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Volumn 16, Issue 4, 2010, Pages 469-478

PARP and PARG inhibitors-new therapeutic targets in cancer treatment

Author keywords

PARG; PARG inhibitors; PARP; PARP inhibitors

Indexed keywords

2 (2 METHYL 2 PYRROLIDINYL) 1H BENZIMIDAZOLE 4 CARBOXAMIDE; 3 AMINOBENZAMIDE; 8 FLUORO 3,4 DIHYDRO 2 [4 (METHYLAMINOMETHYL)PHENYL]PYRROLO[3,4,5 E,F][2]BENZAZEPIN 6(5H) ONE; 8 HYDROXY 2 METHYL 4(3H) QUINAZOLINONE; ANTINEOPLASTIC AGENT; BENZAMIDE; CARBOPLATIN; CEP 9722; CISPLATIN; CYCLOPHOSPHAMIDE; DNA TOPOISOMERASE INHIBITOR; DOXORUBICIN; GEMCITABINE; GLYCOSIDASE; INO 1001; MK 4827; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; OLAPARIB; PACLITAXEL; PLATINUM COMPLEX; POLY ADP RIBOSE GLYCOHYDROLASE; POLY ADP RIBOSE GLYCOHYDROLASE INHIBITOR; TANNIN; TEMOZOLOMIDE; TOPOTECAN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN;

EID: 78149393537     PISSN: 12194956     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12253-010-9266-6     Document Type: Review
Times cited : (45)

References (108)
  • 1
    • 0033198919 scopus 로고    scopus 로고
    • Poly (ADP-ribosyl)ation reactions in the regulation of nuclear functions
    • D D'amours S Desnoyers I D'silva GG Poirier 1999 Poly (ADP-ribosyl)ation reactions in the regulation of nuclear functions J Biochem 342 249 268
    • (1999) J Biochem , vol.342 , pp. 249-268
    • D'Amours, D.1    Desnoyers, S.2    D'Silva, I.3    Poirier, G.G.4
  • 2
    • 49849093631 scopus 로고    scopus 로고
    • Liquid chromatography-mass spactometric assay for quantitation in human plasma of ABT-888, an orally available, small molecule inhibitor of poly (ADP-ribose) polymerase
    • 18692448
    • RA Parise M Shawaqfeh MJ Egorin JH Beumer 2008 Liquid chromatography-mass spactometric assay for quantitation in human plasma of ABT-888, an orally available, small molecule inhibitor of poly (ADP-ribose) polymerase J Chromatogr B Analyt Technol Biomed Life Sci 872 1-2 141 147 18692448
    • (2008) J Chromatogr B Analyt Technol Biomed Life Sci , vol.872 , Issue.12 , pp. 141-147
    • Parise, R.A.1    Shawaqfeh, M.2    Egorin, M.J.3    Beumer, J.H.4
  • 3
    • 33645288259 scopus 로고    scopus 로고
    • Parp-1 protects homologous recombination from interferenve by Ku and Ligase IV in vertebrate cells
    • 16498404
    • H Hochegger D Dejsuphong T Fukushima C Morrison, et al. 2006 Parp-1 protects homologous recombination from interferenve by Ku and Ligase IV in vertebrate cells EMBO J 25 1305 1314 16498404
    • (2006) EMBO J , vol.25 , pp. 1305-1314
    • Hochegger, H.1    Dejsuphong, D.2    Fukushima, T.3    Morrison, C.4
  • 4
    • 0036733355 scopus 로고    scopus 로고
    • The therapeutic potential of poly (ADP-ribose) polymerase inhibitors
    • 12223530
    • L Virag C Szabo 2002 The therapeutic potential of poly (ADP-ribose) polymerase inhibitors Pharmacol Rev 54 375 429 12223530
    • (2002) Pharmacol Rev , vol.54 , pp. 375-429
    • Virag, L.1    Szabo, C.2
  • 5
    • 0141537080 scopus 로고    scopus 로고
    • Human poly (ADP-ribose) glycohydrolase (PARG) gene and the common promoter sequence it shares with inner mitochondrial membrane translocase 23 (TIM23)
    • 14527731
    • RG Meyer ML Meyer-Ficca EL Jacobson MK Jacobson 2003 Human poly (ADP-ribose) glycohydrolase (PARG) gene and the common promoter sequence it shares with inner mitochondrial membrane translocase 23 (TIM23) Gene 314 181 190 14527731
    • (2003) Gene , vol.314 , pp. 181-190
    • Meyer, R.G.1    Meyer-Ficca, M.L.2    Jacobson, E.L.3    Jacobson, M.K.4
  • 6
    • 19944418213 scopus 로고    scopus 로고
    • Failure to degrade poly (ADP-ribose) increased sensitivity to cytotoxicity and early embryonic lethality
    • 15591342
    • DW Koh AM Lawler MF Poitras, et al. 2004 Failure to degrade poly (ADP-ribose) increased sensitivity to cytotoxicity and early embryonic lethality PNAS 101 51 17699 17704 15591342
    • (2004) PNAS , vol.101 , Issue.51 , pp. 17699-17704
    • Koh, D.W.1    Lawler, A.M.2    Poitras, M.F.3
  • 7
    • 3543031621 scopus 로고    scopus 로고
    • Depletion of the 110-Kilodalton isoform of poly (ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice
    • 15282315
    • U Cortes WM Tong DL Coyle, et al. 2004 Depletion of the 110-Kilodalton isoform of poly (ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice MCB 24 16 7163 7178 15282315
    • (2004) MCB , vol.24 , Issue.16 , pp. 7163-7178
    • Cortes, U.1    Tong, W.M.2    Coyle, D.L.3
  • 8
    • 34547783237 scopus 로고    scopus 로고
    • Spatial and functional relationship between poly (ADP-ribose) polymerase-1 and Poly (ADP-ribose) glycohydrolase in the brain
    • 17640816
    • MF Poitras DW Koh SW Yu, et al. 2007 Spatial and functional relationship between poly (ADP-ribose) polymerase-1 and Poly (ADP-ribose) glycohydrolase in the brain Neuroscience 148 1 198 211 17640816
    • (2007) Neuroscience , vol.148 , Issue.1 , pp. 198-211
    • Poitras, M.F.1    Koh, D.W.2    Yu, S.W.3
  • 9
    • 34548183836 scopus 로고    scopus 로고
    • PolyADP-ribosylation and cancer
    • 17645773
    • M Miwa Matsutani 2007 PolyADP-ribosylation and cancer Cancer Sci 98 10 1528 1535 17645773
    • (2007) Cancer Sci , vol.98 , Issue.10 , pp. 1528-1535
    • Miwa, M.1    Matsutani2
  • 10
    • 33744986316 scopus 로고    scopus 로고
    • Poly (ADP-ribose) glycohydrolase silencing protects against H2O2-induced cell death
    • C Blenn FR Althaus M Manlanga 2006 Poly (ADP-ribose) glycohydrolase silencing protects against H2O2-induced cell death J Biochem 396 419 429
    • (2006) J Biochem , vol.396 , pp. 419-429
    • Blenn, C.1    Althaus, F.R.2    Manlanga, M.3
  • 11
    • 33947380240 scopus 로고    scopus 로고
    • Current development of clinical poly (ADP-ribose) inhibitor in oncology
    • 17332279
    • K Ratnam JA Low 2007 Current development of clinical poly (ADP-ribose) inhibitor in oncology Clin Cancer Res 13 5 1383 1388 17332279
    • (2007) Clin Cancer Res , vol.13 , Issue.5 , pp. 1383-1388
    • Ratnam, K.1    Low, J.A.2
  • 12
    • 0032901754 scopus 로고    scopus 로고
