Selective labeling of IRAP by the tritiated AT4 receptor ligand [3H]Angiotensin IV and its stable analog [3H]AL-11

Molecular and Cellular Endocrinology

Volumn 311, Issue 1-2, 2009, Pages 77-86

  Demaegdt, Heidi ^a   Lukaszuk, Aneta ^a   De Buyser, Evi ^a   De Backer, Jean Paul ^a   Szemenyei, Erzsébet ^b   Tóth, Géza ^b   Chakravarthy, Sridhara ^c   Panicker, Mitradas ^c   Michotte, Yvette ^a   Tourwé, Dirk ^a   Vauquelin, Georges ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c TATA INSTITUTE OF FUNDAMENTAL RESEARCH   (India)

Author keywords

AL 11; Ang IV; IRAP

Indexed keywords

1,10 PHENANTHROLINE; ANGIOTENSIN 4 RECEPTOR; ANGIOTENSIN II [3-8]; ANGIOTENSIN RECEPTOR; CYSTYL AMINOPEPTIDASE; EDETIC ACID; MICROSOMAL AMINOPEPTIDASE; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL MEMBRANE; CHO CELL; CONTROLLED STUDY; FEMALE; HIPPOCAMPUS; IODINATION; LIGAND BINDING; MEMORY CONSOLIDATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING;

ANGIOTENSIN II; ANIMALS; BINDING, COMPETITIVE; BIOLOGICAL ASSAY; CHO CELLS; CRICETINAE; CRICETULUS; CYSTINYL AMINOPEPTIDASE; HUMANS; KINETICS; LIGANDS; MICE; RECEPTORS, ANGIOTENSIN; STAINING AND LABELING; TRITIUM;

EID: 69249232045     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2009.07.020     Document Type: Article

References (37)

