Association study between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia: A meta-analysis

Schizophrenia Research

Volumn 96, Issue 1-3, 2007, Pages 112-118

  Li, Dawei ^a,b,c   He, Lin ^a,c  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b ROCKEFELLER UNIVERSITY   (United States)

^c Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

Author keywords

Case control; Chromosome 6p; Dysbindin; Linkage disequilibrium (LD); Psychosis; Transmission disequilibrium test (TDT)

Indexed keywords

ARTICLE; DTNBP1 GENE; GENE; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HUMAN; MEDICAL LITERATURE; PRIORITY JOURNAL; PUBLICATION; SCHIZOPHRENIA; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

CARRIER PROTEINS; HUMANS; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; SCHIZOPHRENIA;

EID: 34848819064     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.schres.2007.05.017     Document Type: Article

References (42)

1. Benson M.A., Newey S.E., Martin-Rendon E., Hawkes R., and Blake D.J. Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain. J. Biol. Chem. 276 (2001) 24232-24241
2. Cho H.J., Meira-Lima I., Cordeiro Q., Michelon L., Sham P., Vallada H., and Collier D.A. Population-based and family-based studies on the serotonin transporter gene polymorphisms and bipolar disorder: a systematic review and meta-analysis. Mol. Psychiatry 10 (2005) 771-781
3. Chotai J., Serretti A., Lattuada E., Lorenzi C., and Lilli R. Gene-environment interaction in psychiatric disorders as indicated by season of birth variations in tryptophan hydroxylase (TPH), serotonin transporter (5-HTTLPR) and dopamine receptor (DRD4) gene polymorphisms. Psychiatry Res. 119 (2003) 99-111
4. Cochran W.G. The combination of estimates from different experiments. Biometrics 10 (1954) 101-129
5. Colditz G.A., Burdick E., and Mosteller F. Heterogeneity in meta-analysis of data from epidemiologic studies: a commentary. Am. J. Epidemiol. 142 (1995) 371-382
6. DerSimonian R., and Laird N. Meta-analysis in clinical trials. Control. Clin. Trials 7 (1986) 177-188
7. Egger M., Davey Smith G., Schneider M., and Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 315 (1997) 629-634
8. Faraone S.V., Taylor L., and Tsuang M.T. The molecular genetics of schizophrenia: an emerging consensus. Expert. Rev. Mol. Med. (2002) 1-13
9. Funke B., Finn C.T., Plocik A.M., Lake S., DeRosse P., Kane J.M., Kucherlapati R., and Malhotra A.K. Association of the DTNBP1 locus with schizophrenia in a U.S. population. Am. J. Hum. Genet. 75 (2004) 891-898
10. Hall D., Gogos J.A., and Karayiorgou M. The contribution of three strong candidate schizophrenia susceptibility genes in demographically distinct populations. Genes Brain. Behav. 3 (2004) 240-248
11. Harrison P.J., and Owen M.J. Genes for schizophrenia? Recent findings and their pathophysiological implications. Lancet 361 (2003) 417-419
12. Harrison P.J., and Weinberger D.R. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol. Psychiatry 10 (2005) 40-68 (imgae 45)
13. Higgins J.P., and Thompson S.G. Quantifying heterogeneity in a meta-analysis. Stat. Med. 21 (2002) 1539-1558
14. Kirov G., Ivanov D., Williams N.M., Preece A., Nikolov I., Milev R., Koleva S., Dimitrova A., Toncheva D., O'Donovan M.C., and Owen M.J. Strong evidence for association between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia in 488 parent-offspring trios from Bulgaria. Biol. Psychiatry 55 (2004) 971-975
