Treatment with a novel poly(ADP-ribose) glycohydrolase inhibitor reduces development of septic shock-like syndrome induced by zymosan in mice

Critical Care Medicine

Volumn 32, Issue 6, 2004, Pages 1365-1374

  Genovese, Tiziana ^a   Di Paola, Rosanna ^a   Catalano, Paolo ^a   Li, Jia He ^b   Xu, Weizheng ^c   Massuda, Edmond ^c   Caputi, Achille P ^a   Zhang, Jie ^c   Cuzzocrea, Salvatore ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b Lilium Pharmaceuticals   (United States)

^c GUILFORD PHARMACEUTICALS INC   (United States)

Author keywords

Neytrophil infiltration; Organ injury; Poly(ADP ribose) glycohydrolase inhibitor; Zymosan induced multiple organ failure

Indexed keywords

GLUCOSIDASE; GLYCOSIDASE INHIBITOR; GPI 18214; INTERLEUKIN 1BETA; POLY(ADENOSINE DIPHOSPHATE RIBOSE); POLY(ADENOSINE DIPHOSPHATE RIBOSE)GLYCOHYDROLASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ZYMOSAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; ENZYME INHIBITION; IC 50; ILEUM; INFLAMMATION; LEUKOCYTE; LIPID PEROXIDATION; LUNG PARENCHYMA; MALE; MORTALITY; MOUSE; MULTIPLE ORGAN FAILURE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PERITONEAL CAVITY; PERITONEUM EXUDATE; PRIORITY JOURNAL; SEPTIC SHOCK; TOXICITY; WEIGHT REDUCTION;

ACUTE DISEASE; AMIDES; ANIMALS; GLYCOSIDE HYDROLASES; INTERLEUKIN-1; MALE; MALONDIALDEHYDE; MICE; MICE, INBRED STRAINS; MULTIPLE ORGAN FAILURE; PERITONITIS; PEROXIDASE; SHOCK, SEPTIC; TANNINS; TUMOR NECROSIS FACTOR-ALPHA; ZYMOSAN;

EID: 2942558562     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000127775.70867.0C     Document Type: Article

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