-
1
-
-
73649170794
-
The treatment of chronic ulcerative colitis with 6-mercaptopurine
-
Bean RH. The treatment of chronic ulcerative colitis with 6-mercaptopurine. Med J Aust 1962;49:592-3.
-
(1962)
Med J Aust
, vol.49
, pp. 592-593
-
-
Bean, R.H.1
-
2
-
-
12344291265
-
Impact of the increasing use of immunosuppressants in Crohn's disease on the need for intestinal surgery
-
Cosnes J, Nion-Larmurier I, Beaugerie L, Afchain P, Tiret E, Gendre JP. Impact of the increasing use of immunosuppressants in Crohn's disease on the need for intestinal surgery. Gut 2005;54:237-41.
-
(2005)
Gut
, vol.54
, pp. 237-241
-
-
Cosnes, J.1
Nion-Larmurier, I.2
Beaugerie, L.3
Afchain, P.4
Tiret, E.5
Gendre, J.P.6
-
3
-
-
33745650894
-
Adverse events leading to modification of therapy in a large cohort of patients with inflammatory bowel disease
-
Hindorf U, Lindqvist M, Hildebrand H, Fagerberg U, Almer S. Adverse events leading to modification of therapy in a large cohort of patients with inflammatory bowel disease. Aliment Pharmacol Ther 2006;24:331-42.
-
(2006)
Aliment Pharmacol Ther
, vol.24
, pp. 331-342
-
-
Hindorf, U.1
Lindqvist, M.2
Hildebrand, H.3
Fagerberg, U.4
Almer, S.5
-
4
-
-
3242762099
-
Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants
-
Schaeffeler E, Fischer C, Brockmeier D, Wernet D, Moerike K, Eichelbaum M et al. Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants. Pharmacogenetics 2004;14:407-17.
-
(2004)
Pharmacogenetics
, vol.14
, pp. 407-417
-
-
Schaeffeler, E.1
Fischer, C.2
Brockmeier, D.3
Wernet, D.4
Moerike, K.5
Eichelbaum, M.6
-
5
-
-
0018822866
-
Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity
-
Weinshilboum RM, Sladek SL. Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity. Am J Hum Genet 1980;32:651-62.
-
(1980)
Am J Hum Genet
, vol.32
, pp. 651-662
-
-
Weinshilboum, R.M.1
Sladek, S.L.2
-
6
-
-
77949429893
-
Pharmacogenetics of thiopurines in inflammatory bowel disease
-
Derijks LJ, Wong DR. Pharmacogenetics of thiopurines in inflammatory bowel disease. Curr Pharm Des 2010;16:145-54.
-
(2010)
Curr Pharm Des
, vol.16
, pp. 145-154
-
-
Derijks, L.J.1
Wong, D.R.2
-
7
-
-
0030986251
-
Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity
-
Tai HL, Krynetski EY, Schuetz EG, Yanishevski Y, Evans WE. Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity. Proc Natl Acad Sci U S A 1997;94:6444-9.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 6444-6449
-
-
Tai, H.L.1
Krynetski, E.Y.2
Schuetz, E.G.3
Yanishevski, Y.4
Evans, W.E.5
-
8
-
-
4344579337
-
Pharmacogenetics of thiopurine S-methyltransferase and thiopurine therapy
-
Evans WE. Pharmacogenetics of thiopurine S-methyltransferase and thiopurine therapy. Ther Drug Monit 2004;26:186-91.
-
(2004)
Ther Drug Monit
, vol.26
, pp. 186-191
-
-
Evans, W.E.1
-
9
-
-
45849107951
-
Clinical pharmacology and pharmacogenetics of thiopurines
-
Sahasranaman S, Howard D, Roy S. Clinical pharmacology and pharmacogenetics of thiopurines. Eur J Clin Pharmacol 2008;64:753-67.
-
(2008)
Eur J Clin Pharmacol
, vol.64
, pp. 753-767
-
-
Sahasranaman, S.1
Howard, D.2
Roy, S.3
-
10
-
-
0030027378
-
Inhibition of human thiopurine methyltransferase by furosemide, bendroflumethiazide and trichlormethiazide
-
Lysaa RA, Giverhaug T, Wold HL, Aarbakke J. Inhibition of human thiopurine methyltransferase by furosemide, bendroflumethiazide and trichlormethiazide. Eur J Clin Pharmacol 1996;49:393-6.
-
(1996)
Eur J Clin Pharmacol
, vol.49
, pp. 393-396
-
-
Lysaa, R.A.1
Giverhaug, T.2
Wold, H.L.3
Aarbakke, J.4
-
12
-
-
34548102235
-
Inhibition of human thiopurine S-methyltransferase by various nonsteroidal anti-inflammatory drugs in vitro: a mechanism for possible drug interactions
-
Oselin K, Anier K. Inhibition of human thiopurine S-methyltransferase by various nonsteroidal anti-inflammatory drugs in vitro: a mechanism for possible drug interactions. Drug Metab Dispos 2007;35:1452-4.
-
(2007)
Drug Metab Dispos
, vol.35
, pp. 1452-1454
-
-
Oselin, K.1
Anier, K.2
-
13
-
-
0028917479
-
Sulphasalazine inhibition of thiopurine methyltransferase: possible mechanism for interaction with 6-mercaptopurine and azathioprine
-
Szumlanski CL, Weinshilboum RM. Sulphasalazine inhibition of thiopurine methyltransferase: possible mechanism for interaction with 6-mercaptopurine and azathioprine. Br J Clin Pharmacol 1995;39:456-9.