    • An improved nonisotopic test to screen a large series of new inhibitor molecules of poly (ADP-ribose) polymerase activity for therapeutic applications
    • 10353753
    • P Decker EA Miranda G De Murcia S Muller 1999 An improved nonisotopic test to screen a large series of new inhibitor molecules of poly (ADP-ribose) polymerase activity for therapeutic applications Clin Cancer Res 5 1169 1172 10353753
    • (1999) Clin Cancer Res , vol.5 , pp. 1169-1172
    • Decker, P.1    Miranda, E.A.2    De Murcia, G.3    Muller, S.4
  • 13
    • 20144388979 scopus 로고    scopus 로고
    • PARG activity mediates intestinal injury induced by splanchnic artery occlusion and reperfusion
    • 15791006
    • S Cuzzocrea RD Paola E Mazzon, et al. 2005 PARG activity mediates intestinal injury induced by splanchnic artery occlusion and reperfusion FASEB J 19 558 566 15791006
    • (2005) FASEB J , vol.19 , pp. 558-566
    • Cuzzocrea, S.1    Paola, R.D.2    Mazzon, E.3
  • 14
    • 59449085305 scopus 로고    scopus 로고
    • Phase i study of the poly (ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced Solid Tumors
    • 19047122
    • R Plummer C Jones M Middleton, et al. 2008 Phase I study of the poly (ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced Solid Tumors Clin Cancer Res 14 23 7917 7923 19047122
    • (2008) Clin Cancer Res , vol.14 , Issue.23 , pp. 7917-7923
    • Plummer, R.1    Jones, C.2    Middleton, M.3
  • 15
    • 85047697499 scopus 로고    scopus 로고
    • PARP-1 modifies the effectiveness of P53 mediated DNA damage response
    • 11850828
    • MT Valenzuela R Guerrerro MI Nunez, et al. 2002 PARP-1 modifies the effectiveness of P53 mediated DNA damage response Oncogene 21 7 1108 1116 11850828
    • (2002) Oncogene , vol.21 , Issue.7 , pp. 1108-1116
    • Valenzuela, M.T.1    Guerrerro, R.2    Nunez, M.I.3
  • 16
    • 0034725720 scopus 로고    scopus 로고
    • ATP for the DNA ligation step in base excision repair is generated from poly (ADP-ribose)
    • 10930429
    • SL Oei M Ziegler 2000 ATP for the DNA ligation step in base excision repair is generated from poly (ADP-ribose) J Biol Chem 275 23234 23239 10930429
    • (2000) J Biol Chem , vol.275 , pp. 23234-23239
    • Oei, S.L.1    Ziegler, M.2
  • 17
    • 33748065304 scopus 로고    scopus 로고
    • Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly (ADP-ribose) polymerase inhibition
    • 16912188
    • N McCabe NC Turner CJ Lord, et al. 2006 Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly (ADP-ribose) polymerase inhibition Cancer Res 66 16 8109 8115 16912188
    • (2006) Cancer Res , vol.66 , Issue.16 , pp. 8109-8115
    • McCabe, N.1    Turner, N.C.2    Lord, C.J.3
  • 18
    • 0030915587 scopus 로고    scopus 로고
    • Intracellular ATP levels determine cell death fate by apoptosis or necrosis
    • Y Eguchi S Shimizu Y Tsujimoto 1997 Intracellular ATP levels determine cell death fate by apoptosis or necrosis Cancer Res 57 1835 1840 9157970 (Pubitemid 27209706)
    • (1997) Cancer Research , vol.57 , Issue.10 , pp. 1835-1840
    • Eguchi, Y.1    Shimizu, S.2    Tsujimoto, Y.3
  • 19
    • 0032533856 scopus 로고    scopus 로고
    • Functional interactions of p53 with poly(ADP-ribose) polymerase (PARP) during apoptosis following DNA damage: Covalent poly(ADP-ribosyl)ation of p53by exogenous PARP and noncovalent binding of p53 to the Mr 85,000 proteolytic fragment1
    • 9823314
    • SR Kumari H Mendoza-Alvarez R Alvarez-Gonzalez 1998 Functional interactions of p53 with poly(ADP-ribose) polymerase (PARP) during apoptosis following DNA damage: covalent poly(ADP-ribosyl)ation of p53by exogenous PARP and noncovalent binding of p53 to the Mr 85,000 proteolytic fragment1. Cancer Res 58 5075 5078 9823314
    • (1998) Cancer Res , vol.58 , pp. 5075-5078
    • Kumari, S.R.1    Mendoza-Alvarez, H.2    Alvarez-Gonzalez, R.3
  • 20
    • 0035951888 scopus 로고    scopus 로고
    • Caspase-3-mediated processing of poly (ADP-ribose) glycohydrolase during apoptosis
    • EB Affar M Germain E Winstall, et al. 2001 Caspase-3-mediated processing of poly (ADP-ribose) glycohydrolase during apoptosis JBC 276 4 2935 2942
    • (2001) JBC , vol.276 , Issue.4 , pp. 2935-2942
    • Affar, E.B.1    Germain, M.2    Winstall, E.3
  • 21
    • 19444374556 scopus 로고    scopus 로고
    • Mediation of cell death by Poly (ADP-ribose)-1
    • 15911329
    • DW Koh TM Dawson VL Dawson 2005 Mediation of cell death by Poly (ADP-ribose)-1 Pharmacol Res 52 1 5 14 15911329
    • (2005) Pharmacol Res , vol.52 , Issue.1 , pp. 5-14
    • Koh, D.W.1    Dawson, T.M.2    Dawson, V.L.3
  • 22
    • 78149387512 scopus 로고    scopus 로고
    • Differrential PARP cleavage: An indication for existence of multiple forms of cell death in human gilomas
    • Bhaskara, et al (2009) Differrential PARP cleavage: an indication for existence of multiple forms of cell death in human gilomas. Neurology India 57(3)
    • (2009) Neurology India , vol.57 , Issue.3
    • Bhaskara, E.1
  • 23
    • 58249098507 scopus 로고    scopus 로고
    • A novel function of PARP-1 in modulation of autophagy and necrosis under oxidative stress
    • Q Hung YT Wu HL Tan CN Ong HM Shen 2009 A novel function of PARP-1 in modulation of autophagy and necrosis under oxidative stress Cell Death Diff 16 264 277
    • (2009) Cell Death Diff , vol.16 , pp. 264-277
    • Hung, Q.1    Wu, Y.T.2    Tan, H.L.3    Ong, C.N.4    Shen, H.M.5
  • 24
    • 0033538451 scopus 로고    scopus 로고
    • Oxidative stress inhibits apoptosis in human lymphoma cells
    • Y Lee E Shacter 1999 Oxidative stress inhibits apoptosis in human lymphoma cells J Bio Chem 274 19792 19798
    • (1999) J Bio Chem , vol.274 , pp. 19792-19798
    • Lee, Y.1    Shacter, E.2
  • 25
    • 0033568205 scopus 로고    scopus 로고
    • Poly (ADP-ribose) polymerase inhibition in oxidant stressed endothelial cells prevents oncosis and permits caspase activation and apoptosis
    • 10471325
    • JA Walisser RC Thies 1999 Poly (ADP-ribose) polymerase inhibition in oxidant stressed endothelial cells prevents oncosis and permits caspase activation and apoptosis Exp Cell Res 251 12 401 413 10471325
    • (1999) Exp Cell Res , vol.251 , Issue.12 , pp. 401-413
