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Volumn 70, Issue 16, 2010, Pages 2171-2200

Current approaches to the management of diabetic retinopathy and diabetic macular oedema

Author keywords

Aspirin; Atorvastatin; Bevacizumab; Candesartan cilexetil; Corticosteroids; Diabetic macular oedema; Diabetic retinopathy; Enalapril; Fenofibrate; Infliximab; Laser therapy; Lisinopril; Losartan; Mecamylamine; Pegaptanib; Perindopril; PF 4523655; Ranibizumab; Ruboxistaurin; Triamcinolone

Indexed keywords

ACETYLSALICYLIC ACID; AFLIBERCEPT; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; ANTILIPEMIC AGENT; ATORVASTATIN; BEVACIZUMAB; BEVASIRANIB; CANDESARTAN HEXETIL; CORTICOSTEROID; DEXAMETHASONE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; FENOFIBRATE; HEMOGLOBIN A1C; INSULIN; LISINOPRIL; LOSARTAN; MICROPLASMIN; NONSTEROID ANTIINFLAMMATORY AGENT; PEGAPTANIB; PLACEBO; RANIBIZUMAB; RUBOXISTAURIN; SIMVASTATIN; SULINDAC; TRIAMCINOLONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; UREA DERIVATIVE; VITREOSOLVE;

EID: 77958566857     PISSN: 00126667     EISSN: 11791950     Source Type: Journal    
DOI: 10.2165/11538130-000000000-00000     Document Type: Review
Times cited : (31)

References (317)
  • 2
    • 58149229539 scopus 로고    scopus 로고
    • Emerging drugs for diabetic ret-inopathy
    • Mohamed Q, Wong TY. Emerging drugs for diabetic ret-inopathy. Expert Opin Emerg Drugs 2008; 13 (4): 675-94
    • (2008) Expert Opin Emerg Drugs , vol.13 , Issue.4 , pp. 675-694
    • Mohamed, Q.1    Wong, T.Y.2
  • 3
    • 67650254782 scopus 로고    scopus 로고
    • Update on systemic manage-ment of diabetes
    • Masharani U, Rushakoff RJ. Update on systemic manage-ment of diabetes. Int Ophthalmol Clin 2009; 49 (2): 13-33
    • (2009) Int Ophthalmol Clin , vol.49 , Issue.2 , pp. 13-33
    • Masharani, U.1    Rushakoff, R.J.2
  • 4
    • 67749084303 scopus 로고    scopus 로고
    • Modern-day clinical course of type 1 diabetes mellitus after 30 years' duration: The diabetes control and complications trial/epidemiology of diabetes interventions and complications and Pittsburgh epidemiology of diabetes complications experience (1983-2005)
    • on behalf of theDiabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/ EDIC) Research Group
    • Nathan DM, Zinman B, Cleary PA, et al., on behalf of theDiabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/ EDIC) Research Group. Modern-day clinical course of type 1 diabetes mellitus after 30 years' duration: the diabetes control and complications trial/epidemiology of diabetes interventions and complications and Pittsburgh epidemiology of diabetes complications experience (1983-2005). Arch Intern Med 2009; 169 (14): 1307-16
    • (2009) Arch Intern Med , vol.169 , Issue.14 , pp. 1307-1316
    • Nathan, D.M.1    Zinman, B.2    Cleary, P.A.3
  • 5
    • 72249101707 scopus 로고    scopus 로고
    • Rates of pro-gression in diabetic retinopathy during different time periods: A systematic review and meta-analysis
    • Wong TY, Mwamburi M, Klein R, et al. Rates of pro-gression in diabetic retinopathy during different time periods: a systematic review and meta-analysis. Diabetes Care 2009; 32 (12): 2307-13
    • (2009) Diabetes Care , vol.32 , Issue.12 , pp. 2307-2313
    • Wong, T.Y.1    Mwamburi, M.2    Klein, R.3
  • 6
    • 70349473058 scopus 로고    scopus 로고
    • Changes in visualimpairment prevalence by period of diagnosis of diabetes: The Wisconsin Epidemiologic Study of Diabetic Retinop-athy
    • Klein R, Lee KE, Knudtson MD, et al. Changes in visualimpairment prevalence by period of diagnosis of diabetes: the Wisconsin Epidemiologic Study of Diabetic Retinop-athy. Ophthalmology 2009; 116 (10): 1937-42
    • (2009) Ophthalmology , vol.116 , Issue.10 , pp. 1937-1942
    • Klein, R.1    Lee, K.E.2    Knudtson, M.D.3
  • 7
    • 67049087838 scopus 로고    scopus 로고
    • Changes in the diabetic retinopathy epidemiology after 14 years in a population of type 1 and 2 diabetic patients after the new diabetes mellitus diagnosis criteria and a more strict control of the patients
    • Romero-Aroca P, Fernandez-Balart J, Baget-Bernaldiz M,et al. Changes in the diabetic retinopathy epidemiology after 14 years in a population of type 1 and 2 diabetic patients after the new diabetes mellitus diagnosis criteria and a more strict control of the patients. J Diabetes Complications 2009; 23 (4): 229-38
    • (2009) J Diabetes Complications , vol.23 , Issue.4 , pp. 229-238
    • Romero-Aroca, P.1    Fernandez-Balart, J.2    Baget-Bernaldiz, M.3
  • 8
    • 77958048810 scopus 로고    scopus 로고
    • Prevalence andhealthcare costs of diabetic retinopathy: A population-based register study in Sweden
    • Oct
    • Heintz E, Wirehn AB, Peebo BB, et al. Prevalence andhealthcare costs of diabetic retinopathy: a population-based register study in Sweden. Diabetologia 2010 Oct; 53 (10): 2147-54
    • (2010) Diabetologia , vol.53 , Issue.10 , pp. 2147-2154
    • Heintz, E.1    Wirehn, A.B.2    Peebo, B.B.3
  • 9
    • 33750710436 scopus 로고    scopus 로고
    • The North Jutland County Diabetic Retinopathy Study: Population characteristics
    • Knudsen LL, Lervang HH, Lundbye-Christensen S, et al.The North Jutland County Diabetic Retinopathy Study: population characteristics. Br J Ophthalmol 2006; 90 (11): 1404-9
    • (2006) Br J Ophthalmol , vol.90 , Issue.11 , pp. 1404-1409
    • Knudsen, L.L.1    Lervang, H.H.2    Lundbye-Christensen, S.3
  • 10
    • 4444366881 scopus 로고    scopus 로고
    • The prevalence of retinopathy in an unselected population of type 2 diabetes patients from Arhus County, Denmark
    • Hove MN, Kristensen JK, Lauritzen T, et al. The prev-alence of retinopathy in an unselected population of type 2 diabetes patients from Arhus County, Denmark. Acta Ophthalmol Scand 2004; 82 (4): 443-8
    • (2004) Acta Ophthalmol Scand , vol.82 , Issue.4 , pp. 443-448
    • Hove, M.N.1    Kristensen, J.K.2    Lauritzen, T.3
  • 11
    • 77955376918 scopus 로고    scopus 로고
    • Prevalence of dia-betic retinopathy in the United States 2005-2008
    • Zhang X, Saaddine JB, Chou CF, et al. Prevalence of dia-betic retinopathy in the United States, 2005-2008. JAMA 2010; 304 (6): 649-56
    • (2010) JAMA , vol.304 , Issue.6 , pp. 649-656
    • Zhang, X.1    Saaddine, J.B.2    Chou, C.F.3
  • 12
    • 54949133248 scopus 로고    scopus 로고
    • The WisconsinEpidemiologic Study of Diabetic Retinopathy XXII: The twenty-five-year progression of retinopathy in persons with type 1 diabetes
    • Klein R, Knudtson MD, Lee KE, et al. The WisconsinEpidemiologic Study of Diabetic Retinopathy XXII: the twenty-five-year progression of retinopathy in persons with type 1 diabetes. Ophthalmology 2008; 115 (11): 1859-68
    • (2008) Ophthalmology , vol.115 , Issue.11 , pp. 1859-1868
    • Klein, R.1    Knudtson, M.D.2    Lee, K.E.3
  • 13
    • 58149269716 scopus 로고    scopus 로고
    • Projec-tion of diabetic retinopathy and other major eye diseases among people with diabetes mellitus: United States, 2005-2050
    • Saaddine JB, Honeycutt AA, Narayan KM, et al. Projec-tion of diabetic retinopathy and other major eye diseases among people with diabetes mellitus: United States, 2005-2050. Arch Ophthalmol 2008; 126 (12): 1740-7
    • (2008) Arch Ophthalmol , vol.126 , Issue.12 , pp. 1740-1747
    • Saaddine, J.B.1    Honeycutt, A.A.2    Narayan, K.M.3
  • 14
    • 11144356305 scopus 로고    scopus 로고
    • The prevalence of diabetic retinopathy among adults in the United States
    • Kempen JH, O'Colmain BJ, Leske MC, et al. The prev-alence of diabetic retinopathy among adults in the United States. Arch Ophthalmol 2004; 122 (4): 552-63
    • (2004) Arch Ophthalmol , vol.122 , Issue.4 , pp. 552-563
    • Kempen, J.H.1    O'Colmain, B.J.2    Leske, M.C.3
  • 15
    • 67650252211 scopus 로고    scopus 로고
    • Pathophysiology of diabetic macularedema
    • Singh A, Stewart JM. Pathophysiology of diabetic macularedema. Int Ophthalmol Clin 2009; 49 (2): 1-11
    • (2009) Int Ophthalmol Clin , vol.49 , Issue.2 , pp. 1-11
    • Singh, A.1    Stewart, J.M.2
  • 16
    • 52649142151 scopus 로고    scopus 로고
    • Novel potential mechanismsfor diabetic macular edema: Leveraging new investiga-tional approaches
    • Gardner TW, Antonetti DA. Novel potential mechanismsfor diabetic macular edema: leveraging new investiga-tional approaches. Curr Diab Rep 2008; 8 (4): 263-9
    • (2008) Curr Diab Rep , vol.8 , Issue.4 , pp. 263-269
    • Gardner, T.W.1    Antonetti, D.A.2
  • 17
    • 58449114090 scopus 로고    scopus 로고
    • Diabetic macularedema: Pathogenesis and treatment
    • Bhagat N, Grigorian RA, Tutela A, et al. Diabetic macularedema: pathogenesis and treatment. Surv Ophthalmol 2009; 54 (1): 1-32
    • (2009) Surv Ophthalmol , vol.54 , Issue.1 , pp. 1-32
    • Bhagat, N.1    Grigorian, R.A.2    Tutela, A.3
  • 18
    • 77953555650 scopus 로고    scopus 로고
    • Burden of illness ofdiabetic macular edema: Literature review
    • Chen E, Looman M, Laouri M, et al. Burden of illness ofdiabetic macular edema: literature review. Curr Med Res Opin 2010; 26 (7): 1587-97
    • (2010) Curr Med Res Opin , vol.26 , Issue.7 , pp. 1587-1597
    • Chen, E.1    Looman, M.2    Laouri, M.3
  • 19
    • 36749043809 scopus 로고    scopus 로고
    • The North Jutland County Diabetic Retinopathy Study (NCDRS) 2: Non-ophthalmic parameters and clinically significant macular oedema
    • Knudsen LL, Lervang HH, Lundbye-Christensen S, et al.The North Jutland County Diabetic Retinopathy Study (NCDRS) 2: non-ophthalmic parameters and clinically significant macular oedema. Br J Ophthalmol 2007; 91 (12): 1593-5
    • (2007) Br J Ophthalmol , vol.91 , Issue.12 , pp. 1593-1595
    • Knudsen, L.L.1    Lervang, H.H.2    Lundbye-Christensen, S.3
  • 20
    • 0028896755 scopus 로고
    • XV: The long-term incidence of macular edema
    • The Wisconsin Epide-miologic Study of Diabetic Retinopathy
    • Klein R, Klein BE, Moss SE, et al. The Wisconsin Epide-miologic Study of Diabetic Retinopathy. XV: the long-term incidence of macular edema. Ophthalmology 1995; 102 (1): 7-16
    • (1995) Ophthalmology , vol.102 , Issue.1 , pp. 7-16
    • Klein, R.1    Klein, B.E.2    Moss, S.E.3
  • 21
    • 61349121337 scopus 로고    scopus 로고
    • XXIII: The twenty-five-year incidence of macular edema in persons with type 1 diabetes
    • The WisconsinEpidemiologic Study of Diabetic Retinopathy
    • Klein R, Knudtson MD, Lee KE, et al. The WisconsinEpidemiologic Study of Diabetic Retinopathy. XXIII: the twenty-five-year incidence of macular edema in persons with type 1 diabetes. Ophthalmology 2009; 116 (3): 497-503
    • (2009) Ophthalmology , vol.116 , Issue.3 , pp. 497-503
    • Klein, R.1    Knudtson, M.D.2    Lee, K.E.3
  • 22
    • 58149240462 scopus 로고    scopus 로고
    • Resource use andcosts associated with diabetic macular edema in elderly persons
    • Shea AM, Curtis LH, Hammill BG, et al. Resource use andcosts associated with diabetic macular edema in elderly persons. Arch Ophthalmol 2008; 126 (12): 1748-54
    • (2008) Arch Ophthalmol , vol.126 , Issue.12 , pp. 1748-1754
    • Shea, A.M.1    Curtis, L.H.2    Hammill, B.G.3
  • 24
    • 77951299128 scopus 로고    scopus 로고
    • Optical coherence tomography in diabeticmacular edema
    • Baskin DE. Optical coherence tomography in diabeticmacular edema. Curr Opin Ophthalmol 2010; 21 (3): 172-7
    • (2010) Curr Opin Ophthalmol , vol.21 , Issue.3 , pp. 172-177
    • Baskin, D.E.1
  • 25
    • 22844432568 scopus 로고    scopus 로고
    • A standardized method for reportingchanges in macular thickening using optical coherence tomography
    • Chan A, Duker JS. A standardized method for reportingchanges in macular thickening using optical coherence tomography. Arch Ophthalmol 2005; 123 (7): 939-43
    • (2005) Arch Ophthalmol , vol.123 , Issue.7 , pp. 939-943
    • Chan, A.1    Duker, J.S.2
  • 26
    • 33748866298 scopus 로고    scopus 로고
    • Optical coherence tomo-graphic patterns of diabetic macular edema
    • Kim BY, Smith SD, Kaiser PK. Optical coherence tomo-graphic patterns of diabetic macular edema. Am J Oph-thalmol 2006; 142 (3): 406-12
