메뉴 건너뛰기




Volumn 40, Issue 11, 2010, Pages 1037-1047

Thiopurine metabolism monitoring: Implications in inflammatory bowel diseases

Author keywords

6 Thioguanine nucleotides; Azathioprine; Thiopurine metabolites; Thiopurine side effects; TPMT

Indexed keywords

6 METHYLTHIOINOSINE; ALLOPURINOL; AZATHIOPRINE; GLUTATHIONE TRANSFERASE; INOSINE TRIPHOSPHATE; MERCAPTOPURINE; THIOPURINE METHYLTRANSFERASE; TIOGUANINE; XANTHINE DEHYDROGENASE; XANTHINE OXIDASE;

EID: 78649418639     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2010.02346.x     Document Type: Review
Times cited : (26)

References (81)
  • 1
    • 73649170794 scopus 로고
    • The treatment of chronic ulcerative colitis with 6-mercaptopurine
    • Bean RH. The treatment of chronic ulcerative colitis with 6-mercaptopurine. Med J Aust 1962;49:592-3.
    • (1962) Med J Aust , vol.49 , pp. 592-593
    • Bean, R.H.1
  • 2
    • 12344291265 scopus 로고    scopus 로고
    • Impact of the increasing use of immunosuppressants in Crohn's disease on the need for intestinal surgery
    • Cosnes J, Nion-Larmurier I, Beaugerie L, Afchain P, Tiret E, Gendre JP. Impact of the increasing use of immunosuppressants in Crohn's disease on the need for intestinal surgery. Gut 2005;54:237-41.
    • (2005) Gut , vol.54 , pp. 237-241
    • Cosnes, J.1    Nion-Larmurier, I.2    Beaugerie, L.3    Afchain, P.4    Tiret, E.5    Gendre, J.P.6
  • 3
    • 33745650894 scopus 로고    scopus 로고
    • Adverse events leading to modification of therapy in a large cohort of patients with inflammatory bowel disease
    • Hindorf U, Lindqvist M, Hildebrand H, Fagerberg U, Almer S. Adverse events leading to modification of therapy in a large cohort of patients with inflammatory bowel disease. Aliment Pharmacol Ther 2006;24:331-42.
    • (2006) Aliment Pharmacol Ther , vol.24 , pp. 331-342
    • Hindorf, U.1    Lindqvist, M.2    Hildebrand, H.3    Fagerberg, U.4    Almer, S.5
  • 4
    • 3242762099 scopus 로고    scopus 로고
    • Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants
    • Schaeffeler E, Fischer C, Brockmeier D, Wernet D, Moerike K, Eichelbaum M et al. Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants. Pharmacogenetics 2004;14:407-17.
    • (2004) Pharmacogenetics , vol.14 , pp. 407-417
    • Schaeffeler, E.1    Fischer, C.2    Brockmeier, D.3    Wernet, D.4    Moerike, K.5    Eichelbaum, M.6
  • 5
    • 0018822866 scopus 로고
    • Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity
    • Weinshilboum RM, Sladek SL. Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity. Am J Hum Genet 1980;32:651-62.
    • (1980) Am J Hum Genet , vol.32 , pp. 651-662
    • Weinshilboum, R.M.1    Sladek, S.L.2
  • 6
    • 77949429893 scopus 로고    scopus 로고
    • Pharmacogenetics of thiopurines in inflammatory bowel disease
    • Derijks LJ, Wong DR. Pharmacogenetics of thiopurines in inflammatory bowel disease. Curr Pharm Des 2010;16:145-54.
    • (2010) Curr Pharm Des , vol.16 , pp. 145-154
    • Derijks, L.J.1    Wong, D.R.2
  • 7
    • 0030986251 scopus 로고    scopus 로고
    • Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity
    • Tai HL, Krynetski EY, Schuetz EG, Yanishevski Y, Evans WE. Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity. Proc Natl Acad Sci U S A 1997;94:6444-9.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 6444-6449
    • Tai, H.L.1    Krynetski, E.Y.2    Schuetz, E.G.3    Yanishevski, Y.4    Evans, W.E.5
  • 8
    • 4344579337 scopus 로고    scopus 로고
    • Pharmacogenetics of thiopurine S-methyltransferase and thiopurine therapy
    • Evans WE. Pharmacogenetics of thiopurine S-methyltransferase and thiopurine therapy. Ther Drug Monit 2004;26:186-91.
    • (2004) Ther Drug Monit , vol.26 , pp. 186-191
    • Evans, W.E.1
  • 9
    • 45849107951 scopus 로고    scopus 로고
    • Clinical pharmacology and pharmacogenetics of thiopurines
    • Sahasranaman S, Howard D, Roy S. Clinical pharmacology and pharmacogenetics of thiopurines. Eur J Clin Pharmacol 2008;64:753-67.
    • (2008) Eur J Clin Pharmacol , vol.64 , pp. 753-767
    • Sahasranaman, S.1    Howard, D.2    Roy, S.3
  • 10
    • 0030027378 scopus 로고    scopus 로고
    • Inhibition of human thiopurine methyltransferase by furosemide, bendroflumethiazide and trichlormethiazide
    • Lysaa RA, Giverhaug T, Wold HL, Aarbakke J. Inhibition of human thiopurine methyltransferase by furosemide, bendroflumethiazide and trichlormethiazide. Eur J Clin Pharmacol 1996;49:393-6.