    • Walisser, J.A.1    Thies, R.C.2
  • 26
    • 42249107850 scopus 로고    scopus 로고
    • PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2
    • 18239155
    • MT Mathews BC Berk 2008 PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2 Arterioscler Thromb Vasc Biol 28 711 717 18239155
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 711-717
    • Mathews, M.T.1    Berk, B.C.2
  • 27
    • 30444446344 scopus 로고    scopus 로고
    • Critical role of PI3-kinase/Akt activation in the PARP inhibitor induced heart function recovery during ischemia-reperfusion
    • 16337154
    • K Kovacs A Toth P Deres, et al. 2006 Critical role of PI3-kinase/Akt activation in the PARP inhibitor induced heart function recovery during ischemia-reperfusion Biochem Pharmacol 71 4 441 452 16337154
    • (2006) Biochem Pharmacol , vol.71 , Issue.4 , pp. 441-452
    • Kovacs, K.1    Toth, A.2    Deres, P.3
  • 28
    • 0141538207 scopus 로고    scopus 로고
    • +, as a PARP inhibitor and by partial restoration of mitochondrial function
    • 14512702
    • +, as a PARP inhibitor and by partial restoration of mitochondrial function Pharmacology 69 3 150 157 14512702
    • (2003) Pharmacology , vol.69 , Issue.3 , pp. 150-157
    • Klaidman, L.1    Morales, M.2    Kem, S.3
  • 29
    • 20444386251 scopus 로고    scopus 로고
    • Inhibition of PARP prevents oxidant-induced necrosis but not apoptosis in LLC-PK1 cells
    • DM Filipovic X Meng WB Reeves 1999 Inhibition of PARP prevents oxidant-induced necrosis but not apoptosis in LLC-PK1 cells Am J Physiol Renal Physiol 277 428 436
    • (1999) Am J Physiol Renal Physiol , vol.277 , pp. 428-436
    • Filipovic, D.M.1    Meng, X.2    Reeves, W.B.3
  • 30
    • 33749242274 scopus 로고    scopus 로고
    • Protective effects of PARP inhibition on liver microcirculation and function after haemorrhagic shock and resuscitation in male rats
    • 16927075
    • JP Roesner DA Vagts T Iber, et al. 2006 Protective effects of PARP inhibition on liver microcirculation and function after haemorrhagic shock and resuscitation in male rats Intensive Care Med 32 10 1649 1657 16927075
    • (2006) Intensive Care Med , vol.32 , Issue.10 , pp. 1649-1657
    • Roesner, J.P.1    Vagts, D.A.2    Iber, T.3
  • 31
    • 78149392960 scopus 로고    scopus 로고
    • Effects of Poly(ADP-ribose) polymerase (PARP) Inhibitor on NMDA-induced retinal injury
    • E-Abstract 27
    • Oku H, Goto W, Tsujimoto M et al (2003) Effects of Poly(ADP-ribose) polymerase (PARP) Inhibitor on NMDA-induced retinal injury. Invest Ophthalmol Vis Sci 44: E-Abstract 27
    • (2003) Invest Ophthalmol Vis Sci , vol.44
    • Oku, H.1    Goto, W.2    Tsujimoto, M.3
  • 33
    • 0033598713 scopus 로고    scopus 로고
    • Poly (ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion
    • 10570184
    • HC Ha SH Snyder 1999 Poly (ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion PNAS 96 13978 13982 10570184
    • (1999) PNAS , vol.96 , pp. 13978-13982
    • Ha, H.C.1    Snyder, S.H.2
  • 34
    • 0347719407 scopus 로고    scopus 로고
    • Loss of poly (ADP-ribose) glycohydrolase causes progressive neurodegeneration in Drosophila melanogaster
    • 14676324
    • S Hanai M Kanai S Ohashi, et al. 2004 Loss of poly (ADP-ribose) glycohydrolase causes progressive neurodegeneration in Drosophila melanogaster PNAS 101 1 82 86 14676324
    • (2004) PNAS , vol.101 , Issue.1 , pp. 82-86
    • Hanai, S.1    Kanai, M.2    Ohashi, S.3
  • 35
    • 33845931841 scopus 로고    scopus 로고
    • MNNG-induced cell death is controlled by interactions between PARP-1, Poly (ADP-ribose) glycohydrolase, and XRCC1
    • C Keil T Gröbe SL Oei 2006 MNNG-induced cell death is controlled by interactions between PARP-1, Poly (ADP-ribose) glycohydrolase, and XRCC1 J Biochem 281 34394 34405
    • (2006) J Biochem , vol.281 , pp. 34394-34405
    • Keil, C.1    Gröbe, T.2    Oei, S.L.3
  • 36
    • 0035131124 scopus 로고    scopus 로고
    • Early embryonic lethality in PARP-1 Atm double-mutant mice suggests a functional synergy in cell proliferation during development
    • J Ménissier-de Murcia M Mark O Wendling A Wynshaw-Boris G de Murcia 2001 Early embryonic lethality in PARP-1 Atm double-mutant mice suggests a functional synergy in cell proliferation during development MCB 21 5 1828 1832
    • (2001) MCB , vol.21 , Issue.5 , pp. 1828-1832
    • Ménissier-De Murcia, J.1    Mark, M.2    Wendling, O.3    Wynshaw-Boris, A.4    De Murcia, G.5
  • 37
    • 2342524565 scopus 로고    scopus 로고
    • Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks
    • 15021907 [abstract]
    • YG Yang U Cortes S Patnaik M Jasin Z Wang 2004 Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks Oncogene 23 3872 3882 15021907 [abstract]
    • (2004) Oncogene , vol.23 , pp. 3872-3882
    • Yang, Y.G.1    Cortes, U.2    Patnaik, S.3    Jasin, M.4    Wang, Z.5
  • 38
    • 0033539684 scopus 로고    scopus 로고
    • Syncytiotrophoblastic giant cells in Teratocarcinoma like tumors derived from Parp-disrupted mouse embryonic stem cells
    • 10557323
    • T Nozaki M Masutani M Watanabe, et al. 1999 Syncytiotrophoblastic giant cells in Teratocarcinoma like tumors derived from Parp-disrupted mouse embryonic stem cells PNAS 96 23 13345 13350 10557323
    • (1999) PNAS , vol.96 , Issue.23 , pp. 13345-13350
    • Nozaki, T.1    Masutani, M.2    Watanabe, M.3
  • 39
    • 0037178870 scopus 로고    scopus 로고
    • Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly (ADP-ribose) polymerase-1 protein and are poly (ADP-ribosyl) ated
    • 12011073
    • A Saxena R Saffery LH Wong, et al. 2002 Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly (ADP-ribose) polymerase-1 protein and are poly (ADP-ribosyl) ated J Biol Chem 277 26921 26926 12011073
    • (2002) J Biol Chem , vol.277 , pp. 26921-26926
    • Saxena, A.1    Saffery, R.2    Wong, L.H.3
  • 40
    • 0030031171 scopus 로고    scopus 로고
    • Overexpression of poly (ADP-ribose) polymerase promotes cell cycle arrest and inhibits neutrophilic differentiation of NB4 acute promyelocytic leukemia cells
    • 8788037
