Isolation and cloning of rat poly(ADP-ribose) glycohydrolase: Presence of a potential nuclear export signal conserved in mammalian orthologs

Journal of Biochemistry

Volumn 126, Issue 4, 1999, Pages 748-755

  Shimokawa, Takashi ^a,b   Masutani, Mitsuko ^a   Nagasawa, Shingo ^a,d   Nozaki, Tadashige ^a   Ikota, Nobuo ^c   Aoki, Yoshiro ^b   Nakagama, Hitoshi ^a   Sugimura, Takashi ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^d Yanaihara Institute Inc   (Japan)

Author keywords

ADP ribose; NES; NLS; Poly(ADP ribose) glycohydrolase; Rat testis

Indexed keywords

COMPLEMENTARY DNA; GLUTATHIONE TRANSFERASE; GLYCOSIDASE; HYBRID PROTEIN; MESSENGER RNA; NUCLEOTIDE; PEPTIDE FRAGMENT; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PRIMER DNA;

AFFINITY CHROMATOGRAPHY; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME PURIFICATION; ESCHERICHIA COLI; GENE EXPRESSION; INTRACELLULAR TRANSPORT; NONHUMAN; NORTHERN BLOTTING; NUCLEAR LOCALIZATION SIGNAL; PROTEIN DOMAIN; RAT; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; TESTIS; TRANSCRIPTION REGULATION;

ESCHERICHIA COLI; MAMMALIA;

EID: 0032755520     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a022512     Document Type: Article

References (38)