    • (1996) Eur J Clin Pharmacol , vol.49 , pp. 393-396
    • Lysaa, R.A.1    Giverhaug, T.2    Wold, H.L.3    Aarbakke, J.4
  • 11
    • 27644470006 scopus 로고    scopus 로고
    • Thiopurine S-methyltransferase as a target for drug interactions
    • Xin HW, Fischer C, Schwab M, Klotz U. Thiopurine S-methyltransferase as a target for drug interactions. Eur J Clin Pharmacol 2005;6:395-8.
    • (2005) Eur J Clin Pharmacol , vol.6 , pp. 395-398
    • Xin, H.W.1    Fischer, C.2    Schwab, M.3    Klotz, U.4
  • 12
    • 34548102235 scopus 로고    scopus 로고
    • Inhibition of human thiopurine S-methyltransferase by various nonsteroidal anti-inflammatory drugs in vitro: a mechanism for possible drug interactions
    • Oselin K, Anier K. Inhibition of human thiopurine S-methyltransferase by various nonsteroidal anti-inflammatory drugs in vitro: a mechanism for possible drug interactions. Drug Metab Dispos 2007;35:1452-4.
    • (2007) Drug Metab Dispos , vol.35 , pp. 1452-1454
    • Oselin, K.1    Anier, K.2
  • 13
    • 0028917479 scopus 로고
    • Sulphasalazine inhibition of thiopurine methyltransferase: possible mechanism for interaction with 6-mercaptopurine and azathioprine
    • Szumlanski CL, Weinshilboum RM. Sulphasalazine inhibition of thiopurine methyltransferase: possible mechanism for interaction with 6-mercaptopurine and azathioprine. Br J Clin Pharmacol 1995;39:456-9.
    • (1995) Br J Clin Pharmacol , vol.39 , pp. 456-459
    • Szumlanski, C.L.1    Weinshilboum, R.M.2
  • 14
    • 0036161781 scopus 로고    scopus 로고
    • Interaction between azathioprine and aminosalicylates: an in vivo study in patients with Crohn's disease
    • Dewit O, Vanheuverzwyn R, Desager JP, Horsmans Y. Interaction between azathioprine and aminosalicylates: an in vivo study in patients with Crohn's disease. Aliment Pharmacol Ther 2002;16:79-85.
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 79-85
    • Dewit, O.1    Vanheuverzwyn, R.2    Desager, J.P.3    Horsmans, Y.4
  • 15
    • 26244455766 scopus 로고    scopus 로고
    • The pharmacokinetic effect of discontinuation of mesalazine on mercaptopurine metabolite levels in inflammatory bowel disease patients
    • Gilissen LP, Bierau J, Derijks LJ, Bos LP, Hooymans PM, Van Gennip A et al. The pharmacokinetic effect of discontinuation of mesalazine on mercaptopurine metabolite levels in inflammatory bowel disease patients. Aliment Pharmacol Ther 2005;22:605-11.
    • (2005) Aliment Pharmacol Ther , vol.22 , pp. 605-611
    • Gilissen, L.P.1    Bierau, J.2    Derijks, L.J.3    Bos, L.P.4    Hooymans, P.M.5    Van Gennip, A.6
  • 16
    • 0034780344 scopus 로고    scopus 로고
    • Leucopenia resulting from a drug interaction between azathioprine or 6-mercaptopurine and mesalamine, sulphasalazine, or balsalazide
    • Lowry PW, Franklin CL, Weaver AL, Szumlanski CL, Mays DC, Loftus EV et al. Leucopenia resulting from a drug interaction between azathioprine or 6-mercaptopurine and mesalamine, sulphasalazine, or balsalazide. Gut 2001;49:656-64.
    • (2001) Gut , vol.49 , pp. 656-664
    • Lowry, P.W.1    Franklin, C.L.2    Weaver, A.L.3    Szumlanski, C.L.4    Mays, D.C.5    Loftus, E.V.6
  • 17
    • 33847153405 scopus 로고    scopus 로고
    • Monitoring of thiopurine methyltransferase activity in postsurgical patients with Crohn's disease during 1 year of treatment with azathioprine or mesalazine
    • Dilger K, Schaeffeler E, Lukas M, Strauch U, Herfarth H, Muller R et al. Monitoring of thiopurine methyltransferase activity in postsurgical patients with Crohn's disease during 1 year of treatment with azathioprine or mesalazine. Ther Drug Monit 2007;29:1-5.
    • (2007) Ther Drug Monit , vol.29 , pp. 1-5
    • Dilger, K.1    Schaeffeler, E.2    Lukas, M.3    Strauch, U.4    Herfarth, H.5    Muller, R.6
  • 18
    • 31144446293 scopus 로고    scopus 로고
    • Inosine triphosphate pyrophosphatase and thiopurine s-methyltransferase genotypes relationship to azathioprine-induced myelosuppression
    • Zelinkova Z, Derijks LJ, Stokkers PC, Vogels EW, Van Kampen AH, Curvers WL et al. Inosine triphosphate pyrophosphatase and thiopurine s-methyltransferase genotypes relationship to azathioprine-induced myelosuppression. Clin Gastroenterol Hepatol 2006;4:44-9.
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 44-49
    • Zelinkova, Z.1    Derijks, L.J.2    Stokkers, P.C.3    Vogels, E.W.4    Van Kampen, A.H.5    Curvers, W.L.6
  • 19
    • 33845415085 scopus 로고    scopus 로고
    • Thiopurine methyltransferase (TPMT) activity and adverse effects of azathioprine in inflammatory bowel disease: long-term follow-up study of 394 patients
    • Gisbert JP, Nino P, Rodrigo L, Cara C, Guijarro LG. Thiopurine methyltransferase (TPMT) activity and adverse effects of azathioprine in inflammatory bowel disease: long-term follow-up study of 394 patients. Am J Gastroenterol 2006;101:2769-76.