    • (2006) Am J Ophthalmol , vol.142 , Issue.3 , pp. 406-412
    • Kim, B.Y.1    Smith, S.D.2    Kaiser, P.K.3
  • 27
    • 78049480347 scopus 로고    scopus 로고
    • Vitreous trac-tion and epiretinal membranes in diabetic macular oedema using spectral-domain optical coherence tomography
    • Epub 2010 Jun 4
    • Ophir A, Martinez MR, Mosqueda P, et al. Vitreous trac-tion and epiretinal membranes in diabetic macular oedema using spectral-domain optical coherence tomography. Eye (Lond). Epub 2010 Jun 4
    • Eye (Lond)
    • Ophir, A.1    Martinez, M.R.2    Mosqueda, P.3
  • 28
    • 0032997035 scopus 로고    scopus 로고
    • Patterns of diabetic mac-ular edema with optical coherence tomography
    • Otani T, Kishi S, Maruyama Y. Patterns of diabetic mac-ular edema with optical coherence tomography. Am J Ophthalmol 1999; 127 (6): 688-93
    • (1999) Am J Ophthalmol , vol.127 , Issue.6 , pp. 688-693
    • Otani, T.1    Kishi, S.2    Maruyama, Y.3
  • 29
    • 77956395406 scopus 로고    scopus 로고
    • Optical coherencetomography imaging for diabetic retinopathy and mac-ular edema
    • Buabbud JC, Al-latayfeh MM, Sun JK. Optical coherencetomography imaging for diabetic retinopathy and mac-ular edema. Curr Diab Rep 2010; 10 (4): 264-9
    • (2010) Curr Diab Rep , vol.10 , Issue.4 , pp. 264-269
    • Buabbud, J.C.1    Al-Latayfeh, M.M.2    Sun, J.K.3
  • 30
    • 70450178647 scopus 로고    scopus 로고
    • Comparison oftime domain Stratus OCT and spectral domain SLO/OCTfor assessment of macular thickness and volume
    • Forte R, Cennamo GL, Finelli ML, et al. Comparison oftime domain Stratus OCT and spectral domain SLO/OCTfor assessment of macular thickness and volume. Eye (Lond) 2009; 23 (11): 2071-8
    • (2009) Eye (Lond) , vol.23 , Issue.11 , pp. 2071-2078
    • Forte, R.1    Cennamo, G.L.2    Finelli, M.L.3
  • 31
    • 67649946247 scopus 로고    scopus 로고
    • Macular thickness measurements in healthy eyes using six different optical coherence tomography instruments
    • Wolf-Schnurrbusch UE, Ceklic L, Brinkmann CK, et al. Macular thickness measurements in healthy eyes using six different optical coherence tomography instruments. Invest Ophthalmol Vis Sci 2009; 50 (7): 3432-7
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , Issue.7 , pp. 3432-3437
    • Wolf-Schnurrbusch, U.E.1    Ceklic, L.2    Brinkmann, C.K.3
  • 32
    • 72249115457 scopus 로고    scopus 로고
    • Spectral domainoptical coherence tomography in diabetic macular edema
    • Pournaras JA, Erginay A, Lazrak Z, et al. Spectral domainoptical coherence tomography in diabetic macular edema. Ophthalmic Surg Lasers Imaging 2009; 40 (6): 548-53
    • (2009) Ophthalmic Surg Lasers Imaging , vol.40 , Issue.6 , pp. 548-553
    • Pournaras, J.A.1    Erginay, A.2    Lazrak, Z.3
  • 33
    • 77951157629 scopus 로고    scopus 로고
    • Comparing retinal thickness measurements from cirrus spectral domain-and stratus time domain-optical coherence tomography
    • Geitzenauer W, Kiss CG, Durbin MK, et al. Compar-ing retinal thickness measurements from cirrus spectral domain-and stratus time domain-optical coherence tomography. Retina 2010; 30 (4): 596-606
    • (2010) Retina , vol.30 , Issue.4 , pp. 596-606
    • Geitzenauer, W.1    Kiss, C.G.2    Durbin, M.K.3
  • 35
    • 33947504474 scopus 로고    scopus 로고
    • Pathogenesis and classi-fication of proliferative diabetic vitreoretinopathy
    • Kroll P, Rodrigues EB, Hoerle S. Pathogenesis and classi-fication of proliferative diabetic vitreoretinopathy. Oph-thalmologica 2007; 221 (2): 78-94
    • (2007) Ophthalmologica , vol.221 , Issue.2 , pp. 78-94
    • Kroll, P.1    Rodrigues, E.B.2    Hoerle, S.3
  • 36
    • 0022347471 scopus 로고
    • Photocoagulation for diabeticmacular edema: Early Treatment Diabetic Retinopathy Study report no. 1
    • ETDRS Research Group Early Treatment Diabetic Retinopathy Study research group
    • ETDRS Research Group. Photocoagulation for diabeticmacular edema: Early Treatment Diabetic Retinopathy Study report no. 1. Early Treatment Diabetic Retinopathy Study research group. Arch Ophthalmol 1985; 103 (12): 1796-806
    • (1985) Arch Ophthalmol , vol.103 , Issue.12 , pp. 1796-1806
  • 37
    • 67650215674 scopus 로고    scopus 로고
    • Update on laser treatment of diabeticmacular edema
    • Ahmadi MA, Lim JI. Update on laser treatment of diabeticmacular edema. Int Ophthalmol Clin 2009; 49 (2): 87-94
    • (2009) Int Ophthalmol Clin , vol.49 , Issue.2 , pp. 87-94
    • Ahmadi, M.A.1    Lim, J.I.2
  • 38
    • 34249009323 scopus 로고    scopus 로고
    • Visual stan-dards: Aspects and ranges of vision loss with emphasis on population surveys
    • International Council of Ophthalmology Sydney, Australia, April [online] [Accessed 2010 May 5]
    • International Council of Ophthalmology. Visual stan-dards: aspects and ranges of vision loss with emphasis on population surveys. Report prepared for the International Council of Ophthalmology at the 29th International Congress of Ophthalmology, Sydney, Australia, April 2002 [online]. Available from URL: http://www.icoph. org/pdf/visualstandardsreport.pdf [Accessed 2010 May 5].
    • (2002) Report Prepared for the International Council of Ophthalmology at the 29th International Congress of Ophthalmology
  • 39
    • 33947542681 scopus 로고    scopus 로고
    • Vascular endothelialgrowth factor and the potential therapeutic use of pe-gaptanib (Macugen) in diabetic retinopathy
    • Starita C, Patel M, Katz B, et al. Vascular endothelialgrowth factor and the potential therapeutic use of pe-gaptanib (Macugen) in diabetic retinopathy. Dev Oph-thalmol 2007; 39: 122-48
    • (2007) Dev Ophthalmol , vol.39 , pp. 122-148
    • Starita, C.1    Patel, M.2    Katz, B.3
  • 40
    • 54449089002 scopus 로고    scopus 로고
    • Diabeticmacular edema: What is focal and what is diffuse?
    • Browning DJ, Altaweel MM, Bressler NM, et al. Diabeticmacular edema: what is focal and what is diffuse? Am J Ophthalmol 2008; 146 (5): 649-55
    • (2008) Am J Ophthalmol , vol.146 , Issue.5 , pp. 649-655
    • Browning, D.J.1    Altaweel, M.M.2    Bressler, N.M.3
  • 41
    • 0036943831 scopus 로고    scopus 로고
    • Diabeticretinopathy: More than meets the eye
    • Gardner TW, Antonetti DA, Barber AJ, et al. Diabeticretinopathy: more than meets the eye. Surv Ophthalmol 2002; 47 Suppl. 2: S253-62
    • (2002) Surv Ophthalmol , vol.47 , Issue.SUPPL. 2
    • Gardner, T.W.1    Antonetti, D.A.2    Barber, A.J.3
  • 42
    • 28244463942 scopus 로고    scopus 로고
    • Silent substitutionS-cone electroretinogram in subjects with diabetes melli-tus
    • Mortlock KE, Chiti Z, Drasdo N, et al. Silent substitutionS-cone electroretinogram in subjects with diabetes melli-tus. Ophthalmic Physiol Opt 2005; 25 (5): 392-9
    • (2005) Ophthalmic Physiol Opt , vol.25 , Issue.5 , pp. 392-399
    • Mortlock, K.E.1    Chiti, Z.2    Drasdo, N.3
  • 43
    • 77955927858 scopus 로고    scopus 로고
    • Decreased contrast sensitivity in children and adolescents with type 1 diabetes mellitus
    • Epub 2010 Apr 30
    • Georgakopoulos CD, Eliopoulou MI, Exarchou AM, et al.Decreased contrast sensitivity in children and adolescents with type 1 diabetes mellitus. J Pediatr Ophthalmol Strabismus. Epub 2010 Apr 30: 1-6
    • J Pediatr Ophthalmol Strabismus , pp. 1-6
    • Georgakopoulos, C.D.1    Eliopoulou, M.I.2    Exarchou, A.M.3
  • 44
    • 0035098402 scopus 로고    scopus 로고
    • Visual electrophysiological responses inpersons with type 1 diabetes
    • Parisi V, Uccioli L. Visual electrophysiological responses inpersons with type 1 diabetes. Diabetes Metab Res Rev 2001; 17 (1): 12-8
    • (2001) Diabetes Metab Res Rev , vol.17 , Issue.1 , pp. 12-18
    • Parisi, V.1    Uccioli, L.2
  • 45
    • 66349116250 scopus 로고    scopus 로고
    • Adolescents with type 2 diabetes: Early indications of focal retinal neuropathy retinal thinning and venular dilation
    • Bronson-Castain KW, Bearse Jr MA, Neuville J, et al.Adolescents with type 2 diabetes: early indications of focal retinal neuropathy, retinal thinning, and venular dilation. Retina 2009; 29 (5): 618-26
    • (2009) Retina , vol.29 , Issue.5 , pp. 618-626
    • Bronson-Castain, K.W.1    Bearse Jr., M.A.2    Neuville, J.3
  • 46
    • 77958591203 scopus 로고    scopus 로고
    • Insufficient long-term glycemic control is associated with multifocal ERG defects in adolescents with type 1 diabetes
    • Epub 2010 May 19
    • Lakhani E, Wright T, Abdolell M, et al. Insufficient long-term glycemic control is associated with multifocal ERG defects in adolescents with type 1 diabetes. Invest Oph-thalmol Vis Sci. Epub 2010 May 19
    • Invest Ophthalmol Vis Sci
    • Lakhani, E.1    Wright, T.2    Abdolell, M.3
  • 47
    • 0032529103 scopus 로고    scopus 로고
    • Neural apoptosis in theretina during experimental and human diabetes: Early onset and effect of insulin
    • Barber AJ, Lieth E, Khin SA, et al. Neural apoptosis in theretina during experimental and human diabetes: early onset and effect of insulin. J Clin Invest 1998; 102 (4): 783-91
    • (1998) J Clin Invest , vol.102 , Issue.4 , pp. 783-791
    • Barber, A.J.1    Lieth, E.2    Khin, S.A.3
  • 48
    • 67649977021 scopus 로고    scopus 로고
    • Selective loss ofinner retinal layer thickness in type 1 diabetic patients with minimal diabetic retinopathy
    • van Dijk HW, Kok PH, Garvin M, et al. Selective loss ofinner retinal layer thickness in type 1 diabetic patients with minimal diabetic retinopathy. Invest Ophthalmol Vis Sci 2009; 50 (7): 3404-9
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , Issue.7 , pp. 3404-3409
    • Van Dijk, H.W.1    Kok, P.H.2    Garvin, M.3
  • 49
    • 77649250409 scopus 로고    scopus 로고
    • Early detection of retinalthickness changes in diabetes using optical coherence tomography
    • Cabrera DeBuc D, Somfai GM. Early detection of retinalthickness changes in diabetes using optical coherence tomography. Med Sci Monit 2010; 16 (3): MT15-21
    • (2010) Med Sci Monit , vol.16 , Issue.3
    • Cabrera Debuc, D.1    Somfai, G.M.2
  • 50
    • 77955865169 scopus 로고    scopus 로고
    • Decreasedretinal ganglion cell layer thickness in patients with type 1 diabetes
    • van Dijk HW, Verbraak FD, Kok PH, et al. Decreasedretinal ganglion cell layer thickness in patients with type 1 diabetes. Invest Ophthalmol Vis Sci 2010; 51 (7): 3660-5
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , Issue.7 , pp. 3660-3665
    • Van Dijk, H.W.1    Verbraak, F.D.2    Kok, P.H.3
  • 51
    • 70349211901 scopus 로고    scopus 로고
    • Is neuronal dysfunc-tion an early sign of diabetic retinopathy? Microperimetry and spectral domain optical coherence tomography (SD-OCT) study in individuals with diabetes, but no diabetic retinopathy
    • Verma A, Rani PK, Raman R, et al. Is neuronal dysfunc-tion an early sign of diabetic retinopathy? Microperimetry and spectral domain optical coherence tomography (SD-OCT) study in individuals with diabetes, but no diabetic retinopathy. Eye (Lond) 2009; 23 (9): 1824-30
    • (2009) Eye (Lond) , vol.23 , Issue.9 , pp. 1824-1830
    • Verma, A.1    Rani, P.K.2    Raman, R.3
  • 52
    • 0035139461 scopus 로고    scopus 로고
    • Leukocyte-mediated endothelial cell injury and death in the diabetic retina
    • Joussen AM, Murata T, Tsujikawa A, et al. Leukocyte-mediated endothelial cell injury and death in the diabetic retina. Am J Pathol 2001; 158 (1): 147-52
    • (2001) Am J Pathol , vol.158 , Issue.1 , pp. 147-152
    • Joussen, A.M.1    Murata, T.2    Tsujikawa, A.3
  • 53
    • 0030010417 scopus 로고    scopus 로고
    • Retinal bloodflow changes in patients with insulin-dependent diabetes mellitus and no diabetic retinopathy
    • Bursell SE, Clermont AC, Kinsley BT, et al. Retinal bloodflow changes in patients with insulin-dependent diabetes mellitus and no diabetic retinopathy. Invest Ophthalmol Vis Sci 1996; 37 (5): 886-97
    • (1996) Invest Ophthalmol Vis Sci , vol.37 , Issue.5 , pp. 886-897
    • Bursell, S.E.1    Clermont, A.C.2    Kinsley, B.T.3
  • 54
    • 67749088340 scopus 로고    scopus 로고
    • Microvascular lesionsof diabetic retinopathy: Clues towards understanding pathogenesis?
