Genetics in schizophrenia: Where are we and what next?;Genética en la esquizofrenia: ¿dónde estamos y qué viene?

Dialogues in Clinical Neuroscience

Volumn 12, Issue 3, 2010, Pages 289-303

  Tiwari, Arun K ^a   Zai, Clement C ^a   Müller, Daniel J ^a   Kennedy, James L ^a  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

Candidate gene; CNV; Common variant; Copy number variation; GWAS; Linkage; Rare variant; Schizophrenia; Whole genome association study

Indexed keywords

DISRUPTED IN SCHIZOPHRENIA 1 PROTEIN; HISTONE; NOTCH4 RECEPTOR; NOTCH RECEPTOR; NOTCH4 PROTEIN, HUMAN; ONCOPROTEIN;

ARTICLE; BIPOLAR DISORDER; COPY NUMBER VARIATION; GENE LOCUS; GENE MAPPING; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC VARIABILITY; GENETICS; GENOTYPE; HUMAN; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR GENETICS; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; METHODOLOGY; REVIEW;

DNA COPY NUMBER VARIATIONS; GENETICS; GENOME-WIDE ASSOCIATION STUDY; HUMANS; PROTO-ONCOGENE PROTEINS; RECEPTORS, NOTCH; SCHIZOPHRENIA;

EID: 78049494417     PISSN: 12948322     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (126)

1. van Os J, Kapur S. Schizophrenia. Lancet. 2009;374:635-645.
2. Tandon R, Keshavan MS, Nasrallah HA. Schizophrenia, "just the facts" what we know in 2008. 2. Epidemiology and etiology. Schizophr Res. 2008;102:1-18.
3. Sullivan PF, Kendler KS, Neale MC. Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch Gen Psychiatry. 2003;60:1187-1192.
4. Lichtenstein P, Yip BH, Bjork C, et al. Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet. 2009;373:234-239.
5. Botstein D, White RL, Skolnick M, Davis RW. Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am J Hum Genet. 1980;32:314-331.
6. Donis-Keller H, Green P, Helms C, et al. A genetic linkage map of the human genome. Cell. 1987;51:319-337.
7. Shastry BS. Recent developments in the genetics of schizophrenia. Neurogenetics. 1999;2:149-154.
8. Blackwood DH, Thiagarajah T, Malloy P, Pickard BS, Muir WJ. Chromosome abnormalities, mental retardation and the search for genes in bipolar disorder and schizophrenia. Neurotox Res. 2008;14:113-120.
9. Karayiorgou M, Morris MA, Morrow B, et al. Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11. Proc Natl Acad Sci U S A. 1995;92:7612-7616.
10. Murphy KC. Schizophrenia and velo-cardio-facial syndrome. Lancet. 2002;359:426-430.
11. Emamian ES, Hall D, Birnbaum MJ, Karayiorgou M, Gogos JA. Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia. Nat Genet. 2004;36:131-137.
12. Allen NC, Bagade S, McQueen MB, et al. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet. 2008;40:827-834.
13. Dean B, Laws SM, Hone E, et al. Increased levels of apolipoprotein E in the frontal cortex of subjects with schizophrenia. Biol Psychiatry. 2003;54:616-622.
14. Murphy KC, Jones LA, Owen MJ. High rates of schizophrenia in adults with velo-cardio-facial syndrome. Arch Gen Psychiatry. 1999;56:940-945.
15. Gogos JA, Santha M, Takacs Z, et al. The gene encoding proline dehydrogenase modulates sensorimotor gating in mice. Nat Genet. 1999;21:434-439.
16. Maas JW, Bowden CL, Miller AL, et al. Schizophrenia, psychosis, and cerebral spinal fluid homovanillic acid concentrations. Schizophr Bull. 1997;23:147-154.