    • (2006) Am J Gastroenterol , vol.101 , pp. 2769-2776
    • Gisbert, J.P.1    Nino, P.2    Rodrigo, L.3    Cara, C.4    Guijarro, L.G.5
  • 20
    • 33745460088 scopus 로고    scopus 로고
    • Choice of azathioprine or 6-mercaptopurine dose based on thiopurine methyltransferase (TPMT) activity to avoid myelosuppression. A prospective study
    • Gisbert JP, Luna M, Mate J, Gonzalez-Guijarro L, Cara C, Pajares JM. Choice of azathioprine or 6-mercaptopurine dose based on thiopurine methyltransferase (TPMT) activity to avoid myelosuppression. A prospective study. Hepatogastroenterology 2006;53:399-404.
    • (2006) Hepatogastroenterology , vol.53 , pp. 399-404
    • Gisbert, J.P.1    Luna, M.2    Mate, J.3    Gonzalez-Guijarro, L.4    Cara, C.5    Pajares, J.M.6
  • 21
    • 50649110056 scopus 로고    scopus 로고
    • Thiopurine-induced myelotoxicity in patients with inflammatory bowel disease: a review
    • Gisbert JP, Gomollon F. Thiopurine-induced myelotoxicity in patients with inflammatory bowel disease: a review. Am J Gastroenterol 2008;103:1783-800.
    • (2008) Am J Gastroenterol , vol.103 , pp. 1783-1800
    • Gisbert, J.P.1    Gomollon, F.2
  • 22
    • 3242704015 scopus 로고    scopus 로고
    • Thiopurine methyltransferase: should it be measured before commencing thiopurine drug therapy?
    • Sanderson J, Ansari A, Marinaki T, Duley J. Thiopurine methyltransferase: should it be measured before commencing thiopurine drug therapy? Ann Clin Biochem 2004;41(Pt 4):294-302.
    • (2004) Ann Clin Biochem , vol.41 , Issue.PT 4 , pp. 294-302
    • Sanderson, J.1    Ansari, A.2    Marinaki, T.3    Duley, J.4
  • 23
    • 0036721011 scopus 로고    scopus 로고
    • Determination of thiopurine methyltransferase genotype or phenotype optimizes initial dosing of azathioprine for the treatment of Crohn's disease
    • Regueiro M, Mardini H. Determination of thiopurine methyltransferase genotype or phenotype optimizes initial dosing of azathioprine for the treatment of Crohn's disease. J Clin Gastroenterol 2002;35:240-4.
    • (2002) J Clin Gastroenterol , vol.35 , pp. 240-244
    • Regueiro, M.1    Mardini, H.2
  • 24
    • 44749084416 scopus 로고    scopus 로고
    • Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold
    • quiz 604.
    • Gardiner SJ, Gearry RB, Begg EJ, Zhang M, Barclay ML. Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold. Clin Gastroenterol Hepatol 2008;6:654-60; quiz 604.
    • (2008) Clin Gastroenterol Hepatol , vol.6 , pp. 654-660
    • Gardiner, S.J.1    Gearry, R.B.2    Begg, E.J.3    Zhang, M.4    Barclay, M.L.5
  • 25
    • 0037214334 scopus 로고    scopus 로고
    • Safe treatment of thiopurine S-methyltransferase deficient Crohn's disease patients with azathioprine
    • Kaskas BA, Louis E, Hindorf U, Schaeffeler E, Deflandre J, Graepler F et al. Safe treatment of thiopurine S-methyltransferase deficient Crohn's disease patients with azathioprine. Gut 2003;52:140-2.
    • (2003) Gut , vol.52 , pp. 140-142
    • Kaskas, B.A.1    Louis, E.2    Hindorf, U.3    Schaeffeler, E.4    Deflandre, J.5    Graepler, F.6
  • 26
  • 27
    • 42149148677 scopus 로고    scopus 로고
    • Trinucleotide repeat variants in the promoter of the thiopurine S-methyltransferase gene of patients exhibiting ultra-high enzyme activity
    • Roberts RL, Gearry RB, Bland MV, Sies CW, George PM, Burt M et al. Trinucleotide repeat variants in the promoter of the thiopurine S-methyltransferase gene of patients exhibiting ultra-high enzyme activity. Pharmacogenet Genomics 2008;18:434-8.
    • (2008) Pharmacogenet Genomics , vol.18 , pp. 434-438
    • Roberts, R.L.1    Gearry, R.B.2    Bland, M.V.3    Sies, C.W.4    George, P.M.5    Burt, M.6
  • 28
    • 2342420871 scopus 로고    scopus 로고
    • Thiopurine methyltransferase activity influences clinical response to azathioprine in inflammatory bowel disease
    • Cuffari C, Dassopoulos T, Turnbough L, Thompson RE, Bayless TM. Thiopurine methyltransferase activity influences clinical response to azathioprine in inflammatory bowel disease. Clin Gastroenterol Hepatol 2004;2:410-7.
