PON1Q192R genetic polymorphism modifies organophosphorous pesticide effects on semen quality and DNA integrity in agricultural workers from southern Mexico

Toxicology and Applied Pharmacology

Volumn 230, Issue 2, 2008, Pages 261-268

  Perez Herrera N ^a,e   Polanco Minaya, H ^a,b,e   Salazar Arredondo, E ^a,c,e   Solis Heredia M J ^a,e   Hernandez Ochoa I ^a,e   Rojas Garcia E ^d,e   Alvarado Mejia J ^b,e   Borja Aburto, V H ^b,e   Quintanilla Vega, B ^a,e  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

^b UNIVERSIDAD AUTÓNOMA DE YUCATÁN   (Mexico)

^c UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^d UNIVERSIDAD AUTÓNOMA DE NAYARIT   (Mexico)

^e INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

Author keywords

Organophosphorous pesticides; PON1 polymorphisms; Semen quality; Sperm DNA damage

Indexed keywords

DNA; ORGANOPHOSPHATE PESTICIDE; PARAOXON; PHENYLACETIC ACID;

ADULT; AGRICULTURAL WORKER; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DNA DAMAGE; DNA DETERMINATION; DNA NICK TRANSLATION; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HOMOZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEXICO; OCCUPATIONAL EXPOSURE; PATHOGENESIS; REAL TIME POLYMERASE CHAIN REACTION; REPRODUCTIVE TOXICITY; SEMEN ANALYSIS; SPERMATID; SPERMATOGENESIS; SPERMATOZOON; WORLD HEALTH ORGANIZATION;

ADOLESCENT; ADULT; AGRICULTURAL WORKERS' DISEASES; ALCOHOL DRINKING; ARYLDIALKYLPHOSPHATASE; CROSS-SECTIONAL STUDIES; DNA; DNA DAMAGE; GENE FREQUENCY; GENOTYPE; HUMANS; IN SITU NICK-END LABELING; INSECTICIDES; LINEAR MODELS; MALE; MEXICO; MIDDLE AGED; OCCUPATIONAL EXPOSURE; ORGANOPHOSPHORUS COMPOUNDS; POLYMORPHISM, GENETIC; SEMEN; SMOKING; SUBSTANCE-RELATED DISORDERS;

EID: 45049085874     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.02.021     Document Type: Article

References (61)

