What do we (not) know about how paracetamol (acetaminophen) works?

Journal of Clinical Pharmacy and Therapeutics

Volumn 35, Issue 6, 2010, Pages 617-638

  Toussaint, K ^a   Yang, X C ^a   Zielinski, M A ^a   Reigle, K L ^a   Sacavage, S D ^a   Nagar, S ^a   Raffa, R B ^a  

^a TEMPLE UNIVERSITY SCHOOL OF PHARMACY   (United States)

Author keywords

acetaminophen; mechanism of action; paracetamol

Indexed keywords

ACETANILIDE; CANNABINOID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 3; IBUPROFEN; MORPHINE; NITRIC OXIDE SYNTHASE; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE ANTAGONIST; PARACETAMOL; PEROXIDASE; PHENACETIN; PLACEBO; SEROTONIN;

ALLODYNIA; ANALGESIA; ANKLE PAIN; ANKLE SPRAIN; ANTIPYRETIC ACTIVITY; ARTHRALGIA; BLOOD BRAIN BARRIER; BODY TEMPERATURE; BONE PAIN; CLINICAL TRIAL; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG EXCRETION; DRUG MECHANISM; DRUG MEGADOSE; DRUG METABOLISM; DRUG OVERDOSE; DRUG POTENCY; DRUG POTENTIATION; DRUG TRANSPORT; ENZYME INHIBITION; FEVER; HUMAN; HYPERALGESIA; INDUCED HYPOTHERMIA; INFLAMMATION; LIVER TOXICITY; LOADING DRUG DOSE; LOW BACK PAIN; LOW DRUG DOSE; MAXIMUM PLASMA CONCENTRATION; MEDICAL LITERATURE; MENSTRUAL PAIN; MIGRAINE; NONHUMAN; OSTEOARTHRITIS; PAIN; RETROSPECTIVE STUDY; REVIEW; TENSION HEADACHE; THROMBOCYTE AGGREGATION; TREATMENT OUTCOME;

ACETAMINOPHEN; ACETANILIDES; ANALGESIA; ANALGESICS, NON-NARCOTIC; ANALGESICS, OPIOID; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIPYRETICS; DRUG DISCOVERY; HUMANS; HYPERALGESIA; PAIN; PAIN MEASUREMENT;

EID: 78449275829     PISSN: 02694727     EISSN: 13652710     Source Type: Journal    
DOI: 10.1111/j.1365-2710.2009.01143.x     Document Type: Review

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