    • (2004) Clin Gastroenterol Hepatol , vol.2 , pp. 410-417
    • Cuffari, C.1    Dassopoulos, T.2    Turnbough, L.3    Thompson, R.E.4    Bayless, T.M.5
  • 29
    • 52149099443 scopus 로고    scopus 로고
    • Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease
    • Ansari A, Arenas M, Greenfield SM, Morris D, Lindsay J, Gilshenan K et al. Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease. Aliment Pharmacol Ther 2008;28:973-83.
    • (2008) Aliment Pharmacol Ther , vol.28 , pp. 973-983
    • Ansari, A.1    Arenas, M.2    Greenfield, S.M.3    Morris, D.4    Lindsay, J.5    Gilshenan, K.6
  • 30
    • 0034093057 scopus 로고    scopus 로고
    • Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy
    • Colombel JF, Ferrari N, Debuysere H, Marteau P, Gendre JP, Bonaz B et al. Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy. Gastroenterology 2000;118:1025-30.
    • (2000) Gastroenterology , vol.118 , pp. 1025-1030
    • Colombel, J.F.1    Ferrari, N.2    Debuysere, H.3    Marteau, P.4    Gendre, J.P.5    Bonaz, B.6
  • 31
    • 0035871560 scopus 로고    scopus 로고
    • Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine
    • Evans WE, Hon YY, Bomgaars L, Coutre S, Holdsworth M, Janco R et al. Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine. J Clin Oncol 2001;19:2293-301.
    • (2001) J Clin Oncol , vol.19 , pp. 2293-2301
    • Evans, W.E.1    Hon, Y.Y.2    Bomgaars, L.3    Coutre, S.4    Holdsworth, M.5    Janco, R.6
  • 32
    • 77958494120 scopus 로고    scopus 로고
    • Impact of an extensive Thiopurine Methyltransferase genotyping in Inflammatory Bowel Disease patients who experienced myelosuppression during antipurine therapy
    • Dewit O, Moreels T, Baert F, Peeters H, Reenaers C, De Vos M et al. Impact of an extensive Thiopurine Methyltransferase genotyping in Inflammatory Bowel Disease patients who experienced myelosuppression during antipurine therapy. Gastroenterology 2010;138:S-671.
    • (2010) Gastroenterology , vol.138
    • Dewit, O.1    Moreels, T.2    Baert, F.3    Peeters, H.4    Reenaers, C.5    De Vos, M.6
  • 33
    • 33645328058 scopus 로고    scopus 로고
    • Introducing a fast and simple PCR-RFLP analysis for the detection of mutant thiopurine methyltransferase alleles TPMT*3A and TPMT*3C
    • Oender K, Lanschuetzer C, Laimer M, Klausegger A, Paulweber B, Kofler B et al. Introducing a fast and simple PCR-RFLP analysis for the detection of mutant thiopurine methyltransferase alleles TPMT*3A and TPMT*3C. J Eur Acad Dermatol Venereol 2006;20:396-400.
    • (2006) J Eur Acad Dermatol Venereol , vol.20 , pp. 396-400
    • Oender, K.1    Lanschuetzer, C.2    Laimer, M.3    Klausegger, A.4    Paulweber, B.5    Kofler, B.6
  • 34
    • 33747167334 scopus 로고    scopus 로고
    • Pharmacoeconomic analyses of azathioprine, methotrexate and prospective pharmacogenetic testing for the management of inflammatory bowel disease
    • Priest VL, Begg EJ, Gardiner SJ, Frampton CM, Gearry RB, Barclay ML et al. Pharmacoeconomic analyses of azathioprine, methotrexate and prospective pharmacogenetic testing for the management of inflammatory bowel disease. Pharmacoeconomics 2006;24:767-81.
    • (2006) Pharmacoeconomics , vol.24 , pp. 767-781
    • Priest, V.L.1    Begg, E.J.2    Gardiner, S.J.3    Frampton, C.M.4    Gearry, R.B.5    Barclay, M.L.6
  • 35
    • 4644241129 scopus 로고    scopus 로고
    • Cost-effectiveness of thiopurine methyltransferase genotype screening in patients about to commence azathioprine therapy for treatment of inflammatory bowel disease
    • Winter J, Walker A, Shapiro D, Gaffney D, Spooner RJ, Mills PR. Cost-effectiveness of thiopurine methyltransferase genotype screening in patients about to commence azathioprine therapy for treatment of inflammatory bowel disease. Aliment Pharmacol Ther 2004;20:593-9.
    • (2004) Aliment Pharmacol Ther , vol.20 , pp. 593-599
    • Winter, J.1    Walker, A.2    Shapiro, D.3    Gaffney, D.4    Spooner, R.J.5    Mills, P.R.6
  • 36
    • 16344385293 scopus 로고    scopus 로고
    • Cost-effectiveness of thiopurine methyltransferase genotype screening in IBD
    • author reply 791-2.
    • Kitiyakara T, Hayat J, McIntyre AS. Cost-effectiveness of thiopurine methyltransferase genotype screening in IBD. Aliment Pharmacol Ther 2005;21:790-1; author reply 791-2.
    • (2005) Aliment Pharmacol Ther , vol.21 , pp. 790-791
    • Kitiyakara, T.1    Hayat, J.2    McIntyre, A.S.3
  • 37
    • 17644381606 scopus 로고    scopus 로고
    • Thiopurine methyltransferase enzyme activity determination before treatment of inflammatory bowel disease with azathioprine: effect on cost and adverse events
    • Sayani FA, Prosser C, Bailey RJ, Jacobs P, Fedorak RN. Thiopurine methyltransferase enzyme activity determination before treatment of inflammatory bowel disease with azathioprine: effect on cost and adverse events. Can J Gastroenterol 2005;19:147-51.