17. Matsumoto M, Weickert CS, Beltaifa S, et al. Catechol O-methyltransferase (COMT) mRNA expression in the dorsolateral prefrontal cortex of patients with schizophrenia. Neuropsychopharmacology. 2003;28:1521-1530.
18. Tunbridge E, Burnet PW, Sodhi MS, Harrison PJ. Catechol-omethyltransferase (COMT) and proline dehydrogenase (PRODH) mRNAs in the dorsolateral prefrontal cortex in schizophrenia, bipolar disorder, and major depression. Synapse. 2004;51:112-118.
19. Stark KL, Burt RA, Gogos JA, Karayiorgou M. Analysis of prepulse inhibition in mouse lines overexpressing 22q11.2 orthologues. Int J Neuropsychopharmacol. In press.
20. Korostishevsky M, Kaganovich M, Cholostoy A, et al. Is the G72/G30 locus associated with schizophrenia? single nucleotide polymorphisms, haplotypes, and gene expression analysis. Biol Psychiatry. 2004;56:169-176.
21. Otte DM, Bilkei-Gorzo A, Filiou MD, et al. Behavioral changes in G72/G30 transgenic mice. Eur Neuropsychopharmacol. 2009;19:339-348.
22. Blackwood DH, Fordyce A, Walker MT, St Clair DM, Porteous DJ, Muir WJ. Schizophrenia and affective disorders-cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. Am J Hum Genet. 2001;69:428-433.
23. Lipska BK, Peters T, Hyde TM, et al. Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs. Hum Mol Genet. 2006;15:1245-1258.
24. Shi J, Gershon ES, Liu C. Genetic associations with schizophrenia: metaanalyses of 12 candidate genes. Schizophr Res. 2008;104:96-107.
25. Rastogi A, Zai C, Likhodi O, Kennedy JL, Wong AH. Genetic association and post-mortem brain mRNA analysis of DISC1 and related genes in schizophrenia. Schizophr Res. 2009;114:39-49.
26. Clapcote SJ, Lipina TV, Millar JK, et al. Behavioral phenotypes of Disc1 missense mutations in mice. Neuron. 2007;54:387-402.
27. Pletnikov MV, Ayhan Y, Nikolskaia O, et al. Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia. Mol Psychiatry. 2008;13:173-186.
28. Torrey EF, Barci BM, Webster MJ, Bartko JJ, Meador-Woodruff JH, Knable MB. Neurochemical markers for schizophrenia, bipolar disorder, and major depression in postmortem brains. Biol Psychiatry. 2005;57:252-260.
29. Weickert TW, Goldberg TE, Mishara A, et al. Catechol-Omethyltransferase val108/158met genotype predicts working memory response to antipsychotic medications. Biol Psychiatry. 2004;56:677-682.
30. Li D, He L. Association study between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia: a meta-analysis. Schizophr Res. 2007;96:112-118.
31. Talbot K. The sandy (sdy) mouse: a dysbindin-1 mutant relevant to schizophrenia research. Prog Brain Res. 2009;179:87-94.
32. Stefansson H, Sigurdsson E, Steinthorsdottir V, et al. Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet. 2002;71:877-892.
33. Hahn CG, Wang HY, Cho DS, et al. Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia. Nat Med. 2006;12:824-828.
34. Chong VZ, Thompson M, Beltaifa S, Webster MJ, Law AJ, Weickert CS. Elevated neuregulin-1 and ErbB4 protein in the prefrontal cortex of schizophrenic patients. Schizophr Res. 2008;100:270-280.
35. Hong LE, Wonodi I, Stine OC, Mitchell BD, Thaker GK. Evidence of missense mutations on the neuregulin 1 gene affecting function of prepulse inhibition. Biol Psychiatry. 2008;63:17-23.
36. Zhao C, Xu Z, Chen J, et al. Two isoforms of GABA(A) receptor beta2 subunit with different electrophysiological properties: Differential expression and genotypical correlations in schizophrenia. Mol Psychiatry. 2006;11:1092-1105.