1. Chambon, P., Wei, J.D., Doly, J., Strosser, M.T., and Mandel, P. (1966) On the formation of a novel adenylic compound by enzymatic extracts of liver nuclei. Biochem. Biophys. Res. Commun. 25, 638-643
2. Sugimura, T., Fujimura, S., Hasegawa, S., and Kawamura, Y. (1967) Polymerization of the adenosine 5′-diphosphate ribose moiety of NAD by rat liver nuclear enzyme. Biochim. Biophys. Acta 138, 438-441
3. Nishizuka, Y., Ueda, K., Nakazawa, K., and Hayaishi, O. (1967) Studies on the polymer of adenosine diphosphate ribose. I. Enzymic formation from nicotinamide adenine dinucleotide in mammalian nuclei. J. Biol. Chem. 242, 3164-3171
4. Heller, B., Wang, Z.Q., Wagner, E.F., Radons, J., Bürkle, A., Fehsel, K., Burkart, V., and Kolb, H. (1995) Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells. J. Biol. Chem. 270, 11176-11180
5. Wang, Z.Q., Stingl, L., Morrison, C., Jantsch, M., Los, M., Schulze-Osthoff, K., and Wagner, E.F. (1997) PARPis important for genomic stability but dispensable in apoptosis. Genes Dev. 11, 2347-2358
6. de Murcia, J.M., Niedergang, C., Trucco, C., Ricoul, M., Dutrillaux, B., Mark, M., Oliver, F.J., Masson, M., Dierich, A., LeMeur, M., Walztinger, C., Chambon, P., and de Murcia, G. (1997) Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc. Natl. Acad. Sci. USA 94, 7303-7307
7. Eliasson, M.J., Sampei, K., Mandir, A.S., Hurn, P.D., Traystman, R.J., Bao, J., Pieper, A., Wang, Z.Q., Dawson, T.M., Snyder, S.H., and Dawson, V.L. (1997) Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nat. Med. 3, 1089-1095
8. Masutani, M., Nozaki, T., Nishiyama, E., Shimokawa, T., Tachi, Y., Suzuki, H., Nakagama, H., Wakabayashi, K., and Sugimura, T. (1999) Function of poly(ADP-ribose) polymerase in response to DNA damage: gene-desruption study in mice. Mol. Cell. Biochem. 193, 149-152
9. Masutani, M., Suzuki, H., Kamada, N., Watanabe, M., Ueda, O., Nozaki, T., Jishage, K., Watanabe, T., Sugimoto, T., Nakagama, H., Ochiya, T., and Sugimura, T. (1999) Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes. Proc. Natl. Acad. Sci. USA 96, 2301-2304
10. Miwa, M. and Sugimura, T. (1971) Splitting of the ribose-ribose linkage of poly(adenosine diphosphate-ribose) by calf thymus extract. J. Biol. Chem. 246, 6362-6364
11. Ueda, K., Oka, J., Narumiya, S., Miyakawa, N., and Hayaishi, O. (1972) Poly ADP-ribose glycohydrolase from rat liver nuclei, a novel enzyme degrading the polymer. Biochem. Biophys. Res. Commun. 46, 516-523
12. n glycohydrolase in human erythrocytes. Biochem. Biophys. Res. Commun. 136, 1110-1115
13. Burzio, L.O., Riquelme, P.T., Ohtsuka, E., and Koide, S.S. (1976) Evidence for two variants of poly(adenosine diphosphate ribose) glycohydrolase in rat testis. Arch. Biochem. Biophys. 173, 306-319
14. Abe, H. and Tanuma, S. (1996) Properties of poly(ADP-ribose) glycohydrolase purified from pig testis nuclei. Arch. Biochem. Biophys. 336, 139-146
15. Lin, W., Ame, J.C., Aboul-Ela, N., Jacobson, E.L., and Jacobson, M.K. (1997) Isolation and characterization of the cDNA encoding bovine poly(ADP-ribose) glycohydrolase. J. Biol. Chem. 272, 11895-11901
16. Shimokawa, T., Masutani, M., Nozaki, T., Nakagama, H., Araki, S., Aoki, Y., and Sugimura, T. (1998) The human poly(ADP-ribose) glycohydrolase maps to chromosome 10q11.23-21.1 by fluorescence in situ hybridization. Human Cell 11, 243-246
17. Shimokawa, T., Masutani, M., Ishiguro, Y., Araki, S., Aoki, Y., Nakagama, H., and Sugimura, T. (1999) Linkage mapping of the rat poly(ADP-ribose) glycohydrolase (Parg) gene to chromosome 16. Exp. Anim. 48, 217-218
18. Winstall, E., Affar, E.B., Shah, R., Bourassa, S., Scovassi, A.I., and Poirier, G.G. (1999) Poly(ADP-ribose) glycohydrolase is present and active in mammalian cells as a 110-kDa protein. Exp. Cell Res. 246, 395-398
19. Wen, W., Meinkoth, J.L., Tsien, R.Y., and Taylor, S.S. (1995) Identification of a signal for rapid export of proteins from the nucleus. Cell 82, 463-473
20. Stommel, J.M., Marchenko, N.D., Jimenez, G.S., Moll, U.M., Hope, T.J., and Wahl, G.M. (1999) A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking. EMBO J. 18, 1660-1672
21. Roth, J., Dobbelstein, M., Freedman, D.A., Shenk, T., and Levine, A.J. (1998) Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein. EMBO J. 17, 554-564
22. Fischer, U., Huber, J., Boelens, W.C., Mattaj, I.W., and Luhrmann, R. (1995) The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs. Cell 82, 475-483
23. Ikejima, M., Noguchi, S., Yamashita, R., Suzuki, H., Sugimura, T., and Miwa, M. (1989) Expression of human poly(ADP-ribose) polymerase with DNA-dependent enzymatic activity in Escherichia coli. Biochem. Biophys. Res. Commun. 163, 739-745
24. Miwa, M. and Sugimura, T. (1984) Structure of poly(ADP-ribose). Methods Enzymol. 106, 441-450
25. Keith, G., Desgres, J., and de Murcia, G. (1990) Use of two-dimensional thin-layer chromatography for the components study of poly(adenosine diphosphate ribose). Anal. Biochem. 191, 309-313
26. Brochu, G., Shah, G.M., and Poirier, G.G. (1994) Purification of poly (ADP-ribose) glycohydrolase and detection of its isoforms by a zymogram following one- or two-dimensional electrophoresis. Anal. Biochem. 218, 265-272
27. Slama, J.T., Aboul-Ela, N., and Jacobson, M.K. (1995) Mechanism of inhibition of poly(ADP-ribose) glycohydrolase by adenosine diphosphate (hydroxymethyl) pyrrolidinediol. J. Med. Chem. 38, 4332-4336
28. Slama, J.T., Aboul-Ela, N., Goli, D.M., Cheesman, B.V., Simmons, A.M., and Jacobson, M.K. (1995) Specific inhibition of poly(ADP-ribose) glycohydrolase by adenosine diphosphate (hydroxymethyl)pyrrolidinediol. J. Med. Chem. 38, 389-393
29. Thomassin, H., Jacobson, M.K., Guay, J., Verreault, A., Aboulela, N., Menard, L., and Poirier, G.G. (1990) An affinity matrix for the purification of poly(ADP-ribose) glycohydrolase. Nucleic Acids Res. 18, 4691-4694
30. Masutani, M., Nozaki, T., Hitomi, Y., Ikejima, M., Nagasaki, K., de Prati, A.C., Kurata, S., Natori, S., Sugimura, T., and Esumi, H. (1994) Cloning and functional expression of poly(ADP-ribose) polymerase cDNA from Sarcophaga peregrina. Eur. J. Biochem. 220, 607-614
31. Frohman, M.A., Dush, M.K., and Martin, G.R. (1988) Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. Proc. Natl. Acad. Sci. USA 85, 8998-9002
32. Kozak, M. (1984) Compilation and analysis of sequences up-stream from the translational start site in eukaryotic mRNAs. Nucleic Acids Res. 12, 857-872
33. Dingwall, C. and Laskey, R.A. (1991) Nuclear targeting sequences-a consensus? Trends Biochem. Sci. 16, 478-481
34. Hicks, G.R. and Raikhel, N.V. (1995) Protein import into the nucleus: an integrated view. Annu. Rev. Cell Dev. Biol. 11, 155-188
35. Horton, P. and Nakai, K. (1997) Better prediction of protein cellular localization sites with the x nearest neighbors classifier. Iamb 5, 147-152
36. Smith, S., Giriat, I., Schmitt, A., and de Lange, T. (1998) Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. Science 282, 1484-1487
37. Johansson, M. (1999) A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) homologues. Genomics 57, 442-445
38. Berghammer, H., Ebner, M., Marksteiner, R., and Aur, B., (1999) pADPRT-2: a novel mammalian polymerizing(ADP-ribosyl)transferase gene related to truncated pADPRT homologues in plants and Caenorhabditis elegans. FEBS Lett. 449, 259-263