    • (2005) Can J Gastroenterol , vol.19 , pp. 147-151
    • Sayani, F.A.1    Prosser, C.2    Bailey, R.J.3    Jacobs, P.4    Fedorak, R.N.5
  • 38
    • 27744574836 scopus 로고    scopus 로고
    • A cost-effectiveness analysis of alternative disease management strategies in patients with Crohn's disease treated with azathioprine or 6-mercaptopurine
    • Dubinsky MC, Reyes E, Ofman J, Chiou CF, Wade S, Sandborn WJ. A cost-effectiveness analysis of alternative disease management strategies in patients with Crohn's disease treated with azathioprine or 6-mercaptopurine. Am J Gastroenterol 2005;100:2239-47.
    • (2005) Am J Gastroenterol , vol.100 , pp. 2239-2247
    • Dubinsky, M.C.1    Reyes, E.2    Ofman, J.3    Chiou, C.F.4    Wade, S.5    Sandborn, W.J.6
  • 39
    • 9144252139 scopus 로고    scopus 로고
    • Reviewing the mechanism of action of thiopurine drugs: towards a new paradigm in clinical practice
    • Cara CJ, Pena AS, Sans M, Rodrigo L, Guerrero-Esteo M, Hinojosa J et al. Reviewing the mechanism of action of thiopurine drugs: towards a new paradigm in clinical practice. Med Sci Monit 2004;10:RA247-54.
    • (2004) Med Sci Monit , vol.10
    • Cara, C.J.1    Pena, A.S.2    Sans, M.3    Rodrigo, L.4    Guerrero-Esteo, M.5    Hinojosa, J.6
  • 40
    • 0031863228 scopus 로고    scopus 로고
    • Quantitation of three-month intraindividual variability and influence of sex and menstrual cycle phase on CYP1A2, N-acetyltransferase-2, and xanthine oxidase activity determined with caffeine phenotyping
    • Kashuba AD, Bertino JS Jr, Kearns GL, Leeder JS, James AW, Gotschall R et al. Quantitation of three-month intraindividual variability and influence of sex and menstrual cycle phase on CYP1A2, N-acetyltransferase-2, and xanthine oxidase activity determined with caffeine phenotyping. Clin Pharmacol Ther 1998;63:540-51.
    • (1998) Clin Pharmacol Ther , vol.63 , pp. 540-551
    • Kashuba, A.D.1    Bertino Jr, J.S.2    Kearns, G.L.3    Leeder, J.S.4    James, A.W.5    Gotschall, R.6
  • 42
    • 0026621673 scopus 로고
    • Racial and gender differences in N-acetyltransferase, xanthine oxidase, and CYP1A2 activities
    • Relling MV, Lin JS, Ayers GD, Evans WE. Racial and gender differences in N-acetyltransferase, xanthine oxidase, and CYP1A2 activities. Clin Pharmacol Ther 1992;52:643-58.
    • (1992) Clin Pharmacol Ther , vol.52 , pp. 643-658
    • Relling, M.V.1    Lin, J.S.2    Ayers, G.D.3    Evans, W.E.4
  • 43
    • 0026346078 scopus 로고
    • Human liver xanthine oxidase: nature and extent of individual variation
    • Guerciolini R, Szumlanski C, Weinshilboum RM. Human liver xanthine oxidase: nature and extent of individual variation. Clin Pharmacol Ther 1991;50:663-72.
    • (1991) Clin Pharmacol Ther , vol.50 , pp. 663-672
    • Guerciolini, R.1    Szumlanski, C.2    Weinshilboum, R.M.3
  • 48
    • 0029043008 scopus 로고
    • Hematotoxicity caused by azathioprine genetically determined and aggravated by xanthine oxidase deficiency in a patient following renal transplantation
    • Serre-Debeauvais F, Bayle F, Amirou M, Bechtel Y, Boujet C, Vialtel P et al. Hematotoxicity caused by azathioprine genetically determined and aggravated by xanthine oxidase deficiency in a patient following renal transplantation. Presse Med 1995;24:987-8.
    • (1995) Presse Med , vol.24 , pp. 987-988
    • Serre-Debeauvais, F.1    Bayle, F.2    Amirou, M.3    Bechtel, Y.4    Boujet, C.5    Vialtel, P.6
  • 49
    • 0029793841 scopus 로고    scopus 로고
    • Azathioprine and allopurinol: the price of an avoidable drug interaction
    • Kennedy DT, Hayney MS, Lake KD. Azathioprine and allopurinol: the price of an avoidable drug interaction. Ann Pharmacother 1996;30:951-4.
    • (1996) Ann Pharmacother , vol.30 , pp. 951-954
    • Kennedy, D.T.1    Hayney, M.S.2    Lake, K.D.3
  • 50
    • 33846820178 scopus 로고    scopus 로고
    • Effect of allopurinol on clinical outcomes in inflammatory bowel disease nonresponders to azathioprine or 6-mercaptopurine
    • Sparrow MP, Hande SA, Friedman S, Cao D, Hanauer SB. Effect of allopurinol on clinical outcomes in inflammatory bowel disease nonresponders to azathioprine or 6-mercaptopurine. Clin Gastroenterol Hepatol 2007;5:209-14.