    • Curtis TM, Gardiner TA, Stitt AW. Microvascular lesionsof diabetic retinopathy: clues towards understanding pathogenesis? Eye (Lond) 2009; 23 (7): 1496-508
    • (2009) Eye (Lond) , vol.23 , Issue.7 , pp. 1496-1508
    • Curtis, T.M.1    Gardiner, T.A.2    Stitt, A.W.3
  • 55
    • 37349105431 scopus 로고    scopus 로고
    • Importance of pericytesand mechanisms of pericyte loss during diabetes retinop-athy
    • Ejaz S, Chekarova I, Ejaz A, et al. Importance of pericytesand mechanisms of pericyte loss during diabetes retinop-athy. Diabetes Obes Metab 2008; 10 (1): 53-63
    • (2008) Diabetes Obes Metab , vol.10 , Issue.1 , pp. 53-63
    • Ejaz, S.1    Chekarova, I.2    Ejaz, A.3
  • 56
    • 0346777254 scopus 로고    scopus 로고
    • Vascularendothelial growth factor and diabetic retinopathy: Pathophysiological mechanisms and treatment perspectives
    • Caldwell RB, Bartoli M, Behzadian MA, et al. Vascularendothelial growth factor and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives. Diabetes Metab Res Rev 2003; 19 (6): 442-55
    • (2003) Diabetes Metab Res Rev , vol.19 , Issue.6 , pp. 442-455
    • Caldwell, R.B.1    Bartoli, M.2    Behzadian, M.A.3
  • 57
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
    • Diabetes Control and Complications Trial ResearchGroup
    • Diabetes Control and Complications Trial ResearchGroup. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993; 329 (14): 977-86
    • (1993) N Engl J Med , vol.329 , Issue.14 , pp. 977-986
  • 58
    • 0028915217 scopus 로고
    • Progression of retinopathy with intensive versus conventional treatment in the Diabetes Control and Complications Trial
    • Diabetes Control and Complications Trial ResearchGroup
    • Diabetes Control and Complications Trial ResearchGroup. Progression of retinopathy with intensive versus conventional treatment in the Diabetes Control and Complications Trial. Ophthalmology 1995; 102 (4): 647-61
    • (1995) Ophthalmology , vol.102 , Issue.4 , pp. 647-661
  • 59
    • 59749087840 scopus 로고    scopus 로고
    • The effect ofglycaemic control on the quantitative characteristics of retinopathy lesions in patients with type 2 diabetes melli-tus: 10-year follow-up study
    • Kalesnykiene V, Sorri I, Voutilainen R, et al. The effect ofglycaemic control on the quantitative characteristics of retinopathy lesions in patients with type 2 diabetes melli-tus: 10-year follow-up study. Graefes Arch Clin Exp Ophthalmol 2009; 247 (3): 335-41
    • (2009) Graefes Arch Clin Exp Ophthalmol , vol.247 , Issue.3 , pp. 335-341
    • Kalesnykiene, V.1    Sorri, I.2    Voutilainen, R.3
  • 60
    • 34547935418 scopus 로고    scopus 로고
    • The polyol pathway as a mechanism for dia-betic retinopathy: Attractive, elusive, and resilient
    • Lorenzi M. The polyol pathway as a mechanism for dia-betic retinopathy: attractive, elusive, and resilient. Exp Diabetes Res 2007; 2007: 61038
    • (2007) Exp Diabetes Res , vol.2007 , pp. 61038
    • Lorenzi, M.1
  • 61
    • 42049118293 scopus 로고    scopus 로고
    • Clinical review: The role of advancedglycation end products in progression and complications of diabetes
    • Goh SY, Cooper ME. Clinical review: the role of advancedglycation end products in progression and complications of diabetes. J Clin Endocrinol Metab 2008; 93 (4): 1143-52
    • (2008) J Clin Endocrinol Metab , vol.93 , Issue.4 , pp. 1143-1152
    • Goh, S.Y.1    Cooper, M.E.2
  • 62
    • 33847765812 scopus 로고    scopus 로고
    • Inhibition of diabeticleukostasis and blood-retinal barrier breakdown with a soluble form of a receptor for advanced glycation end products
    • Kaji Y, Usui T, Ishida S, et al. Inhibition of diabeticleukostasis and blood-retinal barrier breakdown with a soluble form of a receptor for advanced glycation end products. Invest Ophthalmol Vis Sci 2007; 48 (2): 858-65
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , Issue.2 , pp. 858-865
    • Kaji, Y.1    Usui, T.2    Ishida, S.3
  • 63
    • 31644450524 scopus 로고    scopus 로고
    • Upregulation ofRAGE and its ligands in proliferative retinal disease
    • Pachydaki SI, Tari SR, Lee SE, et al. Upregulation ofRAGE and its ligands in proliferative retinal disease. Exp Eye Res 2006; 82 (5): 807-15
    • (2006) Exp Eye Res , vol.82 , Issue.5 , pp. 807-815
    • Pachydaki, S.I.1    Tari, S.R.2    Lee, S.E.3
  • 64
    • 34547674399 scopus 로고    scopus 로고
    • Critical role of induciblenitric oxide synthase in degeneration of retinal capillaries in mice with streptozotocin-induced diabetes
    • Zheng L, Du Y, Miller C, et al. Critical role of induciblenitric oxide synthase in degeneration of retinal capillaries in mice with streptozotocin-induced diabetes. Diabetolo-gia 2007; 50 (9): 1987-96
    • (2007) Diabetologia , vol.50 , Issue.9 , pp. 1987-1996
    • Zheng, L.1    Du, Y.2    Miller, C.3
  • 65
    • 36549002610 scopus 로고    scopus 로고
    • PKC inhibition and diabetic mi-crovascular complications
    • Clarke M, Dodson PM. PKC inhibition and diabetic mi-crovascular complications. Best Pract Res Clin En-docrinol Metab 2007; 21 (4): 573-86
    • (2007) Best Pract Res Clin En-docrinol Metab , vol.21 , Issue.4 , pp. 573-586
    • Clarke, M.1    Dodson, P.M.2
  • 66
    • 42449135678 scopus 로고    scopus 로고
    • Immunological mechanisms inthe pathogenesis of diabetic retinopathy
    • Adamis AP, Berman AJ. Immunological mechanisms inthe pathogenesis of diabetic retinopathy. Semin Im-munopathol 2008; 30 (2): 65-84
    • (2008) Semin Immunopathol , vol.30 , Issue.2 , pp. 65-84
    • Adamis, A.P.1    Berman, A.J.2
  • 67
    • 55849126672 scopus 로고    scopus 로고
    • Vascular endothelialgrowth factor and diabetic complications
    • Wirostko B, Wong TY, Simo R. Vascular endothelialgrowth factor and diabetic complications. Prog Retin Eye Res 2008; 27 (6): 608-21
    • (2008) Prog Retin Eye Res , vol.27 , Issue.6 , pp. 608-621
    • Wirostko, B.1    Wong, T.Y.2    Simo, R.3
  • 68
    • 41149099068 scopus 로고    scopus 로고
    • Contributions of inflammatory processes to thedevelopment of the early stages of diabetic retinopathy
    • Kern TS. Contributions of inflammatory processes to thedevelopment of the early stages of diabetic retinopathy. Exp Diabetes Res 2007; 2007: 95103
    • (2007) Exp Diabetes Res , vol.2007 , pp. 95103
    • Kern, T.S.1
  • 69
    • 0036517850 scopus 로고    scopus 로고
    • Nonsteroidalanti-inflammatory drugs prevent early diabetic retinop-athy via TNF-alpha suppression
    • Joussen AM, Poulaki V, Mitsiades N, et al. Nonsteroidalanti-inflammatory drugs prevent early diabetic retinop-athy via TNF-alpha suppression. FASEB J 2002; 16 (3): 438-40
    • (2002) FASEB J , vol.16 , Issue.3 , pp. 438-440
    • Joussen, A.M.1    Poulaki, V.2    Mitsiades, N.3
  • 70
    • 33846991924 scopus 로고    scopus 로고
    • Extracellular carbonicanhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation
    • Gao BB, Clermont A, Rook S, et al. Extracellular carbonicanhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation. Nat Med 2007; 13 (2): 181-8
    • (2007) Nat Med , vol.13 , Issue.2 , pp. 181-188
    • Gao, B.B.1    Clermont, A.2    Rook, S.3
  • 71
    • 33748705959 scopus 로고    scopus 로고
    • Role of angiotensin II inretinal leukostasis in the diabetic rat
    • Chen P, Scicli GM, Guo M, et al. Role of angiotensin II inretinal leukostasis in the diabetic rat. Exp Eye Res 2006; 83 (5): 1041-51
    • (2006) Exp Eye Res , vol.83 , Issue.5 , pp. 1041-1051
    • Chen, P.1    Scicli, G.M.2    Guo, M.3
  • 72
    • 35148898712 scopus 로고    scopus 로고
    • Suppression ofdiabetes-induced retinal inflammation by blocking the angiotensin II type 1 receptor or its downstream nuclear factor-kappaB pathway
    • Nagai N, Izumi-Nagai K, Oike Y, et al. Suppression ofdiabetes-induced retinal inflammation by blocking the angiotensin II type 1 receptor or its downstream nuclear factor-kappaB pathway. Invest Ophthalmol Vis Sci 2007; 48 (9): 4342-50
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , Issue.9 , pp. 4342-4350
    • Nagai, N.1    Izumi-Nagai, K.2    Oike, Y.3
  • 73
    • 61349171233 scopus 로고    scopus 로고
    • Blockade of angiotensin IIattenuates VEGF-mediated blood-retinal barrier breakdown in diabetic retinopathy
    • Kim JH, Kim JH, Yu YS, et al. Blockade of angiotensin IIattenuates VEGF-mediated blood-retinal barrier breakdown in diabetic retinopathy. J Cereb Blood Flow Metab 2009; 29 (3): 621-8
    • (2009) J Cereb Blood Flow Metab , vol.29 , Issue.3 , pp. 621-628
    • Kim, J.H.1    Kim, J.H.2    Yu, Y.S.3
  • 74
    • 0034628425 scopus 로고    scopus 로고
    • Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy: The Diabetes Control and Complications Trial
    • Diabetes Control and Complications Trial Research Group Epidemiology of Diabetes Interventions and Complications Research Group
    • Diabetes Control and Complications Trial Research Group. Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. N Engl J Med 2000; 342 (6): 381-9
    • (2000) N Engl J Med , vol.342 , Issue.6 , pp. 381-389
  • 75
    • 0037093012 scopus 로고    scopus 로고
    • Effect of intensive therapy on the microvascular complications of type 1 diabetes mellitus
    • Diabetes Control and Complications Trial/Epidemiologyof Diabetes Interventions and Complications Research Group
    • Diabetes Control and Complications Trial/Epidemiologyof Diabetes Interventions and Complications Research Group. Effect of intensive therapy on the microvascular complications of type 1 diabetes mellitus. JAMA 2002; 287 (19): 2563-9
    • (2002) JAMA , vol.287 , Issue.19 , pp. 2563-2569
  • 76
    • 58149252632 scopus 로고    scopus 로고
    • Prolonged effect ofintensive therapy on the risk of retinopathy complications in patients with type 1 diabetes mellitus: 10 years after the Diabetes Control and Complications Trial
    • White NH, Sun W, Cleary PA, et al. Prolonged effect ofintensive therapy on the risk of retinopathy complications in patients with type 1 diabetes mellitus: 10 years after the Diabetes Control and Complications Trial. Arch Oph-thalmol 2008; 126 (12): 1707-15
    • (2008) Arch Ophthalmol , vol.126 , Issue.12 , pp. 1707-1715
    • White, N.H.1    Sun, W.2    Cleary, P.A.3
  • 77
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
    • UK Prospective Diabetes Study Group
    • UK Prospective Diabetes Study Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998; 352 (9131): 837-53
    • (1998) Lancet , vol.352 , Issue.9131 , pp. 837-853
  • 78
    • 34548087845 scopus 로고    scopus 로고
    • Management of dia-betic retinopathy: A systematic review
    • Mohamed Q, Gillies MC, Wong TY. Management of dia-betic retinopathy: a systematic review. JAMA 2007; 298 (8): 902-16
    • (2007) JAMA , vol.298 , Issue.8 , pp. 902-916
    • Mohamed, Q.1    Gillies, M.C.2    Wong, T.Y.3
  • 79
    • 0032511580 scopus 로고    scopus 로고
    • Tight blood pres-sure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38
    • UK Prospective Diabetes Study Group
    • UK Prospective Diabetes Study Group. Tight blood pres-sure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. BMJ 1998; 317 (7160): 703-13
    • (1998) BMJ , vol.317 , Issue.7160 , pp. 703-713
  • 80
    • 0036190137 scopus 로고    scopus 로고
    • Effects of ag-gressive blood pressure control in normotensive type 2 diabetic patients on albuminuria, retinopathy and strokes
    • Schrier RW, Estacio RO, Esler A, et al. Effects of ag-gressive blood pressure control in normotensive type 2 diabetic patients on albuminuria, retinopathy and strokes. Kidney Int 2002; 61 (3): 1086-97