    • M Bhatia JB Kirkland KA Meckling-Gill 1996 Overexpression of poly (ADP-ribose) polymerase promotes cell cycle arrest and inhibits neutrophilic differentiation of NB4 acute promyelocytic leukemia cells Cell Growth Differ 7 1 91 100 8788037
    • (1996) Cell Growth Differ , vol.7 , Issue.1 , pp. 91-100
    • Bhatia, M.1    Kirkland, J.B.2    Meckling-Gill, K.A.3
  • 41
    • 0029070255 scopus 로고
    • Modulation of poly (ADP-ribose) polymerase during neutrophilic and monocytic differentiation of promyelocytic (NB4) and myelocytic (HL-60) leukaemia cells
    • M Bhatia JB Kirkland KA Meckling-Gill 1995 Modulation of poly (ADP-ribose) polymerase during neutrophilic and monocytic differentiation of promyelocytic (NB4) and myelocytic (HL-60) leukaemia cells J Biochem 308 131 137
    • (1995) J Biochem , vol.308 , pp. 131-137
    • Bhatia, M.1    Kirkland, J.B.2    Meckling-Gill, K.A.3
  • 42
    • 27644526152 scopus 로고    scopus 로고
    • Down-modulation of poly(ADP-ribose) polymerase-1 (PARP-1) in human TUR leukemia cells restores transcriptional responsiveness for differentiation and cell cycle arrest
    • 16323285 [abstract]
    • K Harnacke M Kruhoffer TF Orntoft R Hass 2005 Down-modulation of poly(ADP-ribose) polymerase-1 (PARP-1) in human TUR leukemia cells restores transcriptional responsiveness for differentiation and cell cycle arrest Eur J Cell Biol 84 11 885 896 16323285 [abstract]
    • (2005) Eur J Cell Biol , vol.84 , Issue.11 , pp. 885-896
    • Harnacke, K.1    Kruhoffer, M.2    Orntoft, T.F.3    Hass, R.4
  • 43
    • 0035796038 scopus 로고    scopus 로고
    • Involvement of poly(ADP-ribose) polymerase in trophoblastic cell differentiation during tumorigenesis
    • M Masutani T Nozaki M Watanabe, et al. 2001 Involvement of poly(ADP-ribose) polymerase in trophoblastic cell differentiation during tumorigenesis Mutant Res 477 111 117
    • (2001) Mutant Res , vol.477 , pp. 111-117
    • Masutani, M.1    Nozaki, T.2    Watanabe, M.3
  • 44
    • 15044344581 scopus 로고    scopus 로고
    • Genetic alteration of poly(ADP-ribose) polymerase-1 in human germ cell tumors
    • 15709096
    • M Shiokawa M Masutani H Fujihara, et al. 2005 Genetic alteration of poly(ADP-ribose) polymerase-1 in human germ cell tumors Jpn J Clin Oncol 35 2 97 102 15709096
    • (2005) Jpn J Clin Oncol , vol.35 , Issue.2 , pp. 97-102
    • Shiokawa, M.1    Masutani, M.2    Fujihara, H.3
  • 45
    • 1642368155 scopus 로고    scopus 로고
    • Expression and activity of poly(ADP-ribose) glycohydrolase in cultured astrocytes, neurons, and C6 glioma cells
    • 14559156 [abstract]
    • MB Sevigny JM Silva WC Lan CC Alano RA Swanson 2003 Expression and activity of poly(ADP-ribose) glycohydrolase in cultured astrocytes, neurons, and C6 glioma cells Mol Brain Res 117 2 213 220 14559156 [abstract]
    • (2003) Mol Brain Res , vol.117 , Issue.2 , pp. 213-220
    • Sevigny, M.B.1    Silva, J.M.2    Lan, W.C.3    Alano, C.C.4    Swanson, R.A.5
  • 46
    • 0038682011 scopus 로고    scopus 로고
    • PARP goes transcription
    • 12809599
    • W Kraus J Lis 2003 PARP goes transcription Cell 113 6 677 683 12809599
    • (2003) Cell , vol.113 , Issue.6 , pp. 677-683
    • Kraus, W.1    Lis, J.2
  • 47
    • 20144389926 scopus 로고    scopus 로고
    • PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator
    • [abstract]
    • R Pavri B Lewis TK Kim, et al. 2005 PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator Moll Cell 18 1 83 96 [abstract]
    • (2005) Moll Cell , vol.18 , Issue.1 , pp. 83-96
    • Pavri, R.1    Lewis, B.2    Kim, T.K.3
  • 48
    • 20444503830 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex
    • 15940627 [abstract]
    • M Idogawa T Yamada K Honda, et al. 2005 Poly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex Gastroenterology 128 7 1919 1936 15940627 [abstract]
    • (2005) Gastroenterology , vol.128 , Issue.7 , pp. 1919-1936
    • Idogawa, M.1    Yamada, T.2    Honda, K.3
  • 49
    • 0033536186 scopus 로고    scopus 로고
    • Regulation of the human poly(ADP-ribose) polymerase promoter by ETS transcription factor
    • 10435618
    • VA Soldatenkov A Albor BKR Patel, et al. 1999 Regulation of the human poly(ADP-ribose) polymerase promoter by ETS transcription factor Oncogene 18 27 3954 3962 10435618
    • (1999) Oncogene , vol.18 , Issue.27 , pp. 3954-3962
    • Soldatenkov, V.A.1    Albor, A.2    Patel, B.K.R.3
  • 51
    • 34250838558 scopus 로고    scopus 로고
    • A key role for poly (ADP-ribose)-1 during human dendritic cell maturation
    • A Aldinussi G Gerlini S Fossati, et al. 2007 A key role for poly (ADP-ribose)-1 during human dendritic cell maturation J Immuno 179 305 312
    • (2007) J Immuno , vol.179 , pp. 305-312
    • Aldinussi, A.1    Gerlini, G.2    Fossati, S.3
  • 52
    • 37849007576 scopus 로고    scopus 로고
    • Regulation of poly(ADP-ribose) polymerase-1 (PARP-1) gene expression through the post-translational modification of Sp1: A nuclear target protein of PARP-1
    • 10.1186/1471-2199-8-96
    • K Zaniolo S Desnoyers S Leclerc S Guérin 2007 Regulation of poly(ADP-ribose) polymerase-1 (PARP-1) gene expression through the post-translational modification of Sp1: a nuclear target protein of PARP-1 BMC Genomics 8 96 10.1186/1471-2199-8-96
    • (2007) BMC Genomics , vol.8 , pp. 96
    • Zaniolo, K.1    Desnoyers, S.2    Leclerc, S.3    Guérin, S.4
  • 53
    • 0035012606 scopus 로고    scopus 로고
    • DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression
    • 11359911
    • WM Tong MP Hande PM Lansdorp ZQ Wang 2001 DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression Mol Cell Biol 21 12 4046 4054 11359911
    • (2001) Mol Cell Biol , vol.21 , Issue.12 , pp. 4046-4054
    • Tong, W.M.1    Hande, M.P.2    Lansdorp, P.M.3    Wang, Z.Q.4
  • 54
    • 0037223273 scopus 로고    scopus 로고
    • Medulloblastoma in mice lacking p53 and PARP
    • 12507884
    • CG Eberhart 2003 Medulloblastoma in mice lacking p53 and PARP Am J Pathol 162 1 7 10 12507884
    • (2003) Am J Pathol , vol.162 , Issue.1 , pp. 7-10
    • Eberhart, C.G.1
  • 55
    • 20644432426 scopus 로고    scopus 로고
    • Regulation of RNA polymerase II-dependent transcription by poly(ADP- ribosyl)ation of transcription factors
