, 233:60-69.
    • (2007) Toxicology , vol.233 , pp. 60-69
    • Duysen, E.G.1    Li, B.2    Darvesh, S.3    Lockridge, O.4
  • 27
    • 0032847516 scopus 로고    scopus 로고
    • Identification of 167 polymorphisms in 88 genes from candidate neurodegeneration pathways
    • Emahazion T., Jobs M., Howell W.M., Siegfried M., Wyoni P.-I., Prince J., Brookes A.J. Identification of 167 polymorphisms in 88 genes from candidate neurodegeneration pathways. Gene 1999, 238:315-324.
    • (1999) Gene , vol.238 , pp. 315-324
    • Emahazion, T.1    Jobs, M.2    Howell, W.M.3    Siegfried, M.4    Wyoni, P.-I.5    Prince, J.6    Brookes, A.J.7
  • 29
    • 78649721694 scopus 로고    scopus 로고
    • Food Environment Research Agency
    • Food Environment Research Agency Pesticide Usage Statistics 2009, http://pusstats.csl.gov.uk/index.cfm.
    • (2009) Pesticide Usage Statistics
  • 30
    • 34548493254 scopus 로고    scopus 로고
    • Glutathione S-transferase conjugation of organophosphorus pesticides yields S-phospho-, S-aryl-, and S-alkylglutathione derivatives
    • Fujioka K., Casida J.E. Glutathione S-transferase conjugation of organophosphorus pesticides yields S-phospho-, S-aryl-, and S-alkylglutathione derivatives. Chem. Res. Toxicol. 2007, 20:1211-1217.
    • (2007) Chem. Res. Toxicol. , vol.20 , pp. 1211-1217
    • Fujioka, K.1    Casida, J.E.2
  • 31
    • 36048956333 scopus 로고    scopus 로고
    • Genetic variability in the cytochrome P450-Paraoxonase 1 (PON1) pathway for detoxification of organophosphorus compounds
    • Furlong C.E. Genetic variability in the cytochrome P450-Paraoxonase 1 (PON1) pathway for detoxification of organophosphorus compounds. J. Biochem. Mol. Toxicol. 2007, 21:197-205.
    • (2007) J. Biochem. Mol. Toxicol. , vol.21 , pp. 197-205
    • Furlong, C.E.1
  • 32
    • 0036265837 scopus 로고    scopus 로고
    • Pharmacogenomic considerations of the paraoxonase polymorphisms
    • Furlong C.E., Cole T.B., Jarvik G.P., Costa L.G. Pharmacogenomic considerations of the paraoxonase polymorphisms. Pharmacogenomics 2002, 3:341-348.
    • (2002) Pharmacogenomics , vol.3 , pp. 341-348
    • Furlong, C.E.1    Cole, T.B.2    Jarvik, G.P.3    Costa, L.G.4
  • 33
    • 0000981390 scopus 로고
    • Organic phosphorus pesticides
    • Academic Press, London
    • Gallo M.A., Lawryk N.J. Organic phosphorus pesticides. Handbook of Pesticide Toxicology 1991, vol. 2:917-1053. Academic Press, London.
    • (1991) Handbook of Pesticide Toxicology , vol.2 , pp. 917-1053
    • Gallo, M.A.1    Lawryk, N.J.2
  • 35
    • 0034695048 scopus 로고    scopus 로고
    • Cytogenetic response without changes in peripheral cholinesterase enzymes following exposure to a sheep dip containing diazinon in vivo and in vitro
    • Hatjian B.A., Mutch E., Williams F.M., Blain P.G., Edwards J.W. Cytogenetic response without changes in peripheral cholinesterase enzymes following exposure to a sheep dip containing diazinon in vivo and in vitro. Mutat. Res. 2000, 472:85-92.
    • (2000) Mutat. Res. , vol.472 , pp. 85-92
    • Hatjian, B.A.1    Mutch, E.2    Williams, F.M.3    Blain, P.G.4    Edwards, J.W.5
  • 37
    • 33646692496 scopus 로고    scopus 로고
    • Organophosphorous chemicals: potent inhibitors of the human metabolism of steroid hormones and xenobiotics
    • Hodgson E., Rose R.L. Organophosphorous chemicals: potent inhibitors of the human metabolism of steroid hormones and xenobiotics. Drug Metab. Rev. 2006, 38:149-162.
    • (2006) Drug Metab. Rev. , vol.38 , pp. 149-162
    • Hodgson, E.1    Rose, R.L.2
  • 38
    • 40349098592 scopus 로고    scopus 로고
    • Structure and catalytic properties of carboxylesterase isozymes involved in metabolic activation of prodrugs
    • Hosokawa M. Structure and catalytic properties of carboxylesterase isozymes involved in metabolic activation of prodrugs. Molecules 2008, 13:412-431.
