Synergistic modulation of cystinyl aminopeptidase by divalent cation chelators

Biochemical Pharmacology

Volumn 68, Issue 5, 2004, Pages 893-900

  Demaegdt, Heidi ^a   Laeremans, Hilde ^a   De Backer, Jean Paul ^a   Mosselmans, Sabrina ^a   Le, Minh Tam ^a   Kersemans, Veerle ^b   Michotte, Yvette ^a   Vauquelin, Georges ^a   Vanderheyden, Patrick M L ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

1,10 PHE; 1,10 phenanthrolin; Ang; angiotensin; Chinese hamster ovary cells; CHO K1; EDTA; EGTA; ethylene diamine tetraacetic acid; ethylene glycol bis(2 aminoethylether) N,N,N , N tetraacetic acid; HEK293; insulin regulated aminopeptidase; IRAP

Indexed keywords

1,10 PHENANTHROLINE; ANGIOTENSIN II [3-8]; ANILINE DERIVATIVE; CHELATING AGENT; CYSTYL AMINOPEPTIDASE; EDETIC ACID; EGTAZIC ACID; LEUCINE 4 NITROANILIDE; UNCLASSIFIED DRUG; ZINC;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL LINE; CELL MEMBRANE; CHO CELL; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG POTENTIATION; DRUG PROTEIN BINDING; ENZYME ACTIVITY; FEMALE; NONHUMAN; PRIORITY JOURNAL;

ANGIOTENSIN II; ANIMALS; CATIONS, DIVALENT; CHELATING AGENTS; CHO CELLS; CRICETINAE; CYSTINYL AMINOPEPTIDASE; EDETIC ACID; EGTAZIC ACID; FEMALE; IODINE RADIOISOTOPES; PHENANTHROLINES; RADIOLIGAND ASSAY;

EID: 3843132896     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2004.05.046     Document Type: Article

References (46)