    • DOI 10.1074/jbc.273.48.31644
    • SL Oei J Griesenbeck M Schweiger M Ziegler 1998 Regulation of RNA polymerase II-dependent transcription by poly(ADP-ribosyl)ation of transcription factors JBC 273 31644 31647 (Pubitemid 29177091)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.48 , pp. 31644-31647
    • Oei, S.L.1    Griesenbeck, J.2    Schweiger, M.3    Ziegler, M.4
  • 56
    • 0242496900 scopus 로고    scopus 로고
    • Transcriptional coactivation of nuclear factor Kappa B-dependent gene expression by p300 is regulated by poly (ADP)-ribose polymerase-1
    • PO Hassa C Buerki C Lombardi R Imhof MO Hottiger 2003 Transcriptional coactivation of nuclear factor Kappa B-dependent gene expression by p300 is regulated by poly (ADP)-ribose polymerase-1 JBC 278 46 45145 45153
    • (2003) JBC , vol.278 , Issue.46 , pp. 45145-45153
    • Hassa, P.O.1    Buerki, C.2    Lombardi, C.3    Imhof, R.4    Hottiger, M.O.5
  • 57
    • 0032489545 scopus 로고    scopus 로고
    • Interaction of Oct-1 and automodification domain of poly (ADP-ribose) synthetase
    • 9537509
    • J Nie S Sakamoto D Song Z Qu K Ota T Taniguchi 1998 Interaction of Oct-1 and automodification domain of poly (ADP-ribose) synthetase FEBS Lett 424 1-2 27 32 9537509
    • (1998) FEBS Lett , vol.424 , Issue.12 , pp. 27-32
    • Nie, J.1    Sakamoto, S.2    Song, D.3    Qu, Z.4    Ota, K.5    Taniguchi, T.6
  • 58
    • 0030940546 scopus 로고    scopus 로고
    • Identification of interaction partners for the basic-helix-loop-helix protein E47
    • 9050988
    • TN Dear T Hainzl M Follo 1997 Identification of interaction partners for the basic-helix-loop-helix protein E47 Oncogene 14 891 898 9050988
    • (1997) Oncogene , vol.14 , pp. 891-898
    • Dear, T.N.1    Hainzl, T.2    Follo, M.3
  • 59
    • 0032959888 scopus 로고    scopus 로고
    • Poly (ADP-Ribose) polymerase binds with transcription enhancer factor 1 to MCAT1 elements to regulate muscle-specific transcription
    • AJ Butler CP Ordhal 1999 Poly (ADP-Ribose) polymerase binds with transcription enhancer factor 1 to MCAT1 elements to regulate muscle-specific transcription Mol Cell Boil 19 1 296 306
    • (1999) Mol Cell Boil , vol.19 , Issue.1 , pp. 296-306
    • Butler, A.J.1    Ordhal, C.P.2
  • 60
    • 0019995276 scopus 로고
    • Participation of poly(ADP-ribosyl)ation in the depression of RNA synthesis caused by treatment of mouse lymphoma cells with methylnitrosourea
    • T Taniguchi M Agemori I Kameshita M Nishikimi Y Shizuta 1982 Participation of poly(ADP-ribosyl)ation in the depression of RNA synthesis caused by treatment of mouse lymphoma cells with methylnitrosourea J BC 257 4027 4030
    • (1982) J BC , vol.257 , pp. 4027-4030
    • Taniguchi, T.1    Agemori, M.2    Kameshita, I.3    Nishikimi, M.4    Shizuta, Y.5
  • 61
    • 0032755520 scopus 로고    scopus 로고
    • Isolation and cloning of rat poly (ADP-ribose) glycohydrolase: Presence of a potential nuclear export signal conserved in mammalian orthologs
    • 10502684
    • T Shimokawa M Masutani S Nagasawa, et al. 1999 Isolation and cloning of rat poly (ADP-ribose) glycohydrolase: presence of a potential nuclear export signal conserved in mammalian orthologs J. Biochem 126 748 755 10502684
    • (1999) J. Biochem , vol.126 , pp. 748-755
    • Shimokawa, T.1    Masutani, M.2    Nagasawa, S.3
  • 62
    • 23944439186 scopus 로고    scopus 로고
    • Gallotannin inhibits the expression of chemokines and inflammatory cytokines in A549 cells
    • 15976037
    • K Erdelyi A Kiss E Bankondi, et al. 2005 Gallotannin inhibits the expression of chemokines and inflammatory cytokines in A549 cells Mol Pharmacol 68 895 904 15976037
    • (2005) Mol Pharmacol , vol.68 , pp. 895-904
    • Erdelyi, K.1    Kiss, A.2    Bankondi, E.3
  • 63
    • 71749119589 scopus 로고    scopus 로고
    • Global analysis of transcriptional regulation by poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in MCF-7 human breast cancer cells
    • 19812418 [abstract]
    • KM Frizzell MJ Gamble JG Berrocal 2009 Global analysis of transcriptional regulation by poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in MCF-7 human breast cancer cells J Biol Chem 284 49 33926 33938 19812418 [abstract]
    • (2009) J Biol Chem , vol.284 , Issue.49 , pp. 33926-33938
    • Frizzell, K.M.1    Gamble, M.J.2    Berrocal, J.G.3
  • 64
    • 0030984490 scopus 로고    scopus 로고
    • PARP is important for genomic stability but dispensable in? Apoptosis
    • 9308963
    • ZQ Wang L Stingl C Morrison, et al. 1997 PARP is important for genomic stability but dispensable in? Apoptosis Genes Dev 11 2347 2358 9308963
    • (1997) Genes Dev , vol.11 , pp. 2347-2358
    • Wang, Z.Q.1    Stingl, L.2    Morrison, C.3
  • 65
    • 0036984640 scopus 로고    scopus 로고
    • Role of angiogenesis in tumor growth and metastasis
    • 12516034
    • J Folkman 2002 Role of angiogenesis in tumor growth and metastasis Semin Oncol 29 15 18 12516034
    • (2002) Semin Oncol , vol.29 , pp. 15-18
    • Folkman, J.1
  • 66
    • 34548514842 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase (PARP) inhibition or PARP-1 gene deletion reduces angiogenesis
    • 17714938
    • L Tentori PM Lacal A Muzi, et al. 2007 Poly(ADP-ribose) polymerase (PARP) inhibition or PARP-1 gene deletion reduces angiogenesis Eur J Cancer 43 14 2124 2133 17714938
    • (2007) Eur J Cancer , vol.43 , Issue.14 , pp. 2124-2133
    • Tentori, L.1    Lacal, P.M.2    Muzi, A.3
  • 67
    • 46749119301 scopus 로고    scopus 로고
    • Inhibition of angiogenesis by the poly (ADP-ribose) polymerase inhibitor PJ-34
    • A Pyriochou G Olah EA Deitch C Szabo A Papapetropoulos 2008 Inhibition of angiogenesis by the poly (ADP-ribose) polymerase inhibitor PJ-34 IJMM 22 113 118
    • (2008) IJMM , vol.22 , pp. 113-118
    • Pyriochou, A.1    Olah, G.2    Deitch, E.A.3    Szabo, C.4    Papapetropoulos, A.5
  • 68
    • 33749347804 scopus 로고    scopus 로고
    • Pharmacological inhibition of poly (ADP-ribose) polymerase inhibits angiogenesis
    • 17007818