    • (2008) Molecules , vol.13 , pp. 412-431
    • Hosokawa, M.1
  • 40
    • 0035949809 scopus 로고    scopus 로고
    • Biotransformation of organophosphorus compounds
    • Jokanovic M. Biotransformation of organophosphorus compounds. Toxicology 2001, 166:139-160.
    • (2001) Toxicology , vol.166 , pp. 139-160
    • Jokanovic, M.1
  • 42
    • 0346445341 scopus 로고    scopus 로고
    • Imperial College Press, London, L. Karalliedde, S. Feldman, J. Henry, T. Marrs (Eds.)
    • Organophosphates and Health 2001, Imperial College Press, London. L. Karalliedde, S. Feldman, J. Henry, T. Marrs (Eds.).
    • (2001) Organophosphates and Health
  • 43
    • 4243091080 scopus 로고    scopus 로고
    • Academic Press, London, R.I. Krieger (Ed.)
    • Handbook of Pesticide Toxicology 2001, Academic Press, London. 2nd ed. R.I. Krieger (Ed.).
    • (2001) Handbook of Pesticide Toxicology
  • 44
    • 0345505719 scopus 로고    scopus 로고
    • Association between human paraoxonase gene polymorphism and chronic symptoms in pesticide-exposed workers
    • Lee B.W., London L., Paulauskis J., Myers J., Christiani D.C. Association between human paraoxonase gene polymorphism and chronic symptoms in pesticide-exposed workers. J. Occup. Environ. Med. 2003, 45:118-122.
    • (2003) J. Occup. Environ. Med. , vol.45 , pp. 118-122
    • Lee, B.W.1    London, L.2    Paulauskis, J.3    Myers, J.4    Christiani, D.C.5
  • 45
    • 27544478172 scopus 로고    scopus 로고
    • Butyrylcholinesterase, paraoxonase, and albumin esterase, but not carboxylesterase, are present in human plasma
    • Li B., Sedlacek M., Manoharan I., Boopathy R., Duysen E.G., Masson P., Lockridge O. Butyrylcholinesterase, paraoxonase, and albumin esterase, but not carboxylesterase, are present in human plasma. Biochem. Pharmacol. 2005, 70:1673-1684.
    • (2005) Biochem. Pharmacol. , vol.70 , pp. 1673-1684
    • Li, B.1    Sedlacek, M.2    Manoharan, I.3    Boopathy, R.4    Duysen, E.G.5    Masson, P.6    Lockridge, O.7
  • 48
    • 11244290324 scopus 로고    scopus 로고
    • The presence of dialkylphosphates in fresh fruit juices: implication for organophosphorus pesticide exposure and risk assessments
    • Lu C., Bravo R., Caltabiano L.M., Irish R.M., Weerasekera G., Barr D.B. The presence of dialkylphosphates in fresh fruit juices: implication for organophosphorus pesticide exposure and risk assessments. J. Toxicol. Environ. Health 2005, 68:209-227.
    • (2005) J. Toxicol. Environ. Health , vol.68 , pp. 209-227
    • Lu, C.1    Bravo, R.2    Caltabiano, L.M.3    Irish, R.M.4    Weerasekera, G.5    Barr, D.B.6
  • 49
    • 32044445089 scopus 로고    scopus 로고
    • Organic diets significantly lower children's dietary exposure to organophosphorous pesticides
    • Lu C., Toepel K., Irish R., Fenske R.A., Barr D.B., Bravo R. Organic diets significantly lower children's dietary exposure to organophosphorous pesticides. Environ. Health Perspect. 2006, 114:260-263.
    • (2006) Environ. Health Perspect. , vol.114 , pp. 260-263
    • Lu, C.1    Toepel, K.2    Irish, R.3    Fenske, R.A.4    Barr, D.B.5    Bravo, R.6
  • 51
    • 0030827926 scopus 로고    scopus 로고
    • Effect of the molecular polymorphisms of human paraoxonase (PON1) on the rate of hydrolysis of paraoxon
    • Mackness B., Mackness M.I., Arrol S., Turkie W., Durrington P.N. Effect of the molecular polymorphisms of human paraoxonase (PON1) on the rate of hydrolysis of paraoxon. Br. J. Pharmacol. 1997, 122:265-268.
    • (1997) Br. J. Pharmacol. , vol.122 , pp. 265-268
    • Mackness, B.1    Mackness, M.I.2    Arrol, S.3    Turkie, W.4    Durrington, P.N.5
  • 52
    • 34249734238 scopus 로고    scopus 로고
    • A gene-environment study of the paraoxonase 1 gene and pesticides in amyotrophic lateral sclerosis
    • Morahan J.M., Yu B., Trent R.J., Pamphlett R. A gene-environment study of the paraoxonase 1 gene and pesticides in amyotrophic lateral sclerosis. Neurotoxicology 2007, 28:532-540.
