Phosphoramidate pronucleotides: A comparison of the phosphoramidase substrate specificity of human and Escherichia coli histidine triad nucleotide binding proteins

Molecular Pharmaceutics

Volumn 4, Issue 2, 2007, Pages 208-217

  Chou, Tsui Fen ^a   Baraniak, Janina ^b   Kaczmarek, Renata ^b   Zhou, Xin ^a   Cheng, Jilin ^a   Ghosh, Brahma ^a   Wagner, Carston R ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b CENTRE OF MOLECULAR AND MACROMOLECULAR STUDIES   (Poland)

Author keywords

Escherichia coli hinT; Fluorogenic phosphoramidates; Histidine triad nucleotide binding proteins (Hints); Human Hint1; Phosphoramidase

Indexed keywords

ADENOSINE KINASE; ADENOSINE PHOSPHATE; BACTERIAL ENZYME; HISTIDINE TRIAD NUCLEOTIDE BINDING PROTEIN; INDOLE DERIVATIVE; NUCLEOSIDE DERIVATIVE; NUCLEOSIDE PHOSPHORAMIDIC ACID DERIVATIVE; NUCLEOTIDE BINDING PROTEIN; PHOSPHORAMIDIC ACID DERIVATIVE; TRYPTAMINE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL BOND; CONTROLLED STUDY; DIASTEREOISOMER; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; ESCHERICHIA COLI; FLUORESCENCE ANALYSIS; HUMAN; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; PRONUCLEUS; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; STEADY STATE; STEREOCHEMISTRY;

AMIDES; AMIDOHYDROLASES; BINDING SITES; ESCHERICHIA COLI; FLUORESCENCE; HISTIDINE; HUMANS; HYDROGEN BONDING; MOLECULAR STRUCTURE; NUCLEOTIDES; PHOSPHORIC ACIDS; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 34247380394     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp060070y     Document Type: Article

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