1. Hooper N.M. Families of zinc metalloproteases. FEBS Lett. 354:1994;1-6
2. Rasmussen T.E., Pedraza-Diaz S., Hardre R., Laustsen P.G., Carrion A.G., Kristensen T. Structure of the human oxytocinase/insulin-regulated aminopeptidase gene and localization to chromosome 5q21. Eur. J. Biochem. 267:2000;2297-2306
3. Keller S.R., Scott H.M., Mastick C.C., Aebersold R., Lienhard G.E. Cloning and characterization of a novel insulin-regulated membrane aminopeptidase from Glut4 vesicles. J. Biol. Chem. 270:1995;23612-23618
4. Rogi T., Tsujimoto M., Nakazato H., Mizutani S., Tomoda Y. Human placental leucine aminopeptidase/oxytocinase. A new member of type II membrane-spanning zinc metallopeptidase family. J. Biol. Chem. 271:1996;56-61
5. Laustsen P.G., Vang S., Kristensen T. Mutational analysis of the active site of human insulin-regulated aminopeptidase. Eur. J. Biochem. 268(1 (January)):2001;98-104
6. Rudberg P.C., Tholander F., Thunnissen M.M., Haeggstrom J.Z. Leukotriene A4 hydrolase/aminopeptidase. Glutamate 271 is a catalytic residue with specific roles in two distinct enzyme mechanisms. J. Biol. Chem. 277:2002;1398-1404
7. Luciani N., Marie-Claire C., Ruffet E., Beaumont A., Roques B.P., Fournie-Zaluski M.C. Characterization of Glu350 as a critical residue involved in the N-terminal amine binding site of aminopeptidase N (EC 3.4.11.2): insights into its mechanism of action. Biochemistry. 37:1998;686-692
8. Herbst J.J., Ross S.A., Scott H.M., Bobin S.A., Morris N.J., Lienhard G.E., et al. Insulin stimulates cell surface aminopeptidase activity toward vasopressin in adipocytes. Am. J. Physiol. 272:1997;600-606
9. Matsumoto H., Rogi T., Yamashiro K., Kodama S., Tsuruoka N., Hattori A., et al. Characterization of a recombinant soluble form of human placental leucine aminopeptidase/oxytocinase expressed in Chinese hamster ovary cells. Eur. J. Biochem. 267:2000;46-52
10. Matsumoto H., Nagasaka T., Hattori A., Rogi T., Tsuruoka N., Mizutani S., et al. Expression of placental leucine aminopeptidase/oxytocinase in neuronal cells and its action on neuronal peptides. Eur. J. Biochem. 268:2001;3259-3266
11. Albiston A.L., McDowall S.G., Matsacos D., Sim P., Clune E., Mustafa T., et al. Evidence that the angiotensin IV (AT4) receptor is the enzyme Insulin-regulated aminopeptidase. J. Biol. Chem. 276:2001;48623-48626
12. El Messari S., Leloup C., Quignon M., Brisorgueil M.J., Penicaud L., Arluison M. Immunocytochemical localization of the insulin-responsive glucose transporter 4 (Glut4) in the rat central nervous system. J. Comp. Neurol. 399:1998;492-512
13. 125I ]Ang IV binding and catalytic activity. Biochem Pharmacol 2004;68:885-92.
14. Harding J.W., Cook V.I., Miller-Wing A.V., Hanesworth J.M., Sardinia M.F., Hall K.L., et al. Identification of an AII(3-8) [AIV] binding site in guinea pig hippocampus. Brain Res. 583:1992;340-343
15. de Gasparo M., Catt K.J., Inagami T., Wright J.W., Unger T. International Union of Pharmacology. XXIII. The angiotensin II receptors. Pharmacol. Rev. 52:2000;415-472
16. Albiston A.L., Mustafa T., McDowall S.G., Mendelsohn F.A., Lee J., Chai S.Y. AT4 receptor is insulin-regulated membrane aminopeptidase: potential mechanisms of memory enhancement. Trends Endocrinol. Metab. 14:2003;72-77
17. Alescio-Lautier B., Paban V., Soumireu-Mourat B. Neuromodulation of memory in the hippocampus by vasopressin. Eur. J. Pharmacol. 405:2000;63-72
18. Kovacs G.L., De Wied D. Peptidergic modulation of learning and memory processes. Pharmacol. Rev. 46:1994;269-291
19. Matsuoka N., Yamazaki M., Yamaguchi I. Changes in brain somatostatin in memory-deficient rats: comparison with cholinergic markers. Neuroscience. 66:1995;617-626
20. Johnson A.O., Subtil A., Petrush R., Kobylarz K., Keller S.R., McGraw T.E. Identification of an insulin-responsive, slow endocytic recycling mechanism in Chinese hamster ovary cells. J. Biol. Chem. 273:1998;17968-17977
21. Lim S.N., Bonzelius F., Low S.H., Wille H., Weimbs T., Herman G.A. Identification of discrete classes of endosome-derived small vesicles as a major cellular pool for recycling membrane proteins. Mol. Biol. Cell. 12:2001;981-995
22. Handa R.K. Metabolism alters the selectivity of angiotensin-(1-7) receptor ligands for angiotensin receptors. J. Am. Soc. Nephrol. 11 (August):2000;1377-1386