37. Martucci L, Wong AH, De Luca V, et al. N-methyl-D-aspartate receptor NR2B subunit gene GRIN2B in schizophrenia and bipolar disorder: Polymorphisms and mRNA levels. Schizophr Res. 2006;84:214-221.
38. Lopez-Figueroa AL, Norton CS, Lopez-Figueroa MO, et al. Serotonin 5-HT1A, 5-HT1B, and 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder, and schizophrenia. Biol Psychiatry. 2004;55:225-233.
39. Li D, Duan Y, He L. Association study of serotonin 2A receptor (5-HT2A) gene with schizophrenia and suicidal behavior using systematic meta-analysis. Biochem Biophys Res Commun. 2006;340:1006-1015.
40. Soderlund J, Schroder J, Nordin C, et al. Activation of brain interleukin-1beta in schizophrenia. Mol Psychiatry. 2009;14:1069-1071.
41. Stefansson H, Ophoff RA, Steinberg S, et al. Common variants conferring risk of schizophrenia. Nature. 2009;460:744-747.
42. Glatt SJ, Wang RS, Yeh YC, Tsuang MT, Faraone SV. Five NOTCH4 polymorphisms show weak evidence for association with schizophrenia: evidence from meta-analyses. Schizophr Res. 2005;73:281-290.
43. Wang Z, Wei J, Zhang X, et al. A review and re-evaluation of an association between the NOTCH4 locus and schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2006;141B:902-906.
44. Hashimoto R, Straub RE, Weickert CS, Hyde TM, Kleinman JE, Weinberger DR. Expression analysis of neuregulin-1 in the dorsolateral prefrontal cortex in schizophrenia. Mol Psychiatry. 2004;9:299-307.
45. Munafo MR, Thiselton DL, Clark TG, Flint J. Association of the NRG1 gene and schizophrenia: a meta-analysis. Mol Psychiatry. 2006;11:539-546.
46. Li D, Collier DA, He L. Meta-analysis shows strong positive association of the neuregulin 1 (NRG1) gene with schizophrenia. Hum Mol Genet. 2006;15:1995-2002.
47. Etherton MR, Blaiss CA, Powell CM, Sudhof TC. Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments. Proc Natl Acad Sci U S A. 2009;106:17998-18003.
48. Siuciak JA, McCarthy SA, Chapin DS, Tin AN. Behavioral and neurochemical characterization of mice deficient in the phosphodiesterase-4B (PDE4B) enzyme. Psychopharmacology (Berl). 2008;197:115-126.
49. Fatemi SH, King DP, Reutiman TJ, et al. PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia. Schizophr Res. 2008;101:36-49.
50. Kahler AK, Otnaess MK, Wirgenes KV, et al. Association study of PDE4B gene variants in Scandinavian schizophrenia and bipolar disorder multicenter case-control samples. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:86-96.
51. Tomppo L, Hennah W, Lahermo P, et al. Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses. Biol Psychiatry. 2009;65:1055-1062.
52. Guidotti A, Auta J, Davis JM, et al. Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study. Arch Gen Psychiatry. 2000;57:1061-1069.
53. Erbel-Sieler C, Dudley C, Zhou Y, et al. Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors. Proc Natl Acad Sci U S A. 2004;101:13648-13653.
54. Grillet N, Pattyn A, Contet C, Kieffer BL, Goridis C, Brunet JF. Generation and characterization of Rgs4 mutant mice. Mol Cell Biol. 2005;25:4221-4228.
55. Erdely HA, Tamminga CA, Roberts RC, Vogel MW. Regional alterations in RGS4 protein in schizophrenia. Synapse. 2006;59:472-479.
56. Millar JK, Wilson-Annan JC, Anderson S, et al. Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum Mol Genet. 2000;9:1415-1423.
57. St Clair D, Blackwood D, Muir W, et al. Association within a family of a balanced autosomal translocation with major mental illness. Lancet. 1990;336:13-16.
