Lack of association between the ITPA 94C>A polymorphism and adverse effects from azathioprine

Pharmacogenetics

Volumn 14, Issue 11, 2004, Pages 779-781

  Gearry, Richard B ^a   Roberts, Rebecca L ^a   Barclay, Murray L ^a   Kennedy, Martin A ^a  

^a CHRISTCHURCH HOSPITAL   (New Zealand)

Author keywords

6 mercaptopurine; Adverse effects; Azathioprine; Inflammatory bowel disease; Inosine triphosphate pyrophosphatase; ITPA; Thiopurine methyltransferase

Indexed keywords

AZATHIOPRINE; INOSINE TRIPHOSPHATE; INOSINE TRIPHOSPHATE PYROPHOSPHATASE; MERCAPTOPURINE; THIOPURINE METHYLTRANSFERASE; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; ADULT; ARTHRALGIA; ARTICLE; BONE MARROW SUPPRESSION; CONFIDENCE INTERVAL; CONTROLLED STUDY; DRUG HYPERSENSITIVITY; DRUG TOLERABILITY; DRUG WITHDRAWAL; ENTERITIS; FEVER; FLU LIKE SYNDROME; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HUMAN CELL; ITPA GENE; LETHARGY; MAJOR CLINICAL STUDY; MISSENSE MUTATION; MYALGIA; NAUSEA; PANCREATITIS; POPULATION RESEARCH; PRIORITY JOURNAL; RASH; SIDE EFFECT; SINGLE NUCLEOTIDE POLYMORPHISM; TOXIC HEPATITIS; TPMT2 GENE; TPMT3 GENE; VOMITING;

AZATHIOPRINE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; POLYMORPHISM, GENETIC; PYROPHOSPHATASES;

EID: 9244237558     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008571-200411000-00010     Document Type: Article

References (6)

1. Gearry R, Barclay M, Burt M, Collett J, Chapman B. Thiopurine drug adverse effects in a population of New Zealand patients with inflammatory bowel disease. Pharmacoepidemiol Drug Saf 2004; 13:563-567.
2. Marinaki A, Ansari A, Duley J, Arenas M, Sumi S, Lewis CM, et al. Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase). Pharmacogenetics 2004; 14:181-187.
3. Sumi S, Marinaki AM, Arenas M, Fairbanks L, Shobowale-Bakre M, Rees DC, et al. Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency. Hum Genet 2002; 111:360-367.
4. Gearry RB, Barclay ML, Burt MJ, Collett JA, Chapman BA, Roberts RL, Kennedy MA. Thiopurine S-methyltransferase (TPMT) genotype does not predict adverse drug reactions to thiopurine drugs in patients with inflammatory bowel disease. Aliment Pharmacol Ther 2003; 18:395-400.
5. Ciulla TA, Sklar RM, Hauser SL. A simple method for DNA purification from peripheral blood. Anal Biochem 1988; 174:485-488.
6. Roberts RL, Barclay ML, Gearry RB, Kennedy MA. A multiplexed allele-specific polymerase chain reaction assay for the detection of common thiopurine S-methyltransferase (TPMT) mutations. Clin Chim Acta 2004; 341:49-53.