Leptin receptor (Lepr) is a negative modulator of bone mechanosensitivity and genetic variations in Lepr may contribute to the differential osteogenic response to mechanical stimulation in the C57BL/6J and C3H/HeJ pair of mouse strains

Journal of Biological Chemistry

Volumn 285, Issue 48, 2010, Pages 37607-37618

  Kapur, Sonia ^a   Amoui, Mehran ^a   Kesavan, Chandrasekhar ^a   Wang, Xiaoguang ^a   Mohan, Subburaman ^a,b   Baylink, David J ^b   Lau, K H William ^a,b  

^a Jerry L Pettis Memorial VA Medical Center   (United States)

^b LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANABOLIC RESPONSE; BONE FORMATION; CODING REGION; GENETIC VARIATION; IN-VITRO; LEPTIN BINDING; LEPTIN RECEPTORS; MECHANICAL STIMULATION; MECHANICAL STIMULUS; MECHANOSENSITIVITY; MOUSE STRAIN; OSTEOGENIC RESPONSE; SINGLE NUCLEOTIDE POLYMORPHISMS; STEADY SHEAR; WHETHER DIFFERENCES; WILD TYPES;

BONE; GENES; HORMONES; LOADING; PHOSPHORYLATION; SHEAR STRESS; STRENGTH OF MATERIALS;

SIGNALING;

JANUS KINASE 2; LEPTIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SMALL INTERFERING RNA; STAT3 PROTEIN;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE METABOLISM; C3H MOUSE; C57BL 6 MOUSE; CONTROLLED STUDY; ENZYME ASSAY; ENZYME PHOSPHORYLATION; FEMALE; GENETIC VARIABILITY; IN VITRO STUDY; MALE; MECHANICAL STIMULATION; MECHANICAL STRESS; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SHEAR STRESS; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; STIMULUS RESPONSE; STRAIN DIFFERENCE; UPREGULATION; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BONE AND BONES; CELLS, CULTURED; DOWN-REGULATION; GENETIC VARIATION; MALE; MECHANOTRANSDUCTION, CELLULAR; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; OSTEOBLASTS; OSTEOGENESIS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, LEPTIN; SHEAR STRENGTH; STRESS, MECHANICAL;

MUS;

EID: 78549247860     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.169714     Document Type: Article

References (55)