1. Aitken R.J., and Fisher H. Reactive oxygen species generation and human spermatozoa: the balance of benefit and risk. Bioassays 16 (1994) 259-267
2. Adler I.D. Mouse spermatogonia and spermatocyte sensitivity to chemical mutagens. Cytogenet. Cell Genet., 33 (1982) 95-100
3. Allebrant K.V., Souza R.L., and Chautard-Freire-Maia E.A. Variability of the paraoxonase gene (PON1) in Euro- and Afri-Brazilians. Toxicol. Appl. Pharmacol. 3 (2002) 151-156
4. Brophy V.H., Jampsa R.L., Clendenning J.B., Mckinstry L.A., and Furlong C.E. Effects of 5′regulatory-region polymorphism on paraoxonase-gene (PON1) expression. Am. J. Hum. Genet. 68 (2001) 1428-1436
5. Burruel V.R., Raabe O.G., Overstreet J.W., Wilson B.W., and Wiley L.M. Paternal effects from methamidophos administration in mice. Toxicol. Appl. Pharmacol. 165 (2000) 148-157
6. Bustos-Obregon E., and González-Hormazabal P. Effect of a single dose of malathion on spermatogenesis in mice. Asian J. Androl. 5 (2003) 105-107
7. Chen J., Kumar M., Chan W., Berkowitz G., and Wetmur J.G. Increased of genetic variation on PON1 activity in neonates. Environ. Health Perspect. 111 (2003) 1403-1409
8. Cherry N., Mackness N., Durrington P., Povey A., Dippnall M., Smith T., and Mackness B. Paraoxonase (PON1) polymorphisms in farmers attributing ill health to sheep dip. Lancet. 359 (2002) 763-764
9. Davies H.G., Richter R.J., Keifer M., Broomfield C.A., Sowalla J., and Furlong C.E. The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin. Nat. Genet. 14 (1996) 334-336
10. Eckerson H.W., White C.M., and La Du B.N. The human serum paraoxonase/arylesterase polymorphism. Am. J. Hum. Genet. 35 (1983) 1126-1138
11. Flegal K.M., Ogden C.L., and Carrol M.D. Prevalence and trends in overweight in Mexican-American adults and children. Nutr. Rev. 62 (2004) 144-148
12. Furlong C.E., Richter R.J., Seidel S.L., and Motulsky A.G. Role of genetic polymorphism of human plasma paraoxonase/arylesterase in hydrolysis of the insecticide metabolites chlorpyrifos oxon and paraoxon. Am. J. Hum. Genet. 43 (1988) 230-238
13. Gamboa R., Zamora J., Rodríguez-Pérez J.M., Fragoso J.M., Cardoso G., Posadas-Romero C., and Vargas-Alarcón G. Distribution of paraoxonase PON1 gene polymorphisms in Mexican populations Its role in the lipid profile. Exp. Mol. Pathol. 80 (2006) 85-90
14. Geldmacher-von Mallinckrodt M., and Diepgen T.L. The human serum paraoxonase-polymorphism and specificity. Toxicol. Environ. Chem. 18 (1988) 79-196
15. Hales B.F., Aguilar-Mahecha A., and Robaire B. The stress response in gametes and embryos alter paternal chemical exposures. Toxicol. Appl. Pharmacol. 207 (2005) 514-520
16. Haley R.W., Billecke S., and La Du. Association of low PON1 type Q (type A) arylesterase activity with neurologic symptom complexes in Gulf War veterans. Toxicol. Appl. Pharmacol. 157 (1999) 227-233
17. Hernández A.F., Mackness B., Rodrigo L., López O., Pla A., Gil F., Durrington P.N., Pena G., Parrón T., Serrano J.L., and Mackness M.I. Paraoxonase activity and genetic polymorphisms in greenhouse workers with long term pesticide exposure. Hum. Exp. Toxicol. 22 (2003) 565-574
18. Hotopf M., Mackness M.I., Nikolau V., Collier D.A., Curtis C., David A., Durrington P., Hull L., Ismail K., Peakman M., Unwin C., Wessely S., and Mackness B. Paraoxonase in Persian Gulf War Veterans. J. Occup. Environ. Med. 45 (2003) 668-675
19. IARC. IARC monographs on the evaluation of carcinogenic risks to humans. Occupational exposures in insecticide application, and some pesticide vol. 53 (1991), IARC, Lyon, France.
20. INEGI. Instituto Nacional de Estadística Geografía e Informática (2005). http://www.inegi.gob.mx Available at: http://www.inegi.gob.mx
21. Johnson L. Efficiency of spermatogenesis in humans and animals (1997), College Station, Texas
22. Jokanovick M. Biotransformation of organophosphorus compounds. Toxicology 166 (2001) 139-160