    • (2007) Neurotoxicology , vol.28 , pp. 532-540
    • Morahan, J.M.1    Yu, B.2    Trent, R.J.3    Pamphlett, R.4
  • 54
    • 0011414050 scopus 로고    scopus 로고
    • Monitoring occupational exposures to organophosphorus compounds
    • Imperial College Press, London, L. Karalliedde, S. Feldman, J. Henry, T. Marrs (Eds.)
    • Moretto A., Lotti M. Monitoring occupational exposures to organophosphorus compounds. Organophosphates and Health 2001, 407-429. Imperial College Press, London. L. Karalliedde, S. Feldman, J. Henry, T. Marrs (Eds.).
    • (2001) Organophosphates and Health , pp. 407-429
    • Moretto, A.1    Lotti, M.2
  • 55
    • 33846451402 scopus 로고    scopus 로고
    • The Relationship between PON1 phenotype and PON1-192 genotype in detoxification of three oxons by human liver
    • Mutch E., Daly A.K., Williams F.M. The Relationship between PON1 phenotype and PON1-192 genotype in detoxification of three oxons by human liver. Drug Metab. Dispos. 2007, 35:315-320.
    • (2007) Drug Metab. Dispos. , vol.35 , pp. 315-320
    • Mutch, E.1    Daly, A.K.2    Williams, F.M.3
  • 56
    • 33745211682 scopus 로고    scopus 로고
    • Diazinon, chlorpyrifos and parathion are metabolised by multiple cytochromes P450 in human liver
    • Mutch E., Williams F.M. Diazinon, chlorpyrifos and parathion are metabolised by multiple cytochromes P450 in human liver. Toxicology 2006, 224:22-32.
    • (2006) Toxicology , vol.224 , pp. 22-32
    • Mutch, E.1    Williams, F.M.2
  • 58
    • 21944435940 scopus 로고    scopus 로고
    • Genetic and other sources of variation in the activity of serum paraoxonase/diazoxonase in humans: consequences for risk from exposure to diazinon
    • O'Leary K.A., Edwards R.J., Town M.M., Boobis A.R. Genetic and other sources of variation in the activity of serum paraoxonase/diazoxonase in humans: consequences for risk from exposure to diazinon. Pharmacogenet. Genomics 2005, 15:51-60.
    • (2005) Pharmacogenet. Genomics , vol.15 , pp. 51-60
    • O'Leary, K.A.1    Edwards, R.J.2    Town, M.M.3    Boobis, A.R.4
  • 63
    • 78649757367 scopus 로고    scopus 로고
    • Prospective cohort study of sheep dip exposure and 'dipper's flu'.
    • Povey, A.C., Rees, H.G., Thompson, J.P., Karalliedde, L., 2010. Prospective cohort study of sheep dip exposure and 'dipper's flu'. HSE Res. Rep. 775, http://www.hse.gov.uk/research/rrpdf/rr775.pdf.
    • (2010) HSE Res. Rep. , pp. 775
    • Povey, A.C.1    Rees, H.G.2    Thompson, J.P.3    Karalliedde, L.4
  • 64
    • 0029927503 scopus 로고    scopus 로고
    • Exposure to sheep dip and the incidence of acute symptoms in a group of Welsh sheep farmers
    • Rees H. Exposure to sheep dip and the incidence of acute symptoms in a group of Welsh sheep farmers. Occup. Environ. Med. 1996, 53:258-263.
    • (1996) Occup. Environ. Med. , vol.53 , pp. 258-263
    • Rees, H.1
  • 65
    • 0033461179 scopus 로고    scopus 로고
    • Determination of paraoxonase (PON1) status requires more than genotyping
    • Richter R.J., Furlong C.E. Determination of paraoxonase (PON1) status requires more than genotyping. Pharmacogenetics 1999, 9:745-753.
    • (1999) Pharmacogenetics , vol.9 , pp. 745-753
    • Richter, R.J.1    Furlong, C.E.2
  • 67
    • 36049039119 scopus 로고    scopus 로고
    • Human carboxylesterases and their role in xenobiotic and endobiotic metabolism
    • Ross M.K., Crow J.A. Human carboxylesterases and their role in xenobiotic and endobiotic metabolism. J. Biochem. Mol. Toxicol. 2007, 21:187-196.