58. Kamnasaran D, Muir WJ, Ferguson-Smith MA, Cox DW. Disruption of the neuronal PAS3 gene in a family affected with schizophrenia. J Med Genet. 2003;40:325-332.
59. Pickard BS, Christoforou A, Thomson PA, et al. Interacting haplotypes at the NPAS3 locus alter risk of schizophrenia and bipolar disorder. Mol Psychiatry. 2009;14:874-884.
60. Pickard BS, Malloy MP, Christoforou A, et al. Cytogenetic and genetic evidence supports a role for the kainate-type glutamate receptor gene, GRIK4, in schizophrenia and bipolar disorder. Mol Psychiatry. 2006;11:847-857.
61. Millar JK, Pickard BS, Mackie S, et al. DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. Science. 2005;310:1187-1191.
62. Straub RE, Jiang Y, MacLean CJ, et al. Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. Am J Hum Genet. 2002;71:337-348.
63. Chumakov I, Blumenfeld M, Guerassimenko O, et al. Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. Proc Natl Acad Sci U S A. 2002;99:13675-13680.
64. Ng MY, Levinson DF, Faraone SV, et al. Meta-analysis of 32 genomewide linkage studies of schizophrenia. Mol Psychiatry. 2009;14:774-785.
65. Lewis CM, Levinson DF, Wise LH, et al. Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia. Am J Hum Genet. 2003;73:34-48.
66. Holmans PA, Riley B, Pulver AE, et al. Genomewide linkage scan of schizophrenia in a large multicenter pedigree sample using single nucleotide polymorphisms. Mol Psychiatry. 2009;14:786-795.
67. Carroll LS, Williams NM, Moskvina V, et al. Evidence for rare and common genetic risk variants for schizophrenia at protein kinase C, alpha. Mol Psychiatry. In press.
68. Williams NM, Norton N, Williams H, et al. A systematic genomewide linkage study in 353 sib pairs with schizophrenia. Am J Hum Genet. 2003;73:1355-1367.
69. Risch N, Merikangas K. The future of genetic studies of complex human diseases. Science. 1996;273:1516-1517.
70. Wang DG, Fan JB, Siao CJ, Berno A, et al. Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science. 1998;280:1077-1082.
71. LaFramboise T. Single nucleotide polymorphism arrays: a decade of biological, computational and technological advances. Nucleic Acids Res. 2009;37:4181-4193.
72. Lander ES, Linton LM, Birren B, et al. Initial sequencing and analysis of the human genome. Nature. 2001;409:860-921.
73. Sachidanandam R, Weissman D, Schmidt et al. A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature. 2001;409:928-933.
74. A haplotype map of the human genome. Nature. 2005;437:1299-1320.
75. Frazer KA, Ballinger DG, Cox DR, et al. A second generation human haplotype map of over 3.1 million SNPs. Nature. 2007;449:851-861.
76. Sham P, Bader JS, Craig I, O'Donovan M, Owen M. DNA pooling: a tool for large-scale association studies. Nat Rev Genet. 2002;3:862-871.
77. Mah S, Nelson MR, Delisi LE, et al. Identification of the semaphorin receptor PLXNA2 as a candidate for susceptibility to schizophrenia. Mol Psychiatry. 2006;11:471-478.
78. Fujii T, Iijima Y, Kondo H, Shizuno T, et al. Failure to confirm an association between the PLXNA2 gene and schizophrenia in a Japanese population. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31:873-877.
79. Takeshita M, Yamada K, Hattori E, et al. Genetic examination of the PLXNA2 gene in Japanese and Chinese people with schizophrenia. Schizophr Res. 2008;99:359-364.
80. Betcheva ET, Mushiroda T, Takahashi A, et al. Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population. J Hum Genet. 2009;54:98-107.
