메뉴 건너뛰기




Volumn 3, Issue 10, 2005, Pages 1007-1014

6-Thioguanosine diphosphate and triphosphate levels in red blood cells and response to azathioprine therapy in Crohn's disease

Author keywords

[No Author keywords available]

Indexed keywords

6 THIOGUANOSINE DIPHOSPHATE; AZATHIOPRINE; DRUG METABOLITE; IMMUNOSUPPRESSIVE AGENT; INFLIXIMAB; NUCLEOTIDE; THIOGUANOSINE TRIPHOSPHATE; TIOGUANINE; UNCLASSIFIED DRUG;

EID: 26244436603     PISSN: 15423565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1542-3565(05)00697-X     Document Type: Article
Times cited : (87)

References (38)
  • 1
    • 0018888679 scopus 로고
    • Treatment of Crohn's disease with 6-mercaptopurine: A long-term randomized, double-blind study
    • D.H. Present, B.I. Korelitz, N. Wisch Treatment of Crohn's disease with 6-mercaptopurine a long-term randomized, double-blind study N Engl J Med 302 1980 981 987
    • (1980) N Engl J Med , vol.302 , pp. 981-987
    • Present, D.H.1    Korelitz, B.I.2    Wisch, N.3
  • 2
    • 68949125991 scopus 로고
    • Double-masked trial of azathioprine in multiple sclerosis
    • W. Huglus Double-masked trial of azathioprine in multiple sclerosis Lancet 2 1988 179 186
    • (1988) Lancet , vol.2 , pp. 179-186
    • Huglus, W.1
  • 3
    • 0037397004 scopus 로고    scopus 로고
    • Azathioprine: Old drug, new actions
    • J.S. Maltzman, G.A. Koretzky Azathioprine old drug, new actions J Clin Invest 111 2003 1122 1124
    • (2003) J Clin Invest , vol.111 , pp. 1122-1124
    • Maltzman, J.S.1    Koretzky, G.A.2
  • 4
    • 0027181038 scopus 로고
    • Azathioprine combined with prednisolone or monotherapy with prednisone in active Crohn's disease
    • K. Ewe, A. Press, C.C. Singe Azathioprine combined with prednisolone or monotherapy with prednisone in active Crohn's disease Gastroenterology 105 1993 367 376
    • (1993) Gastroenterology , vol.105 , pp. 367-376
    • Ewe, K.1    Press, A.2    Singe, C.C.3
  • 5
    • 0033003888 scopus 로고    scopus 로고
    • Randomised trial of mycophenolate mofetil versus azathioprine for treatment of chronic active Crohn's disease
    • M.F. Neurath, R. Wanitschke, M. Peters Randomised trial of mycophenolate mofetil versus azathioprine for treatment of chronic active Crohn's disease Gut 44 1999 625 628
    • (1999) Gut , vol.44 , pp. 625-628
    • Neurath, M.F.1    Wanitschke, R.2    Peters, M.3
  • 6
    • 0036278519 scopus 로고    scopus 로고
    • The efficacy of azathioprine for the treatment of inflammatory bowel disease: A 30 year review
    • A.G. Fraser, T.R. Orchard, D.P. Jewell The efficacy of azathioprine for the treatment of inflammatory bowel disease a 30 year review Gut 50 2002 485 489
    • (2002) Gut , vol.50 , pp. 485-489
    • Fraser, A.G.1    Orchard, T.R.2    Jewell, D.P.3
  • 7
    • 0003244127 scopus 로고    scopus 로고
    • Immunology of inflammatory bowel disease
    • R.R. Rich 2nd ed. St. Louis Mosby
    • M.F. Neurath, S. Finotto, W. Strober Immunology of inflammatory bowel disease R.R. Rich 2nd ed. Clinical immunology 87 2001 St. Louis Mosby 1-87.21
    • (2001) Clinical Immunology , vol.87
    • Neurath, M.F.1    Finotto, S.2    Strober, W.3
  • 8
    • 0037103310 scopus 로고    scopus 로고
    • De novo purine synthesis inhibition and antileukemic effects of mercaptopurine alone or in combination with methotrexate in vivo
    • T. Dervieux, T.L. Brenner, Y.Y. Hon De novo purine synthesis inhibition and antileukemic effects of mercaptopurine alone or in combination with methotrexate in vivo Blood 100 2002 1240 1247
    • (2002) Blood , vol.100 , pp. 1240-1247
    • Dervieux, T.1    Brenner, T.L.2    Hon, Y.Y.3
  • 9
    • 4444353986 scopus 로고    scopus 로고
    • Postoperative maintenance of Crohn's disease remission with 6-mercaptopurine, mesalamine, or placebo: A 2-year trial
