Evidence that Human Histidine Triad Nucleotide Binding Protein 3 (Hint3) is a Distinct Branch of the Histidine Triad (HIT) Superfamily

Journal of Molecular Biology

Volumn 373, Issue 4, 2007, Pages 978-989

  Chou, Tsui Fen ^a   Cheng, Jilin ^a   Tikh, Ilya B ^a   Wagner, Carston R ^a,b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b University of Minnesota   (United States)

Author keywords

human Hint1; human Hint3 1; human Hint3 2; lysyl tRNA synthetase; phosphoramidase

Indexed keywords

ADENOSINE PHOSPHATE; ALANINE; HISTIDINE; HISTIDINE TRIAD NUCLEOTIDE BINDING PROTEIN 3; HOMODIMER; HYDROLASE; ISOENZYME; LYSINE TRANSFER RNA LIGASE; NUCLEOTIDE BINDING PROTEIN; OLIGOMER; PHOSPHORAMIDASE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BAY REGION BINDING SITE; CATALYST; CONTROLLED STUDY; ENZYME SUBSTRATE; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYDROLYSIS; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN FAMILY; SINGLE NUCLEOTIDE POLYMORPHISM; STRUCTURAL PROTEOMICS;

ESCHERICHIA COLI; EUKARYOTA; PROKARYOTA;

EID: 34848863632     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2007.08.023     Document Type: Article

References (29)

