Predicting memapsin 2 (β-secretase) hydrolytic activity

Protein Science

Volumn 19, Issue 11, 2010, Pages 2175-2185

  Li, Xiaoman ^a,b   Bo, Huang ^c   Zhang, Xuejun C ^c   Hartsuck, Jean A ^a   Tang, Jordan ^a,b  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^c INSTITUTE OF BIOPHYSICS   (China)

Author keywords

amyloid; secretase; Activity prediction; Alzheimer's disease; BACE1; Memapsin 2; Subsite specificity

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ASPARTIC ACID; BETA SECRETASE; LYSINE; METHIONINE; PHENYLALANINE; VALINE;

ALGORITHM; ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; HYDROLYSIS; MOLECULAR MODEL; MUTATION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN VARIANT; TRANSGENIC MOUSE;

ALGORITHMS; AMINO ACID SEQUENCE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; CATALYTIC DOMAIN; CELL LINE; HUMANS; HYDROLYSIS; KINETICS; MICE; MODELS, CHEMICAL; MODELS, STATISTICAL; MOLECULAR SEQUENCE ANNOTATION; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; REGRESSION ANALYSIS; SEQUENCE ANALYSIS, PROTEIN; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBSTRATE SPECIFICITY;

MUS MUSCULUS;

EID: 78349299010     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.502     Document Type: Article

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