23. Jørgensen N., Andersen A.G., Eustache F., Irvine D.S., Suominen J., Petersen J.H., Andersen A.N., Auger J., Cawood E.H.H., Horte A., Jensen T.K., Jouannet P., Keiding N., Vierula M., Toppari J., and Skakkebæk N.E. Regional differences in semen quality in Europe. Hum. Reprod. 16 (2001) 1012-1019
24. Kamijima M., Hibi H., Gotoh M., Taki K., Saito I., Wang H., Itohara S., Yamada T., Ichihara G., Shibata E., Nakajima T., and Takeuchi Y. A survey of semen indices in insecticide sprayers. J. Occup. Health. 46 (2004) 109-118
25. Kelada S.N., Eaton D.L., Wang S.S., Rothman N.R., and Khoury M. The role of genetic polymorphisms in environmental health. Environ. Health Perspect. 111 (2003) 1055-1064
26. La Du B.N., Piko J.I., Eckerson H.W., Vincent-Viry M., and Siest G. An improved method for phenotyping individuals for the human serum paraoxonase arylesterase polymorphism. Ann. Boil. Clin. 44 (1986) 369-372
27. La Du B.N. Structural and functional diversity of paraoxonases. Nat. med. 2 (1996) 1186-1187
28. Lee, B.W., London, L., Paulauskis, J., Myers, J., Christiani, D.C., 2003. Association between human paraoxonase gene polymorphism and chronic symptoms in pesticide-exposed workers. Occup. Environ. Med. 45, 118-122.
29. Lee C.H., Kamijima M., Kim H., Shibate E., Ueyama J., Suzuki T., Takagi K., Saito I., Gotoh M., Hibi H., Naito H., and Nakajima T. 8-Hydroxydeoxyguanosine levels in human leukocyte and urine according to exposure to organophosphorus pesticides and paraoxonase 1 genotype. Int. Arch. Occup. Environ. Health 80 (2007) 217-227
30. Li H.L., Liu D.P., and Liang C.C. Paraoxonase gene polymorphisms, oxidative stress, and diseases. J. Mol. Med. 81 (2003) 766-779
31. Liu Y.J., Huang P.L., Chang Y.F., Chen Y.H., Chiou Y.H., Xu Z.L., and Wong R.H. GSTP1 genetic polymorphism is associated with a higher risk of DNA damage in pesticide-exposed fruit growers. Cancer Epidemiol. Biomarkers Prev. 15 (2006) 659-666
32. Mackness M.I., Arrol S., and Durrington P.N. Paraoxonase prevents accumulation of lipoperoxides in low-density lipoprotein. FEBS Lett. 286 (1991) 152-154
33. Mackness B., Mackness M.I., Arrol S., Turke W., and Durrington P.N. Effect of the human serum paraoxonase 55 and 192 genetic polymorphism on the protection by high density lipoprotein against low density lipoprotein oxidative modification. FEBS Lett. 423 (1998) 57-60
34. Mackness B., Durrington P.N., and Mackness M.I. Low paraoxonase in Persian Gulf War veterans self-reporting Gulf War Syndrome. Biochem. Biophys. Res. Commun. 276 (2000) 729-733
35. Marchetti F., Bishop J.B., Lowe X., Generoso W.M., Hozier J., and Wyrobek A.K. Etoposide induces hereditable chromosomal aberrations and aneuploidy during male meiosis in the mouse. Proc. Natl. Acad. Sci. 98 (2001) 3952-3957
36. Mathew G., Vijayalaxmi K.K., and Rahiman M.A. Methyl parathion-induced sperm shape abnormalities in mouse. Mutat. Res. 280 (1992) 169-173
37. Meeker J.D., Ryan L., Barr D.B., Herrick R.F., Bennertt D.H., Bravo R., and Hauser R. The relationship of urinary metabolites of carbaryl/naphthalene and chlorpyrifos with human semen quality. Environ. Health Perspect. 112 (2004) 1665-1670
38. Meeker J.D., Singh N.P., Ryan L., Duty L.R., Barr D.B., Herrick R.F., Bennett H.D., Hausser, and Russ. Urinary levels of insecticide metabolites and DNA damage in human sperm. Human. Reprod. 19 (2004) 2573-2580
39. Padungtod C., Niu T., Wang Z., Savitz D.A., Christiani C., Ryan L.M., and Xu X. Paraoxonase polymorphism and its effect on male reproductive outcomes among Chinese pesticide factory workers. Am. J. Ind. Med. 36 (1999) 379-387
40. Padungtod C., Savitz D.A., Overstreet J.W., Christiani D.C., Ryan L.M., and Xu X. Occupational pesticide exposure and semen quality among Chinese workers. J. Occup. Environ. Med. 42 (2000) 982-992
41. Piña-Guzmán B., Solís-Heredia, and Quintanilla-Vega B. Diazinon alters sperm chromatin structure in mice by phosphorilating nuclear protamines. Toxicol. Appl. Pharmacol. 202 (2005) 189-198
42. Piña-Guzmán B., Solís-Heredia M.J., Rojas-García A.E., Urióstegui-Acosta M., and Quintanilla-Vega B. Genetic damage caused by methyl-parathion in mouse spermatozoa is related to oxidative stress. Toxicol. Appl. Pharmacol. 216 (2006) 216-224