1. Brenner C. Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases. Biochemistry 41 (2002) 9003-9014
2. Bieganowski P., Garrison P.N., Hodawadekar S.C., Faye G., Barnes L.D., and Brenner C. Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3. J. Biol. Chem. 277 (2002) 10852-10860
3. Krakowiak A., Pace H.C., Blackburn G.M., Adams M., Mekhalfia A., Kaczmarek R., et al. Biochemical, crystallographic, and mutagenic characterization of Hint, the AMP-lysine hydrolase, with novel substrates and inhibitors. J. Biol. Chem. 279 (2004) 18711-18716
4. 31P NMR and genetic analysis establish hinT as the only Escherichia coli purine nucleoside phosphoramidase and as essential for growth under high salt conditions. J. Biol. Chem. 280 (2005) 15356-15361
5. Chou T.-F., Baraniak J., Kaczmarek R., Zhou X., Cheng J., Ghosh B., and Wagner C.R. Phosphoramidate pronucleotides: a comparison of the phosphoramidase substrate specificity of human and E. coli histidine triad nucleotide binding proteins (Hint1). Mol. Pharm. 4 (2007) 208-217
6. Chou T.-F., and Wagner C.R. Lysyl-tRNA synthetase-generated lysyl-adenylate is a substrate for histidine triad nucleotide binding proteins. J. Biol. Chem. 282 (2007) 4719-4727
7. Chou T.-F., Tikh I.B., Horta B.A., Ghosh B., de Alencastro R.B., and Wagner C.R. Engineered monomeric human histidine triad nucleotide binding protein 1 hydrolyzes fluorogenic acyl-adenylate and lysyl-tRNA synthetase-generated lysyl-adenylate. J. Biol. Chem. 282 (2007) 15137-15147
8. Razin E., Zhang Z.C., Nechushtan H., Frenkel S., Lee Y.N., Arudchandran R., and Rivera J. Suppression of microphthalmia transcriptional activity by its association with protein kinase C-interacting protein 1 in mast cells. J. Biol. Chem. 274 (1999) 34272-34276
9. Lee Y.N., and Razin E. Nonconventional involvement of LysRS in the molecular mechanism of USF2 transcriptional activity in Fc{varepsilon}RI-activated mast cells. Mol. Cell. Biol. 25 (2005) 8904-8912
10. Yannay-Cohen N., and Razin E. Translation and transcription: the dual functionality of LysRS in mast cells. Mol. Cells 22 (2006) 127-132
11. Lee Y.N., Nechushtan H., Figov N., and Razin E. The function of lysyl-tRNA synthetase and Ap4A as signaling regulators of MITF activity in FcepsilonRI-activated mast cells. Immunity 20 (2004) 145-151
12. Li H., Zhang Y., Su T., Santella R.M., and Weinstein I. B. Hint1 is a haplo-insufficient tumor suppressor in mice. Oncogene 25 (2006) 713-721
13. Yuan B.Z., Jefferson A.M., Popescu N.C., and Reynolds S.H. Aberrant gene expression in human non small cell lung carcinoma cells exposed to demethylating agent 5-aza-2′-deoxycytidine. Neoplasia 6 (2004) 412-429
14. Weiske J., and Huber O. The histidine triad protein Hint1 triggers apoptosis independent of its enzymatic activity. J. Biol. Chem. 281 (2006) 27356-27366
15. Wang L., Zhang Y., Li H., Xu Z., Santella R.M., and Weinstein I.B. Hint1 inhibits growth and activator protein-1 activity in human colon cancer cells. Cancer Res. 67 (2007) 4700-4708
16. Martin J., Magnino F., Schmidt K., Piguet A.-C., Lee J.-S., Semela D., et al. Hint2, a mitochondrial apoptotic sensitizer downregulated in hepatocellular carcinoma. Gastroenterology 130 (2006) 2179-2188
17. Korsisaari N., Rossi D.J., Luukko K., Huebner K., Henkemeyer M., and Makela T.P. The histidine triad protein Hint is not required for murine development or Cdk7 function. Mol. Cell. Biol. 23 (2003) 3929-3935
18. Seidle H.F., Bieganowski P., and Brenner C. Disease-associated mutations inactivate AMP-lysine hydrolase activity of Aprataxin. J. Biol. Chem. 280 (2005) 20927-20931
19. Kijas A.W., Harris J.L., Harris J.M., and Lavin M.F. Aprataxin forms a discrete branch in the HIT superfamily of proteins with both DNA/RNA binding and nucleotide hydrolase activities. J. Biol. Chem. 81 (2006) 13939-13948
20. Ahel I., Rass U., El-Khamisy S.F., Katyal S., Clements P.M., McKinnon P.J., et al. The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. Nature 443 (2006) 713-716
21. Kern D., Lorber B., Boulanger Y., and Giege R. A peculiar property of aspartyl-tRNA synthetase from Bakers' yeast: chemical modification of the protein by the enzymatically synthesized aminoacyl adenylate. Biochemistry 24 (1985) 1321-1332
22. Jakubowski H. Misacylation of tRNALys with noncognate amino acids by lysyl-tRNA synthetase. Biochemistry 38 (1999) 8088-8093
23. Khvorova A., Motorin Y., and Wolfson A.D. Pyrophosphate mediates the effect of certain tRNA mutations on aminoacylation of yeast tRNA(Phe). Nucleic Acids Res. 27 (1999) 4451-4456
24. Wolfson A.D., and Uhlenbeck O.C. Modulation of tRNAAla identity by inorganic pyrophosphatase. Proc. Natl Acad. Sci. USA 99 (2002) 5965-5970
25. Adams S.R., Campbell R.E., Gross L.A., Martin B.R., Walkup G.K., Yao Y., et al. New biarsenical ligands and tetracysteine motifs for protein labeling in vitro and in vivo: synthesis and biological applications. J. Am. Chem. Soc. 124 (2002) 6063-6076
26. Machleidt T., Robers M., and Hanson G.T. Protein labeling with FlAsH and ReAsH. Methods Mol. Biol. 356 (2007) 209-220
27. Sticha K.R., Sieg C.A., Bergstrom C.P., Hanna P.E., and Wagner C.R. Overexpression and large-scale purification of recombinant hamster polymorphic arylamine N-acetyltransferase as a dihydrofolate reductase fusion protein. Protein Expression Purif. 10 (1997) 141-153
28. Klein M.G., Yao Y., Slosberg E.D., Lima C.D., Doki Y., and Weinstein I.B. Characterization of PKCI and comparative studies with FHIT, related members of the HIT protein family. Exp. Cell Res. 244 (1998) 26-32
29. Wyatt J.P. Light scattering and the absolute characterization of macromolecules. Anal. Chim. Acta 272 (1993) 1-40