    • M Rajesh P Mukhopadhyay S Bátkai, et al. 2006 Pharmacological inhibition of poly (ADP-ribose) polymerase inhibits angiogenesis BBRC 350 2 352 357 17007818
    • (2006) BBRC , vol.350 , Issue.2 , pp. 352-357
    • Rajesh, M.1    Mukhopadhyay, P.2    Bátkai, S.3
  • 69
    • 33750046338 scopus 로고    scopus 로고
    • Poly (ADP-ribose) polymerase inhibition decreases angiogenesis
    • 17046715
    • M Rajesh P Mukhopadhyay G Godlewski 2006 Poly (ADP-ribose) polymerase inhibition decreases angiogenesis BBRC 350 4 1056 1062 17046715
    • (2006) BBRC , vol.350 , Issue.4 , pp. 1056-1062
    • Rajesh, M.1    Mukhopadhyay, P.2    Godlewski, G.3
  • 70
    • 0018149712 scopus 로고
    • Synthesis of DNA and poly (Adenosine Diphosphate Ribose) in normal and chronic lymphocytic leukemia lymphocytes
    • NA Berger JW Adams GW Sikorski, et al. 1978 Synthesis of DNA and poly (Adenosine Diphosphate Ribose) in normal and chronic lymphocytic leukemia lymphocytes J Clin Inves 62 111 118
    • (1978) J Clin Inves , vol.62 , pp. 111-118
    • Berger, N.A.1    Adams, J.W.2    Sikorski, G.W.3
  • 71
    • 0019151522 scopus 로고
    • ADP-ribosylation of nuclear proteins in normal lymphocytes and in low- grade malignant non-Hodgkin lymphoma cells
    • 6245868
    • K Wielckens M Garbrecht M Kittler H Hilz 1980 ADP-ribosylation of nuclear proteins in normal lymphocytes and in low- grade malignant non-Hodgkin lymphoma cells Eur J Biochem 104 279 287 6245868
    • (1980) Eur J Biochem , vol.104 , pp. 279-287
    • Wielckens, K.1    Garbrecht, M.2    Kittler, M.3    Hilz, H.4
  • 72
    • 0020621890 scopus 로고
    • Abberation of poly (adenosine diphosphate ribose) in human colon adenomatous polyps and cancers
    • 6406058
    • K Hirai K Ueda O Hayaishi 1983 Abberation of poly (adenosine diphosphate ribose) in human colon adenomatous polyps and cancers Cancer Res 43 3441 3446 6406058
    • (1983) Cancer Res , vol.43 , pp. 3441-3446
    • Hirai, K.1    Ueda, K.2    Hayaishi, O.3
  • 73
    • 0019788529 scopus 로고
    • Poly (ADP-ribose) synthesis in human cervical cancer cell diagnostic cytological usefulness
    • 6277470
    • M Fukushima OK Kuzuya K Ikai 1981 Poly (ADP-ribose) synthesis in human cervical cancer cell diagnostic cytological usefulness Cancer Lett 14 227 236 6277470
    • (1981) Cancer Lett , vol.14 , pp. 227-236
    • Fukushima, M.1    Kuzuya, O.K.2    Ikai, K.3
  • 74
    • 0035029463 scopus 로고    scopus 로고
    • Enhanced polyadenosine diphosphate ribosylation in cirrhotic liver and carcinoma tissues in patients with hepatocellular carcinoma
    • 11339428
    • M Shiobara M Miyazaki H Ito, et al. 2001 Enhanced polyadenosine diphosphate ribosylation in cirrhotic liver and carcinoma tissues in patients with hepatocellular carcinoma J Gastroenterol Hepatol 16 338 344 11339428
    • (2001) J Gastroenterol Hepatol , vol.16 , pp. 338-344
    • Shiobara, M.1    Miyazaki, M.2    Ito, H.3
  • 75
    • 67449162124 scopus 로고    scopus 로고
    • Relationship of PARG with colorectal carcinoma PARP, VEGF and b-FGF in colorectal carcinoma
    • L Lin J Li YL Wang, et al. 2009 Relationship of PARG with colorectal carcinoma PARP, VEGF and b-FGF in colorectal carcinoma Chin J Cancer Res 21 2 135 141
    • (2009) Chin J Cancer Res , vol.21 , Issue.2 , pp. 135-141
    • Lin, L.1    Li, J.2    Wang, Y.L.3
  • 76
    • 67349218363 scopus 로고    scopus 로고
    • PARP inhibitors: New partners in the therapy of cancer and inflammatory diseases
    • (in press). Doi:10.1016
    • Leal AP et al (2009) PARP inhibitors: New partners in the therapy of cancer and inflammatory diseases. Free Radic Biol Med (in press). Doi:10.1016
    • (2009) Free Radic Biol Med
    • Leal, A.P.1
  • 77
    • 84954358647 scopus 로고    scopus 로고
    • A high-throughput RNA interference screen for DNA repair determinants of PARP inhibitor sensitivity
    • CJ Lord S McDonald S Swift, et al. 2008 A high-throughput RNA interference screen for DNA repair determinants of PARP inhibitor sensitivity DNA Repair (Amst) 7 2010 2019
    • (2008) DNA Repair (Amst) , vol.7 , pp. 2010-2019
    • Lord, C.J.1    McDonald, S.2    Swift, S.3
  • 78
    • 43249085571 scopus 로고    scopus 로고
    • A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor
    • 18388863
    • NC Turner CJ Lord E Iorns, et al. 2008 A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor EMBO J 27 9 1368 1377 18388863
    • (2008) EMBO J , vol.27 , Issue.9 , pp. 1368-1377
    • Turner, N.C.1    Lord, C.J.2    Iorns, E.3
  • 79
    • 49249119415 scopus 로고    scopus 로고
    • A synthetic lethal therapeutic approach: Poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair
    • 18591545
    • A Ashworth 2008 A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair J Clin Oncol 26 22 3785 3790 18591545
    • (2008) J Clin Oncol , vol.26 , Issue.22 , pp. 3785-3790
    • Ashworth, A.1
  • 80
    • 17244375049 scopus 로고    scopus 로고
    • Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
    • 15829966 [abstract]
    • HE Bryant N Schultz HD Thomas, et al. 2005 Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase Nature 434 913 917 15829966 [abstract]
    • (2005) Nature , vol.434 , pp. 913-917
    • Bryant, H.E.1    Schultz, N.2    Thomas, H.D.3
  • 81
    • 21644482340 scopus 로고    scopus 로고
    • Targeting the DNA repair defect of BRCA tumours
    • 15955736
    • N Turner A Tutt A Ashworth 2005 Targeting the DNA repair defect of BRCA tumours Curr Opin Pharmacol 5 4 388 393 15955736
    • (2005) Curr Opin Pharmacol , vol.5 , Issue.4 , pp. 388-393
    • Turner, N.1    Tutt, A.2    Ashworth, A.3
  • 82
    • 33745867950 scopus 로고    scopus 로고
    • The inhibition and treatment of breast cancer with poly (ADP-ribose) polymerase (PARP-1) inhibitors
    • 16810332
    • JA De Soto X Wang Y Tominaga, et al. 2006 The inhibition and treatment of breast cancer with poly (ADP-ribose) polymerase (PARP-1) inhibitors Int J Biol Sci 2 4 179 185 16810332
    • (2006) Int J Biol Sci , vol.2 , Issue.4 , pp. 179-185
    • De Soto, J.A.1    Wang, X.2    Tominaga, Y.3
  • 83
    • 33749316516 scopus 로고    scopus 로고
    • PARP-1 inhibitors: Are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers?