-
(1995)
Br J Clin Pharmacol
, vol.39
, pp. 456-459
-
-
Szumlanski, C.L.1
Weinshilboum, R.M.2
-
14
-
-
0036161781
-
Interaction between azathioprine and aminosalicylates: an in vivo study in patients with Crohn's disease
-
Dewit O, Vanheuverzwyn R, Desager JP, Horsmans Y. Interaction between azathioprine and aminosalicylates: an in vivo study in patients with Crohn's disease. Aliment Pharmacol Ther 2002;16:79-85.
-
(2002)
Aliment Pharmacol Ther
, vol.16
, pp. 79-85
-
-
Dewit, O.1
Vanheuverzwyn, R.2
Desager, J.P.3
Horsmans, Y.4
-
15
-
-
26244455766
-
The pharmacokinetic effect of discontinuation of mesalazine on mercaptopurine metabolite levels in inflammatory bowel disease patients
-
Gilissen LP, Bierau J, Derijks LJ, Bos LP, Hooymans PM, Van Gennip A et al. The pharmacokinetic effect of discontinuation of mesalazine on mercaptopurine metabolite levels in inflammatory bowel disease patients. Aliment Pharmacol Ther 2005;22:605-11.
-
(2005)
Aliment Pharmacol Ther
, vol.22
, pp. 605-611
-
-
Gilissen, L.P.1
Bierau, J.2
Derijks, L.J.3
Bos, L.P.4
Hooymans, P.M.5
Van Gennip, A.6
-
16
-
-
0034780344
-
Leucopenia resulting from a drug interaction between azathioprine or 6-mercaptopurine and mesalamine, sulphasalazine, or balsalazide
-
Lowry PW, Franklin CL, Weaver AL, Szumlanski CL, Mays DC, Loftus EV et al. Leucopenia resulting from a drug interaction between azathioprine or 6-mercaptopurine and mesalamine, sulphasalazine, or balsalazide. Gut 2001;49:656-64.
-
(2001)
Gut
, vol.49
, pp. 656-664
-
-
Lowry, P.W.1
Franklin, C.L.2
Weaver, A.L.3
Szumlanski, C.L.4
Mays, D.C.5
Loftus, E.V.6
-
17
-
-
33847153405
-
Monitoring of thiopurine methyltransferase activity in postsurgical patients with Crohn's disease during 1 year of treatment with azathioprine or mesalazine
-
Dilger K, Schaeffeler E, Lukas M, Strauch U, Herfarth H, Muller R et al. Monitoring of thiopurine methyltransferase activity in postsurgical patients with Crohn's disease during 1 year of treatment with azathioprine or mesalazine. Ther Drug Monit 2007;29:1-5.
-
(2007)
Ther Drug Monit
, vol.29
, pp. 1-5
-
-
Dilger, K.1
Schaeffeler, E.2
Lukas, M.3
Strauch, U.4
Herfarth, H.5
Muller, R.6
-
18
-
-
31144446293
-
Inosine triphosphate pyrophosphatase and thiopurine s-methyltransferase genotypes relationship to azathioprine-induced myelosuppression
-
Zelinkova Z, Derijks LJ, Stokkers PC, Vogels EW, Van Kampen AH, Curvers WL et al. Inosine triphosphate pyrophosphatase and thiopurine s-methyltransferase genotypes relationship to azathioprine-induced myelosuppression. Clin Gastroenterol Hepatol 2006;4:44-9.
-
(2006)
Clin Gastroenterol Hepatol
, vol.4
, pp. 44-49
-
-
Zelinkova, Z.1
Derijks, L.J.2
Stokkers, P.C.3
Vogels, E.W.4
Van Kampen, A.H.5
Curvers, W.L.6
-
19
-
-
33845415085
-
Thiopurine methyltransferase (TPMT) activity and adverse effects of azathioprine in inflammatory bowel disease: long-term follow-up study of 394 patients
-
Gisbert JP, Nino P, Rodrigo L, Cara C, Guijarro LG. Thiopurine methyltransferase (TPMT) activity and adverse effects of azathioprine in inflammatory bowel disease: long-term follow-up study of 394 patients. Am J Gastroenterol 2006;101:2769-76.
-
(2006)
Am J Gastroenterol
, vol.101
, pp. 2769-2776
-
-
Gisbert, J.P.1
Nino, P.2
Rodrigo, L.3
Cara, C.4
Guijarro, L.G.5
-
20
-
-
33745460088
-
Choice of azathioprine or 6-mercaptopurine dose based on thiopurine methyltransferase (TPMT) activity to avoid myelosuppression. A prospective study
-
Gisbert JP, Luna M, Mate J, Gonzalez-Guijarro L, Cara C, Pajares JM. Choice of azathioprine or 6-mercaptopurine dose based on thiopurine methyltransferase (TPMT) activity to avoid myelosuppression. A prospective study. Hepatogastroenterology 2006;53:399-404.
-
(2006)
Hepatogastroenterology
, vol.53
, pp. 399-404
-
-
Gisbert, J.P.1
Luna, M.2
Mate, J.3
Gonzalez-Guijarro, L.4
Cara, C.5
Pajares, J.M.6
-
21
-
-
50649110056
-
Thiopurine-induced myelotoxicity in patients with inflammatory bowel disease: a review
-
Gisbert JP, Gomollon F. Thiopurine-induced myelotoxicity in patients with inflammatory bowel disease: a review. Am J Gastroenterol 2008;103:1783-800.
-
(2008)
Am J Gastroenterol
, vol.103
, pp. 1783-1800
-
-
Gisbert, J.P.1
Gomollon, F.2
-
22
-
-
3242704015
-
Thiopurine methyltransferase: should it be measured before commencing thiopurine drug therapy?