    • S.B. Hanauer, B.I. Korelitz, P. Rutgeerts Postoperative maintenance of Crohn's disease remission with 6-mercaptopurine, mesalamine, or placebo a 2-year trial Gastroenterology 127 2004 723 729
    • (2004) Gastroenterology , vol.127 , pp. 723-729
    • Hanauer, S.B.1    Korelitz, B.I.2    Rutgeerts, P.3
  • 10
    • 4444366271 scopus 로고    scopus 로고
    • Azathioprine and mesalamine for prevention of relapse after conservative surgery for Crohn's disease
    • S. Ardizzone, G. Maconi, G.M. Sampietro Azathioprine and mesalamine for prevention of relapse after conservative surgery for Crohn's disease Gastroenterology 127 2004 730 740
    • (2004) Gastroenterology , vol.127 , pp. 730-740
    • Ardizzone, S.1    MacOni, G.2    Sampietro, G.M.3
  • 11
    • 0028790186 scopus 로고
    • A controlled double blind study of azathioprine in the management of Crohn's disease
    • S. Candy, J. Wright, M. Gerber A controlled double blind study of azathioprine in the management of Crohn's disease Gut 37 1995 674 678
    • (1995) Gut , vol.37 , pp. 674-678
    • Candy, S.1    Wright, J.2    Gerber, M.3
  • 12
    • 0000742451 scopus 로고
    • Basic biochemical effects and mechanism of action of 6-thioguanine
    • G.A. LePage Basic biochemical effects and mechanism of action of 6-thioguanine Cancer Res 23 1963 1202 1206
    • (1963) Cancer Res , vol.23 , pp. 1202-1206
    • Lepage, G.A.1
  • 13
    • 0035423158 scopus 로고    scopus 로고
    • Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells
    • T. Dervieux, J.G. Blanco, E.Y. Krynetski Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells Cancer Res 61 2001 5810 5816
    • (2001) Cancer Res , vol.61 , pp. 5810-5816
    • Dervieux, T.1    Blanco, J.G.2    Krynetski, E.Y.3
  • 14
    • 0032851120 scopus 로고    scopus 로고
    • Human RNase H-mediated RNA cleavage from DNA-RNA duplexes is inhibited by 6deoxythioguanosine incorporation into DNA
    • N.F. Krynetskaia, E.Y. Krynetski, W.E. Evans Human RNase H-mediated RNA cleavage from DNA-RNA duplexes is inhibited by 6deoxythioguanosine incorporation into DNA Mol Pharmacol 56 1999 841 848
    • (1999) Mol Pharmacol , vol.56 , pp. 841-848
    • Krynetskaia, N.F.1    Krynetski, E.Y.2    Evans, W.E.3
  • 15
    • 0037428478 scopus 로고    scopus 로고
    • Structure and dynamics of thioguanine-modified duplex DNA
    • L. Somerville, E.Y. Krynetski, N.F. Krynetskaia Structure and dynamics of thioguanine-modified duplex DNA J Biol Chem 278 2003 1005 1011
    • (2003) J Biol Chem , vol.278 , pp. 1005-1011
    • Somerville, L.1    Krynetski, E.Y.2    Krynetskaia, N.F.3
  • 16
    • 0027239758 scopus 로고
    • The George Hitchings and Gertrude Elion Lecture. the pharmacology of azathioprine
    • G.B. Elion The George Hitchings and Gertrude Elion Lecture. The pharmacology of azathioprine Ann N Y Acad Sci 685 1993 400 407
    • (1993) Ann N Y Acad Sci , vol.685 , pp. 400-407
    • Elion, G.B.1
  • 17
    • 0038326642 scopus 로고    scopus 로고
    • Differential control of cell cycle, proliferation, and survival of primary T lymphocytes by purine and pyrimidine nucleotides
    • L. Quemeneur, L.M. Gerland, M. Flacher Differential control of cell cycle, proliferation, and survival of primary T lymphocytes by purine and pyrimidine nucleotides J Immunol 170 2003 4986 4995
    • (2003) J Immunol , vol.170 , pp. 4986-4995
    • Quemeneur, L.1    Gerland, L.M.2    Flacher, M.3
  • 18
    • 0029842160 scopus 로고    scopus 로고
    • Quantification of 6-thioguanine in peripheral blood leukocyte DNA in Crohn's disease patients on maintenance 6-mercaptopurine therapy
    • C. Cuffari, E.G. Seidman, S. Latour Quantification of 6-thioguanine in peripheral blood leukocyte DNA in Crohn's disease patients on maintenance 6-mercaptopurine therapy Can J Physiol Pharmacol 74 1996 580 585
    • (1996) Can J Physiol Pharmacol , vol.74 , pp. 580-585
    • Cuffari, C.1    Seidman, E.G.2    Latour, S.3
  • 19