81. Shifman S, Johannesson M, Bronstein M, et al. Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women. PLoS Genet. 2008;4:e28.
82. Hong SE, Shugart YY, Huang DT, et al. Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations. Nat Genet. 2000;26:93-96.
83. Herz J, Chen Y. Reelin, lipoprotein receptors and synaptic plasticity. Nat Rev Neurosci. 2006;7:850-859.
84. Wedenoja J, Loukola A, Tuulio-Henriksson A, et al. Replication of linkage on chromosome 7q22 and association of the regional Reelin gene with working memory in schizophrenia families. Mol Psychiatry. 2008;13:673-684.
85. Wedenoja J, Tuulio-Henriksson A, Suvisaari J, et al. Replication of association between working memory and reelin, a potential modifier gene in schizophrenia. Biol Psychiatry. 2010;67:983-991.
86. Kahler AK, Djurovic S, Kulle B, et al. Association analysis of schizophrenia on 18 genes involved in neuronal migration: MDGA1 as a new susceptibility gene. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:1089-1100.
87. Kirov G, Zaharieva I, Georgieva L, et al. A genome-wide association study in 574 schizophrenia trios using DNA pooling. Mol Psychiatry. 2009;14:796-803.
88. Keshavan MS, Kennedy JL, Murray R, eds. Neurodevelopment and Schizophrenia. Cambridge, UK: Cambridge University Press; 2004.
89. Lencz T, Morgan TV, Athanasiou M, et al. Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia. Mol Psychiatry. 2007;12:572-580.
90. Sun S, Wang F, Wei J, et al. Association between interleukin-3 receptor alpha polymorphism and schizophrenia in the Chinese population. Neurosci Lett. 2008;440:35-37.
91. Sun S, Wei J, Li H, et al. A family-based study of the IL3RA gene on susceptibility to schizophrenia in a Chinese Han population. Brain Res. 2009;1268:13-16.
92. Sullivan PF, Lin D, Tzeng JY, et al. Genomewide association for schizophrenia in the CATIE study: results of stage 1. Mol Psychiatry. 2008;13:570-584.
93. O'Donovan MC, Craddock N, Norton N, et al. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet. 2008;40:1053-1055.
94. Esslinger C, Walter H, Kirsch P, et al. Neural mechanisms of a genomewide supported psychosis variant. Science. 2009;324:605.
95. Riley B, Thiselton D, Maher BS, et al. Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample. Mol Psychiatry. 2010;15:29-37.
96. Purcell SM, Wray NR, Stone JL, et al. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature. 2009;460:748-752.
97. Steinberg S, Mors O, Borglum AD, et al. Expanding the range of ZNF804A variants conferring risk of psychosis. Mol Psychiatry. 2010. In press.
98. Need AC, Ge D, Weale ME, et al. A genome-wide investigation of SNPs and CNVs in schizophrenia. PLoS Genet. 2009;5:e1000373.
99. Shi J, Levinson DF, Duan J, et al. Common variants on chromosome 6p22.1 are associated with schizophrenia. Nature. 2009;460:753-757.
100. Athanasiu L, Mattingsdal M, Kahler AK, et al. Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort. J Psychiatr Res. 2010;44:748-753.
101. Schulze TG, Detera-Wadleigh SD, Akula N, et al. Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder. Mol Psychiatry. 2009;14:487-491.
102. Moon HJ, Yim SV, Lee WK, et al. Identification of DNA copy-number aberrations by array-comparative genomic hybridization in patients with schizophrenia. Biochem Biophys Res Commun. 2006;344:531-539.
103. Wilson GM, Flibotte S, Chopra V, Melnyk BL, Honer WG, Holt RA. DNA copy-number analysis in bipolar disorder and schizophrenia reveals aberrations in genes involved in glutamate signaling. Hum Mol Genet. 2006;15:743-749.
104. Mizuguchi T, Hashimoto R, Itokawa M, et al. Microarray comparative genomic hybridization analysis of 59 patients with schizophrenia. J Hum Genet. 2008;53:914-919.