-
Sanderson J, Ansari A, Marinaki T, Duley J. Thiopurine methyltransferase: should it be measured before commencing thiopurine drug therapy? Ann Clin Biochem 2004;41(Pt 4):294-302.
-
(2004)
Ann Clin Biochem
, vol.41
, Issue.PT 4
, pp. 294-302
-
-
Sanderson, J.1
Ansari, A.2
Marinaki, T.3
Duley, J.4
-
23
-
-
0036721011
-
Determination of thiopurine methyltransferase genotype or phenotype optimizes initial dosing of azathioprine for the treatment of Crohn's disease
-
Regueiro M, Mardini H. Determination of thiopurine methyltransferase genotype or phenotype optimizes initial dosing of azathioprine for the treatment of Crohn's disease. J Clin Gastroenterol 2002;35:240-4.
-
(2002)
J Clin Gastroenterol
, vol.35
, pp. 240-244
-
-
Regueiro, M.1
Mardini, H.2
-
24
-
-
44749084416
-
Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold
-
quiz 604.
-
Gardiner SJ, Gearry RB, Begg EJ, Zhang M, Barclay ML. Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold. Clin Gastroenterol Hepatol 2008;6:654-60; quiz 604.
-
(2008)
Clin Gastroenterol Hepatol
, vol.6
, pp. 654-660
-
-
Gardiner, S.J.1
Gearry, R.B.2
Begg, E.J.3
Zhang, M.4
Barclay, M.L.5
-
25
-
-
0037214334
-
Safe treatment of thiopurine S-methyltransferase deficient Crohn's disease patients with azathioprine
-
Kaskas BA, Louis E, Hindorf U, Schaeffeler E, Deflandre J, Graepler F et al. Safe treatment of thiopurine S-methyltransferase deficient Crohn's disease patients with azathioprine. Gut 2003;52:140-2.
-
(2003)
Gut
, vol.52
, pp. 140-142
-
-
Kaskas, B.A.1
Louis, E.2
Hindorf, U.3
Schaeffeler, E.4
Deflandre, J.5
Graepler, F.6
-
26
-
-
0036790212
-
Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease
-
Ansari A, Hassan C, Duley J, Marinaki A, Shobowale-Bakre E-M, Seed P et al. Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease. Aliment Pharmacol Ther 2002;16:1743-50.
-
(2002)
Aliment Pharmacol Ther
, vol.16
, pp. 1743-1750
-
-
Ansari, A.1
Hassan, C.2
Duley, J.3
Marinaki, A.4
Shobowale-Bakre, E.5
Seed, P.6
-
27
-
-
42149148677
-
Trinucleotide repeat variants in the promoter of the thiopurine S-methyltransferase gene of patients exhibiting ultra-high enzyme activity
-
Roberts RL, Gearry RB, Bland MV, Sies CW, George PM, Burt M et al. Trinucleotide repeat variants in the promoter of the thiopurine S-methyltransferase gene of patients exhibiting ultra-high enzyme activity. Pharmacogenet Genomics 2008;18:434-8.
-
(2008)
Pharmacogenet Genomics
, vol.18
, pp. 434-438
-
-
Roberts, R.L.1
Gearry, R.B.2
Bland, M.V.3
Sies, C.W.4
George, P.M.5
Burt, M.6
-
28
-
-
2342420871
-
Thiopurine methyltransferase activity influences clinical response to azathioprine in inflammatory bowel disease
-
Cuffari C, Dassopoulos T, Turnbough L, Thompson RE, Bayless TM. Thiopurine methyltransferase activity influences clinical response to azathioprine in inflammatory bowel disease. Clin Gastroenterol Hepatol 2004;2:410-7.
-
(2004)
Clin Gastroenterol Hepatol
, vol.2
, pp. 410-417
-
-
Cuffari, C.1
Dassopoulos, T.2
Turnbough, L.3
Thompson, R.E.4
Bayless, T.M.5
-
29
-
-
52149099443
-
Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease
-
Ansari A, Arenas M, Greenfield SM, Morris D, Lindsay J, Gilshenan K et al. Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease. Aliment Pharmacol Ther 2008;28:973-83.
-
(2008)
Aliment Pharmacol Ther
, vol.28
, pp. 973-983
-
-
Ansari, A.1
Arenas, M.2
Greenfield, S.M.3
Morris, D.4
Lindsay, J.5
Gilshenan, K.6
-
30
-
-
0034093057
-
Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy
-
Colombel JF, Ferrari N, Debuysere H, Marteau P, Gendre JP, Bonaz B et al. Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy. Gastroenterology 2000;118:1025-30.
-
(2000)
Gastroenterology
, vol.118
, pp. 1025-1030
-
-
Colombel, J.F.1
Ferrari, N.2
Debuysere, H.3
Marteau, P.4
Gendre, J.P.5
Bonaz, B.6
-
31
-
-
0035871560
-
Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine
-
Evans WE, Hon YY, Bomgaars L, Coutre S, Holdsworth M, Janco R et al. Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine. J Clin Oncol 2001;19:2293-301.
-
(2001)
J Clin Oncol
, vol.19
, pp. 2293-2301
-
-
Evans, W.E.1
Hon, Y.Y.2
Bomgaars, L.3
Coutre, S.4
Holdsworth, M.5
Janco, R.6
-
32
-
-
77958494120
-
Impact of an extensive Thiopurine Methyltransferase genotyping in Inflammatory Bowel Disease patients who experienced myelosuppression during antipurine therapy
-
Dewit O, Moreels T, Baert F, Peeters H, Reenaers C, De Vos M et al. Impact of an extensive Thiopurine Methyltransferase genotyping in Inflammatory Bowel Disease patients who experienced myelosuppression during antipurine therapy. Gastroenterology 2010;138:S-671.