    • (2002) Kidney Int , vol.61 , Issue.3 , pp. 1086-1097
    • Schrier, R.W.1    Estacio, R.O.2    Esler, A.3
  • 81
    • 0032477583 scopus 로고    scopus 로고
    • Effect oflisinopril on progression of retinopathy in normotensive people with type 1 diabetes
    • The EUCLID Study Group: EURODIAB Controlled Trial of Lisinopril in Insulin-Dependent Diabetes Mellitus
    • Chaturvedi N, Sjolie AK, Stephenson JM, et al. Effect oflisinopril on progression of retinopathy in normotensive people with type 1 diabetes. The EUCLID Study Group: EURODIAB Controlled Trial of Lisinopril in Insulin-Dependent Diabetes Mellitus. Lancet 1998; 351 (9095): 28-31
    • (1998) Lancet , vol.351 , Issue.9095 , pp. 28-31
    • Chaturvedi, N.1    Sjolie, A.K.2    Stephenson, J.M.3
  • 82
    • 53749100124 scopus 로고    scopus 로고
    • Effect of can-desartan on prevention (DIRECT-Prevent 1) and progression (DIRECT-Protect 1) of retinopathy in type 1 diabetes: Randomised, placebo-controlled trials
    • Chaturvedi N, Porta M, Klein R, et al. Effect of can-desartan on prevention (DIRECT-Prevent 1) and progression (DIRECT-Protect 1) of retinopathy in type 1 diabetes: randomised, placebo-controlled trials. Lancet 2008; 372 (9647): 1394-402
    • (2008) Lancet , vol.372 , Issue.9647 , pp. 1394-1402
    • Chaturvedi, N.1    Porta, M.2    Klein, R.3
  • 83
    • 53749108177 scopus 로고    scopus 로고
    • Effect of candesartan onprogression and regression of retinopathy in type 2 diabetes (DIRECT-Protect 2): A randomised placebo-controlled trial
    • Sjolie AK, Klein R, Porta M, et al. Effect of candesartan onprogression and regression of retinopathy in type 2 diabetes (DIRECT-Protect 2): a randomised placebo-controlled trial. Lancet 2008; 372 (9647): 1385-93
    • (2008) Lancet , vol.372 , Issue.9647 , pp. 1385-1393
    • Sjolie, A.K.1    Klein, R.2    Porta, M.3
  • 84
    • 36049001784 scopus 로고    scopus 로고
    • Effect of fe-nofibrate on the need for laser treatment for diabetic ret-inopathy (FIELD study): A randomised controlled trial
    • Keech AC, Mitchell P, Summanen PA, et al. Effect of fe-nofibrate on the need for laser treatment for diabetic ret-inopathy (FIELD study): a randomised controlled trial. Lancet 2007; 370 (9600): 1687-97
    • (2007) Lancet , vol.370 , Issue.9600 , pp. 1687-1697
    • Keech, A.C.1    Mitchell, P.2    Summanen, P.A.3
  • 85
    • 0035663189 scopus 로고    scopus 로고
    • Beneficial effects ofintensive therapy of diabetes during adolescence: Outcomes after the conclusion of the Diabetes Control and Complications Trial (DCCT)
    • White NH, Cleary PA, Dahms W, et al. Beneficial effects ofintensive therapy of diabetes during adolescence: outcomes after the conclusion of the Diabetes Control and Complications Trial (DCCT). J Pediatr 2001; 139 (6): 804-12
    • (2001) J Pediatr , vol.139 , Issue.6 , pp. 804-812
    • White, N.H.1    Cleary, P.A.2    Dahms, W.3
  • 86
    • 77951843664 scopus 로고    scopus 로고
    • Effect of prior in-tensive therapy in type 1 diabetes on 10-year progression of retinopathy in the DCCT/EDIC: Comparison of adults and adolescents
    • White NH, Sun W, Cleary PA, et al. Effect of prior in-tensive therapy in type 1 diabetes on 10-year progression of retinopathy in the DCCT/EDIC: comparison of adults and adolescents. Diabetes 2010; 59 (5): 1244-53
    • (2010) Diabetes , vol.59 , Issue.5 , pp. 1244-1253
    • White, N.H.1    Sun, W.2    Cleary, P.A.3
  • 87
    • 77954654472 scopus 로고    scopus 로고
    • Effects ofmedical therapies on retinopathy progression in type 2 diabetes
    • Chew EY, Ambrosius WT, Davis MD, et al. Effects ofmedical therapies on retinopathy progression in type 2 diabetes. N Engl J Med 2010; 363 (3): 233-44
    • (2010) N Engl J Med , vol.363 , Issue.3 , pp. 233-244
    • Chew, E.Y.1    Ambrosius, W.T.2    Davis, M.D.3
  • 88
    • 45149131667 scopus 로고    scopus 로고
    • Effects ofintensive glucose lowering in type 2 diabetes
    • Gerstein HC, Miller ME, Byington RP, et al. Effects ofintensive glucose lowering in type 2 diabetes. N Engl J Med 2008; 358 (24): 2545-59
    • (2008) N Engl J Med , vol.358 , Issue.24 , pp. 2545-2559
    • Gerstein, H.C.1    Miller, M.E.2    Byington, R.P.3
  • 89
    • 0031729874 scopus 로고    scopus 로고
    • Early worsening of diabetic retinopathy in the Diabetes Control and Complications Trial
    • Diabetes Control and Complications Trial ResearchGroup. Early worsening of diabetic retinopathy in the Diabetes Control and Complications Trial. Arch Oph-thalmol 1998; 116 (7): 874-86
    • (1998) Arch Ophthalmol , vol.116 , Issue.7 , pp. 874-886
  • 90
    • 9844260061 scopus 로고    scopus 로고
    • Risk of adverseeffects of intensified treatment in insulin-dependent diabetes mellitus: A meta-analysis
    • Egger M, Davey Smith G, Stettler C, et al. Risk of adverseeffects of intensified treatment in insulin-dependent diabetes mellitus: a meta-analysis. Diabet Med 1997; 14 (11): 919-28
    • (1997) Diabet Med , vol.14 , Issue.11 , pp. 919-928
    • Egger, M.1    Davey Smith, G.2    Stettler, C.3
  • 91
    • 69949166204 scopus 로고    scopus 로고
    • Effects of blood pressure lowering and intensive glucose control on the incidence and progression of retinopathy in patients with type 2 diabetes mellitus: A randomised controlled trial
    • on behalf of theAdRem project team and ADVANCE management committee
    • Beulens JW, Patel A, Vingerling JR, et al., on behalf of theAdRem project team and ADVANCE management committee. Effects of blood pressure lowering and intensive glucose control on the incidence and progression of retinopathy in patients with type 2 diabetes mellitus: a randomised controlled trial. Diabetologia 2009; 52 (10): 2027-36
    • (2009) Diabetologia , vol.52 , Issue.10 , pp. 2027-2036
    • Beulens, J.W.1    Patel, A.2    Vingerling, J.R.3
  • 92
    • 45149133036 scopus 로고    scopus 로고
    • Intensive bloodglucose control and vascular outcomes in patients with type 2 diabetes
    • Patel A, MacMahon S, Chalmers J, et al. Intensive bloodglucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 2008; 358 (24): 2560-72
    • (2008) N Engl J Med , vol.358 , Issue.24 , pp. 2560-2572
    • Patel, A.1    MacMahon, S.2    Chalmers, J.3
  • 93
    • 0024456469 scopus 로고
    • Is blood pressure apredictor of the incidence or progression of diabetic ret-inopathy?
    • Klein R, Klein BE, Moss SE, et al. Is blood pressure apredictor of the incidence or progression of diabetic ret-inopathy? Arch Intern Med 1989; 149 (11): 2427-32
    • (1989) Arch Intern Med , vol.149 , Issue.11 , pp. 2427-2432
    • Klein, R.1    Klein, B.E.2    Moss, S.E.3
  • 94
    • 0036673902 scopus 로고    scopus 로고
    • Blood pres-sure, lipids, and obesity are associated with retinopathy: The Hoorn study
    • van Leiden HA, Dekker JM, Moll AC, et al. Blood pres-sure, lipids, and obesity are associated with retinopathy: the Hoorn study. Diabetes Care 2002; 25 (8): 1320-5
    • (2002) Diabetes Care , vol.25 , Issue.8 , pp. 1320-1325
    • Van Leiden, H.A.1    Dekker, J.M.2    Moll, A.C.3
  • 95
    • 77953764092 scopus 로고    scopus 로고
    • Riskfactors associated with diabetic retinopathy in patients with diabetes mellitus type 2
    • Chatziralli IP, Sergentanis TN, Keryttopoulos P, et al. Riskfactors associated with diabetic retinopathy in patients with diabetes mellitus type 2. BMC Res Notes 2010; 3: 153
    • (2010) BMC Res Notes , vol.3 , pp. 153
    • Chatziralli, I.P.1    Sergentanis, T.N.2    Keryttopoulos, P.3
  • 96
    • 0034074955 scopus 로고    scopus 로고
    • Effect of bloodpressure control on diabetic microvascular complications in patients with hypertension and type 2 diabetes
    • Estacio RO, Jeffers BW, Gifford N, et al. Effect of bloodpressure control on diabetic microvascular complications in patients with hypertension and type 2 diabetes. Diabetes Care 2000; 23 Suppl. 2: B54-64
    • (2000) Diabetes Care , vol.23 , Issue.SUPPL. 2
    • Estacio, R.O.1    Jeffers, B.W.2    Gifford, N.3
  • 97
    • 67649635807 scopus 로고    scopus 로고
    • Renal and retinaleffects of enalapril and losartan in type 1 diabetes
    • Mauer M, Zinman B, Gardiner R, et al. Renal and retinaleffects of enalapril and losartan in type 1 diabetes. N Engl J Med 2009; 361 (1): 40-51
    • (2009) N Engl J Med , vol.361 , Issue.1 , pp. 40-51
    • Mauer, M.1    Zinman, B.2    Gardiner, R.3
  • 98
    • 79959330386 scopus 로고    scopus 로고
    • Effect of trando-lapril on regression of retinopathy in hypertensive patients with type 2 diabetes: A prespecified analysis of the BENEDICT trial
    • Epub 2010 Jun 10
    • Ruggenenti P, Iliev I, Filipponi M, et al. Effect of trando-lapril on regression of retinopathy in hypertensive patients with type 2 diabetes: a prespecified analysis of the BENEDICT trial. J Ophthalmol. Epub 2010 Jun 10
    • J Ophthalmol
    • Ruggenenti, P.1    Iliev, I.2    Filipponi, M.3
  • 99
    • 77953479027 scopus 로고    scopus 로고
    • The renin-angiotensin system in retinal health and disease: Its influence on neurons glia and the vasculature
    • Fletcher EL, Phipps JA, Ward MM, et al. The renin-angiotensin system in retinal health and disease: its influence on neurons, glia and the vasculature. Prog Retin Eye Res 2010; 29 (4): 284-311
    • (2010) Prog Retin Eye Res , vol.29 , Issue.4 , pp. 284-311
    • Fletcher, E.L.1    Phipps, J.A.2    Ward, M.M.3
  • 100
    • 50949116171 scopus 로고    scopus 로고
    • Angiotensin II type 1receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina
    • Kurihara T, Ozawa Y, Nagai N, et al. Angiotensin II type 1receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina. Diabetes 2008; 57 (8): 2191-8
    • (2008) Diabetes , vol.57 , Issue.8 , pp. 2191-2198
    • Kurihara, T.1    Ozawa, Y.2    Nagai, N.3
  • 101
    • 2442451618 scopus 로고    scopus 로고
    • Angiotensin type q1receptor blockers induce peroxisome proliferator-activated receptor-gamma activity
    • Schupp M, Janke J, Clasen R, et al. Angiotensin type q1receptor blockers induce peroxisome proliferator-activated receptor-gamma activity. Circulation 2004; 109 (17): 2054-7
    • (2004) Circulation , vol.109 , Issue.17 , pp. 2054-2057
    • Schupp, M.1    Janke, J.2    Clasen, R.3
  • 102
    • 77958560845 scopus 로고    scopus 로고
    • The effect of statins on diabetic retinopathy
    • Washington, DC, June 9-13, 2006. Webcast [online] [Accessed 2009 Nov 18]
    • Dodson P. The effect of statins on diabetic retinopathy.American Diabetes Association 66th Scientific Sessions, Washington, DC, June 9-13, 2006. Webcast [online]. Available from URL: https://www.diabetesconnect.org/Adv-SearchResult. aspx?typ=10&sr=adv&cgr=9&tit=&spk=&ses=&kwd= atorvastatin; [Accessed 2009 Nov 18]
    • American Diabetes Association 66th Scientific Sessions
    • Dodson, P.1
  • 103
    • 67449108376 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-alpha (PPARalpha): At the crossroads of obesity, diabetes and cardiovascular disease
    • Fruchart JC. Peroxisome proliferator-activated receptor-alpha (PPARalpha): at the crossroads of obesity, diabetes and cardiovascular disease. Atherosclerosis 2009; 205 (1): 1-8
    • (2009) Atherosclerosis , vol.205 , Issue.1 , pp. 1-8
    • Fruchart, J.C.1
  • 104
    • 34247108235 scopus 로고    scopus 로고
    • Fenofibrate regulates retinalendothelial cell survival through the AMPK signal trans-duction pathway
