-
1
-
-
0036527429
-
Protein kinases - the major drug targets of the twenty-first century?
-
Cohen P (2002) Protein kinases - the major drug targets of the twenty-first century? Nat Rev Drug Discov 1(4):309-315.
-
(2002)
Nat Rev Drug Discov
, vol.1
, Issue.4
, pp. 309-315
-
-
Cohen, P.1
-
2
-
-
0026342401
-
Crystal-structure of the catalytic subunit of cyclic adenosine-monophosphate dependent protein-kinase
-
Knighton DR, et al. (1991) Crystal-structure of the catalytic subunit of cyclic adenosine-monophosphate dependent protein-kinase. Science 253(5018):407-414.
-
(1991)
Science
, vol.253
, Issue.5018
, pp. 407-414
-
-
Knighton, D.R.1
-
3
-
-
0029993727
-
Active and inactive protein kinases: Structural basis for regulation
-
Johnson LN, Noble ME, Owen DJ (1996) Active and inactive protein kinases: Structural basis for regulation. Cell 85(2):149-158.
-
(1996)
Cell
, vol.85
, Issue.2
, pp. 149-158
-
-
Johnson, L.N.1
Noble, M.E.2
Owen, D.J.3
-
4
-
-
0037013143
-
The conformational plasticity of protein kinases
-
Huse M, Kuriyan J (2002) The conformational plasticity of protein kinases. Cell 109(3):275-282.
-
(2002)
Cell
, vol.109
, Issue.3
, pp. 275-282
-
-
Huse, M.1
Kuriyan, J.2
-
5
-
-
34250878954
-
Mechanisms of specificity in protein phosphorylation
-
Ubersax JA, Ferrell JE, Jr (2007) Mechanisms of specificity in protein phosphorylation. Nat Rev Mol Cell Biol 8(7):530-541.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, Issue.7
, pp. 530-541
-
-
Ubersax, J.A.1
Ferrell Jr, J.E.2
-
6
-
-
4444353636
-
Regulation of protein kinases; controlling activity through activation segment conformation
-
Nolen B, Taylor S, Ghosh G (2004) Regulation of protein kinases; controlling activity through activation segment conformation. Mol Cell 15(5):661-675.
-
(2004)
Mol Cell
, vol.15
, Issue.5
, pp. 661-675
-
-
Nolen, B.1
Taylor, S.2
Ghosh, G.3
-
7
-
-
0037032835
-
The protein kinase complement of the human genome
-
Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (2002) The protein kinase complement of the human genome. Science 298(5600):1912-1934.
-
(2002)
Science
, vol.298
, Issue.5600
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
8
-
-
0034924175
-
Haspin-like proteins: A new family of evolutionarily conserved putative eukaryotic protein kinases
-
Higgins JM (2001) Haspin-like proteins: A new family of evolutionarily conserved putative eukaryotic protein kinases. Protein Sci 10(8):1677-1684.
-
(2001)
Protein Sci
, vol.10
, Issue.8
, pp. 1677-1684
-
-
Higgins, J.M.1
-
9
-
-
0037365635
-
Structure, functionandevolution of haspinandhaspin- related proteins, a distinctive group of eukaryotic protein kinases
-
Higgins JM (2003) Structure, functionandevolution of haspinandhaspin- related proteins, a distinctive group of eukaryotic protein kinases. Cell Mol Life Sci 60(3):446-462.
-
(2003)
Cell Mol Life Sci
, vol.60
, Issue.3
, pp. 446-462
-
-
Higgins, J.M.1
-
10
-
-
13844252061
-
The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment
-
Dai J, Sultan S, Taylor SS, Higgins JM (2005) The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment. Genes Dev 19(4):472-488.
-
(2005)
Genes Dev
, vol.19
, Issue.4
, pp. 472-488
-
-
Dai, J.1
Sultan, S.2
Taylor, S.S.3
Higgins, J.M.4
-
11
-
-
0035105860
-
Cloning and characterization of human haspin gene encoding haploid germ cell-specific nuclear protein kinase
-
Tanaka H, et al. (2001) Cloning and characterization of human haspin gene encoding haploid germ cell-specific nuclear protein kinase. Mol Hum Reprod 7(3):211-218.
-
(2001)
Mol Hum Reprod
, vol.7
, Issue.3
, pp. 211-218
-
-
Tanaka, H.1
-
12
-
-
0033546159
-
Identification and characterization of a haploid germ cell-specific nuclear protein kinase (Haspin) in spermatid nuclei and its effects on somatic cells
-
Tanaka H, et al. (1999) Identification and characterization of a haploid germ cell-specific nuclear protein kinase (Haspin) in spermatid nuclei and its effects on somatic cells. J Biol Chem 274(24):17049-17057.
-
(1999)
J Biol Chem
, vol.274
, Issue.24
, pp. 17049-17057
-
-
Tanaka, H.1
-
13
-
-
38549168381
-
Centromeric Aurora-B activation requires TD-60, microtubules, and substrate priming phosphorylation
-
Rosasco-Nitcher SE, Lan W, Khorasanizadeh S, Stukenberg PT (2008) Centromeric Aurora-B activation requires TD-60, microtubules, and substrate priming phosphorylation. Science 319(5862):469-472.