15. Kohn Y., Danilovich E., Filon D., Oppenheim A., Karni O., Kanyas K., Turetsky N., Korner M., and Lerer B. Linkage disequilibrium in the DTNBP1 (dysbindin) gene region and on chromosome 1p36 among psychotic patients from a genetic isolate in Israel: findings from identity by descent haplotype sharing analysis. Am. J. Med. Genet. B Neuropsychiatr. Genet. 128 (2004) 65-70
16. Lee S. From diversity to unity. The classification of mental disorders in 21st-century China. Psychiatr. Clin. North Am. 24 (2001) 421-431
17. Lewis C.M., Levinson D.F., Wise L.H., DeLisi L.E., Straub R.E., Hovatta I., Williams N.M., Schwab S.G., Pulver A.E., Faraone S.V., Brzustowicz L.M., Kaufmann C.A., Garver D.L., Gurling H.M., Lindholm E., Coon H., Moises H.W., Byerley W., Shaw S.H., Mesen A., Sherrington R., O'Neill F.A., Walsh D., Kendler K.S., Ekelund J., Paunio T., Lonnqvist J., Peltonen L., O'Donovan M.C., Owen M.J., Wildenauer D.B., Maier W., Nestadt G., Blouin J.L., Antonarakis S.E., Mowry B.J., Silverman J.M., Crowe R.R., Cloninger C.R., Tsuang M.T., Malaspina D., Harkavy-Friedman J.M., Svrakic D.M., Bassett A.S., Holcomb J., Kalsi G., McQuillin A., Brynjolfson J., Sigmundsson T., Petursson H., Jazin E., Zoega T., and Helgason T. Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia. Am. J. Hum. Genet. 73 (2003) 34-48
18. Li D., and He L. Association study of the G-protein signaling 4 (RGS4) and proline dehydrogenase (PRODH) genes with schizophrenia: a meta-analysis. Eur. J. Hum. Genet. 14 (2006) 1130-1135
19. Li D., and He L. Further clarification of the contribution of the tryptophan hydroxylase (TPH) gene to suicidal behavior using systematic allelic and genotypic meta-analyses. Hum. Genet. 119 (2006) 233-240
20. Li D., and He L. Association study between the NMDA receptor 2B subunit gene (GRIN2B) and schizophrenia: a HuGE review and meta-analysis. Genet. Med. 9 (2007) 4-8
21. Li D., and He L. G72/G30 genes and schizophrenia: a systematic meta-analysis of association studies. Genetics 175 (2007) 917-922
22. Li T., Zhang F., Liu X., Sun X., Sham P.C., Crombie C., Ma X., Wang Q., Meng H., Deng W., Yates P., Hu X., Walker N., Murray R.M., St Clair D., and Collier D.A. Identifying potential risk haplotypes for schizophrenia at the DTNBP1 locus in Han Chinese and Scottish populations. Mol. Psychiatry 10 (2005) 1037-1044
23. Li, D., Collier, D.A., He, L., 2006. Meta-analysis shows strong positive association of the neuregulin 1 (NRG1) gene with schizophrenia. Hum Mol Genet 15, 1995-2002.
24. Liao H.M., and Chen C.H. Mutation analysis of the human dystrobrevin-binding protein 1 gene in schizophrenic patients. Schizophr. Res. 71 (2004) 185-189
25. Moises H.W., Yang L., Kristbjarnarson H., Wiese C., Byerley W., Macciardi F., Arolt V., Blackwood D., Liu X., Sjogren B., et al. An international two-stage genome-wide search for schizophrenia susceptibility genes. Nat. Genet. 11 (1995) 321-324
26. Morris D.W., McGhee K.A., Schwaiger S., Scully P., Quinn J., Meagher D., Waddington J.L., Gill M., and Corvin A.P. No evidence for association of the dysbindin gene [DTNBP1] with schizophrenia in an Irish population-based study. Schizophr. Res. 60 (2003) 167-172
27. Munafo M.R., and Flint J. Meta-analysis of genetic association studies. Trends Genet. 20 (2004) 439-444
28. Mutsuddi M., Morris D.W., Waggoner S.G., Daly M.J., Scolnick E.M., and Sklar P. Analysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophrenia. Am. J. Hum. Genet. 79 (2006) 903-909