-
(2010)
Gastroenterology
, vol.138
-
-
Dewit, O.1
Moreels, T.2
Baert, F.3
Peeters, H.4
Reenaers, C.5
De Vos, M.6
-
33
-
-
33645328058
-
Introducing a fast and simple PCR-RFLP analysis for the detection of mutant thiopurine methyltransferase alleles TPMT*3A and TPMT*3C
-
Oender K, Lanschuetzer C, Laimer M, Klausegger A, Paulweber B, Kofler B et al. Introducing a fast and simple PCR-RFLP analysis for the detection of mutant thiopurine methyltransferase alleles TPMT*3A and TPMT*3C. J Eur Acad Dermatol Venereol 2006;20:396-400.
-
(2006)
J Eur Acad Dermatol Venereol
, vol.20
, pp. 396-400
-
-
Oender, K.1
Lanschuetzer, C.2
Laimer, M.3
Klausegger, A.4
Paulweber, B.5
Kofler, B.6
-
34
-
-
33747167334
-
Pharmacoeconomic analyses of azathioprine, methotrexate and prospective pharmacogenetic testing for the management of inflammatory bowel disease
-
Priest VL, Begg EJ, Gardiner SJ, Frampton CM, Gearry RB, Barclay ML et al. Pharmacoeconomic analyses of azathioprine, methotrexate and prospective pharmacogenetic testing for the management of inflammatory bowel disease. Pharmacoeconomics 2006;24:767-81.
-
(2006)
Pharmacoeconomics
, vol.24
, pp. 767-781
-
-
Priest, V.L.1
Begg, E.J.2
Gardiner, S.J.3
Frampton, C.M.4
Gearry, R.B.5
Barclay, M.L.6
-
35
-
-
4644241129
-
Cost-effectiveness of thiopurine methyltransferase genotype screening in patients about to commence azathioprine therapy for treatment of inflammatory bowel disease
-
Winter J, Walker A, Shapiro D, Gaffney D, Spooner RJ, Mills PR. Cost-effectiveness of thiopurine methyltransferase genotype screening in patients about to commence azathioprine therapy for treatment of inflammatory bowel disease. Aliment Pharmacol Ther 2004;20:593-9.
-
(2004)
Aliment Pharmacol Ther
, vol.20
, pp. 593-599
-
-
Winter, J.1
Walker, A.2
Shapiro, D.3
Gaffney, D.4
Spooner, R.J.5
Mills, P.R.6
-
36
-
-
16344385293
-
Cost-effectiveness of thiopurine methyltransferase genotype screening in IBD
-
author reply 791-2.
-
Kitiyakara T, Hayat J, McIntyre AS. Cost-effectiveness of thiopurine methyltransferase genotype screening in IBD. Aliment Pharmacol Ther 2005;21:790-1; author reply 791-2.
-
(2005)
Aliment Pharmacol Ther
, vol.21
, pp. 790-791
-
-
Kitiyakara, T.1
Hayat, J.2
McIntyre, A.S.3
-
37
-
-
17644381606
-
Thiopurine methyltransferase enzyme activity determination before treatment of inflammatory bowel disease with azathioprine: effect on cost and adverse events
-
Sayani FA, Prosser C, Bailey RJ, Jacobs P, Fedorak RN. Thiopurine methyltransferase enzyme activity determination before treatment of inflammatory bowel disease with azathioprine: effect on cost and adverse events. Can J Gastroenterol 2005;19:147-51.
-
(2005)
Can J Gastroenterol
, vol.19
, pp. 147-151
-
-
Sayani, F.A.1
Prosser, C.2
Bailey, R.J.3
Jacobs, P.4
Fedorak, R.N.5
-
38
-
-
27744574836
-
A cost-effectiveness analysis of alternative disease management strategies in patients with Crohn's disease treated with azathioprine or 6-mercaptopurine
-
Dubinsky MC, Reyes E, Ofman J, Chiou CF, Wade S, Sandborn WJ. A cost-effectiveness analysis of alternative disease management strategies in patients with Crohn's disease treated with azathioprine or 6-mercaptopurine. Am J Gastroenterol 2005;100:2239-47.
-
(2005)
Am J Gastroenterol
, vol.100
, pp. 2239-2247
-
-
Dubinsky, M.C.1
Reyes, E.2
Ofman, J.3
Chiou, C.F.4
Wade, S.5
Sandborn, W.J.6
-
39
-
-
9144252139
-
Reviewing the mechanism of action of thiopurine drugs: towards a new paradigm in clinical practice
-
Cara CJ, Pena AS, Sans M, Rodrigo L, Guerrero-Esteo M, Hinojosa J et al. Reviewing the mechanism of action of thiopurine drugs: towards a new paradigm in clinical practice. Med Sci Monit 2004;10:RA247-54.
-
(2004)
Med Sci Monit
, vol.10
-
-
Cara, C.J.1
Pena, A.S.2
Sans, M.3
Rodrigo, L.4
Guerrero-Esteo, M.5
Hinojosa, J.6
-
40
-
-
0031863228
-
Quantitation of three-month intraindividual variability and influence of sex and menstrual cycle phase on CYP1A2, N-acetyltransferase-2, and xanthine oxidase activity determined with caffeine phenotyping
-
Kashuba AD, Bertino JS Jr, Kearns GL, Leeder JS, James AW, Gotschall R et al. Quantitation of three-month intraindividual variability and influence of sex and menstrual cycle phase on CYP1A2, N-acetyltransferase-2, and xanthine oxidase activity determined with caffeine phenotyping. Clin Pharmacol Ther 1998;63:540-51.