-
(2008)
Science
, vol.319
, Issue.5862
, pp. 469-472
-
-
Rosasco-Nitcher, S.E.1
Lan, W.2
Khorasanizadeh, S.3
Stukenberg, P.T.4
-
14
-
-
33750428233
-
Regulation of mitotic chromosome cohesion by Haspin and Aurora B
-
Dai J, Sullivan BA, Higgins JM (2006) Regulation of mitotic chromosome cohesion by Haspin and Aurora B. Dev Cell 11(5):741-750.
-
(2006)
Dev Cell
, vol.11
, Issue.5
, pp. 741-750
-
-
Dai, J.1
Sullivan, B.A.2
Higgins, J.M.3
-
15
-
-
58149387464
-
Identification of small molecule inhibitors of the mitotic kinase Haspin by high-throughput screening using a homogeneous time-resolved fluorescence resonance energy transfer assay
-
Patnaik D, et al. (2008) Identification of small molecule inhibitors of the mitotic kinase Haspin by high-throughput screening using a homogeneous time-resolved fluorescence resonance energy transfer assay. J Biomol Screen 13:1025-1034.
-
(2008)
J Biomol Screen
, vol.13
, pp. 1025-1034
-
-
Patnaik, D.1
-
16
-
-
58149287842
-
A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function
-
Barouch-Bentov R, et al. (2009) A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function. Mol Cell 33(1):43-52.
-
(2009)
Mol Cell
, vol.33
, Issue.1
, pp. 43-52
-
-
Barouch-Bentov, R.1
-
17
-
-
18944386711
-
The active conformation of the PAK1 kinase domain
-
Lei M, Robinson MA, Harrison SC (2005) The active conformation of the PAK1 kinase domain. Structure 13(5):769-778.
-
(2005)
Structure
, vol.13
, Issue.5
, pp. 769-778
-
-
Lei, M.1
Robinson, M.A.2
Harrison, S.C.3
-
18
-
-
0028157664
-
Atomic-structure of the map kinase Erk2 at 2.3-Angstrom resolution
-
Zhang FM, Strand A, Robbins D, Cobb MH, Goldsmith EJ (1994) Atomic-structure of the map kinase Erk2 at 2.3-Angstrom resolution. Nature 367(6465):704-711.
-
(1994)
Nature
, vol.367
, Issue.6465
, pp. 704-711
-
-
Zhang, F.M.1
Strand, A.2
Robbins, D.3
Cobb, M.H.4
Goldsmith, E.J.5
-
19
-
-
0029665852
-
Crystal structure of the p27(Kip1) cyclin-dependent-kinase inhibitor bound to the cyclin A Cdk2 complex
-
Russo AA, Jeffrey PD, Patten AK, Massague J, Pavletich NP (1996) Crystal structure of the p27(Kip1) cyclin-dependent-kinase inhibitor bound to the cyclin A Cdk2 complex. Nature 382(6589):325-331.
-
(1996)
Nature
, vol.382
, Issue.6589
, pp. 325-331
-
-
Russo, A.A.1
Jeffrey, P.D.2
Patten, A.K.3
Massague, J.4
Pavletich, N.P.5
-
20
-
-
25144502820
-
Higher-order substrate recognition of eIF2alpha by the RNA-dependent protein kinase PKR
-
Dar AC, Dever TE, Sicheri F (2005) Higher-order substrate recognition of eIF2alpha by the RNA-dependent protein kinase PKR. Cell 122(6):887-900.
-
(2005)
Cell
, vol.122
, Issue.6
, pp. 887-900
-
-
Dar, A.C.1
Dever, T.E.2
Sicheri, F.3
-
21
-
-
57149120091
-
Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure
-
Komander D, Garg R, Wan PT, Ridley AJ, Barford D (2008) Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure. EMBO J 27(23):3175-3185.
-
(2008)
EMBO J
, vol.27
, Issue.23
, pp. 3175-3185
-
-
Komander, D.1
Garg, R.2
Wan, P.T.3
Ridley, A.J.4
Barford, D.5
-
22
-
-
55049093739
-
Structure and substrate recruitment of the human spindle checkpoint kinase Bub1
-
Kang J, et al. (2008) Structure and substrate recruitment of the human spindle checkpoint kinase Bub1. Mol Cell 32(3):394-405.
-
(2008)
Mol Cell
, vol.32
, Issue.3
, pp. 394-405
-
-
Kang, J.1
-
23
-
-
56549108407
-
Epigenetic regulation of centromeric chromatin: Old dogs, new tricks?
-
Allshire RC, Karpen GH (2008) Epigenetic regulation of centromeric chromatin: Old dogs, new tricks? Nat Rev Genet 9(12):923-937.
-
(2008)
Nat Rev Genet
, vol.9
, Issue.12
, pp. 923-937
-
-
Allshire, R.C.1
Karpen, G.H.2
-
24
-
-
34547588389
-
PrDOS: Prediction of disordered protein regions from amino acid sequence
-
Ishida T, Kinoshita K (2007) PrDOS: prediction of disordered protein regions from amino acid sequence. Nucleic Acids Res 35:W460-464.
-
(2007)
Nucleic Acids Res
, vol.35
-
-
Ishida, T.1
Kinoshita, K.2
-
25
-
-
0029767016
-
Structural basis of cyclin-dependent kinase activation by phosphorylation
-
Russo AA JP, Pavletich NP (1996) Structural basis of cyclin-dependent kinase activation by phosphorylation. Nat Struct Biol 3(8):696-700.
-
(1996)
Nat Struct Biol
, vol.3
, Issue.8
, pp. 696-700
-
-
Russo1
AA, J.P.2
Pavletich, N.P.3
|