29. Numakawa T., Yagasaki Y., Ishimoto T., Okada T., Suzuki T., Iwata N., Ozaki N., Taguchi T., Tatsumi M., Kamijima K., Straub R.E., Weinberger D.R., Kunugi H., and Hashimoto R. Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia. Hum. Mol. Genet. 13 (2004) 2699-2708
30. Owen M.J., Williams N.M., and O'Donovan M.C. The molecular genetics of schizophrenia: new findings promise new insights. Mol. Psychiatry 9 (2004) 14-27
31. Rapoport J.L., Addington A.M., Frangou S., and Psych M.R. The neurodevelopmental model of schizophrenia: update 2005. Mol. Psychiatry 10 (2005) 434-449
32. Schwab S.G., Knapp M., Mondabon S., Hallmayer J., Borrmann-Hassenbach M., Albus M., Lerer B., Rietschel M., Trixler M., Maier W., and Wildenauer D.B. Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families. Am. J. Hum. Genet. 72 (2003) 185-190
33. Straub R.E., Jiang Y., MacLean C.J., Ma Y., Webb B.T., Myakishev M.V., Harris-Kerr C., Wormley B., Sadek H., Kadambi B., Cesare A.J., Gibberman A., Wang X., O'Neill F.A., Walsh D., and Kendler K.S. Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. Am. J. Hum. Genet. 71 (2002) 337-348
34. Straub R.E., MacLean C.J., Ma Y., Webb B.T., Myakishev M.V., Harris-Kerr C., Wormley B., Sadek H., Kadambi B., O'Neill F.A., Walsh D., and Kendler K.S. Genome-wide scans of three independent sets of 90 Irish multiplex schizophrenia families and follow-up of selected regions in all families provides evidence for multiple susceptibility genes. Mol. Psychiatry 7 (2002) 542-559
35. Talbot K., Eidem W.L., Tinsley C.L., Benson M.A., Thompson E.W., Smith R.J., Hahn C.G., Siegel S.J., Trojanowski J.Q., Gur R.E., Blake D.J., and Arnold S.E. Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia. J. Clin. Invest. 113 (2004) 1353-1363
36. Tang J.X., Zhou J., Fan J.B., Li X.W., Shi Y.Y., Gu N.F., Feng G.Y., Xing Y.L., Shi J.G., and He L. Family-based association study of DTNBP1 in 6p22.3 and schizophrenia. Mol. Psychiatry 8 (2003) 717-718
37. Van Den Bogaert A., Schumacher J., Schulze T.G., Otte A.C., Ohlraun S., Kovalenko S., Becker T., Freudenberg J., Jonsson E.G., Mattila-Evenden M., Sedvall G.C., Czerski P.M., Kapelski P., Hauser J., Maier W., Rietschel M., Propping P., Nothen M.M., and Cichon S. The DTNBP1 (dysbindin) gene contributes to schizophrenia, depending on family history of the disease. Am. J. Hum. Genet. 73 (2003) 1438-1443
38. van den Oord E.J., Sullivan P.F., Jiang Y., Walsh D., O'Neill F.A., Kendler K.S., and Riley B.P. Identification of a high-risk haplotype for the dystrobrevin binding protein 1 (DTNBP1) gene in the Irish study of high-density schizophrenia families. Mol. Psychiatry 8 (2003) 499-510
39. Weickert C.S., Straub R.E., McClintock B.W., Matsumoto M., Hashimoto R., Hyde T.M., Herman M.M., Weinberger D.R., and Kleinman J.E. Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain. Arch. Gen. Psychiatry 61 (2004) 544-555
40. Williams M. Genome-based drug discovery: prioritizing disease-susceptibility/disease-associated genes as novel drug targets for schizophrenia. Curr. Opin. Investig. Drugs 4 (2003) 31-36
41. Williams N.M., Preece A., Morris D.W., Spurlock G., Bray N.J., Stephens M., Norton N., Williams H., Clement M., Dwyer S., Curran C., Wilkinson J., Moskvina V., Waddington J.L., Gill M., Corvin A.P., Zammit S., Kirov G., Owen M.J., and O'Donovan M.C. Identification in 2 independent samples of a novel schizophrenia risk haplotype of the dystrobrevin binding protein gene (DTNBP1). Arch. Gen. Psychiatry 61 (2004) 336-344
42. Woolf B. On estimating the relation between blood group and disease. Ann. Hum. Genet. 19 (1955) 251-253