Knock-down of RGS 4 and β tubulin in CHO cells expressing the human MT 1 melatonin receptor prevents melatonin-induced receptor desensitization

Life Sciences

Volumn 75, Issue 22, 2004, Pages 2703-2715

  Witt Enderby, P A ^a   Jarzynka, M J ^a   Krawitt, B J ^a   Melan, M A ^b  

^a DUQUESNE UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Desensitization; Melatonin; Melatonin receptor; Microtubule; RGS proteins; Tubulin

Indexed keywords

BETA TUBULIN; FORSKOLIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; IODINE 125; MELATONIN; MELATONIN 1 RECEPTOR; MELATONIN RECEPTOR; RGS PROTEIN; UNCLASSIFIED DRUG; CYCLIC AMP; CYCLOHEXIMIDE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; MESSENGER RNA; RGS4 PROTEIN; TUBULIN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DESENSITIZATION; HAMSTER; MOLECULAR DYNAMICS; MOLECULAR PROBE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR BINDING; RECEPTOR INTRINSIC ACTIVITY; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; CHO CELL; DRUG ANTAGONISM; HUMAN; METABOLISM; PHYSIOLOGY;

ANIMALS; CHO CELLS; CRICETINAE; CYCLIC AMP; CYCLOHEXIMIDE; FORSKOLIN; GTP-BINDING PROTEIN ALPHA SUBUNITS; HUMANS; MELATONIN; RECEPTOR, MELATONIN, MT1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RGS PROTEINS; RNA, MESSENGER; TUBULIN;

EID: 4544311318     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2004.08.002     Document Type: Article

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