Synthesis and anti-HIV activity of some novel chain-extended phosphoramidate derivatives of d4T (stavudine): Esterase hydrolysis as a rapid predictive test for antiviral potency

Antiviral Chemistry and Chemotherapy

Volumn 9, Issue 2, 1998, Pages 109-115

  McGuigan, C ^a   Tsang, H W ^a   Sutton, P W ^a   De Clercq, E ^b   Balzarini, J ^b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

d4T; HIV; Nucleotide; Phosphoramidate

Indexed keywords

ESTERASE; PHOSPHORAMIDIC ACID DERIVATIVE; STAVUDINE;

ANALYTIC METHOD; ANTIVIRAL ACTIVITY; ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYDROLYSIS; MEMBRANE PERMEABILITY; NONHUMAN; PREDICTION; PRIORITY JOURNAL;

EID: 0031946728     PISSN: 09563202     EISSN: None     Source Type: Journal    
DOI: 10.1177/095632029800900202     Document Type: Article

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