Evaluation and optimization of hepatocyte culture media factors by design of experiments (DoE) methodology

Cytotechnology

Volumn 57, Issue 3, 2008, Pages 251-261

  Dong, Jia ^a   Mandenius, Carl Fredrik ^a   Lübberstedt, Marc ^b   Urbaniak, Thomas ^b   Nüssler, Andreas K N ^c   Knobeloch, Daniel ^b   Gerlach, Jörg C ^b,d   Zeilinger, Katrin ^b  

^a LINKÖPING UNIVERSITY   (Sweden)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Bioreactor; C3A; Culture medium optimization; Design of experiments; Growth factors; Primary human hepatocytes

Indexed keywords

FIBROBLAST GROWTH FACTOR 4; ONCOSTATIN M; SCATTER FACTOR;

ARTICLE; BIOREACTOR; CELL CULTURE; CELL METABOLISM; CONTROLLED STUDY; CULTURE MEDIUM; HUMAN; HUMAN CELL; LIVER CELL;

EID: 54249135754     PISSN: 09209069     EISSN: 15730778     Source Type: Journal    
DOI: 10.1007/s10616-008-9168-6     Document Type: Article

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