In vitro evaluation of a novel bioreactor based on an integral oxygenator and a spirally wound nonwoven polyester matrix for hepatocyte culture as small aggregates

Journal of Hepatology

Volumn 26, Issue 6, 1997, Pages 1379-1392

  Flendrig, Leonard M ^a   La Soe, John W ^a   Jörning, George G A ^a   Steenbeek, Arie ^a   Karlsen, Ole T ^b   Bovée, Wim M M J ^b   Ladiges, Nita C J J ^a   Te Velde, Anje A ^a   Chamuleau, Robert A F M ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b NONE

Author keywords

3D matrix; Aggregates; Bioartificial liver; Bioreactor; Hepatocytes; Liver support; MRI; Oxygenator; Polyester

Indexed keywords

ANIMAL CELL; ARTICLE; ARTIFICIAL LIVER; BIOREACTOR; CYTOARCHITECTURE; LIVER CELL CULTURE; LIVER FAILURE; MEDICAL INSTRUMENTATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OXYGENATOR; PRIORITY JOURNAL;

EID: 0030741849     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(97)80475-8     Document Type: Article

References (53)

1. Takahashi T, Malchesky PS, Nosé Y. Artificial liver. State of the art. Dig Dis Sci. 36:1991;1327-1340.
2. Malchesky PS. Nonbiological liver support: historic overview. Artif Organs. 18:1994;342-347.
3. Davies E, Hodgson HJF. Artificial livers - what's keeping them? Gut. 36:1995;168-170.
4. O'Grady JG, Grinson AES, O'Brien CJ, Pucknell A, Hughes RD, Williams R. Controlled trials of charcoal hemoperfusion and prognostic factors in fulminant hepatic failure. Gastroenterology. 94:1988;1186-1192.
5. Jauregui HO, Gann KL. Memmalian hepatocytes as foundation for treatment in human liver failure. J Cell Biochem. 45:1991;359-365.
6. Uchino J, Tsuburaya T, Kumagai F, Hase T, Hamada T, Komai T, Funatsu A, et al. Hybrid bioartifical liver composed of multiplated hepatocyte monolayers. ASAIO Trans. 34:1988;972-977.
7. Arnaout WS, Moscioni AD, Barbour RL, Demetriou AA. Development of a bioartificial liver: bilirubin conjugation in gunn rats. J Surg Res. 48:1990;379-382.
8. Shnyra A, Bocharov A, Bochkova N, Spirov B. Bioartificial liver using hepatocytes on biosilon microcarriers: treatment of chemically induced acute hepatic failure in rats. Artif Organs. 15:1991;189-197.
9. Wolf CF, Munkelt BE. Bilirubine conjugation by an artificial liver composed of cultured cells and synthetic capillaries. Trans Am Soc Artif Intern Organs. 21:1975;16-27.
10. vitro perfusion. Transplantation. 58:1994;984-988.
11. Sussman NL, Chong MG, Koussayer T, He D, Shang T, Whisennand H, Kelly JH. Reversal of fulminant hepatic failure using an extracorporeal liver assist device. Hepatology. 16:1992;60-65.
12. Dixit V. Development of a bioartificial liver using isolated hepatocytes. Artif Organs. 18:1994;371-384.
13. Jauregui HO, Mullon CJP, Trenkler D, Naik S, Santangini H, Press P, Muller TE, et al. In vivo evaluation of a hollow fiber liver assist device. Hepatology. 21:1995;460-469.
14. Yanagi K, Ookawa K, Mizuno S, Oshima N. Performance of a new hybrid artificial liver support system using hepatocytes entrapped within a hydrogel. Trans Am Soc Artif Intern Org. 35:1989;570-572.
15. Nyberg SL, Shirabe K, Peshwa MV, Sielaff TD, Crotty PL, Mann HJ, Remmel RP, et al. Extracorporeal application of a gel-entrapment, bioartificial liver: demonstration of drug metabolism and other biochemical functions. Cell Transplant. 2:1993;441-452.