-
(1998)
Clin Pharmacol Ther
, vol.63
, pp. 540-551
-
-
Kashuba, A.D.1
Bertino Jr, J.S.2
Kearns, G.L.3
Leeder, J.S.4
James, A.W.5
Gotschall, R.6
-
41
-
-
36549053255
-
The role of xanthine oxidase in thiopurine metabolism: a case report
-
Wong DR, Derijks LJ, Den Dulk MO, Gemmeke EH, Hooymans PM. The role of xanthine oxidase in thiopurine metabolism: a case report. Ther Drug Monit 2007;29:845-8.
-
(2007)
Ther Drug Monit
, vol.29
, pp. 845-848
-
-
Wong, D.R.1
Derijks, L.J.2
Den Dulk, M.O.3
Gemmeke, E.H.4
Hooymans, P.M.5
-
42
-
-
0026621673
-
Racial and gender differences in N-acetyltransferase, xanthine oxidase, and CYP1A2 activities
-
Relling MV, Lin JS, Ayers GD, Evans WE. Racial and gender differences in N-acetyltransferase, xanthine oxidase, and CYP1A2 activities. Clin Pharmacol Ther 1992;52:643-58.
-
(1992)
Clin Pharmacol Ther
, vol.52
, pp. 643-658
-
-
Relling, M.V.1
Lin, J.S.2
Ayers, G.D.3
Evans, W.E.4
-
44
-
-
0242361089
-
Xanthine oxidase activity is influenced by environmental factors in Ethiopians
-
Aklillu E, Carrillo JA, Makonnen E, Bertilsson L, Ingelman-Sundberg M. Xanthine oxidase activity is influenced by environmental factors in Ethiopians. Eur J Clin Pharmacol 2003;59:533-6.
-
(2003)
Eur J Clin Pharmacol
, vol.59
, pp. 533-536
-
-
Aklillu, E.1
Carrillo, J.A.2
Makonnen, E.3
Bertilsson, L.4
Ingelman-Sundberg, M.5
-
45
-
-
40049090510
-
Functional characterization of human xanthine oxidase allelic variants
-
Kudo M, Moteki T, Sasaki T, Konno Y, Ujiie S, Onose A et al. Functional characterization of human xanthine oxidase allelic variants. Pharmacogenet Genomics 2008;18:243-51.
-
(2008)
Pharmacogenet Genomics
, vol.18
, pp. 243-251
-
-
Kudo, M.1
Moteki, T.2
Sasaki, T.3
Konno, Y.4
Ujiie, S.5
Onose, A.6
-
46
-
-
51649130245
-
Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine
-
Hawwa AF, Millership JS, Collier PS, Vandenbroeck K, McCarthy A, Dempsey S et al. Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine. Br J Clin Pharmacol 2008;66:517-28.
-
(2008)
Br J Clin Pharmacol
, vol.66
, pp. 517-528
-
-
Hawwa, A.F.1
Millership, J.S.2
Collier, P.S.3
Vandenbroeck, K.4
McCarthy, A.5
Dempsey, S.6
-
47
-
-
67651163895
-
Novel pharmacogenetic markers for treatment outcome in azathioprine-treated inflammatory bowel disease
-
Smith MA, Marinaki AM, Arenas M, Shobowale-Bakre M, Lewis CM, Ansari A et al. Novel pharmacogenetic markers for treatment outcome in azathioprine-treated inflammatory bowel disease. Aliment Pharmacol Ther 2009;30:375-84.
-
(2009)
Aliment Pharmacol Ther
, vol.30
, pp. 375-384
-
-
Smith, M.A.1
Marinaki, A.M.2
Arenas, M.3
Shobowale-Bakre, M.4
Lewis, C.M.5
Ansari, A.6
-
48
-
-
0029043008
-
Hematotoxicity caused by azathioprine genetically determined and aggravated by xanthine oxidase deficiency in a patient following renal transplantation
-
Serre-Debeauvais F, Bayle F, Amirou M, Bechtel Y, Boujet C, Vialtel P et al. Hematotoxicity caused by azathioprine genetically determined and aggravated by xanthine oxidase deficiency in a patient following renal transplantation. Presse Med 1995;24:987-8.
-
(1995)
Presse Med
, vol.24
, pp. 987-988
-
-
Serre-Debeauvais, F.1
Bayle, F.2
Amirou, M.3
Bechtel, Y.4
Boujet, C.5
Vialtel, P.6
-
49
-
-
0029793841
-
Azathioprine and allopurinol: the price of an avoidable drug interaction
-
Kennedy DT, Hayney MS, Lake KD. Azathioprine and allopurinol: the price of an avoidable drug interaction. Ann Pharmacother 1996;30:951-4.
-
(1996)
Ann Pharmacother
, vol.30
, pp. 951-954
-
-
Kennedy, D.T.1
Hayney, M.S.2
Lake, K.D.3
-
50
-
-
33846820178
-
Effect of allopurinol on clinical outcomes in inflammatory bowel disease nonresponders to azathioprine or 6-mercaptopurine
-
Sparrow MP, Hande SA, Friedman S, Cao D, Hanauer SB. Effect of allopurinol on clinical outcomes in inflammatory bowel disease nonresponders to azathioprine or 6-mercaptopurine. Clin Gastroenterol Hepatol 2007;5:209-14.