    • 0242464926 scopus 로고    scopus 로고
    • CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes
    • I. Tiede, G. Fritz, S. Strand CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes J Clin Invest 111 2003 1133 1145
    • (2003) J Clin Invest , vol.111 , pp. 1133-1145
    • Tiede, I.1    Fritz, G.2    Strand, S.3
  • 20
    • 0036202803 scopus 로고    scopus 로고
    • 6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease
    • M.C. Dubinsky, H. Yang, P.V. Hassard 6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease Gastroenterology 122 2002 904 915
    • (2002) Gastroenterology , vol.122 , pp. 904-915
    • Dubinsky, M.C.1    Yang, H.2    Hassard, P.V.3
  • 21
    • 4444224484 scopus 로고    scopus 로고
    • Azathioprine, 6-mercaptopurine in inflammatory bowel disease: Pharmacology, efficacy, and safety
    • M.C. Dubinsky Azathioprine, 6-mercaptopurine in inflammatory bowel disease pharmacology, efficacy, and safety Clin Gastroenterol Hepatol 2 2004 731 743
    • (2004) Clin Gastroenterol Hepatol , vol.2 , pp. 731-743
    • Dubinsky, M.C.1
  • 22
    • 3242732900 scopus 로고    scopus 로고
    • Clinical significance of azathioprine active metabolite concentrations in inflammatory bowel disease
    • S. Wright, D.S. Sanders, A.J. Lobo Clinical significance of azathioprine active metabolite concentrations in inflammatory bowel disease Gut 53 2004 1123 1128
    • (2004) Gut , vol.53 , pp. 1123-1128
    • Wright, S.1    Sanders, D.S.2    Lobo, A.J.3
  • 23
    • 0034771188 scopus 로고    scopus 로고
    • Measurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel disease
    • P.W. Lowry, C.L. Franklin, A.L. Weaver Measurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel disease Gut 49 2001 665 670
    • (2001) Gut , vol.49 , pp. 665-670
    • Lowry, P.W.1    Franklin, C.L.2    Weaver, A.L.3
  • 24
  • 25
    • 10344247722 scopus 로고    scopus 로고
    • Therapeutic drug monitoring of thiopurine drugs in patients with inflammatory bowel disease or autoimmune hepatitis
    • B. Wusk, G.A. Kullak-Ublick, C. Rammert Therapeutic drug monitoring of thiopurine drugs in patients with inflammatory bowel disease or autoimmune hepatitis Eur J Gastroenterol Hepatol 16 2004 1407 1413
    • (2004) Eur J Gastroenterol Hepatol , vol.16 , pp. 1407-1413
    • Wusk, B.1    Kullak-Ublick, G.A.2    Rammert, C.3
  • 26
    • 0031863222 scopus 로고    scopus 로고
    • Thiopurine S-methyltransferase activity in human erythrocytes: A new HPLC method using 6-thioguanine as substrate
    • T. Kroplin, N. Weyer, S. Gutsche Thiopurine S-methyltransferase activity in human erythrocytes a new HPLC method using 6-thioguanine as substrate Eur J Clin Pharmacol 54 1998 265 271
    • (1998) Eur J Clin Pharmacol , vol.54 , pp. 265-271
    • Kroplin, T.1    Weyer, N.2    Gutsche, S.3
  • 27
    • 0034745462 scopus 로고    scopus 로고
    • High-throughput genotyping of thiopurine S-methyltransferase by denaturing HPLC
    • E. Schaeffeler, T. Lang, U.M. Zanger High-throughput genotyping of thiopurine S-methyltransferase by denaturing HPLC Clin Chem 47 2001 548 555
    • (2001) Clin Chem , vol.47 , pp. 548-555
    • Schaeffeler, E.1    Lang, T.2    Zanger, U.M.3
  • 28
    • 3242762099 scopus 로고    scopus 로고
    • Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants
    • E. Schaeffeler, C. Fischer, D. Brockmeier Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants Pharmacogenetics 14 2004 407 417
    • (2004) Pharmacogenetics , vol.14 , pp. 407-417
    • Schaeffeler, E.1    Fischer, C.2    Brockmeier, D.3
  • 29
    • 3042748324 scopus 로고    scopus 로고
    • Thioguanine-nucleotides do not predict efficacy of 6-tioguanine in Crohn's Disease
    • K.R. Herrlinger, K. Fellermann, C. Fischer Thioguanine-nucleotides do not predict efficacy of 6-tioguanine in Crohn's Disease Aliment Pharmacol Ther 19 2004 1269 1276
    • (2004) Aliment Pharmacol Ther , vol.19 , pp. 1269-1276
