Inhibition of serotonin 5-hydroxytryptamine2C receptor function through heterodimerization: Receptor dimers bind two molecules of ligand and one G-protein

Journal of Biological Chemistry

Volumn 280, Issue 48, 2005, Pages 40144-40151

  Herrick Davis, Katharine ^a   Grinde, Ellinor ^a   Harrigan, Timothy J ^a   Mazurkiewicz, Joseph E ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CELLS; DIMERIZATION; DIMERS; FLUORESCENCE; MOLECULAR STRUCTURE; RESONANCE;

G-PROTEIN-COUPLED RECEPTORS (GPCRS); HETERODIMERIZATION; INOSITOL PHOSPHATE (IP) SIGNALING; LIVING CELLS;

PROTEINS;

G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INOSITOL PHOSPHATE; LIGAND; MUSCARINIC M1 RECEPTOR; SEROTONIN 2C RECEPTOR;

ARTICLE; CELL MEMBRANE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DIMERIZATION; EMBRYO; ENDOCYTOSIS; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; LIGAND BINDING; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RECEPTOR BINDING; RECEPTOR INTRINSIC ACTIVITY; STOICHIOMETRY; WILD TYPE;

ARGININE; BACTERIAL PROTEINS; BLOTTING, WESTERN; CELL LINE; CELL MEMBRANE; DIMERIZATION; DNA, COMPLEMENTARY; ENDOCYTOSIS; FLUORESCENCE RESONANCE ENERGY TRANSFER; GREEN FLUORESCENT PROTEINS; GTP-BINDING PROTEINS; HUMANS; IMMUNOPRECIPITATION; LIGANDS; LUMINESCENT PROTEINS; MICROSCOPY, CONFOCAL; MODELS, BIOLOGICAL; MUTAGENESIS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN BINDING; RECEPTOR, SEROTONIN, 5-HT2C; SERINE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION;

EID: 28844437680     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M507396200     Document Type: Article

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