Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1

Journal of Pharmacology and Experimental Therapeutics

Volumn 310, Issue 2, 2004, Pages 469-476

  Sun, Zejin ^a   Murry, Daryl J ^b   Sanghani, Sonal P ^a   Davis, Wilhelmina I ^a   Kedishvili, Natalia Y ^a   Zou, Qin ^a   Hurley, Thomas D ^a   Bosron, William F ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLESTERASE 1A1; CARBOXYLESTERASE 2; CARBOXYLESTERASE 3; ISOENZYME; METHYLPHENIDATE; UNCLASSIFIED DRUG;

ARTICLE; ATTENTION DEFICIT DISORDER; CATALYSIS; CHIRALITY; COLON; CONTROLLED STUDY; DRUG CLEARANCE; DRUG HYDROLYSIS; ENANTIOMER; ENZYME KINETICS; ENZYME PURIFICATION; FIRST PASS EFFECT; HUMAN; HUMAN TISSUE; INSECT CELL; ISOMER; NONHUMAN; PRIORITY JOURNAL; STEREOCHEMISTRY;

ANIMALS; CARBOXYLIC ESTER HYDROLASES; CELL LINE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYDROLYSIS; INSECTS; ISOENZYMES; LIVER; METHYLPHENIDATE; STEREOISOMERISM;

EID: 3342939961     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.067116     Document Type: Article

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