1. Akhter, M. P., Cullen, D. M., Pedersen, E. A., Kimmel, D. B., and Recker, R. R. (1998) Calcif. Tissue Int. 63, 442-449
2. Kodama, Y., Umemura, Y., Nagasawa, S., Beamer, W. G., Donahue, L. R., Rosen, C. R., Baylink, D. J., and Farley, J. R. (2000) Calcif. Tissue Int. 66, 298-306
3. Robling, A. G., and Turner, C. H. (2002) Bone 31, 562-569
4. Kesavan, C., Mohan, S., Oberholtzer, S., Wergedal, J. E., and Baylink, D. J. (2005) J. Appl. Physiol. 99, 1951-1957
5. Kesavan, C., Mohan, S., Srivastava, A. K., Kapoor, S., Wergedal, J. E., Yu, H., and Baylink, D. J. (2006) Bone 39, 634-643
6. Kesavan, C., Baylink, D. J., Kapoor, S., and Mohan, S. (2007) Bone 41, 223-230
7. Lau, K. H., Kapur, S., Kesavan, C., and Baylink, D. J. (2006) J. Biol. Chem. 281, 9576-9588
8. Robling, A. G., Li, J., Shultz, K. L., Beamer, W. G., and Turner, C. H. (2003) FASEB J. 17, 324-326
9. Srivastava, A. K., Kapur, S., Mohan, S., Yu, H., Kapur, S., Wergedal, J., and Baylink, D. J. (2005) J. Bone Miner. Res. 20, 1041-1050
10. Saxon, L. K., Robling, A. G., Alam, I., and Turner, C. H. (2005) Bone 36, 454-464
11. Hamrick, M. W., Pennington, C., Newton, D., Xie, D., and Isales, C. (2004) Bone 34, 376-383
12. Turner, C. H., Alam, I., Sun, O., Li, J., Fuchs, R. K., Edenberg, H. J., Koller, D. L., Foroud, T., and Econs, M. J. (2005) J. Bone Miner. Res. 20, Suppl. 1, S28, abstract 1108
13. Thomas, T. (2004) Curr. Opin. Pharmacol. 4, 295-300
14. Ducy, P., Amling, M., Takeda, S., Priemel, M., Schilling, A. F., Beil, F. T., Shen, J., Vinson, C., Rueger, J. M., and Karsenty, G. (2000) Cell 100, 197-207
15. Gordeladze, J. O., and Reseland, J. E. (2003) J. Cell Biochem. 88, 706-712
16. Wang, X., Rundle, C. H., Wergedal, J. E., Srivastava, A. K., Mohan, S., and Lau, K. H. (2007) Calcif. Tissue Int. 80, 374-382
17. Namae, M., Mori, Y., Yasuda, K., Kadowaki, T., Kanazawa, Y., and Komeda, K. (1998) Lab. Anim. Sci. 48, 103-104
18. Sheng, M. H., Lau, K. H., Beamer, W. G., Baylink, D. J., and Wergedal, J. E. (2004) Bone 35, 711-719
19. Kapur, S., Baylink, D. J., and Lau, K. H. (2003) Bone 32, 241-251
20. Hillsley, M. V., and Frangos, J. A. (1994) Biotechnol. Bioeng. 43, 573-581
21. Reseland, J. E., Syversen, U., Bakke, I., Qvigstad, G., Eide, L. G., Hjertner, O., Gordeladze, J. O., and Drevon, C. A. (2001) J. Bone Miner. Res. 16, 1426-1433
22. Frühbeck, G. (2006) Biochem. J. 393, 7-20
23. Tartaglia, L. A. (1997) J. Biol. Chem. 272, 6093-6096
24. Ghilardi, N., and Skoda, R. C. (1997) Mol. Endocrinol. 11, 393-399
25. Thompson, D. B., Ravussin, E., Bennett, P. H., and Bogardus, C. (1997) Hum. Mol. Genet. 6, 675-679
26. de Luis Roman, D., de la Fuente, R. A., Sagrado, M. G., Izaola, O., and Vicente, R. C. (2006) Arch. Med. Res. 37, 854-859
27. Fairbrother, U. L., Tankó, L. B., Walley, A. J., Christiansen, C., Froguel, P., and Blakemore, A. I. (2007) J. Bone Miner. Res. 22, 544-550
28. Robling, A. G., Warden, S. J., Shultz, K. L., Beamer, W. G., and Turner, C. H. (2007) J. Bone Miner. Res. 22, 984-991
29. Aarden, E. M., Burger, E. H., and Nijweide, P. J. (1994) J. Cell Biochem. 55, 287-299
30. Lanyon, L. E. (1993) Calcif. Tissue Int. 53, Suppl. 1, S102-S106; discussion S106-S107