16. Koebe HG, Wick M, Cramer U, Lange V, Schildberg FW. Collagen gel immobilisation provides a suitable cell matrix for long term human hepatocyte cultures in hybrid reactors. Int J Artif Organs. 17:1994;95-106.
17. Takeshita K, Ishibashi H, Suzuki M, Yamamoto T, Akaike T, Kodama M. High cell-density culture system of hepatocytes entrapped in a three-dimensional hollow fiber module with collagen gel. Artif Organs. 19:1995;191-193.
18. Fremond B, Malandain C, Guyomard C, Chesne C, Guillouzo A, Campion J. Correction of bilirubin conjugation in the gunn rat using hepatocytes immobilized in alginate gel beads as an extracorporeal bioartifical liver. Cell Transplant. 2:1993;453-460.
19. Matthew HWT, Basu S, Peterson WD, Salley SO, Klein MD. Performance of plasma perfused, microencapsulated hepatocytes: prospects for extracorporeal liver support. J Pediatr Surg. 28:1993;1423-1428.
20. Miyoshi H, Yanagi K, Fukuda H, Ohshima N. Long-term continuous culture of hepatocytes in a packed-bed reactor tilizing porous resin. Biotech Bioeng. 43:1994;635-644.
21. Nyberg SL, Madhusudan VP, William DP, Hu W-C, Cerra FB. Evolution of the bioartificial liver: the need for randomized clinical trials. Am J Surg. 166:1993;512-521.
22. Sussman NL, Gislason GT, Kelly JH. Extracorporeal liver support. Application to fulminant hepatic failure. J Clin Gastroenterol. 18:1994;320-324.
23. Rozga J, Morsiani E, Lepage E, Moscioni AD, Giorgio T, Demetriou AA. Isolated hepatocytes in a bioartificial liver: a single group view and experience. Biotech Bioeng. 43:1994;645-653.
24. Chamuleau RAFM, Flendrig LM, la Soe JW, Ladiges NCJJ, te Velde AA. Bioartificial liver and its clinical significance anno 1994. Transplantology. 5:1994;166-170.
25. Landry J, Bernier D, Ouellet C, Goyette R, Marceau N. Spheroidal aggregate culture of rat liver cells: histotypic reorganization, biomatrix deposition and maintenance of functional activities. J Cell Biol. 101:1985;914-923.
26. Koide N, Shinji T, Tanabe T, Asano K, Kawaguchi M, Sakaguchi K, Koide Y, et al. Continued high albumin production by multicellular spheroids of adult rat hepatocytes formed in the presence of liver-derived proteoglycans. Biochem Biophys Res Commun. 161:1989;385-391.
27. Lazar A, Peshwa MV, Wu FJ, Chi C, Cerra FB, Hu W-C. Formation of porcine hepatocyte spheroids for use in a bioartificial liver. Cell Transplant. 4:1995;259-268.
28. Rotem A, Toner M, Bhatia S, Foy BD, Tompkins RG, Yarmush ML. Oxygen is a factor determining in vitro tissue assembly: effects on attachment and spreading of hepatocytes. Biotech Bioeng. 43:1994;654-660.
29. Catapano G, De Bartolo L, Lombardi CP, Drioli E. The effect of oxygen transport resistanceson the viability and functions of isolated rat hepatocytes. Int J Artif Organs. 19:1996;61-71.
30. Gerlach J, Klöppel K, Stoll P, Vienken J, Müller C. Gas supply across membranes in bioreactors for hepatocyte culture. Artif Organs. 14:1990;328-333.
31. te Velde AA, Ladiges NCJJ, Flendrig LM, Chamuleau RAFM. Functional activity of isolated pig hepatocytes attached to different extracellular matrix substrates. Implications for application of pig hepatocytes in a bioartificial liver. J Hepatol. 23:1995;184-192.
32. Karlsen OT, Creyghton JHN, Mehlkopf AF, Bovée WMMJ. A steady state perfusion experiment. Proc ISMRM, 4th Scientific Meeting. 1996;1308.