    • (2007) Clin Gastroenterol Hepatol , vol.5 , pp. 209-214
    • Sparrow, M.P.1    Hande, S.A.2    Friedman, S.3    Cao, D.4    Hanauer, S.B.5
  • 51
    • 63849218270 scopus 로고    scopus 로고
    • Normal thiopurine methyltransferase phenotype testing in a Crohn disease patient with azathioprine induced myelosuppression
    • Leung M, Piatkov I, Rochester C, Boyages SC, Leong RWL. Normal thiopurine methyltransferase phenotype testing in a Crohn disease patient with azathioprine induced myelosuppression. Internal Medicine Journal 2009;39:121-6.
    • (2009) Internal Medicine Journal , vol.39 , pp. 121-126
    • Leung, M.1    Piatkov, I.2    Rochester, C.3    Boyages, S.C.4    Leong, R.W.L.5
  • 52
    • 76449085161 scopus 로고    scopus 로고
    • Low-dose azathioprine or mercaptopurine in combination with allopurinol can bypass many adverse drug reactions in patients with inflammatory bowel disease
    • Ansari A, Patel N, Sanderson J, O'Donohue J, Duley JA, Florin TH. Low-dose azathioprine or mercaptopurine in combination with allopurinol can bypass many adverse drug reactions in patients with inflammatory bowel disease. Aliment Pharmacol Ther 2010;31:640-7.
    • (2010) Aliment Pharmacol Ther , vol.31 , pp. 640-647
    • Ansari, A.1    Patel, N.2    Sanderson, J.3    O'Donohue, J.4    Duley, J.A.5    Florin, T.H.6
  • 54
    • 12144285961 scopus 로고    scopus 로고
    • Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase)
    • Marinaki AM, Ansari A, Duley JA, Arenas M, Sumi S, Lewis CM et al. Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase). Pharmacogenetics 2004;14:181-7.
    • (2004) Pharmacogenetics , vol.14 , pp. 181-187
    • Marinaki, A.M.1    Ansari, A.2    Duley, J.A.3    Arenas, M.4    Sumi, S.5    Lewis, C.M.6
  • 55
    • 9244237558 scopus 로고    scopus 로고
    • Lack of association between the ITPA 94C>A polymorphism and adverse effects from azathioprine
    • Gearry RB, Roberts RL, Barclay ML, Kennedy MA. Lack of association between the ITPA 94C>A polymorphism and adverse effects from azathioprine. Pharmacogenetics 2004;14:779-81.
    • (2004) Pharmacogenetics , vol.14 , pp. 779-781
    • Gearry, R.B.1    Roberts, R.L.2    Barclay, M.L.3    Kennedy, M.A.4
  • 56
    • 0038805258 scopus 로고    scopus 로고
    • Thioguanine: a potential alternate thiopurine for IBD patients allergic to 6-mercaptopurine or azathioprine
    • Dubinsky MC, Feldman EJ, Abreu MT, Targan SR, Vasiliauskas EA. Thioguanine: a potential alternate thiopurine for IBD patients allergic to 6-mercaptopurine or azathioprine. Am J Gastroenterol 2003;98:1058-63.
    • (2003) Am J Gastroenterol , vol.98 , pp. 1058-1063
    • Dubinsky, M.C.1    Feldman, E.J.2    Abreu, M.T.3    Targan, S.R.4    Vasiliauskas, E.A.5
  • 58
    • 15444367938 scopus 로고    scopus 로고
    • ITPA genotyping test does not improve detection of Crohn's disease patients at risk of azathioprine/6-mercaptopurine induced myelosuppression
    • Allorge D, Hamdan R, Broly F, Libersa C, Colombel JF. ITPA genotyping test does not improve detection of Crohn's disease patients at risk of azathioprine/6-mercaptopurine induced myelosuppression. Gut 2005;54:565.
    • (2005) Gut , vol.54 , pp. 565
    • Allorge, D.1    Hamdan, R.2    Broly, F.3    Libersa, C.4    Colombel, J.F.5
  • 59
    • 67349087340 scopus 로고    scopus 로고
    • TPMT but not ITPA gene polymorphism influences the risk of azathioprine intolerance in renal transplant recipients
    • Kurzawski M, Dziewanowski K, Lener A, Drozdzik M. TPMT but not ITPA gene polymorphism influences the risk of azathioprine intolerance in renal transplant recipients. Eur J Clin Pharmacol 2009;65:533-40.
    • (2009) Eur J Clin Pharmacol , vol.65 , pp. 533-540
    • Kurzawski, M.1    Dziewanowski, K.2    Lener, A.3    Drozdzik, M.4
  • 60
    • 0034765504 scopus 로고    scopus 로고
    • Pharmacokinetic considerations in the treatment of inflammatory bowel disease
    • Schwab M, Klotz U. Pharmacokinetic considerations in the treatment of inflammatory bowel disease. Clin Pharmacokinet 2001;40:723-51.
    • (2001) Clin Pharmacokinet , vol.40 , pp. 723-751
    • Schwab, M.1    Klotz, U.2
  • 61
    • 33746265794 scopus 로고    scopus 로고
    • Divergent activities of human glutathione transferases in the bioactivation of azathioprine
    • Eklund BI, Moberg M, Bergquist J, Mannervik B. Divergent activities of human glutathione transferases in the bioactivation of azathioprine. Mol Pharmacol 2006;70:747-54.