-
(2007)
Clin Gastroenterol Hepatol
, vol.5
, pp. 209-214
-
-
Sparrow, M.P.1
Hande, S.A.2
Friedman, S.3
Cao, D.4
Hanauer, S.B.5
-
51
-
-
63849218270
-
Normal thiopurine methyltransferase phenotype testing in a Crohn disease patient with azathioprine induced myelosuppression
-
Leung M, Piatkov I, Rochester C, Boyages SC, Leong RWL. Normal thiopurine methyltransferase phenotype testing in a Crohn disease patient with azathioprine induced myelosuppression. Internal Medicine Journal 2009;39:121-6.
-
(2009)
Internal Medicine Journal
, vol.39
, pp. 121-126
-
-
Leung, M.1
Piatkov, I.2
Rochester, C.3
Boyages, S.C.4
Leong, R.W.L.5
-
52
-
-
76449085161
-
Low-dose azathioprine or mercaptopurine in combination with allopurinol can bypass many adverse drug reactions in patients with inflammatory bowel disease
-
Ansari A, Patel N, Sanderson J, O'Donohue J, Duley JA, Florin TH. Low-dose azathioprine or mercaptopurine in combination with allopurinol can bypass many adverse drug reactions in patients with inflammatory bowel disease. Aliment Pharmacol Ther 2010;31:640-7.
-
(2010)
Aliment Pharmacol Ther
, vol.31
, pp. 640-647
-
-
Ansari, A.1
Patel, N.2
Sanderson, J.3
O'Donohue, J.4
Duley, J.A.5
Florin, T.H.6
-
53
-
-
0036820724
-
Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency
-
Sumi S, Marinaki AM, Arenas M, Fairbanks L, Shobowale-Bakre M, Rees DC et al. Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency. Hum Genet 2002;5:360-7.
-
(2002)
Hum Genet
, vol.5
, pp. 360-367
-
-
Sumi, S.1
Marinaki, A.M.2
Arenas, M.3
Fairbanks, L.4
Shobowale-Bakre, M.5
Rees, D.C.6
-
54
-
-
12144285961
-
Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase)
-
Marinaki AM, Ansari A, Duley JA, Arenas M, Sumi S, Lewis CM et al. Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase). Pharmacogenetics 2004;14:181-7.
-
(2004)
Pharmacogenetics
, vol.14
, pp. 181-187
-
-
Marinaki, A.M.1
Ansari, A.2
Duley, J.A.3
Arenas, M.4
Sumi, S.5
Lewis, C.M.6
-
55
-
-
9244237558
-
Lack of association between the ITPA 94C>A polymorphism and adverse effects from azathioprine
-
Gearry RB, Roberts RL, Barclay ML, Kennedy MA. Lack of association between the ITPA 94C>A polymorphism and adverse effects from azathioprine. Pharmacogenetics 2004;14:779-81.
-
(2004)
Pharmacogenetics
, vol.14
, pp. 779-781
-
-
Gearry, R.B.1
Roberts, R.L.2
Barclay, M.L.3
Kennedy, M.A.4
-
56
-
-
0038805258
-
Thioguanine: a potential alternate thiopurine for IBD patients allergic to 6-mercaptopurine or azathioprine
-
Dubinsky MC, Feldman EJ, Abreu MT, Targan SR, Vasiliauskas EA. Thioguanine: a potential alternate thiopurine for IBD patients allergic to 6-mercaptopurine or azathioprine. Am J Gastroenterol 2003;98:1058-63.
-
(2003)
Am J Gastroenterol
, vol.98
, pp. 1058-1063
-
-
Dubinsky, M.C.1
Feldman, E.J.2
Abreu, M.T.3
Targan, S.R.4
Vasiliauskas, E.A.5
-
57
-
-
0043168014
-
6-thioguanine can cause serious liver injury in inflammatory bowel disease patients
-
Dubinsky MC, Vasiliauskas EA, Singh H, Abreu MT, Papadakis KA, Tran T et al. 6-thioguanine can cause serious liver injury in inflammatory bowel disease patients. Gastroenterology 2003;125:298-303.
-
(2003)
Gastroenterology
, vol.125
, pp. 298-303
-
-
Dubinsky, M.C.1
Vasiliauskas, E.A.2
Singh, H.3
Abreu, M.T.4
Papadakis, K.A.5
Tran, T.6
-
58
-
-
15444367938
-
ITPA genotyping test does not improve detection of Crohn's disease patients at risk of azathioprine/6-mercaptopurine induced myelosuppression
-
Allorge D, Hamdan R, Broly F, Libersa C, Colombel JF. ITPA genotyping test does not improve detection of Crohn's disease patients at risk of azathioprine/6-mercaptopurine induced myelosuppression. Gut 2005;54:565.
-
(2005)
Gut
, vol.54
, pp. 565
-
-
Allorge, D.1
Hamdan, R.2
Broly, F.3
Libersa, C.4
Colombel, J.F.5
-
59
-
-
67349087340
-
TPMT but not ITPA gene polymorphism influences the risk of azathioprine intolerance in renal transplant recipients
-
Kurzawski M, Dziewanowski K, Lener A, Drozdzik M. TPMT but not ITPA gene polymorphism influences the risk of azathioprine intolerance in renal transplant recipients. Eur J Clin Pharmacol 2009;65:533-40.
-
(2009)
Eur J Clin Pharmacol
, vol.65
, pp. 533-540
-
-
Kurzawski, M.1
Dziewanowski, K.2
Lener, A.3
Drozdzik, M.4
-
60
-
-
0034765504
-
Pharmacokinetic considerations in the treatment of inflammatory bowel disease
-
Schwab M, Klotz U. Pharmacokinetic considerations in the treatment of inflammatory bowel disease. Clin Pharmacokinet 2001;40:723-51.
