Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis

Nature Medicine

Volumn 15, Issue 9, 2009, Pages 1072-1076

  Echtermeyer, Frank ^a   Bertrand, Jessica ^b   Dreier, Rita ^c   Meinecke, Ingmar ^b,d   Neugebauer, Katja ^b   Fuerst, Martin ^e   Lee, Yun Jong ^f   Song, Yeong Wook ^f   Herzog, Christine ^a   Theilmeier, Gregor ^a   Pap, Thomas ^b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b Institute of Experimental Musculoskeletal Medicine   (Germany)

^c Institute for Physiological Chemistry and Pathobiochemistry   (Germany)

^d UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^e UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^f Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ADAMTS 5 PROTEIN; COLLAGEN TYPE 10; METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN ANTIBODY; STRESS ACTIVATED PROTEIN KINASE; STROMELYSIN; SYNDECAN 4; SYNDECAN 4 ANTIBODY; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARTILAGE CELL; CARTILAGE DEGENERATION; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVATION; ENZYME SYNTHESIS; HUMAN; HUMAN TISSUE; KNEE OSTEOARTHRITIS; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RAT; WILD TYPE;

ADAM PROTEINS; ANIMALS; CARTILAGE; CHONDROCYTES; COLLAGEN TYPE X; DISEASE MODELS, ANIMAL; HUMANS; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 3; MICE; MICE, KNOCKOUT; OSTEOARTHRITIS; RATS; RNA, MESSENGER; SYNDECAN-4;

MURINAE; MUS;

EID: 69949118870     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.1998     Document Type: Article

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