    • (2006) Mol Pharmacol , vol.70 , pp. 747-754
    • Eklund, B.I.1    Moberg, M.2    Bergquist, J.3    Mannervik, B.4
  • 62
    • 33846136090 scopus 로고    scopus 로고
    • Glutathione-S-transferase genotypes and the adverse effects of azathioprine in young patients with inflammatory bowel disease
    • Stocco G, Martelossi S, Barabino A, Decorti G, Bartoli F, Montico M et al. Glutathione-S-transferase genotypes and the adverse effects of azathioprine in young patients with inflammatory bowel disease. Inflamm Bowel Dis 2007;13:57-64.
    • (2007) Inflamm Bowel Dis , vol.13 , pp. 57-64
    • Stocco, G.1    Martelossi, S.2    Barabino, A.3    Decorti, G.4    Bartoli, F.5    Montico, M.6
  • 63
    • 0034528822 scopus 로고    scopus 로고
    • The use of 6-mercaptopurine in patients with inflammatory bowel disease after failure of azathioprine therapy
    • Boulton-Jones JR, Pritchard K, Mahmoud AA. The use of 6-mercaptopurine in patients with inflammatory bowel disease after failure of azathioprine therapy. Aliment Pharmacol Ther 2000;14:1561-5.
    • (2000) Aliment Pharmacol Ther , vol.14 , pp. 1561-1565
    • Boulton-Jones, J.R.1    Pritchard, K.2    Mahmoud, A.A.3
  • 64
    • 37549016742 scopus 로고    scopus 로고
    • Tolerability and safety of mercaptopurine in azathioprine-intolerant patients with inflammatory bowel disease
    • Lees CW, Maan AK, Hansoti B, Satsangi J, Arnott ID. Tolerability and safety of mercaptopurine in azathioprine-intolerant patients with inflammatory bowel disease. Aliment Pharmacol Ther 2008;27:220-7.
    • (2008) Aliment Pharmacol Ther , vol.27 , pp. 220-227
    • Lees, C.W.1    Maan, A.K.2    Hansoti, B.3    Satsangi, J.4    Arnott, I.D.5
  • 65
    • 60349108861 scopus 로고    scopus 로고
    • Mercaptopurine treatment should be considered in azathioprine intolerant patients with inflammatory bowel disease
    • Hindorf U, Johansson M, Eriksson A, Kvifors E, Almer SH. Mercaptopurine treatment should be considered in azathioprine intolerant patients with inflammatory bowel disease. Aliment Pharmacol Ther 2009;29:654-61.
    • (2009) Aliment Pharmacol Ther , vol.29 , pp. 654-661
    • Hindorf, U.1    Johansson, M.2    Eriksson, A.3    Kvifors, E.4    Almer, S.H.5
  • 66
    • 0242464926 scopus 로고    scopus 로고
    • CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes
    • Tiede I, Fritz G, Strand S, Poppe D, Dvorsky R, Strand D et al. CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes. J Clin Invest 2003;111:1133-45.
    • (2003) J Clin Invest , vol.111 , pp. 1133-1145
    • Tiede, I.1    Fritz, G.2    Strand, S.3    Poppe, D.4    Dvorsky, R.5    Strand, D.6
  • 67
    • 26244436603 scopus 로고    scopus 로고
    • 6-Thioguanosine diphosphate and triphosphate levels in red blood cells and response to azathioprine therapy in Crohn's disease
    • Neurath MF, Kiesslich R, Teichgraber U, Fischer C, Hofmann U, Eichelbaum M et al. 6-Thioguanosine diphosphate and triphosphate levels in red blood cells and response to azathioprine therapy in Crohn's disease. Clin Gastroenterol Hepatol 2005;3:1007-14.
    • (2005) Clin Gastroenterol Hepatol , vol.3 , pp. 1007-1014
    • Neurath, M.F.1    Kiesslich, R.2    Teichgraber, U.3    Fischer, C.4    Hofmann, U.5    Eichelbaum, M.6
  • 68
    • 0034067784 scopus 로고    scopus 로고
    • Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease
    • Dubinsky MC, Lamothe S, Yang HY, Targan SR, Sinnett D, Theoret Y et al. Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease. Gastroenterology 2000;118:705-13.
    • (2000) Gastroenterology , vol.118 , pp. 705-713
    • Dubinsky, M.C.1    Lamothe, S.2    Yang, H.Y.3    Targan, S.R.4    Sinnett, D.5    Theoret, Y.6
  • 69
    • 0034771188 scopus 로고    scopus 로고
    • Measurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel disease
    • Lowry PW, Franklin CL, Weaver AL, Pike MG, Mays DC, Tremaine WJ et al. Measurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel disease. Gut 2001;49:665-70.
    • (2001) Gut , vol.49 , pp. 665-670
    • Lowry, P.W.1    Franklin, C.L.2    Weaver, A.L.3    Pike, M.G.4    Mays, D.C.5    Tremaine, W.J.6
  • 70
    • 33646011261 scopus 로고    scopus 로고
    • Association of 6-thioguanine nucleotide levels and inflammatory bowel disease activity: a meta-analysis
    • Osterman MT, Kundu R, Lichtenstein GR, Lewis JD. Association of 6-thioguanine nucleotide levels and inflammatory bowel disease activity: a meta-analysis. Gastroenterology 2006;130:1047-53.
    • (2006) Gastroenterology , vol.130 , pp. 1047-1053
    • Osterman, M.T.1    Kundu, R.2    Lichtenstein, G.R.3    Lewis, J.D.4
  • 71
    • 34347393465 scopus 로고    scopus 로고
    • 6-Thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active crohn disease: results from a randomized, controlled, open trial
    • Reinshagen M, Schutz E, Armstrong VW, Behrens C, Von Tirpitz C, Stallmach A et al. 6-Thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active crohn disease: results from a randomized, controlled, open trial. Clin Chem 2007;53:1306-14.