1. Albiston A.L., McDowall S.G., Matsacos D., Sim P., Clune E., Mustafa T., Lee J., Mendelsohn F.A., Simpson R.J., Connolly L.M., and Chai S.Y. Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin-regulated aminopeptidase. J. Biol. Chem. 276 (2001) 48623-48626
2. Axén A., Lindeberg G., Demaegdt H., Vauquelin G., Karlen A., and Hallberg M. Cyclic insulin-regulated aminopeptidase (IRAP)/AT4 receptor ligands. J. Pept. Sci. 12 (2006) 705-713
3. Axén A., Andersson H., Lindeberg G., Rönnholm H., Kortesmaa J., Demaegdt H., Vauquelin G., Karlén A., and Hallberg M. Small potent ligands to the insulin-regulated aminopeptidase (IRAP)/AT4 receptor. J. Pept. Sci. 13 (2007) 434-444
4. Chai S.Y., Fernando R., Peck G., Ye S.Y., Mendelsohn F.A., Jenkins T.A., and Albiston A.L. The angiotensin IV/AT4 receptor. Cell. Mol. Life Sci. 61 (2004) 2728-2737
5. Chansel D., Czekalski S., Vandermeersch S., Ruffet E., Fournie-Zaluski M.C., and Ardaillou R. Characterization of angiotensin IV-degrading enzymes and receptors on rat mesangial cells. Am. J. Physiol. 275 (1998) F535-F542
6. 2+ in mesangial cells. Eur. J. Pharmacol. 414 (2001) 165-175
7. Chen H., Roques B.P., and Fournié-Zaluski M.C. Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor. Bioorg. Med. Chem. Lett. 9 (1999) 1511-1516
8. Cheng Y.C., and Prusoff W.H. Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50 percent inhibition (IC50) of an enzymatic reaction. Biochem. Pharmacol. 22 (1973) 3039-3046
9. Demaegdt H., Vanderheyden P., De Backer J.P., Mosselmans S., Laeremans H., Le M.T., Kersemans V., Michotte Y., and Vauquelin G. Endogenous cystinyl aminopeptidase in Chinese hamster ovary cells: characterization by [(125)I]Ang IV binding and catalytic activity. Biochem. Pharmacol. 68 (2004) 885-892
10. Demaegdt H., Laeremans H., De Backer J.P., Mosselmans S., Le M.T., Kersemans V., Michotte Y., Vauquelin G., and Vanderheyden P. Synergistic modulation of cystinyl aminopeptidase by divalent cation chelators. Biochem. Pharmacol. 68 (2004) 893-900
11. Demaegdt H., Lenaerts P.J., Swales J., De Backer J.P., Laeremans H., Le M.T., Kersemans K., Vogel L.K., Michotte Y., Vanderheyden P., and Vauquelin G. Angiotensin AT4 receptor ligand interaction with cystinyl aminopeptidase and aminopeptidase N: [125I]Angiotensin IV only binds to the cystinyl aminopeptidase apo-enzyme. Eur. J. Pharmacol. 546 (2006) 19-27
12. Demaegdt H., Smitz L., De Backer J.P., Le M.T., Bauwens M., Szemenyei E., Tóth G., Michotte Y., Vanderheyden P., and Vauquelin G. Translocation of the insulin-regulated aminopeptidase to the cell surface: detection by radioligand binding. Br. J. Pharmacol. 154 (2008) 872-881
13. Demaegdt H. How is the insulin regulated aminopeptidase involved in the physiological and in vitro effects of Angiotensin IV? Review. In: Miura H., and Sasaki Y. (Eds). Angiotensin Research Progress (2008), Nova Publishers Group 93-119 (Chapter IV)
14. Dulin N., Madhun Z.T., Chang C.H., Berti-Mattera L., Dickens D., and Douglas J.G. Angiotensin IV receptors and signaling in opossum kidney cells. Am. J. Physiol. 269 (1995) 644-652
15. Fernando R.N., Albiston A.L., and Chai S.Y. The insulin-regulated aminopeptidase IRAP is colocalised with GLUT4 in the mouse hippocampus-potential role in modulation of glucose uptake in neurones?. Eur. J. Neurosci 28 (2008) 588-598
16. Garreau I., Chansel D., Vandermeersch S., Fruitier I., Piot J.M., and Ardaillou R. Hemorphins inhibit angiotensin IV binding and interact with aminopeptidase N. Peptides. 19 (1998) 1339-1348
17. Goto Y., Hattori A., Ishii Y., Mizutani S., and Tsujimoto M. Enzymatic properties of human aminopeptidase A. Regulation of its enzymatic activity by calcium and angiotensin IV. J. Biol. Chem. 281 (2006) 23503-23513
18. Handa R.K., Harding J.W., and Simasko S.M. Characterization and function of the bovine kidney epithelial angiotensin receptor subtype 4 using angiotensin IV and divalinal angiotensin IV as receptor ligands. J. Pharmacol. Exp. Ther. 291 (1999) 1242-1249