    • Kim J, Ahn JH, Kim JH, et al. Fenofibrate regulates retinalendothelial cell survival through the AMPK signal trans-duction pathway. Exp Eye Res 2007; 84 (5): 886-93
    • (2007) Exp Eye Res , vol.84 , Issue.5 , pp. 886-893
    • Kim, J.1    Ahn, J.H.2    Kim, J.H.3
  • 105
    • 47349117843 scopus 로고    scopus 로고
    • Selective activation ofperoxisome proliferator-activated receptor (PPAR)alpha and PPAR gamma induces neoangiogenesis through a vascular endothelial growth factor-dependent mechanism
    • Biscetti F, Gaetani E, Flex A, et al. Selective activation ofperoxisome proliferator-activated receptor (PPAR)alpha and PPAR gamma induces neoangiogenesis through a vascular endothelial growth factor-dependent mechanism. Diabetes 2008; 57 (5): 1394-404
    • (2008) Diabetes , vol.57 , Issue.5 , pp. 1394-1404
    • Biscetti, F.1    Gaetani, E.2    Flex, A.3
  • 106
    • 70449717330 scopus 로고    scopus 로고
    • Peroxisomeproliferator-activated receptors and angiogenesis
    • Biscetti F, Straface G, Pitocco D, et al. Peroxisomeproliferator- activated receptors and angiogenesis. Nutr Metab Cardiovasc Dis 2009; 19 (11): 751-9
    • (2009) Nutr Metab Cardiovasc Dis , vol.19 , Issue.11 , pp. 751-759
    • Biscetti, F.1    Straface, G.2    Pitocco, D.3
  • 107
    • 77954640887 scopus 로고    scopus 로고
    • Reduction in risk of progression of diabetic ret-inopathy
    • Klein BE. Reduction in risk of progression of diabetic ret-inopathy. N Engl J Med 2010; 363 (3): 287-8
    • (2010) N Engl J Med , vol.363 , Issue.3 , pp. 287-288
    • Klein, B.E.1
  • 108
    • 33947519380 scopus 로고    scopus 로고
    • Laser treatment of diabetic retinopathy
    • Lang GE. Laser treatment of diabetic retinopathy. DevOphthalmol 2007; 39: 48-68
    • (2007) DevOphthalmol , vol.39 , pp. 48-68
    • Lang, G.E.1
  • 109
    • 0023489543 scopus 로고
    • Indicationsfor photocoagulation treatment of diabetic retinopathy: Diabetic Retinopathy Study Report no. 14
    • Diabetic Retinopathy Study Research Group
    • Diabetic Retinopathy Study Research Group. Indicationsfor photocoagulation treatment of diabetic retinopathy: Diabetic Retinopathy Study Report no. 14. Int Ophthal-mol Clin 1987; 27 (4): 239-53
    • (1987) Int Ophthal-mol Clin , vol.27 , Issue.4 , pp. 239-253
  • 110
    • 33947508712 scopus 로고    scopus 로고
    • Laser treatment in diabetic ret-inopathy
    • Neubauer AS, Ulbig MW. Laser treatment in diabetic ret-inopathy. Ophthalmologica 2007; 221 (2): 95-102
    • (2007) Ophthalmologica , vol.221 , Issue.2 , pp. 95-102
    • Neubauer, A.S.1    Ulbig, M.W.2
  • 111
    • 34748924210 scopus 로고    scopus 로고
    • Visual side effects of suc-cessful scatter laser photocoagulation surgery for pro-liferative diabetic retinopathy: A literature review
    • Fong DS, Girach A, Boney A. Visual side effects of suc-cessful scatter laser photocoagulation surgery for pro-liferative diabetic retinopathy: a literature review. Retina 2007; 27 (7): 816-24
    • (2007) Retina , vol.27 , Issue.7 , pp. 816-824
    • Fong, D.S.1    Girach, A.2    Boney, A.3
  • 112
    • 6344272096 scopus 로고    scopus 로고
    • Diabetic macular edema: A reviewof past, present, and future therapies
    • Thompson MJ, Ip MS. Diabetic macular edema: a reviewof past, present, and future therapies. Int Ophthalmol Clin 2004; 44 (4): 51-67
    • (2004) Int Ophthalmol Clin , vol.44 , Issue.4 , pp. 51-67
    • Thompson, M.J.1    Ip, M.S.2
  • 113
    • 0017233461 scopus 로고
    • Preliminaryreport on effects of photocoagulation therapy: The Diabetic Retinopathy Study Research Group
    • Diabetic Retinopathy Study Research Group
    • Diabetic Retinopathy Study Research Group. Preliminaryreport on effects of photocoagulation therapy: the Diabetic Retinopathy Study Research Group. Am J Oph-thalmol 1976; 81 (4): 383-96
    • (1976) Am J Oph-thalmol , vol.81 , Issue.4 , pp. 383-396
  • 114
    • 0025892104 scopus 로고
    • Early photocoagulation for diabetic retinopathy: ETDRS report no. 9
    • Early Treatment Diabetic Retinopathy Study ResearchGroup
    • Early Treatment Diabetic Retinopathy Study ResearchGroup. Early photocoagulation for diabetic retinopathy: ETDRS report no. 9. Ophthalmology 1991; 98 (5 Suppl.): 766-85
    • (1991) Ophthalmology , vol.98 , Issue.5 SUPPL. , pp. 766-785
  • 115
    • 4043051036 scopus 로고    scopus 로고
    • Progressiveenlargement of scattered photocoagulation scars in diabetic retinopathy
    • Maeshima K, Utsugi-Sutoh N, Otani T, et al. Progressiveenlargement of scattered photocoagulation scars in diabetic retinopathy. Retina 2004; 24 (4): 507-11
    • (2004) Retina , vol.24 , Issue.4 , pp. 507-511
    • Maeshima, K.1    Utsugi-Sutoh, N.2    Otani, T.3
  • 116
    • 0026075103 scopus 로고
    • Progressiveenlargement of laser scars following grid laser photo-coagulation for diffuse diabetic macular edema
    • Schatz H, Madeira D, McDonald HR, et al. Progressiveenlargement of laser scars following grid laser photo-coagulation for diffuse diabetic macular edema. Arch Ophthalmol 1991; 109 (11): 1549-51
    • (1991) Arch Ophthalmol , vol.109 , Issue.11 , pp. 1549-1551
    • Schatz, H.1    Madeira, D.2    McDonald, H.R.3
  • 117
    • 0030811111 scopus 로고    scopus 로고
    • Subretinal fibrosis indiabetic macular edema: ETDRS report 23
    • Early Treatment Diabetic Retinopathy Study Research Group
    • Fong DS, Segal PP, Myers F, et al. Subretinal fibrosis indiabetic macular edema: ETDRS report 23. Early Treatment Diabetic Retinopathy Study Research Group. Arch Ophthalmol 1997; 115 (7): 873-7
    • (1997) Arch Ophthalmol , vol.115 , Issue.7 , pp. 873-877
    • Fong, D.S.1    Segal, P.P.2    Myers, F.3
  • 118
    • 11144300139 scopus 로고    scopus 로고
    • Subthreshold diodemicropulse photocoagulation for the treatment of clinically significant diabetic macular oedema
    • Luttrull JK, Musch DC, Mainster MA. Subthreshold diodemicropulse photocoagulation for the treatment of clinically significant diabetic macular oedema. Br J Ophthal-mol 2005; 89 (1): 74-80
    • (2005) Br J Ophthalmol , vol.89 , Issue.1 , pp. 74-80
    • Luttrull, J.K.1    Musch, D.C.2    Mainster, M.A.3
  • 119
    • 0032898544 scopus 로고    scopus 로고
    • Clinical applications of theMicroPulse diode laser
    • Moorman CM, Hamilton AM. Clinical applications of theMicroPulse diode laser. Eye 1999; 13 (Pt 2): 145-50
    • (1999) Eye , vol.13 , Issue.PART 2 , pp. 145-150
    • Moorman, C.M.1    Hamilton, A.M.2
  • 120
    • 34848895745 scopus 로고    scopus 로고
    • Subthresholdmicropulse diode laser photocoagulation for clinically significant diabetic macular oedema: A three-year follow up
    • Sivaprasad S, Sandhu R, Tandon A, et al. Subthresholdmicropulse diode laser photocoagulation for clinically significant diabetic macular oedema: a three-year follow up. Clin Experiment Ophthalmol 2007; 35 (7): 640-4
    • (2007) Clin Experiment Ophthalmol , vol.35 , Issue.7 , pp. 640-644
    • Sivaprasad, S.1    Sandhu, R.2    Tandon, A.3
  • 121
    • 44049105847 scopus 로고    scopus 로고
    • Subthreshold diodemicropulse panretinal photocoagulation for proliferative diabetic retinopathy
    • Luttrull JK, Musch DC, Spink CA. Subthreshold diodemicropulse panretinal photocoagulation for proliferative diabetic retinopathy. Eye (Lond) 2008; 22 (5): 607-12
    • (2008) Eye (Lond) , vol.22 , Issue.5 , pp. 607-612
    • Luttrull, J.K.1    Musch, D.C.2    Spink, C.A.3
  • 122
    • 34247164981 scopus 로고    scopus 로고
    • Comparison of themodified Early Treatment Diabetic Retinopathy Study and mild macular grid laser photocoagulation strategies for diabetic macular edema
    • Fong DS, Strauber SF, Aiello LP, et al. Comparison of themodified Early Treatment Diabetic Retinopathy Study and mild macular grid laser photocoagulation strategies for diabetic macular edema. Arch Ophthalmol 2007; 125 (4): 469-80
    • (2007) Arch Ophthalmol , vol.125 , Issue.4 , pp. 469-480
    • Fong, D.S.1    Strauber, S.F.2    Aiello, L.P.3
  • 123
    • 70349973297 scopus 로고    scopus 로고
    • Prospective randomisedcontrolled trial comparing sub-threshold micropulse diode laser photocoagulation and conventional green laser for clinically significant diabetic macular oedema
    • Figueira J, Khan J, Nunes S, et al. Prospective randomisedcontrolled trial comparing sub-threshold micropulse diode laser photocoagulation and conventional green laser for clinically significant diabetic macular oedema. Br J Ophthalmol 2009; 93 (10): 1341-4
    • (2009) Br J Ophthalmol , vol.93 , Issue.10 , pp. 1341-1344
    • Figueira, J.1    Khan, J.2    Nunes, S.3
  • 124
    • 77953344075 scopus 로고    scopus 로고
    • Microperimetryand fundus autofluorescence in diabetic macular edema: Subthreshold micropulse diode laser versus modified early treatment diabetic retinopathy study laser photocoagula-tion
    • Vujosevic S, Bottega E, Casciano M, et al. Microperimetryand fundus autofluorescence in diabetic macular edema: subthreshold micropulse diode laser versus modified early treatment diabetic retinopathy study laser photocoagula-tion. Retina 2010; 30 (6): 908-16
    • (2010) Retina , vol.30 , Issue.6 , pp. 908-916
    • Vujosevic, S.1    Bottega, E.2    Casciano, M.3
  • 125
    • 77954719034 scopus 로고    scopus 로고
    • Effects of con-ventional argon panretinal laser photocoagulation on retinal nerve fibre layer and driving visual fields in diabetic retinopathy
    • Muqit MM, Wakely L, Stanga PE, et al. Effects of con-ventional argon panretinal laser photocoagulation on retinal nerve fibre layer and driving visual fields in diabetic retinopathy. Eye (Lond) 2010; 24 (7): 1136-42
    • (2010) Eye (Lond) , vol.24 , Issue.7 , pp. 1136-1142
    • Muqit, M.M.1    Wakely, L.2    Stanga, P.E.3
  • 126
    • 77949415646 scopus 로고    scopus 로고
    • Comparison of laserphotocoagulation for diabetic retinopathy using 532-nm standard laser versus multispot pattern scan laser
    • Nagpal M, Marlecha S, Nagpal K. Comparison of laserphotocoagulation for diabetic retinopathy using 532-nm standard laser versus multispot pattern scan laser. Retina 2010; 30 (3): 452-8
    • (2010) Retina , vol.30 , Issue.3 , pp. 452-458
    • Nagpal, M.1    Marlecha, S.2    Nagpal, K.3
  • 127
    • 77952143228 scopus 로고    scopus 로고
    • Single-session vs multiple-session pattern scanning laser panretinal photocoagulation in proliferative diabetic retinopathy: The Manchester Pascal Study
    • Muqit MM, Marcellino GR, Henson DB, et al. Single-session vs multiple-session pattern scanning laser panretinal photocoagulation in proliferative diabetic retinopathy: the Manchester Pascal Study. Arch Ophthalmol 2010; 128 (5): 525-33
    • (2010) Arch Ophthalmol , vol.128 , Issue.5 , pp. 525-533
    • Muqit, M.M.1    Marcellino, G.R.2    Henson, D.B.3
  • 128
    • 0842332559 scopus 로고    scopus 로고
    • Surgical and other treat-ments of diabetic macular edema: An update
    • Christoforidis JB, D'Amico DJ. Surgical and other treat-ments of diabetic macular edema: an update. Int Oph-thalmol Clin 2004; 44 (1): 139-60
    • (2004) Int Ophthalmol Clin , vol.44 , Issue.1 , pp. 139-160
    • Christoforidis, J.B.1    D'Amico, D.J.2
  • 129
    • 0026486596 scopus 로고
    • Vitrectomy in the man-agement of diabetic eye disease
    • Ho T, Smiddy WE, Flynn Jr HW. Vitrectomy in the man-agement of diabetic eye disease. Surv Ophthalmol 1992; 37 (3): 190-202
    • (1992) Surv Ophthalmol , vol.37 , Issue.3 , pp. 190-202
    • Ho, T.1    Smiddy, W.E.2    Flynn Jr., H.W.3
  • 130