    • (2007) Clin Chem , vol.53 , pp. 1306-1314
    • Reinshagen, M.1    Schutz, E.2    Armstrong, V.W.3    Behrens, C.4    Von Tirpitz, C.5    Stallmach, A.6
  • 73
    • 33745665758 scopus 로고    scopus 로고
    • Pharmacogenetics during standardised initiation of thiopurine treatment in inflammatory bowel disease
    • Hindorf U, Lindqvist M, Peterson C, Soderkvist P, Strom M, Hjortswang H et al. Pharmacogenetics during standardised initiation of thiopurine treatment in inflammatory bowel disease. Gut 2006;55:1423-31.
    • (2006) Gut , vol.55 , pp. 1423-1431
    • Hindorf, U.1    Lindqvist, M.2    Peterson, C.3    Soderkvist, P.4    Strom, M.5    Hjortswang, H.6
  • 74
    • 72549100745 scopus 로고    scopus 로고
    • Optimizing conventional therapies for inflammatory bowel disease
    • Sparrow MP, Irving PM, Hanauer SB. Optimizing conventional therapies for inflammatory bowel disease. Curr Gastroenterol Rep 2009;11:496-503.
    • (2009) Curr Gastroenterol Rep , vol.11 , pp. 496-503
    • Sparrow, M.P.1    Irving, P.M.2    Hanauer, S.B.3
  • 75
    • 67650362066 scopus 로고    scopus 로고
    • Interaction between homocystein metabolism and TPMT activity in IBD patients under azathioprine
    • Roblin X, Chartier A, Ducros V. Interaction between homocystein metabolism and TPMT activity in IBD patients under azathioprine. Gastroenterology 2006;130(Suppl 2):A199.
    • (2006) Gastroenterology , vol.130 , Issue.SUPPL 2
    • Roblin, X.1    Chartier, A.2    Ducros, V.3
  • 76
    • 75349094042 scopus 로고    scopus 로고
    • Algorithms outperform metabolite tests in predicting response of patients with inflammatory bowel disease to thiopurines
    • Waljee AK, Joyce JC, Wang S, Saxena A, Hart M, Zhu J et al. Algorithms outperform metabolite tests in predicting response of patients with inflammatory bowel disease to thiopurines. Clin Gastroenterol Hepatol 2010;8:143-50.
    • (2010) Clin Gastroenterol Hepatol , vol.8 , pp. 143-150
    • Waljee, A.K.1    Joyce, J.C.2    Wang, S.3    Saxena, A.4    Hart, M.5    Zhu, J.6
  • 77
    • 0035186469 scopus 로고    scopus 로고
    • 6-Mercaptopurine metabolite levels in children with inflammatory bowel disease
    • Gupta P, Gokhale R, Kirschner B. 6-Mercaptopurine metabolite levels in children with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2001;33:450-54.
    • (2001) J Pediatr Gastroenterol Nutr , vol.33 , pp. 450-454
    • Gupta, P.1    Gokhale, R.2    Kirschner, B.3
  • 78
    • 0035037706 scopus 로고    scopus 로고
    • Utilisation of erythrocyte 6-thioguanine metabolite levels to optimise therapy in patients with inflammatory bowel disease
    • Cuffari C, Hunt S, Bayless T. Utilisation of erythrocyte 6-thioguanine metabolite levels to optimise therapy in patients with inflammatory bowel disease. Gut 2001;48:642-46.
    • (2001) Gut , vol.48 , pp. 642-646
    • Cuffari, C.1    Hunt, S.2    Bayless, T.3
  • 79
    • 0035134907 scopus 로고    scopus 로고
    • Therapeutic drug monitoring of azathioprine and 6-mercaptopurine metabolites in Crohn disease
    • Belaiche J, Desager JP, Horsmans Y, Louis E. Therapeutic drug monitoring of azathioprine and 6-mercaptopurine metabolites in Crohn disease. Scand J Gastroenterol 2001;36:71-6.
    • (2001) Scand J Gastroenterol , vol.36 , pp. 71-76
    • Belaiche, J.1    Desager, J.P.2    Horsmans, Y.3    Louis, E.4
  • 80
    • 4544294487 scopus 로고    scopus 로고
    • The utility of 6-thioguanine metabolite levels in managing patients with inflammatory bowel disease
    • Goldenberg BA, Rawsthorne P, Bernstein CN. The utility of 6-thioguanine metabolite levels in managing patients with inflammatory bowel disease. Am J Gastroenterol 2004;99:1744-48.
    • (2004) Am J Gastroenterol , vol.99 , pp. 1744-1748
    • Goldenberg, B.A.1    Rawsthorne, P.2    Bernstein, C.N.3
  • 81
    • 3543150184 scopus 로고    scopus 로고
    • Indicators of clinical response to treatment with six-mercaptopurine or azathioprine in patients with inflammatory bowel disease
    • Achkar JP, Stevens T, Easley K, Brzezinski A, Seidner D, Lashner B. Indicators of clinical response to treatment with six-mercaptopurine or azathioprine in patients with inflammatory bowel disease. Inflamm Bowel Dis 2004;10:339-45.
    • (2004) Inflamm Bowel Dis , vol.10 , pp. 339-345
    • Achkar, J.P.1    Stevens, T.2    Easley, K.3    Brzezinski, A.4    Seidner, D.5    Lashner, B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.