Effects of dietary diacylglycerol oil containing phytosterols in mayonnaise on abdominal fat and blood cholesterol levels in Japanese men

Japanese Pharmacology and Therapeutics

Volumn 35, Issue 9, 2007, Pages 973-987

  Takeshita, Masao ^a   Saito, Shinichiro ^a   Moriwaki, Junya ^a   Takase, Hideto ^a   Yamada, Naoto ^a   Shiiba, Daisuke ^a   Kudo, Naoto ^a   Nakajima, Yoshinobu ^a   Tokimitsu, Ichiro ^a  

^a KAO CORPORATION   (Japan)

Author keywords

Cholesterol; Diacylglycerol; Obesity; Phytosterols

Indexed keywords

ANTIOBESITY AGENT; APOLIPOPROTEIN B; CHOLESTEROL; DIACYLGLYCEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHYTOSTEROL; PLACEBO; TRIACYLGLYCEROL; VITAMIN;

ABDOMINAL FAT; ABSENCE OF SIDE EFFECTS; ADULT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIETARY INTAKE; DOUBLE BLIND PROCEDURE; FOOD; HUMAN; INTRAABDOMINAL FAT; JAPANESE; MALE; MAYONNAISE; MONOTHERAPY; NORMAL HUMAN; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; STATISTICAL SIGNIFICANCE; SUBCUTANEOUS FAT; VITAMIN BLOOD LEVEL;