    • 77949484223 scopus 로고    scopus 로고
    • Surgical management of the late complica-tions of proliferative diabetic retinopathy
    • Newman DK. Surgical management of the late complica-tions of proliferative diabetic retinopathy. Eye (Lond) 2010; 24 (3): 441-9
    • (2010) Eye (Lond) , vol.24 , Issue.3 , pp. 441-449
    • Newman, D.K.1
  • 131
    • 0025289369 scopus 로고
    • Earlyvitrectomy for severe vitreous hemorrhage in diabetic ret-inopathy. Four-year results of a randomized trial: Diabetic Retinopathy Vitrectomy Study Report 5
    • Diabetic Retinopathy Vitrectomy Study Group
    • Diabetic Retinopathy Vitrectomy Study Group. Earlyvitrectomy for severe vitreous hemorrhage in diabetic ret-inopathy. Four-year results of a randomized trial: Diabetic Retinopathy Vitrectomy Study Report 5. Arch Ophthalmol 1990; 108 (7): 958-64
    • (1990) Arch Ophthalmol , vol.108 , Issue.7 , pp. 958-964
  • 132
    • 65349096220 scopus 로고    scopus 로고
    • Pars plana vit-rectomy for diabetic fibrovascular proliferation with and without internal limiting membrane peeling
    • Chang PY, Yang CM, Yang CH, et al. Pars plana vit-rectomy for diabetic fibrovascular proliferation with and without internal limiting membrane peeling. Eye (Lond) 2009; 23 (4): 960-5
    • (2009) Eye (Lond) , vol.23 , Issue.4 , pp. 960-965
    • Chang, P.Y.1    Yang, C.M.2    Yang, C.H.3
  • 133
    • 33947494271 scopus 로고    scopus 로고
    • Surgery for diabetic retinopathy
    • Helbig H. Surgery for diabetic retinopathy. Ophthalmolo-gica 2007; 221 (2): 103-11
    • (2007) Ophthalmologica , vol.221 , Issue.2 , pp. 103-111
    • Helbig, H.1
  • 134
    • 54249088395 scopus 로고    scopus 로고
    • Vitrectomy outcomes in eyes with diabetic macular edema and vitreomacular traction
    • Diabetic Retinopathy Clinical Research Network WritingCommittee, on behalf of the DRCR.net
    • Laidlaw DA. Vitrectomy for diabetic macular oedema. Eye2008; 22 (10): 1337-41
    • (2008) Ophthalmology , vol.22 , Issue.10 , pp. 1337-1341
    • Laidlaw, D.A.1
  • 135
    • 66149104784 scopus 로고    scopus 로고
    • Long-term fol-low-up of vitrectomy for diffuse nontractional diabetic macular edema
    • Kumagai K, Furukawa M, Ogino N, et al. Long-term fol-low-up of vitrectomy for diffuse nontractional diabetic macular edema. Retina 2009; 29 (4): 464-72
    • (2009) Retina , vol.29 , Issue.4 , pp. 464-472
    • Kumagai, K.1    Furukawa, M.2    Ogino, N.3
  • 136
    • 67650252238 scopus 로고    scopus 로고
    • Small gauge, sutureless sur-gery techniques for diabetic vitrectomy
    • Goldenberg DT, Hassan TS. Small gauge, sutureless sur-gery techniques for diabetic vitrectomy. Int Ophthalmol Clin 2009; 49 (2): 141-51
    • (2009) Int Ophthalmol Clin , vol.49 , Issue.2 , pp. 141-151
    • Goldenberg, D.T.1    Hassan, T.S.2
  • 137
    • 33748189291 scopus 로고    scopus 로고
    • Diabetic vitrectomy:risks, prognosis, future trends
    • Mason III JO, Colagross CT, Vail R. Diabetic vitrectomy:risks, prognosis, future trends. Curr Opin Ophthalmol 2006; 17 (3): 281-5
    • (2006) Curr Opin Ophthalmol , vol.17 , Issue.3 , pp. 281-285
    • Mason Iii, J.O.1    Colagross, C.T.2    Vail, R.3
  • 138
    • 70449727113 scopus 로고    scopus 로고
    • Transconjunctival su-tureless vitrectomy for the treatment of vitreoretinal complications in patients with diabetes mellitus
    • Yang SJ, Yoon SY, Kim JG, et al. Transconjunctival su-tureless vitrectomy for the treatment of vitreoretinal complications in patients with diabetes mellitus. Ophthalmic Surg Lasers Imaging 2009; 40 (5): 461-6
    • (2009) Ophthalmic Surg Lasers Imaging , vol.40 , Issue.5 , pp. 461-466
    • Yang, S.J.1    Yoon, S.Y.2    Kim, J.G.3
  • 139
    • 78650173491 scopus 로고    scopus 로고
    • Comparison of clinical out-comes between 23-gauge and 20-gauge vitrectomy in patients with proliferative diabetic retinopathy
    • Epub 2010 Jul 24
    • Park DH, Shin JP, Kim SY. Comparison of clinical out-comes between 23-gauge and 20-gauge vitrectomy in patients with proliferative diabetic retinopathy. Retina. Epub 2010 Jul 24
    • Retina
    • Park, D.H.1    Shin, J.P.2    Kim, S.Y.3
  • 140
    • 77950375279 scopus 로고    scopus 로고
    • Short-term outcomeof bimanual 23-gauge transconjunctival sutureless vit-rectomy for patients with complicated vitreoretinopathies
    • Park KH, Woo SJ, Hwang JM, et al. Short-term outcomeof bimanual 23-gauge transconjunctival sutureless vit-rectomy for patients with complicated vitreoretinopathies. Ophthalmic Surg Lasers Imaging 2010; 41 (2): 207-14
    • (2010) Ophthalmic Surg Lasers Imaging , vol.41 , Issue.2 , pp. 207-214
    • Park, K.H.1    Woo, S.J.2    Hwang, J.M.3
  • 141
    • 77952117893 scopus 로고    scopus 로고
    • Role of residualvitreous cortex removal in prevention of postoperative vitreous hemorrhage in diabetic vitrectomy
    • Cheema RA, Mushtaq J, Cheema MA. Role of residualvitreous cortex removal in prevention of postoperative vitreous hemorrhage in diabetic vitrectomy. Int Ophthalmol 2010; 30 (2): 137-42
    • (2010) Int Ophthalmol , vol.30 , Issue.2 , pp. 137-142
    • Cheema, R.A.1    Mushtaq, J.2    Cheema, M.A.3
  • 142
    • 67349285875 scopus 로고    scopus 로고
    • Microincisionvitrectomy surgery and intravitreal bevacizumab as a surgical adjunct to treat diabetic traction retinal detachment
    • Oshima Y, Shima C, Wakabayashi T, et al. Microincisionvitrectomy surgery and intravitreal bevacizumab as a surgical adjunct to treat diabetic traction retinal detachment. Ophthalmology 2009; 116 (5): 927-38
    • (2009) Ophthalmology , vol.116 , Issue.5 , pp. 927-938
    • Oshima, Y.1    Shima, C.2    Wakabayashi, T.3
  • 143
    • 70549089033 scopus 로고    scopus 로고
    • Intravitrealinjection of bevacizumab before vitrectomy for proliferative diabetic retinopathy
    • Modarres M, Nazari H, Falavarjani KG, et al. Intravitrealinjection of bevacizumab before vitrectomy for proliferative diabetic retinopathy. Eur J Ophthalmol 2009; 19 (5): 848-52
    • (2009) Eur J Ophthalmol , vol.19 , Issue.5 , pp. 848-852
    • Modarres, M.1    Nazari, H.2    Falavarjani, K.G.3
  • 144
    • 66149143624 scopus 로고    scopus 로고
    • Intraoperativebleeding during vitrectomy for diabetic tractional retinal detachment with versus without preoperative intravitreal bevacizumab (IBeTra study)
    • da R Lucena D, Ribeiro JA, Costa RA, et al. Intraoperativebleeding during vitrectomy for diabetic tractional retinal detachment with versus without preoperative intravitreal bevacizumab (IBeTra study). Br J Ophthalmol 2009; 93 (5): 688-91
    • (2009) Br J Ophthalmol , vol.93 , Issue.5 , pp. 688-691
    • Da Lucena R, D.1    Ribeiro, J.A.2    Costa, R.A.3
  • 145
    • 67749147367 scopus 로고    scopus 로고
    • Bevacizumab pretreat-ment in vitrectomy with silicone oil for severe diabetic retinopathy
    • Yeh PT, Yang CM, Lin YC, et al. Bevacizumab pretreat-ment in vitrectomy with silicone oil for severe diabetic retinopathy. Retina 2009; 29 (6): 768-74
    • (2009) Retina , vol.29 , Issue.6 , pp. 768-774
    • Yeh, P.T.1    Yang, C.M.2    Lin, Y.C.3
  • 146
    • 77952257913 scopus 로고    scopus 로고
    • Dose ofintravitreal bevacizumab (Avastin) used as preoperative adjunct therapy for proliferative diabetic retinopathy
    • Hattori T, Shimada H, Nakashizuka H, et al. Dose ofintravitreal bevacizumab (Avastin) used as preoperative adjunct therapy for proliferative diabetic retinopathy. Retina 2010; 30 (5): 761-4
    • (2010) Retina , vol.30 , Issue.5 , pp. 761-764
    • Hattori, T.1    Shimada, H.2    Nakashizuka, H.3
  • 147
    • 77955612774 scopus 로고    scopus 로고
    • Use of pe-gaptanib for recurrent and non-clearing vitreous haemorrhage in proliferative diabetic retinopathy
    • Epub 2010 Mar 12
    • Hornan D, Edmeades N, Krishnan R, et al. Use of pe-gaptanib for recurrent and non-clearing vitreous haemorrhage in proliferative diabetic retinopathy. Eye (Lond). Epub 2010 Mar 12
    • Eye (Lond)
    • Hornan, D.1    Edmeades, N.2    Krishnan, R.3
  • 148
    • 70349440840 scopus 로고    scopus 로고
    • Intravitrealbevacizumab for prevention of early postvitrectomy hemorrhage in diabetic patients
    • Ahmadieh H, Shoeibi N, Entezari M, et al. Intravitrealbevacizumab for prevention of early postvitrectomy hemorrhage in diabetic patients. Ophthalmology 2009; 116 (10):1943-8
    • (2009) Ophthalmology , vol.116 , Issue.10 , pp. 1943-1948
    • Ahmadieh, H.1    Shoeibi, N.2    Entezari, M.3
  • 149
    • 77952096101 scopus 로고    scopus 로고
    • Intravitrealbevacizumab for surgical treatment of severe proliferative diabetic retinopathy
    • di Lauro R, De Ruggiero P, di Lauro R, et al. Intravitrealbevacizumab for surgical treatment of severe proliferative diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol 2010; 248 (6): 785-91
    • (2010) Graefes Arch Clin Exp Ophthalmol , vol.248 , Issue.6 , pp. 785-791
    • Di Lauro, R.1    De Ruggiero, P.2    Di Lauro, R.3
  • 150
    • 77954477722 scopus 로고    scopus 로고
    • Experiencewith intravitreal bevacizumab as a preoperative adjunct in 23-G vitrectomy for advanced proliferative diabetic retinopathy
    • Epub Apr 23
    • Hernandez-Da Mota SE, Nunez-Solorio SM. Experiencewith intravitreal bevacizumab as a preoperative adjunct in 23-G vitrectomy for advanced proliferative diabetic retinopathy. Eur J Ophthalmol. Epub 2010 Apr 23; 20 (6): 7
    • (2010) Eur J Ophthalmol , vol.20 , Issue.6 , pp. 7
    • Hernandez-Da Mota, S.E.1    Nunez-Solorio, S.M.2
  • 151
    • 77952095607 scopus 로고    scopus 로고
    • Intravitreal injection of bev-acizumab and triamcinolone acetonide at the end of vitrectomy for diabetic vitreous hemorrhage: A comparative study
    • Park DH, Shin JP, Kim SY. Intravitreal injection of bev-acizumab and triamcinolone acetonide at the end of vitrectomy for diabetic vitreous hemorrhage: a comparative study. Graefes Arch Clin Exp Ophthalmol 2010; 248 (5): 641-50
    • (2010) Graefes Arch Clin Exp Ophthalmol , vol.248 , Issue.5 , pp. 641-650
    • Park, D.H.1    Shin, J.P.2    Kim, S.Y.3
  • 152
  • 153
    • 26844520874 scopus 로고    scopus 로고
    • Pooledefficacy results from two multinational randomized controlled clinical trials of a single intravitreous injection of highly purified ovine hyaluronidase (Vitrase) for the management of vitreous hemorrhage
    • Kuppermann BD, Thomas EL, de Smet MD, et al. Pooledefficacy results from two multinational randomized controlled clinical trials of a single intravitreous injection of highly purified ovine hyaluronidase (Vitrase) for the management of vitreous hemorrhage. Am J Ophthalmol 2005; 140 (4): 573-84
    • (2005) Am J Ophthalmol , vol.140 , Issue.4 , pp. 573-584
    • Kuppermann, B.D.1    Thomas, E.L.2    De Smet, M.D.3
  • 157
    • 77949656341 scopus 로고    scopus 로고
    • A placebo-controlled trial of microplasmin intravitreous injection to facilitate posterior vitreous detachment before vitrectomy
    • Benz MS, Packo KH, Gonzalez V, et al. A placebo-controlled trial of microplasmin intravitreous injection to facilitate posterior vitreous detachment before vitrectomy. Ophthalmology 2010; 117 (4): 791-7
    • (2010) Ophthalmology , vol.117 , Issue.4 , pp. 791-797
    • Benz, M.S.1    Packo, K.H.2    Gonzalez, V.3
  • 158
    • 68549096118 scopus 로고    scopus 로고
    • Intravitrealplasmin without associated vitrectomy as a treatment for refractory diabetic macular edema