    • 16906222
    • JA De Soto CX Deng 2006 PARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers? Int J Med Sci 3 4 117 123 16906222
    • (2006) Int J Med Sci , vol.3 , Issue.4 , pp. 117-123
    • De Soto, J.A.1    Deng, C.X.2
  • 84
    • 31044446360 scopus 로고    scopus 로고
    • PARP inhibitors for cancer therapy
    • 15836799 [abstract]
    • NJ Curtin 2005 PARP inhibitors for cancer therapy Expert Rev Mol Med 7 4 1 20 15836799 [abstract]
    • (2005) Expert Rev Mol Med , vol.7 , Issue.4 , pp. 1-20
    • Curtin, N.J.1
  • 85
    • 54249167431 scopus 로고    scopus 로고
    • Potentiation of temozolomide cytotoxicity by poly(ADP)ribose polymerase inhibitor ABT-888 requires a conversion of single stranded DNA damages to double-stranded DNA breaks
    • 18922977
    • X Liu Y Shi R Guan, et al. 2008 Potentiation of temozolomide cytotoxicity by poly(ADP)ribose polymerase inhibitor ABT-888 requires a conversion of single stranded DNA damages to double-stranded DNA breaks Mol Cancer Res 6 10 1621 1629 18922977
    • (2008) Mol Cancer Res , vol.6 , Issue.10 , pp. 1621-1629
    • Liu, X.1    Shi, Y.2    Guan, R.3
  • 86
    • 1342285197 scopus 로고    scopus 로고
    • Poly (ADP-ribose) polymerase (PARP-1) and P53 independently function in regulating double strand break repair in primate cells
    • S Suesse CJ Scholz A Buerkle LW Iler 2004 Poly (ADP-ribose) polymerase (PARP-1) and P53 independently function in regulating double strand break repair in primate cells Nucleic Acids Res 32 2669 2680
    • (2004) Nucleic Acids Res , vol.32 , pp. 2669-2680
    • Suesse, S.1    Scholz, C.J.2    Buerkle, A.3    Iler, L.W.4
  • 87
    • 0018990986 scopus 로고
    • Novel inhibitors of poly (ADP-ribose) synthetase
    • MR Purnell WJD Whish 1980 Novel inhibitors of poly (ADP-ribose) synthetase J Biochem 185 775 777
    • (1980) J Biochem , vol.185 , pp. 775-777
    • Purnell, M.R.1    Whish, W.J.D.2
  • 88
    • 0026601666 scopus 로고
    • Specific inhibitors of poly (ADP-ribose) synthetase and mono(ADP-ribosyl) transferase
    • 1530940
    • M Banasik H Komura M Shimoyama K Ueda 1992 Specific inhibitors of poly (ADP-ribose) synthetase and mono(ADP-ribosyl) transferase J Biol Chem 267 1569 1575 1530940
    • (1992) J Biol Chem , vol.267 , pp. 1569-1575
    • Banasik, M.1    Komura, H.2    Shimoyama, M.3    Ueda, K.4
  • 89
    • 2942558562 scopus 로고    scopus 로고
    • Treatment with a novel poly(ADP-ribose) glycohydrolase inhibitor reduces development of septic shock-like syndrome induced by zymosan in mice
    • 15187521
    • T Genovese R Di Paola P Catalano, et al. 2004 Treatment with a novel poly(ADP-ribose) glycohydrolase inhibitor reduces development of septic shock-like syndrome induced by zymosan in mice Crit Care Med 32 6 1365 1374 15187521
    • (2004) Crit Care Med , vol.32 , Issue.6 , pp. 1365-1374
    • Genovese, T.1    Di Paola, R.2    Catalano, P.3
  • 91
    • 57349108170 scopus 로고    scopus 로고
    • Mono-galloyl glucose derivatives are potent poly(ADP-ribose) glycohydrolase (PARG) inhibitors and partially reduced PARP-1 dependent cell death
    • L Formentini P Arapistas M Pitelli, et al. 2008 Mono-galloyl glucose derivatives are potent poly(ADP-ribose) glycohydrolase (PARG) inhibitors and partially reduced PARP-1 dependent cell death BJP 155 1235 1249
    • (2008) BJP , vol.155 , pp. 1235-1249
    • Formentini, L.1    Arapistas, P.2    Pitelli, M.3
  • 92
    • 0032947513 scopus 로고    scopus 로고
    • BRCA1 and BRCA2 in breast cancer
    • 10369075
    • X Yang ME Lippman 1999 BRCA1 and BRCA2 in breast cancer Breast Cancer Res Treat 54 1 1 10 10369075
    • (1999) Breast Cancer Res Treat , vol.54 , Issue.1 , pp. 1-10
    • Yang, X.1    Lippman, M.E.2
  • 93
    • 33745867950 scopus 로고    scopus 로고
    • The inhibition and treatment of breast cancer with poly (ADP-ribose) polymerase (PARP-1) inhibitors
    • 16810332
    • JA De Soto X Wang Y Tominaga, et al. 2006 The inhibition and treatment of breast cancer with poly (ADP-ribose) polymerase (PARP-1) inhibitors Int J Biol Sci 2 4 179 185 16810332
    • (2006) Int J Biol Sci , vol.2 , Issue.4 , pp. 179-185
    • De Soto, J.A.1    Wang, X.2    Tominaga, Y.3
  • 94
    • 14244258961 scopus 로고    scopus 로고
    • PARP inhibition sensitizes p53-deficient breast cancer cells to doxorubicin-induced apoptosis
    • JA Munozo-Gamez D Martin-Olivia R Aguilar-Quesada 2005 PARP inhibition sensitizes p53-deficient breast cancer cells to doxorubicin-induced apoptosis Biochem J 386 119 125
    • (2005) Biochem J , vol.386 , pp. 119-125
    • Munozo-Gamez, J.A.1    Martin-Olivia, D.2    Aguilar-Quesada, R.3
  • 95
    • 55949092708 scopus 로고    scopus 로고
    • High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs
    • 18971340
    • S Rottenberg JE Jaspers A Kersbergen, et al. 2008 High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs PNAS 105 44 17079 17084 18971340
    • (2008) PNAS , vol.105 , Issue.44 , pp. 17079-17084
    • Rottenberg, S.1    Jaspers, J.E.2    Kersbergen, A.3
  • 97
    • 34249784216 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models
    • 17505006