    • (2007) J. Biochem. Mol. Toxicol. , vol.21 , pp. 187-196
    • Ross, M.K.1    Crow, J.A.2
  • 68
    • 0004194682 scopus 로고    scopus 로고
    • Royal College of Physicians of London and the Royal College of Psychiatrists, Royal College of Physicians of London and the Royal College of Psychiatrists, London.
    • Royal College of Physicians of London and the Royal College of Psychiatrists Organophosphate Sheep Dip: Clinical Aspects of Long Term Low-dose Exposure 1998, Royal College of Physicians of London and the Royal College of Psychiatrists, London.
    • (1998) Organophosphate Sheep Dip: Clinical Aspects of Long Term Low-dose Exposure
  • 69
    • 10644293868 scopus 로고    scopus 로고
    • Biotransformation of chlorpyrifos and diazinon by human liver microsomes and recombinant human cytochrome p450s (CYP)
    • Sams C., Cocker J., Lennard M.S. Biotransformation of chlorpyrifos and diazinon by human liver microsomes and recombinant human cytochrome p450s (CYP). Xenobiotica 2004, 34:861-873.
    • (2004) Xenobiotica , vol.34 , pp. 861-873
    • Sams, C.1    Cocker, J.2    Lennard, M.S.3
  • 74
  • 75
    • 0034861252 scopus 로고    scopus 로고
    • Metabolism of chlorpyrifos by human cytochrome p450 isoforms and human, mouse and rat liver microsomes
    • Tang J., Cao Y., Rose R.L., Brimfield A.A., Dai D., Goldtsein J.A., Hodgson E. Metabolism of chlorpyrifos by human cytochrome p450 isoforms and human, mouse and rat liver microsomes. Drug Metab. Dispos. 2001, 29:1201-1204.
    • (2001) Drug Metab. Dispos. , vol.29 , pp. 1201-1204
    • Tang, J.1    Cao, Y.2    Rose, R.L.3    Brimfield, A.A.4    Dai, D.5    Goldtsein, J.A.6    Hodgson, E.7
  • 76
    • 0022869845 scopus 로고
    • Progress in warble fly eradication
    • Tarry D.W. Progress in warble fly eradication. Parasitol. Today 1986, 2:111-116.
    • (1986) Parasitol. Today , vol.2 , pp. 111-116
    • Tarry, D.W.1
  • 77
    • 0033792112 scopus 로고    scopus 로고
    • Paraoxonase polymorphisms, pesticide exposure and Parkinson's disease in a Caucasian population
    • Taylor M.C., Le Couteur D.C., Mellick G.D., Board P.B. Paraoxonase polymorphisms, pesticide exposure and Parkinson's disease in a Caucasian population. J. Neural Transm. 2000, 107:979-983.
    • (2000) J. Neural Transm. , vol.107 , pp. 979-983
    • Taylor, M.C.1    Le Couteur, D.C.2    Mellick, G.D.3    Board, P.B.4
  • 78
    • 23844530260 scopus 로고    scopus 로고
    • Genetic polymorphisms and mechanisms of neurotoxicity: overview
    • Tiffany-Castiglioni E., Venkatraj V., Qian Y. Genetic polymorphisms and mechanisms of neurotoxicity: overview. Neurotoxicology 2005, 26:641-649.
    • (2005) Neurotoxicology , vol.26 , pp. 641-649
    • Tiffany-Castiglioni, E.1    Venkatraj, V.2    Qian, Y.3
  • 79
    • 0037026733 scopus 로고    scopus 로고
    • Monte Carlo analysis of the human chlorpyrifos-oxonase (PON1) polymorphism using a physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model
    • Timchalk C., Kousba A., Poet T.S. Monte Carlo analysis of the human chlorpyrifos-oxonase (PON1) polymorphism using a physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model. Toxicol. Lett. 2002, 135(2002):51-59.
    • (2002) Toxicol. Lett. , vol.135 , Issue.2002 , pp. 51-59
    • Timchalk, C.1    Kousba, A.2    Poet, T.S.3
  • 82
    • 0347906100 scopus 로고    scopus 로고
    • Veterinary Products Committee
    • Veterinary Products Committee Annual Report for 2000 2000, http://www.vpc.gov.uk/Public/AR/vpcar00.pdf.
    • (2000) Annual Report for 2000
  • 83
    • 0037380036 scopus 로고    scopus 로고
    • Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity
    • Winrow C.J., Hemming M.L., Allen D.M., Quistad G.B., Casida J.E., Barlow C. Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity. Nat. Genet. 2003, 33:477-485.
    • (2003) Nat. Genet. , vol.33 , pp. 477-485
    • Winrow, C.J.1    Hemming, M.L.2    Allen, D.M.3    Quistad, G.B.4    Casida, J.E.5    Barlow, C.6


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