EID: 35948976954     PISSN: 03863603     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. th June 2007.
2. th June 2007.
3. Kissebah AH, Vydelingum N, Murray R, Evans DJ, Hartz AJ, Kalkhoff RK, et al. Relation of body fat distribution to metabolic complications of obesity. J Clin Endocrinol Metab 1982 ; 54 : 254-60.
4. Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 1988 ; 37 : 1595-607.
5. Kaplan NM. The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. Arch Intern Med 1989 ; 149 : 1514-20.
6. th June 2007.
7. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al. American Heart Association ; National Heart, Lung, and Blood Institute. Diagnosis and management of the metabolic syndrome : an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005 ; 112 : 2735-52.
8. Japanese source
9. Hayashi T, Boyko EJ, Leonetti DL, McNeely MJ, Newell-Morris L, Kahn SE, et al. Visceral adiposity and the risk of impaired glucose tolerance : a prospective study among Japanese Americans. Diabetes Care 2003 ; 26 : 650-5.
10. Boyko EJ, Fujimoto WY, Leonetti DL, Newell-Morris L. Visceral adiposity and risk of type 2 diabetes : a prospective study among Japanese Americans. Diabetes Care 2000 ; 23 : 465-71.
11. Hayashi T, Boyko EJ, Leonetti DL, McNeely MJ, Newell-Morris L, Kahn SE, et al. Visceral adiposity is an independent predictor of incident hypertension in Japanese Americans. Ann Intern Med 2004 ; 140 : 992-1000.
12. Matsuzawa Y, Fujioka S, Tokunaga K, Tarui S. A Novel classification : visderal fat obesity and subcutaneous fat obesity. In : Berry EM, Blondheim SH, Eliahou HE, Shafrir E. John Libbey, editors. Recent Advance in Obesity Research : V. London : 1987. p. 92-6.
13. Fujimoto WY, Bergstrom RW, Boyko EJ, Chen KW, Leonetti DL, Newell-Morris L, et al. Visceral adiposity and incident coronary heart disease in Japanese-American men. The 10-year follow-up results of the Seattle Japanese-American Community Diabetes Study. Diabetes Care 1999 ; 22 : 1808-12.
14. Keys A. Coronary heart disease in seven countries. Circulation 1970 ; 41 (suppl 1) : 1-211.
15. Kannel WB, Castelli WP, Gordon T, McNamara PM. Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham study. Ann Intern Med 1971 ; 74 : 1-12.
16. Martin MJ, Hulley SB, Browner WS, Kuller LH, Wentworth D. Serum cholesterol, blood pressure, and mortality : implications from a cohort of 361,662 men. Lancet 1986 ; 2 : 933-6.
17. Nakamura H, Arakawa K, Itakura H, Kitabatake A, Goto Y, Toyota T, et al. Related Articles, Links Primary prevention of cardiovascular disease with pravastatin in Japan (MEGA Study) : a prospective randomised controlled trial. Lancet 2006 ; 368 : 1155-63.
18. Tada N, Yoshida H. Diacylglycerol on lipid metabolism. Curr Opin Lipidol 2003 ; 14 : 29-33.
19. Kimura S, Tsuchiya H, Inage H, Meguro S, Matsuo N, Tokimitsu I. Effects of dietary diacylglycerol on the energy metabolism. Int J Vitam Nutr Res 2006 ; 76 : 75-9.
20. Kamphuis MM, Mela DJ, Westerterp-Plantenga MS. Diacylglycerols affect substrate oxidation and appetite in humans. Am J Clin Nutr 2003 ; 77 : 1133-9.
21. Saito S, Tomonobu K, Hase T, Tokimitsu I. Effects of diacylglycerol on postprandial energy expenditure and respiratory quotient in healthy subjects. Nutrition 2006 ; 22 : 30-5.
22. Murase T, Aoki M, Wakisaka T, Hase T, Tokimitsu I. Anti-obesity effect of dietary diacylglycerol in C57BL/6J mice : dietary diacylglycerol stimulates intestinal lipid metabolism. J Lipid Res 2002 ; 43 : 1312-9.
23. Meng X, Zou D, Shi Z, Duan Z, Mao Z. Dietary diacylglycerol prevents high-fat diet-induced lipid accumulation in rat liver and abdominal adipose tissue. Lipids 2004 ; 39 : 37-41.
24. Nagao T, Watanabe H, Goto N, Onizawa K, Taguchi H, Matsuo N, et al. Dietary diacylglycerol suppresses accumulation of body fat compared to triacylglycerol in men in a double-blind controlled trial. J Nutr 2000 ; 130 : 792-7.
25. Maki KC, Davidson MH, Tsushima R, Matsuo N, Tokimitsu I, Umporowicz DM, et al. Consumption of diacylglycerol oil as part of a reduced-energy diet enhances loss of body weight and fat in comparison with consumption of a triacylglycerol control oil 1. Am J Clin Nutr 2002 ; 76 : 1230-6.
26. Ikeda I, Tanaka K, Sugano M, Vahouny GV, Gallo LL. Inhibition of cholesterol absorption in rats by plant sterols. J Lipid Res 1988 ; 29 : 1573-82.
27. Ostlund RE. Phytosterols in human nutrition. Annu Rev Nutr 2002 ; 22 : 533-49.
28. Miettinen TA, Puska P, Gylling H, Vanhanen H, Vartiainen E. Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population. N Engl J Med 1995 ; 333 : 1308-12.
29. Gylling H, Radhakrishnan R, Miettinen TA. Reduction of serum cholestesrol in postmenopausal women with previous myocardial infarction and cholestrol malabsorption induced by dietary sitostanol ester margarine : women and dietary sitostanol. Circulation 1997 ; 96 : 4226-31.
30. Katan MB, Grundy SM, Jones P, Law M, Miettinen T, Paoletti R. Stresa Workshop Participants. Efficacy and safety of plant stands and sterols in the management of blood cholesterol levels. Mayo Clin Proc 2003 ; 78 : 965-78.
31. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002 ; 106 : 3143-421.
32. Goto N, Mori H, Katsuragi H, Toi T, Yasukawa T, Shimasaki H. Effect of Diacylglycerol containing phytosterol on reducing blood cholesterol level. J Jpn Oil Chem Soc 1999 ; 48 : 235-40.
33. Takeshita M, Saito S, Katsuragi Y, Yasunaga K, Matsuo N, Tokimitsu I, et al. Combination of plant sterols and diacylglycerol oil lowers serum cholesterol and lipoprotein (a) concentrations in postmenopausal women with mild to moderate hypercholesterolemia. e-SPEN (the European e-Journal of Clinical Nutrition and Metabolism) 2007 ; 2 : 4-11.
34. Meguro S, Higashi K, Hase T, Honda Y, Otsuka A, Tokimitsu I, et al. Solubilization of phytosterols in diacylglycerol versus triacylglycerol improves the serum cholesterol-lowering effect. Eur J Clin Nutr 2001 ; 55 : 513-7.
35. Saito S, Takeshita M, Tomonobu K, Kudo N, Shiiba D, Hase T, et al. Dose-dependent cholesterol-lowering effect of a mayonnaise-type product with a main component of diacylglycerol-containing plant sterol esters. Nutrition 2006 ; 22 : 174-8.
36. Japanese source
37. Japanese source
38. Watanabe T, Shimizu M, Sugiura M, Sato M, Kohori J, Yamada N, et al. Optimization of reaction conditions for the production of DAG using immobilized 1, 3-regiospecific lipase lipozyme RM IM. J Am Oil Chem Soc 2003 : 80 ; 1201-7.
39. Saito S, Tomonobu K, Kudo N, Shiiba D, Hase T, Tokimitsu I. Serum retinol, alpha-tocopherol, and beta-carotene levels are not altered by excess ingestion of diacylglycerol-containing plant sterol esters. Ann Nutr Metab 2006 ; 50 : 372-9.
40. Taguchi H, Nagao T, Watanabe H, Onizawa K, Matsuo N, Tokimitsu I, et al. Energy value and digestibility of dietary oil containing mainly 1,3-diacylglycerol are similar to those of triacylglycerol. Lipids 2001 ; 36 : 379-82.
41. Tokunaga K, Matsuzawa Y, Ishikawa K, Tarui S. A novel technique for the determination of body fat by computed tomography. Int J Obes 1983 ; 7 : 437-45.
42. Japanese source
43. Salen G, Shefer S, Nguyen L, Ness GC, Tint GS, Shore V. Sitosterolemia. J Lipid Res 1992 ; 33 : 945-55.
44. Berge KE, Tian H, Graf GA, Yu L, Grishin NV, Schultz J, et al. Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science 2000 ; 290 : 1771-5.
45. Watanabe H, Onizawa K, Naito S, Taguchi H, Goto N, Nagao T, et al. Fat-soluble vitamin status is not affected by diacylglycerol consumption. Ann Nutr Metab 2001 ; 45 : 259-64.