43. Primo-Parmo S.L., Sorenson R.E., Teiber J., and La Du B.N. The human serum paraoxonase/arylesterase gene (PON1) is a member of a multigene family. Genomics. 33 (1996) 498-509
44. Quitanilla-Vega, B., Pérez-Herrera, N., Piña-Guzmán, B., in press. Organophosphorous pesticides alter sperm chromatin structure and DNA integrity: mechanisms of reproductive toxicity. Environ. Res. J.
45. Ranjbar A., Pasalar P., and Abdollahi M. Induction of oxidative stress and acetylcholinesterase inhibition in organophosphorous pesticide manufacturing workers. Hum. Exp. Toxicol. 21 (2002) 179-182
46. Recio R., Robbins W.A., Ocampo-Gómez G., Borja-Aburto V., Morán-Martínez J., Froines J.R., García Hernández R.Ma., and Cebrián M.E. Organophosphorous pesticide exposure increases the frequency of sperm sex null aneuploidy. Environ. Health Perspect. 109 (2001) 31-34
47. Rojas-García A.E., Solís-Heredia M.J., Piña-Guzmán B., Vega L., López-Carrillo L., and Quintanilla-Vega B. Genetic polymorphism and activity of PON1 in a Mexican population. Toxicol. Appl. Pharmacol. 205 (2005) 282-289
48. Sakkas D., Urner F., Bianchi P.G., Bizzarro D., Wagner I., Jaquenoud N., Manicardi G., and Campana A. Sperm chromatin anomalies can influence decondensation after intracytoplasmic sperm injection (ICSI). Hum. Reprod. 11 (1996) 843-973
49. Sánchez-Peña L.C., Reyes B.E., López-Carrillo L., Recio R., Morán-Martínez J., Cebrián M.E., and Quintanilla-Vega B. Organophosphorous pesticide exposure alters sperm chromatin structure in Mexican agricultural workers. Toxicol. Appl. Pharmacol. 196 (2004) 108-113
50. Sega G.A. Adducts in sperm protamine and DNA vs. mutation frequency. Prog. Clin. Biol. Res. 372 (1991) 521-530
51. Sobarzo C., and Bustos-Obregón E. Sperm quality in mice acutely treated with parathion. Asian J. Androl. 2 (2000) 147-150
52. Sotomayor R.E., and Sega G.A. Unscheduled DNA synthesis assay in mammalian spermatogenic cells: an update. Environ. Mol. Mutagen. 36 (2000) 255-265
53. Spano M., Kolstad H., Larsen S.B., Cordelli E., Leter G., and Giwercman A. The applicability of the flow cytometric sperm chromatin structure assay to epidemiological studies. Hum. Reprod., 13 (1998) 2495-2505
54. Suehiro T., Nakamura T., Inoue M., Shinoki T., Ikeda Y., Kumon Y., Shindo M., Tanaka H., and Hashimoto K. A polymorphism upstream from the human paraoxonase (PON1) gene and its association with PON1 expression. Atherosclerosis 150 (2000) 295-298
55. Summer A.T., Taggart M.H., Mezzanotte R., and Ferruci L. Patterns of digestion of human chromosomes by restriction endonucleases demonstrated by in situ nick translation. Histochem. J. 22 (1990) 639-652
56. Swan S.H., Kruse R.L., Liu F., Barr D.B., Drobnis E.Z., Redmon J.B., Wang C., Brazil C., Overstreet J.W., and the Study for Future Families Research Group. Semen quality in relation to biomarkers of pesticide exposure. Environ. Health Perspect. 111 (2003) 1478-1484
57. Tahmaz N., Soutar A., and Cherrie J.W. Chronic fatigue and organophosphate pesticides in sheep farming: a retrospective study amongst people reporting to a UK pharmacovigilance scheme. Ann. Occup. Hyg. 47 (2003) 261-267
58. Tomlinson M.J., Moffatt O., Manicardi G.C., Bizarro D., Afnan M., and Sakkas D. Interrelationships between seminal parameters and sperm nuclear DNA damage before and after density gradient centrifugation: implications for assisted conception. Hum. Reprod. 16 (2001) 2160-2165
59. Vasilic Z., Drevenkar V., Stengl B., Frobe Z., and Rumenjak V. Diethylphosphorous metabolites in serum and urine of persons poisoned by phosalone. Chem. Biol. Interact. 87 (1993) 305-313
60. World Health Organization. WHO Laboratory Manual for the Examination of Human Semen and Semen-Cervical Mucus Interaction (2002), Cambridge Univ. Press, Cambridge
61. Xia Y., Cheng S., Bian Q., Xu L., Collins M.D., Chang H.C., Song L., Liu J., Wang S., and Wang X. Genotoxic effects on spermatozoa of carbaryl-exposed workers. Toxicol. Sci. 85 (2005) 615-623