19. Handa R.K. Characterization and signaling of the AT(4) receptor in human proximal tubule epithelial (HK-2) cells. J. Am. Soc. Nephrol. 12 (2001) 440-449
20. Harding J.W., Wright J.W., Swanson G.N., Hanesworth J.M., and Krebs L.T. AT4 receptors: specificity and distribution. Kidney Int. 46 (1994) 1510-1512
21. Krebs L.T., Kramar E.A., Hanesworth J.M., Sardinia M.F., Ball A.E., Wright J.W., and Harding J.W. Characterization of the binding properties and physiological action of divalinal-angiotensin IV, a putative AT4 receptor antagonist. Regul. Pept. 67 (1996) 123-130
22. Laeremans H., Demaegdt H., De Backer J.P., Le M.T., Kersemans V., Michotte Y., Vauquelin G., and Vanderheyden P.M. Metal ion modulation of cystinyl aminopeptidase. Biochem. J. 390 (2005) 351-357
23. Lahoutte T., Mertens J., Caveliers V., Franken P.R., Everaert H., and Bossuyt A. Comparative biodistribution of iodinated amino acids in rats: selection of the optimal analog for oncologic imaging outside the brain. J. Nucl. Med. 44 (2003) 1489-1494
24. Le M.T., Vanderheyden P.M., Szaszák M., Hunyady L., Kersemans V., and Vauquelin G. Peptide and nonpeptide antagonist interaction with constitutively active human AT1 receptors. Biochem. Pharmacol. 65 (2003) 1329-1938
25. Lee J., Mustafa T., McDowall S.G., Mendelsohn F.A., Brennan M., Lew R.A., Albiston A.L., and Chai S.Y. Structure-activity study of LVV-hemorphin-7: angiotensin AT4 receptor ligand and inhibitor of insulin-regulated aminopeptidase. J. Pharmacol. Exp. Ther. 305 (2003) 205-211
26. Lew R.A., Mustafa T., Ye S., McDowall S.G., Chai S.Y., and Albiston A.L. Angiotensin AT4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP). J. Neurochem. 86 (2003) 344-350
27. Lukaszuk A., Demaegdt H., Szemenyei E., Tóth G., Tymecka D., Misicka A., Karoyan V., Vanderheyden P., Vauquelin G., and Tourwé D. β-Homo-amino acid scan of Angiotensin IV. J. Med. Chem. 51 (2008) 2291-2296
28. Matsumoto H., Nagasaka T., Hattori A., Rogi T., Tsuruoka N., Mizutani S., and Tsujimoto M. Expression of placental leucine aminopeptidase/oxytocinase in neuronal cells and its action on neuronal peptides. Eur. J. Biochem. 268 (2001) 3259-3266
29. Santos A.N., Langner J., Herrmann M., and Riemann D. Aminopeptidase N/CD13 is directly linked to signal transduction pathways in monocytes. Cell Immunol. 201 (2000) 22-32
30. Sardinia M.F., Hanesworth J.M., Krebs L.T., and Harding J.W. AT4 receptor binding characteristics: d-amino acid- and glycine-substituted peptides. Peptides 14 (1993) 949-954
31. Sardinia M.F., Hanesworth J.M., Krishnan F., and Harding J.W. AT4 receptor structure-binding relationship: N-terminal-modified angiotensin IV analogues. Peptides 15 (1994) 1399-1406
32. Stragier B., Demaegdt H., De Bundel D., Smolders I., Sarre S., Vauquelin G., Ebinger G., Michotte Y., and Vanderheyden P. Involvement of insulin-regulated aminopeptidase and/or aminopeptidase N in the angiotensin IV-induced effect on dopamine release in the striatum of the rat. Brain Res. 1131 (2007) 97-105
33. Tóth G., Lovas S., and Ötvös F. Tritium labelling of neuropeptides. In: Irvine G.B., and Williams C.H. (Eds). Methods in Molecular Biology, Neuropeptide Protocols (1997), Humana Press, New Jersey 219-230
34. Vauquelin G., Michotte Y., Smolders I., Sarre S., Ebinger G., Dupont A., and Vanderheyden P. Cellular targets for angiotensin II fragments: pharmacological and molecular evidence. JRAAS 3 (2002) 195-204
35. Wright J.W., Yamamoto B.J., and Harding J.W. Angiotensin receptor subtype mediated physiologies and behaviors: new discoveries and clinical targets. Prog. Neurobiol. 84 (2008) 157-181
36. Wright J.W., Krebs L.T., Stobb J.W., and Harding J.W. The angiotensin IV system: functional implications. Front. Neuroendocrinol. 16 (1995) 23-52
37. Yang R., Smolders I., De Bundel D., Fouyn R., Demaegdt H., Michotte Y., Vanderheyden P., and Dupont A.G. Brain and peripheral AT1 receptors mediate renal vasoconstrictor and blood pressure responses to Angiotensin IV in the rat. J. Hypertension 26 (2008) 998-1007