-
(2001)
Clin Pharmacokinet
, vol.40
, pp. 723-751
-
-
Schwab, M.1
Klotz, U.2
-
61
-
-
33746265794
-
Divergent activities of human glutathione transferases in the bioactivation of azathioprine
-
Eklund BI, Moberg M, Bergquist J, Mannervik B. Divergent activities of human glutathione transferases in the bioactivation of azathioprine. Mol Pharmacol 2006;70:747-54.
-
(2006)
Mol Pharmacol
, vol.70
, pp. 747-754
-
-
Eklund, B.I.1
Moberg, M.2
Bergquist, J.3
Mannervik, B.4
-
62
-
-
33846136090
-
Glutathione-S-transferase genotypes and the adverse effects of azathioprine in young patients with inflammatory bowel disease
-
Stocco G, Martelossi S, Barabino A, Decorti G, Bartoli F, Montico M et al. Glutathione-S-transferase genotypes and the adverse effects of azathioprine in young patients with inflammatory bowel disease. Inflamm Bowel Dis 2007;13:57-64.
-
(2007)
Inflamm Bowel Dis
, vol.13
, pp. 57-64
-
-
Stocco, G.1
Martelossi, S.2
Barabino, A.3
Decorti, G.4
Bartoli, F.5
Montico, M.6
-
63
-
-
0034528822
-
The use of 6-mercaptopurine in patients with inflammatory bowel disease after failure of azathioprine therapy
-
Boulton-Jones JR, Pritchard K, Mahmoud AA. The use of 6-mercaptopurine in patients with inflammatory bowel disease after failure of azathioprine therapy. Aliment Pharmacol Ther 2000;14:1561-5.
-
(2000)
Aliment Pharmacol Ther
, vol.14
, pp. 1561-1565
-
-
Boulton-Jones, J.R.1
Pritchard, K.2
Mahmoud, A.A.3
-
64
-
-
37549016742
-
Tolerability and safety of mercaptopurine in azathioprine-intolerant patients with inflammatory bowel disease
-
Lees CW, Maan AK, Hansoti B, Satsangi J, Arnott ID. Tolerability and safety of mercaptopurine in azathioprine-intolerant patients with inflammatory bowel disease. Aliment Pharmacol Ther 2008;27:220-7.
-
(2008)
Aliment Pharmacol Ther
, vol.27
, pp. 220-227
-
-
Lees, C.W.1
Maan, A.K.2
Hansoti, B.3
Satsangi, J.4
Arnott, I.D.5
-
65
-
-
60349108861
-
Mercaptopurine treatment should be considered in azathioprine intolerant patients with inflammatory bowel disease
-
Hindorf U, Johansson M, Eriksson A, Kvifors E, Almer SH. Mercaptopurine treatment should be considered in azathioprine intolerant patients with inflammatory bowel disease. Aliment Pharmacol Ther 2009;29:654-61.
-
(2009)
Aliment Pharmacol Ther
, vol.29
, pp. 654-661
-
-
Hindorf, U.1
Johansson, M.2
Eriksson, A.3
Kvifors, E.4
Almer, S.H.5
-
66
-
-
0242464926
-
CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes
-
Tiede I, Fritz G, Strand S, Poppe D, Dvorsky R, Strand D et al. CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes. J Clin Invest 2003;111:1133-45.
-
(2003)
J Clin Invest
, vol.111
, pp. 1133-1145
-
-
Tiede, I.1
Fritz, G.2
Strand, S.3
Poppe, D.4
Dvorsky, R.5
Strand, D.6
-
67
-
-
26244436603
-
6-Thioguanosine diphosphate and triphosphate levels in red blood cells and response to azathioprine therapy in Crohn's disease
-
Neurath MF, Kiesslich R, Teichgraber U, Fischer C, Hofmann U, Eichelbaum M et al. 6-Thioguanosine diphosphate and triphosphate levels in red blood cells and response to azathioprine therapy in Crohn's disease. Clin Gastroenterol Hepatol 2005;3:1007-14.
-
(2005)
Clin Gastroenterol Hepatol
, vol.3
, pp. 1007-1014
-
-
Neurath, M.F.1
Kiesslich, R.2
Teichgraber, U.3
Fischer, C.4
Hofmann, U.5
Eichelbaum, M.6
-
68
-
-
0034067784
-
Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease
-
Dubinsky MC, Lamothe S, Yang HY, Targan SR, Sinnett D, Theoret Y et al. Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease. Gastroenterology 2000;118:705-13.
-
(2000)
Gastroenterology
, vol.118
, pp. 705-713
-
-
Dubinsky, M.C.1
Lamothe, S.2
Yang, H.Y.3
Targan, S.R.4
Sinnett, D.5
Theoret, Y.6
-
69
-
-
0034771188
-
Measurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel disease
-
Lowry PW, Franklin CL, Weaver AL, Pike MG, Mays DC, Tremaine WJ et al. Measurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel disease. Gut 2001;49:665-70.
-
(2001)
Gut
, vol.49
, pp. 665-670
-
-
Lowry, P.W.1
Franklin, C.L.2
Weaver, A.L.3
Pike, M.G.4
Mays, D.C.5
Tremaine, W.J.6
-
70
-
-
33646011261
-
Association of 6-thioguanine nucleotide levels and inflammatory bowel disease activity: a meta-analysis
-
Osterman MT, Kundu R, Lichtenstein GR, Lewis JD. Association of 6-thioguanine nucleotide levels and inflammatory bowel disease activity: a meta-analysis. Gastroenterology 2006;130:1047-53.
