The application of phosphoramidate protide technology to acyclovir confers anti-HIV inhibition

Journal of Medicinal Chemistry

Volumn 52, Issue 17, 2009, Pages 5520-5530

  Derudas, Marco ^a   Carta, Davide ^a   Brancale, Andrea ^a   Vanpouille, Christophe ^b   Lisco, Andrea ^b   Margolis, Leonid ^b   Balzarini, Jan ^c   McGuigan, Christopher ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; ALANINE; ALANINE DERIVATIVE; AMINO ACID; CARBOXYPEPTIDASE C; ESTER; FUNCTIONAL GROUP; NUCLEOSIDE; PHENYLALANINE DERIVATIVE; PHOSPHOMONOESTER; PHOSPHORAMIDIC ACID DERIVATIVE; PRODRUG; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CONCENTRATION RESPONSE; DRUG STRUCTURE; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN TISSUE; HYDROLYSIS; MOLECULAR MODEL; PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION; TECHNOLOGY; VIRUS INHIBITION;

ACYCLOVIR; AMIDES; AMINO ACIDS; ANTI-HIV AGENTS; BENZENE; CARBOXYPEPTIDASE C; CATALYTIC DOMAIN; CELL LINE; ENZYME ACTIVATION; ESTERS; HIV-1; HUMANS; MODELS, MOLECULAR; NERVE TISSUE PROTEINS; PHOSPHORIC ACIDS; SIMPLEXVIRUS;

EID: 69949098496     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9007856     Document Type: Article

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