105. Kirov G, Gumus D, Chen W, et al. Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia. Hum Mol Genet. 2008;17:458-465.
106. Xu B, Roos JL, Levy S, van Rensburg EJ, Gogos JA, Karayiorgou M. Strong association of de novo copy number mutations with sporadic schizophrenia. Nat Genet. 2008;40:880-885.
107. Stefansson H, Rujescu D, Cichon S, et al. Large recurrent microdeletions associated with schizophrenia. Nature. 2008;455:232-236.
108. Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature. 2008;455:237-241.
109. Shi YY, He G, Zhang Z, et al. A study of rare structural variants in schizophrenia patients and normal controls from Chinese Han population. Mol Psychiatry. 2008;13:911-913.
110. Kirov G, Grozeva D, Norton N, et al. Support for the involvement of large copy number variants in the pathogenesis of schizophrenia. Hum Mol Genet. 2009;18:1497-1503.
111. Bales AM, Zaleski CA, McPherson EW. Newborn screening programs: Should 22q11 deletion syndrome be added? Genet Med. 2010. In press.
112. Walsh T, McClellan JM, McCarthy SE, et al. Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science. 2008;320:539-543.
113. Ikeda M, Aleksic B, Kirov G, et al. Copy number variation in schizophrenia in the Japanese population. Biol Psychiatry. 2010;67:283-286.
114. Wray NR, Visscher PM. Narrowing the boundaries of the genetic architecture of schizophrenia. Schizophr Bull. 2010;36:14-23.
115. Owen MJ, Craddock N, Jablensky A. The genetic deconstruction of psychosis. Schizophr Bull. 2007;33:905-911.
116. Green EK, Raybould R, Macgregor S, et al. Operation of the schizophrenia susceptibility gene, neuregulin 1, across traditional diagnostic boundaries to increase risk for bipolar disorder. Arch Gen Psychiatry. 2005;62:642-648.
117. Gould TD, Gottesman, II. Psychiatric endophenotypes and the development of valid animal models. Genes Brain Behav. 2006;5:113-119.
118. Holzman PS, Proctor LR, Hughes DW. Eye-tracking patterns in schizophrenia. Science. 1973;181:179-181.
119. Braff D, Stone C, Callaway E, Geyer M, Glick I, Bali L. Prestimulus effects on human startle reflex in normals and schizophrenics. Psychophysiology. 1978;15:339-343.
120. Freedman R, Adler LE, Myles-Worsley M, et al. Inhibitory gating of an evoked response to repeated auditory stimuli in schizophrenic and normal subjects. Human recordings, computer simulation, and an animal model. Arch Gen Psychiatry. 1996;53:1114-1121.
121. Roth WT, Pfefferbaum A, Kelly AF, Berger PA, Kopell BS. Auditory event-related potentials in schizophrenia and depression. Psychiatry Res. 1981;4:199-212.
122. Ivleva EI, Morris DW, Moates AF, Suppes T, Thaker GK, Tamminga CA. Genetics and intermediate phenotypes of the schizophrenia-bipolar disorder boundary. Neurosci Biobehav Rev. 2010;34:897-921.
123. van Os J, Rutten BP, Poulton R. Gene-environment interactions in schizophrenia: review of epidemiological findings and future directions. Schizophr Bull. 2008;34:1066-1082.
124. Mill J, Tang T, Kaminsky Z, et al. Epigenomic profiling reveals DNAmethylation changes associated with major psychosis. Am J Hum Genet. 2008;82:696-711.
125. Ptak C, Petronis A. Epigenetic approaches to psychiatric disorders. Dialogues Clin Neurosci. 2010;12:25-35.
126. Ross CA, Margolis RL, Reading SA, Pletnikov M, Coyle JT. Neurobiology of schizophrenia. Neuron. 2006;52:139-153.