Mono-galloyl glucose derivatives are potent poly(ADP-ribose) glycohydrolase (PARG) inhibitors and partially reduce PARP-1-dependent cell death

British Journal of Pharmacology

Volumn 155, Issue 8, 2008, Pages 1235-1249

  Formentini, L ^a   Arapistas, P ^a   Pittelli, M ^a   Jacomelli, M ^a   Pitozzi, V ^a   Menichetti, S ^a   Romani, A ^a   Giovannelli, L ^a   Moroni, F ^a   Chiarugi, A ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Cell death; PARG; PARP; Poly(ADP ribose); Tannins

Indexed keywords

2 GALLOYL O METHYL ALPHA, BETA DEXTRO GLUCOSE; 2,3 DI(3 GALLOYL 4,5 DIHYDROXY BENZOYL) ALPHA, BETA DEXTRO GLUCOSE; 2,3 DIGALLOYL ALPHA, BETA DEXTRO GLUCOSE; 2,3 DIGALLOYL O METHYL ALPHA, BETA DEXTRO GLUCOSE; 2,3 HEXAHYDROXYDIPHENOYL ALPHA, BETA DEXTRO GLUCOSE; 3 GALLOYL 1,2 O ISOPROPYLIDENE ALPHA DEXTRO GLUCOSE; 3 GALLOYL 1,2 O ISOPROPYLIDENE GLUCOSE; 3 GALLOYL O METHYL ALPHA, BETA DEXTRO GLUCOSE; 3 GALLOYL O METHYL ALPHA,BETA DEXTRO GLUCOSE; ADENOSINE DIPHOSPHATE (HYDROXYMETHYL)PYRROLIDINEDIOL; ENZYME INHIBITOR; EPIGALLOCATECHIN GALLATE; GALLIC ACID; GALLIC ACID METHYL ESTER; GLUCOSE DERIVATIVE; METHYLNITRONITROSOGUANIDINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PENTAGALLOYL GLUCOSE; POLY ADP RIBOSE GLYCOHYDROLASE INHIBITOR; POLYMER; SANGUININ H 6; SCAVENGER; TANNIN; TANNIN DERIVATIVE; TRIGALLOYL GLUCOSE; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CELL DEATH; CYTOTOXICITY; ENZYME ASSAY; ENZYME DEGRADATION; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

CELL DEATH; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; GLYCOSIDE HYDROLASES; HELA CELLS; HUMANS; HYDROLYZABLE TANNINS; MAGNETIC RESONANCE SPECTROSCOPY; POLY(ADP-RIBOSE) POLYMERASES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 57349108170     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.370     Document Type: Article

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