    • JM Albert C Cao KW Kim, et al. 2007 Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models Clin Cancer Res 13 10 3033 3042 17505006
    • (2007) Clin Cancer Res , vol.13 , Issue.10 , pp. 3033-3042
    • Albert, J.M.1    Cao, C.2    Kim, K.W.3
  • 98
    • 58149263490 scopus 로고    scopus 로고
    • Preclinical modeling of a phase 0 clinical trial: Qualification of a pharmacodynamic assay of poly (ADP-ribose) polymerase in tumor biopsies of mouse xenografts
    • 18980982
    • RJ Kinders M Hollingshead S Khin, et al. 2008 Preclinical modeling of a phase 0 clinical trial: qualification of a pharmacodynamic assay of poly (ADP-ribose) polymerase in tumor biopsies of mouse xenografts Clin Cancer Res 14 21 6877 6885 18980982
    • (2008) Clin Cancer Res , vol.14 , Issue.21 , pp. 6877-6885
    • Kinders, R.J.1    Hollingshead, M.2    Khin, S.3
  • 99
    • 34249006299 scopus 로고    scopus 로고
    • ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models
    • 17473206
    • CK Donawho Y Luo TD Penning, et al. 2007 ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models Clin Cancer Res 13 9 2728 2737 17473206
    • (2007) Clin Cancer Res , vol.13 , Issue.9 , pp. 2728-2737
    • Donawho, C.K.1    Luo, Y.2    Penning, T.D.3
  • 100
    • 12444276597 scopus 로고    scopus 로고
    • Identification of potent nontoxic poly (ADP-ribose) polymerase-1 inhibitors: Chemopotentiation and pharmacological studies
    • 12855651
    • CR Calabrese MA Batey HD Thomas 2003 Identification of potent nontoxic poly (ADP-ribose) polymerase-1 inhibitors: chemopotentiation and pharmacological studies Clin Cancer Res 9 2711 2718 12855651
    • (2003) Clin Cancer Res , vol.9 , pp. 2711-2718
    • Calabrese, C.R.1    Batey, M.A.2    Thomas, H.D.3
  • 101
    • 67649575928 scopus 로고    scopus 로고
    • Inhibitory effect of 5-Aminoisoquinolinone on Parp activity in colon carcinoma cell line HT-29
    • LX Hao YL Wang L Cai LI YY 2007 Inhibitory effect of 5- Aminoisoquinolinone on Parp activity in colon carcinoma cell line HT-29 Chin J Cancer 26 6 566 571
    • (2007) Chin J Cancer , vol.26 , Issue.6 , pp. 566-571
    • Hao, L.X.1    Wang, Y.L.2    Cai, L.3    I, Y.Y.L.4
  • 102
    • 67649592959 scopus 로고    scopus 로고
    • A poly (ADP-ribose) polymerase inhibition down-regulates expression of metastasis-related genes in CT26 colon carcinoma cells
    • 19468250
    • M Li MD Threadgill YL Wang L Cai X Lin 2009 A poly (ADP-ribose) polymerase inhibition down-regulates expression of metastasis-related genes in CT26 colon carcinoma cells Pathobiology 76 108 116 19468250
    • (2009) Pathobiology , vol.76 , pp. 108-116
    • Li, M.1    Threadgill, M.D.2    Wang, Y.L.3    Cai, L.4    Lin, X.5
  • 103
    • 0037220314 scopus 로고    scopus 로고
    • Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (ADP-ribose) polymerase inhibitor
    • 12488552
    • L Tentori I Portarena M Barbarino, et al. 2003 Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (ADP-ribose) polymerase inhibitor Mol Pharmacol 63 192 202 12488552
    • (2003) Mol Pharmacol , vol.63 , pp. 192-202
    • Tentori, L.1    Portarena, I.2    Barbarino, M.3
  • 104
    • 10744233684 scopus 로고    scopus 로고
    • Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma
    • 14614022
    • L Tentori C Leonetti M Scarsella, et al. 2003 Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma Clin Cancer Res 9 5370 5379 14614022
    • (2003) Clin Cancer Res , vol.9 , pp. 5370-5379
    • Tentori, L.1    Leonetti, C.2    Scarsella, M.3
  • 105
    • 28244465243 scopus 로고    scopus 로고
    • Poly(ADP-ribose) glycohydrolase inhibitor as chemosensitiser of malignant melanoma for temozolomide
    • 16288862
    • L Tentori C Leonetti M Scarsella, et al. 2005 Poly(ADP-ribose) glycohydrolase inhibitor as chemosensitiser of malignant melanoma for temozolomide Eur J Cancer 41 18 2948 2957 16288862
    • (2005) Eur J Cancer , vol.41 , Issue.18 , pp. 2948-2957
    • Tentori, L.1    Leonetti, C.2    Scarsella, M.3
  • 106
    • 68849126662 scopus 로고    scopus 로고
    • Enhanced radiosensitisation of human glioma cells by combining inhibition of PARP with inhibition of Hsp90
    • 19671736
    • FA Dungey KW Caldecott AJ Chalmers 2009 Enhanced radiosensitisation of human glioma cells by combining inhibition of PARP with inhibition of Hsp90 Mol Cancer Ther 8 8 2243 2254 19671736
    • (2009) Mol Cancer Ther , vol.8 , Issue.8 , pp. 2243-2254
    • Dungey, F.A.1    Caldecott, K.W.2    Chalmers, A.J.3
  • 107
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
    • 19553641
    • PC Fong DS Boss TA Yap, et al. 2009 Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers N Engl J Med 361 123 134 19553641
    • (2009) N Engl J Med , vol.361 , pp. 123-134
    • Fong, P.C.1    Boss, D.S.2    Yap, T.A.3
  • 108
    • 78149370970 scopus 로고    scopus 로고
    • The emerging role of PARP inhibitors in the treatment of epithelial ovarian cancer
    • 10.1155/2010/151750 20049345
    • LT Gien HJ Mackay 2010 The emerging role of PARP inhibitors in the treatment of epithelial ovarian cancer J Oncol 10.1155/2010/151750 20049345
    • (2010) J Oncol
    • Gien, L.T.1    MacKay, H.J.2


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