31. Jones, S. J., Gray, C., Sakamaki, H., Arora, M., Boyde, A., Gourdie, R., and Green, C. (1993) Anat. Embryol. 187, 343-352
32. Dodds, R. A., Ali, N., Pead, M. J., and Lanyon, L. E. (1993) J. Bone Miner. Res. 8, 261-267
33. Cheng, B., Zhao, S., Luo, J., Sprague, E., Bonewald, L. F., and Jiang, J. X. (2001) J. Bone Miner. Res. 16, 249-259
34. Iqbal, J., and Zaidi, M. (2005) Biochem. Biophys. Res. Commun. 328, 751-755
35. Jessop, H. L., Suswillo, R. F., Rawlinson, S. C., Zaman, G., Lee, K., Das- Gupta, V., Pitsillides, A. A., and Lanyon, L. E. (2004) J. Bone Miner. Res. 19, 938-946
36. Hirosawa, M., Minata, M., Harada, K. H., Hitomi, T., Krust, A., and Koizumi, A. (2008) Biochem. Biophys. Res. Commun. 371, 320-323
37. Fernández-Moreno, C., Pichel, J. G., Chesnokova, V., and De Pablo, F. (2004) FEBS Lett. 557, 64-68
38. Lund, I. K., Hansen, J. A., Andersen, H. S., Møller, N. P., and Billestrup, N. (2005) J. Mol. Endocrinol. 34, 339-351
39. Oh, E. S., Gu, H., Saxton, T. M., Timms, J. F., Hausdorff, S., Frevert, E. U., Kahn, B. B., Pawson, T., Neel, B. G., and Thomas, S. M. (1999) Mol. Cell Biol. 19, 3205-3215
40. Arias-Salgado, E. G., Haj, F., Dubois, C., Moran, B., Kasirer-Friede, A., Furie, B. C., Furie, B., Neel, B. G., and Shattil, S. J. (2005) J. Cell Biol. 170, 837-845
41. Reid, I. R. (2008) Osteoporos. Int. 19, 595-606
42. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., and Friedman, J. M. (1994) Nature 372, 425-432
43. Hong, S. C., Yoo, S. W., Cho, G. J., Kim, T., Hur, J. Y., Park, Y. K., Lee, K. W., and Kim, S. H. (2007) Menopause 14, 835-840
44. Lambrinoudaki, I. V., Christodoulakos, G. E., Economou, E. V., Vlachou, S. A., Panoulis, C. P., Alexandrou, A. P., Kouskouni, E. E., and Creatsas, G. C. (2008) Maturitas 59, 62-71
45. Koh, J. M., Kim, D. J., Hong, J. S., Park, J. Y., Lee, K. U., Kim, S. Y., and Kim, G. S. (2002) Eur. J. Endocrinol. 147, 777-783
46. Pedersen, E. A., Akhter, M. P., Cullen, D. M., Kimmel, D. B., and Recker, R. R. (1999) Calcif. Tissue Int. 65, 41-46
47. Niv-Spector, L., Gonen-Berger, D., Gourdou, I., Biener, E., Gussakovsky, E. E., Benomar, Y., Ramanujan, K. V., Taouis, M., Herman, B., Callebaut, I., Djiane, J., and Gertler, A. (2005) Biochem. J. 391, 221-230
48. Fong, T. M., Huang, R. R., Tota, M. R., Mao, C., Smith, T., Varnerin, J., Karpitskiy, V. V., Krause, J. E., and Van der Ploeg, L. H. (1998) Mol. Pharmacol. 53, 234-240
49. Devos, R., Guisez, Y., Van der Heyden, J., White, D. W., Kalai, M., Fountoulakis, M., and Plaetinck, G. (1997) J. Biol. Chem. 272, 18304-18310
50. Biener, E., Charlier, M., Ramanujan, V. K., Daniel, N., Eisenberg, A., Bjørbaek, C., Herman, B., Gertler, A., and Djiane, J. (2005) Biol. Cell 97, 905-919
51. Couturier, C., and Jockers, R. (2003) J. Biol. Chem. 278, 26604-26611
52. Chachisvilis, M., Zhang, Y. L., and Frangos, J. A. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 15463-15468
53. Fleming, I., Bauersachs, J., Fisslthaler, B., and Busse, R. (1998) Circ. Res. 82, 686-695
54. Kimchi-Sarfaty, C., Oh, J. M., Kim, I. W., Sauna, Z. E., Calcagno, A. M., Ambudkar, S. V., and Gottesman, M. M. (2007) Science 315, 525-528
55. Lau, K. H., Kapur, S., Amoui, M., Wang, X., Kesavan, C., Mohan, S., and Baylink, D. J. (2007) J. Bone Miner. Res. 22, Suppl. 1, p. S23, abstract 1223