23. Handa R.K. Characterization and signalling of the AT(4) receptor in human proximal tubule epithelial (HK-2) cells. J. Am. Soc. Nephrol. 12:2001;440-449
24. Lew R.A., Mustafa T., Ye S., McDowall S.G., Chai S.Y., Albiston A.L. Angiotensin AT4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP). J. Neurochem. 86:2003;344-350
25. Lee J., Mustafa T., McDowall S.G., Mendelsohn F.A., Brennan M., Lew R.A., et al. Structure-activity study of LVV-hemorphin-7: angiotensin AT4 receptor ligand and inhibitor of insulin-regulated aminopeptidase. J. Pharmacol. Exp. Ther. 305:2003;205-211
26. Nakanishi Y., Nomura S., Okada M., Ito T., Katsumata Y., Kikkawa F., et al. Immunoaffinity purification and characterization of native placental leucine aminopeptidase/oxytocinase from human placenta. Placenta. 21:2000;628-634
27. Hua G., Tsukamoto K., Taguchi R., Tomita M., Miyajima S., Ikezawa H. Characterization of aminopeptidase N from the brush border membrane of the larvae midgut of silkworm, Bombyx mori as a zinc enzyme. Biochim. Biophys. Acta. 1383:1998;301-310
28. Ito N., Nomura S., Iwase A., Ito T., Kikkawa F., Tsujimoto M., et al. ADAMs, a desintegrin and metalloproteinases, mediate shedding of oxytocinase. Biochem. Biophys. Res. Commun. 314:2004;1008-1013
29. Robinson J.J. Effects of calcium and magnesium on a 41-kDa serine-dependent protease possessing collagen-cleavage activity. J. Cell Biochem. 80:2000;139-145
30. 125I ]angiotensin IV to AT4 receptors in bovine adrenal cortex Peptides. 15:1994;1037-1044
31. Morty R.E., Morehead J. Cloning and characterization of a leucyl aminopeptidase from three pathologic leishmania species. J. Biol. Chem. 277:2002;26057-26065
32. Thunnissen M.M., Nordlund P., Haeggstrom J.Z. Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation. Nat. Struct. Biol. 8:2001;131-135
33. Gomis-Rüth F.X., Kress L.F., Kellerman J., Mayr I., Lee X., Huber R., et al. Refined 2.0 Å X-ray crystal structure of the snake venom zinc-endopeptidase adamalysin II. J. Mol. Biol. 239:1994;513-544
34. 2+, contributes to the substrate specificity of aminopeptidase A. Biochemistry. 39:2000;3061-3068
35. Greenblatt H.M., Almog O., Maras B., Spungin-Bialik A., Barra D., Blumberg S., et al. Streptomyces griseus aminopeptidase: X-ray crystallographic structure at 1.75 Å resolution. J. Mol. Biol. 265:1997;620-636
36. Papir G., Spungin-Bialik A., Ben-Meir D., Fudim E., Gilboa R., Greenblatt H.M., et al. Inhibition of Streptomyces griseus aminopeptidase and effects of calcium ions on catalysis and binding: Comparisons with the homologous enzyme Aeromonas proteolytica aminopeptidase. Eur. J. Biochem. 258:1998;313-319
37. Mizutani S. Physiological roles of placental proteases in feto-placental homeostasis. Nagoya J. Med. 61:1998;85-95
38. Dulin N.O., Madhun Z.T., Chang C., Bert-Mattera L., Dickens D., Douglas J.G. Angiotensin IV receptors and signalling in opossum kidney cells. Am. J. Physiol. 269:1995;644-652
39. Handa R.K. Metabolism alters the selectivity of angiotensin-(1-7) receptor ligands for angiotensin receptors. J. Am. Soc. Nephrol. 12:2001;1377-1386
40. 2+ in mesangial cells. Eur. J. Pharmacol. 414:2001;165-175
41. Chen S., Patel J.M., Block E.R. Angiotensin IV-mediated pulmonary artery vasorelaxation is due to endothelial intracellular calcium release. Am. J. Physiol. Lung Cell Mol. Physiol. 279:2000;849-856
42. Patel J.M., Martens J.R., Li Y.D., Gelband C.H., Raizada M.K., Block E.R. Angiotensin IV receptor-mediated activation of lung endothelial NOS is associated with vasorelaxation. Am. J. Physiol. 275:1998;1061-1068
43. Hall K.L., Venkateswaran S., Hanesworth J.M., Schelling M.E., Harding J.W. Characterization of a functional angiotensin IV receptor on coronary microvascular endothelial cells. Regul. Pept. 58:1995;107-115
44. Mustafa T., Chai S.Y., Mendelsohn F.A.O., Moeller I., Albiston A.L. Characterization of the AT4 receptor in a human neuroblastoma cell line (SK-N-MC). J. Neurochem. 76:2001;1679-1687
45. Vauquelin G., Michotte Y., Smolders I., Sarre S., Ebinger G., Dupont A., et al. Cellular targets for angiotensin II fragments: pharmacological and molecular evidence. J. Renin. Angiotensin Aldosterone Syst. 3:2002;195-204
46. Morfis M., Christopoulos A., Sexton P.M. RAMPs: 5 years on, where to now? Trends Pharmacol. Sci. 24:2003;596-601