Nicotinamide offers multiple protective mechanisms in stroke as a precursor for NAD+, as a PARP inhibitor and by partial restoration of mitochondrial function

Pharmacology

Volumn 69, Issue 3, 2003, Pages 150-157

  Klaidman, Lori ^a   Morales, Maria ^a   Kem, Seyha ^a   Yang, Jun ^a   Chang, Mei Ling ^a   Adams Jr , James D ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Adenosine 5 triphosphate; Glutathione; Mitochondrial respiration; Nicotinamide; Nicotinamide adenine dinucleotide

Indexed keywords

ADENOSINE TRIPHOSPHATE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; BRAIN MITOCHONDRION; BRAIN PERFUSION; CELL FUNCTION; CONTROLLED STUDY; DISEASE MODEL; DRUG MECHANISM; MITOCHONDRIAL RESPIRATION; MOUSE; NEUROPROTECTION; NONHUMAN; PRECURSOR; PRIORITY JOURNAL; STROKE;

ADENOSINE TRIPHOSPHATE; ANIMALS; BRAIN; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; DISEASE MODELS, ANIMAL; MICE; MICE, INBRED BALB C; MITOCHONDRIA; NAD; NEUROPROTECTIVE AGENTS; NIACINAMIDE; POLY(ADP-RIBOSE) POLYMERASES; REPERFUSION;

EID: 0141538207     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000072668     Document Type: Article

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