    • Herrlinger, K.R.1    Fellermann, K.2    Fischer, C.3
  • 30
    • 0028821156 scopus 로고
    • Determination of intracellular levels of 6-mercaptopurine metabolites in erythrocytes utilizing capillary electrophoresis with laser-induced fluorescence detection
    • S.R. Rabel, J.F. Stobaugh, R. Trueworthy Determination of intracellular levels of 6-mercaptopurine metabolites in erythrocytes utilizing capillary electrophoresis with laser-induced fluorescence detection Anal Biochem 224 1995 315 322
    • (1995) Anal Biochem , vol.224 , pp. 315-322
    • Rabel, S.R.1    Stobaugh, J.F.2    Trueworthy, R.3
  • 31
    • 7644238430 scopus 로고    scopus 로고
    • Use of laboratory testing to guide 6-mercaptopurine/azathioprine therapy
    • G.R. Lichtenstein Use of laboratory testing to guide 6-mercaptopurine/ azathioprine therapy Gastroenterology 127 2004 1558 1564
    • (2004) Gastroenterology , vol.127 , pp. 1558-1564
    • Lichtenstein, G.R.1
  • 32
    • 0034067784 scopus 로고    scopus 로고
    • Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease
    • M.C. Dubinsky, S. Lamothe, H.Y. Yang Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease Gastroenterology 118 2000 705 713
    • (2000) Gastroenterology , vol.118 , pp. 705-713
    • Dubinsky, M.C.1    Lamothe, S.2    Yang, H.Y.3
  • 33
    • 0842291670 scopus 로고    scopus 로고
    • Peripheral blood mononuclear cell DNA 6-thioguanine metabolite levels correlate with decreased interferon-gamma production in patients with Crohn's disease on AZA therapy
    • C. Cuffari, D.Y. Li, J. Mahoney Peripheral blood mononuclear cell DNA 6-thioguanine metabolite levels correlate with decreased interferon-gamma production in patients with Crohn's disease on AZA therapy Dig Dis Sci 49 2004 133 137
    • (2004) Dig Dis Sci , vol.49 , pp. 133-137
    • Cuffari, C.1    Li, D.Y.2    Mahoney, J.3
  • 34
    • 0035186469 scopus 로고    scopus 로고
    • 6-mercaptopurine metabolite levels in children with inflammatory bowel disease
    • P. Gupta, R. Gokhale, B.S. Kirschner 6-mercaptopurine metabolite levels in children with inflammatory bowel disease J Pediatr Gastroenterol Nutr 33 2001 450 454
    • (2001) J Pediatr Gastroenterol Nutr , vol.33 , pp. 450-454
    • Gupta, P.1    Gokhale, R.2    Kirschner, B.S.3
  • 35
    • 0029134702 scopus 로고
    • Azathioprine and 6-mercaptopurine in Crohn disease. a meta-analysis
    • D.C. Pearson, G.R. May, G.H. Fick Azathioprine and 6-mercaptopurine in Crohn disease. A meta-analysis Ann Intern Med 123 1995 132 142
    • (1995) Ann Intern Med , vol.123 , pp. 132-142
    • Pearson, D.C.1    May, G.R.2    Fick, G.H.3
  • 36
    • 0001366524 scopus 로고    scopus 로고
    • Evidenzbasierte Immunsuppression bei chronisch entzündlichen Darmerkrankungen
    • M.F. Neurath, E. Stange Evidenzbasierte Immunsuppression bei chronisch entzündlichen Darmerkrankungen Deutsches Arzteblatt 97 2000 1977 1983
    • (2000) Deutsches Arzteblatt , vol.97 , pp. 1977-1983
    • Neurath, M.F.1    Stange, E.2
  • 37
    • 13544261760 scopus 로고    scopus 로고
    • Activation of the phagocyte NADPH oxidase by Rac guanine nucleotide exchange factors in conjunction with ATP and nucleoside diphosphate kinase
    • A. Mizrahi, S. Molshanski-Mor, C. Weinbaum Activation of the phagocyte NADPH oxidase by Rac guanine nucleotide exchange factors in conjunction with ATP and nucleoside diphosphate kinase J Biol Chem 280 2005 3802 3811
    • (2005) J Biol Chem , vol.280 , pp. 3802-3811
    • Mizrahi, A.1    Molshanski-Mor, S.2    Weinbaum, C.3
  • 38
    • 0026758498 scopus 로고
    • The clinical pharmacology of 6-mercaptopurine
    • L. Lennard The clinical pharmacology of 6-mercaptopurine Eur J Clin Pharmacol 43 1992 329 335
    • (1992) Eur J Clin Pharmacol , vol.43 , pp. 329-335
    • Lennard, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.