    • Diaz-Llopis M, Udaondo P, Arevalo F, et al. Intravitrealplasmin without associated vitrectomy as a treatment for refractory diabetic macular edema. J Ocul Pharmacol Ther 2009; 25 (4): 379-84
    • (2009) J Ocul Pharmacol Ther , vol.25 , Issue.4 , pp. 379-384
    • Diaz-Llopis, M.1    Udaondo, P.2    Arevalo, F.3
  • 159
    • 50549220514 scopus 로고
    • Diabetic retinopathy and rheuma-toid arthritis
    • Powell ED, Field RA. Diabetic retinopathy and rheuma-toid arthritis. Lancet 1964; 41: 17-8
    • (1964) Lancet , vol.41 , pp. 17-18
    • Powell, E.D.1    Field, R.A.2
  • 160
    • 0025853982 scopus 로고
    • Effects of aspirin treatment ondiabetic retinopathy: ETDRS report number 8
    • ETDRS Research Group Early Treatment Diabetic Retinopathy Study Research Group
    • ETDRS Research Group. Effects of aspirin treatment ondiabetic retinopathy: ETDRS report number 8. Early Treatment Diabetic Retinopathy Study Research Group. Ophthalmology 1991; 98 (5 Suppl.): 757-65
    • (1991) Ophthalmology , vol.98 , Issue.5 SUPPL. , pp. 757-765
  • 161
    • 0024500488 scopus 로고
    • Effect of aspirin alone and aspirinplus dipyridamole in early diabetic retinopathy: A multi-center randomized controlled clinical trial
    • DAMAD Study Group
    • DAMAD Study Group. Effect of aspirin alone and aspirinplus dipyridamole in early diabetic retinopathy: a multi-center randomized controlled clinical trial. Diabetes 1989; 38 (4): 491-8
    • (1989) Diabetes , vol.38 , Issue.4 , pp. 491-498
  • 163
    • 34548133077 scopus 로고    scopus 로고
    • The effect oflong-term treatment with sulindac on the progression of diabetic retinopathy
    • Hattori Y, Hashizume K, Nakajima K, et al. The effect oflong-term treatment with sulindac on the progression of diabetic retinopathy. Curr Med Res Opin 2007; 23 (8): 1913-7
    • (2007) Curr Med Res Opin , vol.23 , Issue.8 , pp. 1913-1917
    • Hattori, Y.1    Hashizume, K.2    Nakajima, K.3
  • 167
    • 40849085554 scopus 로고    scopus 로고
    • Intravitrealsteroids for macular edema: The past, the present, and the future
    • Cunningham MA, Edelman JL, Kaushal S. Intravitrealsteroids for macular edema: the past, the present, and the future. Surv Ophthalmol 2008; 53 (2): 139-49
    • (2008) Surv Ophthalmol , vol.53 , Issue.2 , pp. 139-149
    • Cunningham, M.A.1    Edelman, J.L.2    Kaushal, S.3
  • 169
    • 67650246081 scopus 로고    scopus 로고
    • Role of steroids in the treatment ofdiabetic macular edema
    • Kuo CH, Gillies MC. Role of steroids in the treatment ofdiabetic macular edema. Int Ophthalmol Clin 2009; 49 (2): 121-34
    • (2009) Int Ophthalmol Clin , vol.49 , Issue.2 , pp. 121-134
    • Kuo, C.H.1    Gillies, M.C.2
  • 170
    • 33747075399 scopus 로고    scopus 로고
    • Intravitreal triamcinolone acetonide: A change ina paradigm
    • Jonas JB. Intravitreal triamcinolone acetonide: a change ina paradigm. Ophthalmic Res 2006; 38 (4): 218-45
    • (2006) Ophthalmic Res , vol.38 , Issue.4 , pp. 218-245
    • Jonas, J.B.1
  • 171
    • 0025959116 scopus 로고
    • Evaluation of a single intravitreal injec-tion of dexamethasone phosphate in vitrectomy surgery for diabetic retinopathy complications
    • Blankenship GW. Evaluation of a single intravitreal injec-tion of dexamethasone phosphate in vitrectomy surgery for diabetic retinopathy complications. Graefes Arch Clin Exp Ophthalmol 1991; 229 (1): 62-5
    • (1991) Graefes Arch Clin Exp Ophthalmol , vol.229 , Issue.1 , pp. 62-65
    • Blankenship, G.W.1
  • 172
    • 0030472037 scopus 로고    scopus 로고
    • Inhibition ofpreretinal and optic nerve head neovascularization in pigs by intravitreal triamcinolone acetonide
    • Danis RP, Bingaman DP, Yang Y, et al. Inhibition ofpreretinal and optic nerve head neovascularization in pigs by intravitreal triamcinolone acetonide. Ophthalmology 1996; 103 (12): 2099-104
    • (1996) Ophthalmology , vol.103 , Issue.12 , pp. 2099-2104
    • Danis, R.P.1    Bingaman, D.P.2    Yang, Y.3
  • 173
    • 0036727854 scopus 로고    scopus 로고
    • Modulation ofpermeability and adhesion molecule expression by human choroidal endothelial cells
    • Penfold PL, Wen L, Madigan MC, et al. Modulation ofpermeability and adhesion molecule expression by human choroidal endothelial cells. Invest Ophthalmol Vis Sci 2002; 43 (9): 3125-30
    • (2002) Invest Ophthalmol Vis Sci , vol.43 , Issue.9 , pp. 3125-3130
    • Penfold, P.L.1    Wen, L.2    Madigan, M.C.3
  • 174
    • 16244370730 scopus 로고    scopus 로고
    • Vascular endothelialgrowth factor reduced and connective tissue growth factor induced by triamcinolone in ARPE19 cells under oxida-tive stress
    • Matsuda S, Gomi F, Oshima Y, et al. Vascular endothelialgrowth factor reduced and connective tissue growth factor induced by triamcinolone in ARPE19 cells under oxida-tive stress. Invest Ophthalmol Vis Sci 2005; 46 (3): 1062-8
    • (2005) Invest Ophthalmol Vis Sci , vol.46 , Issue.3 , pp. 1062-1068
    • Matsuda, S.1    Gomi, F.2    Oshima, Y.3
  • 175
    • 10044242430 scopus 로고    scopus 로고
    • Vitreouslevels of vascular endothelial growth factor and stromal-derived factor 1 in patients with diabetic retinopathy and cystoid macular edema before and after intraocular injection of triamcinolone
    • Brooks Jr HL, Caballero Jr S, Newell CK, et al. Vitreouslevels of vascular endothelial growth factor and stromal-derived factor 1 in patients with diabetic retinopathy and cystoid macular edema before and after intraocular injection of triamcinolone. Arch Ophthalmol 2004; 122 (12): 1801-7
    • (2004) Arch Ophthalmol , vol.122 , Issue.12 , pp. 1801-1807
    • Brooks Jr., H.L.1    Caballero Jr., S.2    Newell, C.K.3
  • 176
    • 77955013602 scopus 로고    scopus 로고
    • Diabetic retinopathy
    • Cheung N, Mitchell P, Wong TY. Diabetic retinopathy.Lancet 2010; 376 (9735): 124-36
    • (2010) Lancet , vol.376 , Issue.9735 , pp. 124-136
    • Cheung, N.1    Mitchell, P.2    Wong, T.Y.3
  • 177
    • 66149151043 scopus 로고    scopus 로고
    • Role of steroids in the man-agement of diabetic macular edema and proliferative diabetic retinopathy
    • Silva PS, Sun JK, Aiello LP. Role of steroids in the man-agement of diabetic macular edema and proliferative diabetic retinopathy. Semin Ophthalmol 2009; 24 (2): 93-9
    • (2009) Semin Ophthalmol , vol.24 , Issue.2 , pp. 93-99
    • Silva, P.S.1    Sun, J.K.2    Aiello, L.P.3
  • 178
    • 65349122995 scopus 로고    scopus 로고
    • Intravitrealtriamcinolone acetonide injection for treatment of refractory diabetic macular edema: A systematic review
    • Yilmaz T, Weaver CD, Gallagher MJ, et al. Intravitrealtriamcinolone acetonide injection for treatment of refractory diabetic macular edema: a systematic review. Ophthalmology 2009; 116 (5): 902-11
    • (2009) Ophthalmology , vol.116 , Issue.5 , pp. 902-911
    • Yilmaz, T.1    Weaver, C.D.2    Gallagher, M.J.3
  • 179
    • 33947529092 scopus 로고    scopus 로고
    • Intravitreal triamcinolone acetonide for diabeticretinopathy
    • Jonas JB. Intravitreal triamcinolone acetonide for diabeticretinopathy. Dev Ophthalmol 2007; 39: 96-110
    • (2007) Dev Ophthalmol , vol.39 , pp. 96-110
    • Jonas, J.B.1
  • 180
    • 33747623255 scopus 로고    scopus 로고
    • Intravitrealtriamcinolone for refractory diabetic macular edema: Two-year results of a double-masked, placebo-controlled, randomized clinical trial
    • Gillies MC, Sutter FK, Simpson JM, et al. Intravitrealtriamcinolone for refractory diabetic macular edema: two-year results of a double-masked, placebo-controlled, randomized clinical trial. Ophthalmology 2006; 113 (9): 1533-8
    • (2006) Ophthalmology , vol.113 , Issue.9 , pp. 1533-1538
    • Gillies, M.C.1    Sutter, F.K.2    Simpson, J.M.3
  • 181
    • 70350574742 scopus 로고    scopus 로고
    • Five-year resultsof a randomized trial with open-label extension of triam-cinolone acetonide for refractory diabetic macular edema
    • Gillies MC, Simpson JM, Gaston C, et al. Five-year resultsof a randomized trial with open-label extension of triam-cinolone acetonide for refractory diabetic macular edema. Ophthalmology 2009; 116 (11): 2182-7
    • (2009) Ophthalmology , vol.116 , Issue.11 , pp. 2182-2187
    • Gillies, M.C.1    Simpson, J.M.2    Gaston, C.3
  • 182
    • 50249149459 scopus 로고    scopus 로고
    • A ran-domized trial comparing intravitreal triamcinolone acet-onide and focal/grid photocoagulation for diabetic macular edema
    • Diabetic Retinopathy Clinical Research Network
    • Diabetic Retinopathy Clinical Research Network. A ran-domized trial comparing intravitreal triamcinolone acet-onide and focal/grid photocoagulation for diabetic macular edema. Ophthalmology 2008; 115 (9): 1447-59
    • (2008) Ophthalmology , vol.115 , Issue.9 , pp. 1447-1459
  • 183
    • 62449171859 scopus 로고    scopus 로고
    • Three-yearfollow-up of a randomized trial comparing focal/grid photocoagulation and intravitreal triamcinolone for diabetic macular edema
    • Beck RW, Edwards AR, Aiello LP, et al. Three-yearfollow-up of a randomized trial comparing focal/grid photocoagulation and intravitreal triamcinolone for diabetic macular edema. Arch Ophthalmol 2009; 127 (3): 245-51
    • (2009) Arch Ophthalmol , vol.127 , Issue.3 , pp. 245-251
    • Beck, R.W.1    Edwards, A.R.2    Aiello, L.P.3
  • 184
    • 73349135368 scopus 로고    scopus 로고
    • Exploratoryanalysis of diabetic retinopathy progression through 3 years in a randomized clinical trial that compares in-travitreal triamcinolone acetonide with focal/grid photo-coagulation
    • Bressler NM, Edwards AR, Beck RW, et al. Exploratoryanalysis of diabetic retinopathy progression through 3 years in a randomized clinical trial that compares in-travitreal triamcinolone acetonide with focal/grid photo-coagulation. Arch Ophthalmol 2009; 127 (12): 1566-71
    • (2009) Arch Ophthalmol , vol.127 , Issue.12 , pp. 1566-1571
    • Bressler, N.M.1    Edwards, A.R.2    Beck, R.W.3
  • 185
    • 45249101790 scopus 로고    scopus 로고
    • Intravitrealtriamcinolone versus laser photocoagulation for persistent diabetic macular oedema
    • Ockrim ZK, Sivaprasad S, Falk S, et al. Intravitrealtriamcinolone versus laser photocoagulation for persistent diabetic macular oedema. Br J Ophthalmol 2008; 92 (6): 795-9
    • (2008) Br J Ophthalmol , vol.92 , Issue.6 , pp. 795-799
    • Ockrim, Z.K.1    Sivaprasad, S.2    Falk, S.3
  • 186
    • 61349185084 scopus 로고    scopus 로고
    • Intravitreal triam-cinolone [letter]
    • Gillies MC, Simpson JM, Zhu M, et al. Intravitreal triam-cinolone [letter]. Ophthalmology 2009; 116 (3): 591
    • (2009) Ophthalmology , vol.116 , Issue.3 , pp. 591
    • Gillies, M.C.1    Simpson, J.M.2    Zhu, M.3
  • 187
    • 65349182974 scopus 로고    scopus 로고
    • Rapid reduction of hardexudates in eyes with diabetic retinopathy after in-travitreal triamcinolone: Data from a randomized, placebo-controlled, clinical trial
    • Larsson J, Kifley A, Zhu M, et al. Rapid reduction of hardexudates in eyes with diabetic retinopathy after in-travitreal triamcinolone: data from a randomized, placebo-controlled, clinical trial. Acta Ophthalmol 2009; 87 (3): 275-80
    • (2009) Acta Ophthalmol , vol.87 , Issue.3 , pp. 275-280
    • Larsson, J.1    Kifley, A.2    Zhu, M.3
  • 188
    • 33646486870 scopus 로고    scopus 로고
    • Triamcinolone asadjunctive treatment to laser panretinal photocoagulation for proliferative diabetic retinopathy
    • Bandello F, Polito A, Pognuz DR, et al. Triamcinolone asadjunctive treatment to laser panretinal photocoagulation for proliferative diabetic retinopathy. Arch Ophthalmol 2006; 124 (5): 643-50