-
(2006)
Gastroenterology
, vol.130
, pp. 1047-1053
-
-
Osterman, M.T.1
Kundu, R.2
Lichtenstein, G.R.3
Lewis, J.D.4
-
71
-
-
34347393465
-
6-Thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active crohn disease: results from a randomized, controlled, open trial
-
Reinshagen M, Schutz E, Armstrong VW, Behrens C, Von Tirpitz C, Stallmach A et al. 6-Thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active crohn disease: results from a randomized, controlled, open trial. Clin Chem 2007;53:1306-14.
-
(2007)
Clin Chem
, vol.53
, pp. 1306-1314
-
-
Reinshagen, M.1
Schutz, E.2
Armstrong, V.W.3
Behrens, C.4
Von Tirpitz, C.5
Stallmach, A.6
-
72
-
-
16444367834
-
6-Thioguanine monitoring in steroid-dependent patients with inflammatory bowel diseases receiving azathioprine
-
Roblin X, Serre-Debeauvais F, Phelip JM, Faucheron JL, Hardy G, Chartier A et al. 6-Thioguanine monitoring in steroid-dependent patients with inflammatory bowel diseases receiving azathioprine. Aliment Pharmacol Ther 2005;21:829-39.
-
(2005)
Aliment Pharmacol Ther
, vol.21
, pp. 829-839
-
-
Roblin, X.1
Serre-Debeauvais, F.2
Phelip, J.M.3
Faucheron, J.L.4
Hardy, G.5
Chartier, A.6
-
73
-
-
33745665758
-
Pharmacogenetics during standardised initiation of thiopurine treatment in inflammatory bowel disease
-
Hindorf U, Lindqvist M, Peterson C, Soderkvist P, Strom M, Hjortswang H et al. Pharmacogenetics during standardised initiation of thiopurine treatment in inflammatory bowel disease. Gut 2006;55:1423-31.
-
(2006)
Gut
, vol.55
, pp. 1423-1431
-
-
Hindorf, U.1
Lindqvist, M.2
Peterson, C.3
Soderkvist, P.4
Strom, M.5
Hjortswang, H.6
-
75
-
-
67650362066
-
Interaction between homocystein metabolism and TPMT activity in IBD patients under azathioprine
-
Roblin X, Chartier A, Ducros V. Interaction between homocystein metabolism and TPMT activity in IBD patients under azathioprine. Gastroenterology 2006;130(Suppl 2):A199.
-
(2006)
Gastroenterology
, vol.130
, Issue.SUPPL 2
-
-
Roblin, X.1
Chartier, A.2
Ducros, V.3
-
76
-
-
75349094042
-
Algorithms outperform metabolite tests in predicting response of patients with inflammatory bowel disease to thiopurines
-
Waljee AK, Joyce JC, Wang S, Saxena A, Hart M, Zhu J et al. Algorithms outperform metabolite tests in predicting response of patients with inflammatory bowel disease to thiopurines. Clin Gastroenterol Hepatol 2010;8:143-50.
-
(2010)
Clin Gastroenterol Hepatol
, vol.8
, pp. 143-150
-
-
Waljee, A.K.1
Joyce, J.C.2
Wang, S.3
Saxena, A.4
Hart, M.5
Zhu, J.6
-
77
-
-
0035186469
-
6-Mercaptopurine metabolite levels in children with inflammatory bowel disease
-
Gupta P, Gokhale R, Kirschner B. 6-Mercaptopurine metabolite levels in children with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2001;33:450-54.
-
(2001)
J Pediatr Gastroenterol Nutr
, vol.33
, pp. 450-454
-
-
Gupta, P.1
Gokhale, R.2
Kirschner, B.3
-
78
-
-
0035037706
-
Utilisation of erythrocyte 6-thioguanine metabolite levels to optimise therapy in patients with inflammatory bowel disease
-
Cuffari C, Hunt S, Bayless T. Utilisation of erythrocyte 6-thioguanine metabolite levels to optimise therapy in patients with inflammatory bowel disease. Gut 2001;48:642-46.
-
(2001)
Gut
, vol.48
, pp. 642-646
-
-
Cuffari, C.1
Hunt, S.2
Bayless, T.3
-
79
-
-
0035134907
-
Therapeutic drug monitoring of azathioprine and 6-mercaptopurine metabolites in Crohn disease
-
Belaiche J, Desager JP, Horsmans Y, Louis E. Therapeutic drug monitoring of azathioprine and 6-mercaptopurine metabolites in Crohn disease. Scand J Gastroenterol 2001;36:71-6.
-
(2001)
Scand J Gastroenterol
, vol.36
, pp. 71-76
-
-
Belaiche, J.1
Desager, J.P.2
Horsmans, Y.3
Louis, E.4
-
80
-
-
4544294487
-
The utility of 6-thioguanine metabolite levels in managing patients with inflammatory bowel disease
-
Goldenberg BA, Rawsthorne P, Bernstein CN. The utility of 6-thioguanine metabolite levels in managing patients with inflammatory bowel disease. Am J Gastroenterol 2004;99:1744-48.
-
(2004)
Am J Gastroenterol
, vol.99
, pp. 1744-1748
-
-
Goldenberg, B.A.1
Rawsthorne, P.2
Bernstein, C.N.3
-
81
-
-
3543150184
-
Indicators of clinical response to treatment with six-mercaptopurine or azathioprine in patients with inflammatory bowel disease
-
Achkar JP, Stevens T, Easley K, Brzezinski A, Seidner D, Lashner B. Indicators of clinical response to treatment with six-mercaptopurine or azathioprine in patients with inflammatory bowel disease. Inflamm Bowel Dis 2004;10:339-45.
-
(2004)
Inflamm Bowel Dis
, vol.10
, pp. 339-345
-
-
Achkar, J.P.1
Stevens, T.2
Easley, K.3
Brzezinski, A.4
Seidner, D.5
Lashner, B.6
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