33. van Eijk HMH, van der Heijden MAH, van Berlo CLH, Soeters PB. Fully automated liquid-chromatographic determination of amino acids. Clin Chem. 34:1988;2510-2513.
34. Montoya JP, Shanley CJ, Merz SI, Bartlett RH. Plasma leakage through microporous membranes. Role of phospholipids. ASAIO J. 38:1992;M399-M405.
35. Butterworth RF, Giuère JF, Michaud J, Lavoie J, Pomeir-Layrargues G. Ammonia: key factor in the pathogenesis of hepatic encephalopathy. Neurochem Pathol. 6:1987;1-12.
36. Meijer AJ, Lamers WH, Chamuleau RAFM. Nitrogen metabolism and ornithine cycle function. Physiol Rev. 70:1990;701-748.
37. Fuchs M, Gerlach J, Encke J, Unger J, Smith M, Neuhaus P, Riedel E. Amino acid metabolism by hepatocytes in a hybrid bioreactor. Int J Artif Org. 17:1994;663-669.
38. Gudbjarnason S, Bing RJ. The redox-potential or the lactatepyruvate system in blood as an indicator of the functional state of cellular oxidation. Biochim Biophys Acta. 60:1962;58-162.
39. Demetriou AA, Rozga J, Podestra L, Lepage E, Morsiani E, Moscioni AD, Hoffman A, et al. Early clinical experience with a hybrid bioartificial liver. Scand J Gastroenterol. 30:1995;111-117.
40. Sussman NL, Gislason GT, Conlin CA, Kelly JH. The hepatix extracorporeal liver assist device: initial clinical experience. Artif Organs. 18:1994;390-396.
41. Ho CS, Wang IC. Animal Cell Bioreactors. 1991;13 Butterworth-Heinemann, Boston.
42. Ho CS, Wang IC. Animal Cell Bioreactors. 1991;14 Butterworth-Heinemann, Boston.
43. Ho CS, Wang IC. Animal Cell Bioreactors. 1991;196 Butterworth-Heinemann, Boston.
44. Ho CS, Wang IC. Animal Cell Bioreactors. 1991;197 Butterworth-Heinemann, Boston.
45. Ho CS, Wang IC. Animal Cell Bioreactors. 1991;358 Butterworth-Heinemann, Boston.
46. Willaert RG, Baron GV, De Backer L. Mass transfer in immobilised cell systems. Willaert RG, Baron GV, De BackerL. Immobilised Living Cell Systems. 1996;2145 John Wiley & Sons, Chichester.
47. Röckel A, Klinke B, Hertel J, Bauer X, Thiel C, Abdelhamid S, Fiegel P, et al. Allergy to dialysis materials. Nephrol Dial Transplant. 4:1989;646-652.
48. Rumpf KW, Seubert S, Seubert A, Jaeger M, Lorvitz HD, Valentin R, Schunemann B, et al. Ethylene-oxide induced IgE antibodies and symptomatology in dialysis patients. Contr Nephrol. 59:1987;145-153.
49. Rozga J, Williams F, Ro M-S, Neuzil DF, Giorgio TD, Backfish G, Mosconi AD, et al. Development of a bioartificial liver: Properties and function of a hollow-fiber module inoculated with liver cells. Hepatology. 17:1993;258-265.
50. Nyberg SL, Remmel RP, Mann HJ, Peshwa MV, Hu W-S, Cerra FB. Primary hepatocytes outperform HepG2 cells as the source of biotransformation functions in a bioartificial liver. Ann Surg. 220:1994;59-67.
51. Gerlach JC, Schnoy N, Encke J, Smith MD, Müller C, Neuhaus P. Improved hepatocyte in vitro maintenance in a culture model with woven multicompartment capillary systems: electron microscopy studies. Hepatology. 22:1995;546-552.
52. Nyberg SL, Platt JL, Shirabe K, Payne WD, Hu W-S, Cerr FB. Immunoprotection of xenocytes in a hollow fiber bioartificial liver. ASAIO J. 38:1992;M463-M467.
53. te Velde AA, Flendrig LM, Ladiges NCJJ, Chamuleau RAFM. Immunological consequences of the use of xeno-geneic hepatocytes in a bioartificial liver for acute hepato failure. Int J Artif Organs. 1996;. in press.