    • (2006) Arch Ophthalmol , vol.124 , Issue.5 , pp. 643-650
    • Bandello, F.1    Polito, A.2    Pognuz, D.R.3
  • 189
    • 36549047019 scopus 로고    scopus 로고
    • Intravitreal triam-cinolone plus sequential grid laser versus triamcinolone or laser alone for treating diabetic macular edema: Six-month outcomes
    • Lam DS, Chan CK, Mohamed S, et al. Intravitreal triam-cinolone plus sequential grid laser versus triamcinolone or laser alone for treating diabetic macular edema: six-month outcomes. Ophthalmology 2007; 114 (12): 2162-7
    • (2007) Ophthalmology , vol.114 , Issue.12 , pp. 2162-2167
    • Lam, D.S.1    Chan, C.K.2    Mohamed, S.3
  • 190
    • 58249105907 scopus 로고    scopus 로고
    • Combinedlaser and intravitreal triamcinolone for proliferative diabetic retinopathy and macular edema: One-year results of a randomized clinical trial
    • Maia Jr OO, Takahashi BS, Costa RA, et al. Combinedlaser and intravitreal triamcinolone for proliferative diabetic retinopathy and macular edema: one-year results of a randomized clinical trial. Am J Ophthalmol 2009; 147 (2): 291-7
    • (2009) Am J Ophthalmol , vol.147 , Issue.2 , pp. 291-297
    • Maia Jr., O.O.1    Takahashi, B.S.2    Costa, R.A.3
  • 191
    • 73349086556 scopus 로고    scopus 로고
    • Comparison of photocoagula-tion with combined intravitreal triamcinolone for diabetic macular edema
    • Lee HY, Lee SY, Park JS. Comparison of photocoagula-tion with combined intravitreal triamcinolone for diabetic macular edema. Korean J Ophthalmol 2009; 23 (3): 153-8
    • (2009) Korean J Ophthalmol , vol.23 , Issue.3 , pp. 153-158
    • Lee, H.Y.1    Lee, S.Y.2    Park, J.S.3
  • 192
    • 76749136263 scopus 로고    scopus 로고
    • Intravitrealtriamcinolone as an adjunct to standard laser therapy in coexisting high-risk proliferative diabetic retinopathy and clinically significant macular edema
    • Mirshahi A, Shenazandi H, Lashay A, et al. Intravitrealtriamcinolone as an adjunct to standard laser therapy in coexisting high-risk proliferative diabetic retinopathy and clinically significant macular edema. Retina 2010; 30 (2): 254-9
    • (2010) Retina , vol.30 , Issue.2 , pp. 254-259
    • Mirshahi, A.1    Shenazandi, H.2    Lashay, A.3
  • 193
    • 34247183571 scopus 로고    scopus 로고
    • Pretreatment ofposterior subtenon injection of triamcinolone acetonide has beneficial effects for grid pattern photocoagulation against diffuse diabetic macular oedema
    • Shimura M, Nakazawa T, Yasuda K, et al. Pretreatment ofposterior subtenon injection of triamcinolone acetonide has beneficial effects for grid pattern photocoagulation against diffuse diabetic macular oedema. Br J Ophthalmol 2007; 91 (4): 449-54
    • (2007) Br J Ophthalmol , vol.91 , Issue.4 , pp. 449-454
    • Shimura, M.1    Nakazawa, T.2    Yasuda, K.3
  • 194
    • 58149463209 scopus 로고    scopus 로고
    • Comparison ofcombination posterior sub-tenon triamcinolone and modified grid laser treatment with intravitreal triamcino-lone treatment in patients with diffuse diabetic macular edema
    • Chung EJ, Freeman WR, Azen SP, et al. Comparison ofcombination posterior sub-tenon triamcinolone and modified grid laser treatment with intravitreal triamcino-lone treatment in patients with diffuse diabetic macular edema. Yonsei Med J 2008; 49 (6): 955-64
    • (2008) Yonsei Med J , vol.49 , Issue.6 , pp. 955-964
    • Chung, E.J.1    Freeman, W.R.2    Azen, S.P.3
  • 195
    • 66749091228 scopus 로고    scopus 로고
    • Randomised con-trolled trial of posterior sub-Tenon triamcinolone as adjunct to panretinal photocoagulation for treatment of diabetic retinopathy
    • Unoki N, Nishijima K, Kita M, et al. Randomised con-trolled trial of posterior sub-Tenon triamcinolone as adjunct to panretinal photocoagulation for treatment of diabetic retinopathy. Br J Ophthalmol 2009; 93 (6): 765-70
    • (2009) Br J Ophthalmol , vol.93 , Issue.6 , pp. 765-770
    • Unoki, N.1    Nishijima, K.2    Kita, M.3
  • 196
    • 77952489006 scopus 로고    scopus 로고
    • Pretreatmentwith intravitreal triamcinolone prior to laser for diabetic macular edema: 6-month results of a randomized, placebo-controlled trial
    • Gillies MC, McAllister IL, Zhu M, et al. Pretreatmentwith intravitreal triamcinolone prior to laser for diabetic macular edema: 6-month results of a randomized, placebo-controlled trial. Invest Ophthalmol Vis Sci 2010; 51: 2322-8
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 2322-2328
    • Gillies, M.C.1    McAllister, I.L.2    Zhu, M.3
  • 197
    • 84877665814 scopus 로고    scopus 로고
    • Three-year follow-up of in-travitreal triamcinolone acetonide injection and macular laser photocoagulation for diffuse diabetic macular edema
    • Kim Y, Kang S, Yi C-H. Three-year follow-up of in-travitreal triamcinolone acetonide injection and macular laser photocoagulation for diffuse diabetic macular edema. Invest Ophthalmol Vis Sci 2010; 51: E-Abstract 4260
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 4260
    • Kim, Y.1    Kang, S.2    Yi, C.-H.3
  • 199
    • 37249013214 scopus 로고    scopus 로고
    • US National Institutes of Health [on-line] [Accessed 2010 May 5]
    • US National Institutes of Health. ClinicalTrials.gov [on-line]. Available from URL: http//clinicaltrials.gov/ [Accessed 2010 May 5].
    • ClinicalTrials.gov
  • 200
    • 61449152762 scopus 로고    scopus 로고
    • Intraocularsustained-release delivery system for triamcinolone acet-onide
    • Mansoor S, Kuppermann BD, Kenney MC. Intraocularsustained-release delivery system for triamcinolone acet-onide. Pharm Res 2009; 26 (4): 770-84
    • (2009) Pharm Res , vol.26 , Issue.4 , pp. 770-784
    • Mansoor, S.1    Kuppermann, B.D.2    Kenney, M.C.3
  • 203
    • 33947275043 scopus 로고    scopus 로고
    • Randomized controlled study of an intravitreous dexa-methasone drug delivery system in patients with persistent macular edema
    • Kuppermann BD, Blumenkranz MS, Haller JA, et al.Randomized controlled study of an intravitreous dexa-methasone drug delivery system in patients with persistent macular edema. Arch Ophthalmol 2007; 125 (3): 309-17
    • (2007) Arch Ophthalmol , vol.125 , Issue.3 , pp. 309-317
    • Kuppermann, B.D.1    Blumenkranz, M.S.2    Haller, J.A.3
  • 204
    • 77749330682 scopus 로고    scopus 로고
    • Randomized controlled trial of an intravitreous dexa-methasone drug delivery system in patients with diabetic macular edema
    • Haller JA, Kuppermann BD, Blumenkranz MS, et al.Randomized controlled trial of an intravitreous dexa-methasone drug delivery system in patients with diabetic macular edema. Arch Ophthalmol 2010; 128 (3): 289-96
    • (2010) Arch Ophthalmol , vol.128 , Issue.3 , pp. 289-296
    • Haller, J.A.1    Kuppermann, B.D.2    Blumenkranz, M.S.3
  • 205
    • 77952148791 scopus 로고    scopus 로고
    • Intravitre-ous dexamethasone effects on different patterns of diabetic macular edema [letter]
    • Kuppermann BD, Chou C, Weinberg DV, et al. Intravitre-ous dexamethasone effects on different patterns of diabetic macular edema [letter]. Arch Ophthalmol 2010; 128 (5): 642-3
    • (2010) Arch Ophthalmol , vol.128 , Issue.5 , pp. 642-643
    • Kuppermann, B.D.1    Chou, C.2    Weinberg, D.V.3
  • 208
    • 77954349303 scopus 로고    scopus 로고
    • Sustainedocular delivery of fluocinolone acetonide by an in-travitreal insert
    • Campochiaro PA, Hafiz G, Shah SM, et al. Sustainedocular delivery of fluocinolone acetonide by an in-travitreal insert. Ophthalmology 2010; 117 (7): 1393-9.e3
    • (2010) Ophthalmology , vol.117 , Issue.7
    • Campochiaro, P.A.1    Hafiz, G.2    Shah, S.M.3
  • 209
    • 77958522879 scopus 로고    scopus 로고
    • Prospective, randomized, multi-center, comparator studyevaluating efficacy and safety of PF-04523655 versus laser in subjects with diabetic macular edema [ClinicalTrials. gov identifier NCT00701181] US National Institutes of Health, ClinicalTrials.gov [online]. Available from URL Accessed 2010 Aug 17
    • Prospective, randomized, multi-center, comparator studyevaluating efficacy and safety of PF-04523655 versus laser in subjects with diabetic macular edema [ClinicalTrials. gov identifier NCT00701181]. US National Institutes of Health, ClinicalTrials.gov [online]. Available from URL: http://www.clinicaltrials.gov [Accessed 2010 Aug 17]
  • 210
    • 77950863290 scopus 로고    scopus 로고
    • Topical mecamylamine for diabetic macular edema
    • Campochiaro PA, Shah SM, Hafiz G, et al. Topical mec-amylamine for diabetic macular edema. Am J Ophthalmol 2010; 149 (5): 839-51
    • (2010) Am J Ophthalmol , vol.149 , Issue.5 , pp. 839-851
    • Campochiaro, P.A.1    Shah, S.M.2    Hafiz, G.3
  • 211
    • 0024818355 scopus 로고
    • Vascular en-dothelial growth factor is a secreted angiogenic mitogen
    • Leung DW, Cachianes G, Kuang WJ, et al. Vascular en-dothelial growth factor is a secreted angiogenic mitogen. Science 1989; 246 (4935): 1306-9
    • (1989) Science , vol.246 , Issue.4935 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.J.3
  • 212
    • 1942454791 scopus 로고    scopus 로고
    • Recruitment ofmarrow-derived endothelial cells to experimental cho-roidal neovascularization by local expression of vascular endothelial growth factor
    • Csaky KG, Baffi JZ, Byrnes GA, et al. Recruitment ofmarrow-derived endothelial cells to experimental cho-roidal neovascularization by local expression of vascular endothelial growth factor. Exp Eye Res 2004; 78 (6): 1107-16
    • (2004) Exp Eye Res , vol.78 , Issue.6 , pp. 1107-1116
    • Csaky, K.G.1    Baffi, J.Z.2    Byrnes, G.A.3
  • 213
    • 0028803509 scopus 로고
    • Vascular endothelial growthfactor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity
    • Alon T, Hemo I, Itin A, et al. Vascular endothelial growthfactor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat Med 1995; 1 (10): 1024-8
    • (1995) Nat Med , vol.1 , Issue.10 , pp. 1024-1028
    • Alon, T.1    Hemo, I.2    Itin, A.3
  • 214
    • 0025194878 scopus 로고
    • 2 terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor
    • 2 terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor. Cancer Res 1990; 50 (6): 1774-8
    • (1990) Cancer Res , vol.50 , Issue.6 , pp. 1774-1778
    • Senger, D.R.1    Connolly, D.T.2    Van De Water, L.3
  • 215
    • 0029010434 scopus 로고
    • Increased microvascular perme-ability and endothelial fenestration induced by vascular endothelial growth factor
    • Roberts WG, Palade GE. Increased microvascular perme-ability and endothelial fenestration induced by vascular endothelial growth factor. J Cell Sci 1995; 108 (Pt 6): 2369-79
    • (1995) J Cell Sci , vol.108 , Issue.PART 6 , pp. 2369-2379
    • Roberts, W.G.1    Palade, G.E.2
  • 216
    • 0031737671 scopus 로고    scopus 로고
    • Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: Vascular endothelial growth factor decreases occludin in retinal endothelial cells
    • and the Penn StateRetina Research Group
    • Antonetti DA, Khin S, Lieth E, et al., and the Penn StateRetina Research Group. Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells. Diabetes 1998; 47 (12): 1953-9
    • (1998) Diabetes , vol.47 , Issue.12 , pp. 1953-1959
    • Antonetti, D.A.1    Khin, S.2    Lieth, E.3
  • 217
    • 0033551811 scopus 로고    scopus 로고
    • Vascularendothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1: A potential mechanism for vascular permeability in diabetic retinopathy and tumors
    • Antonetti DA, Barber AJ, Hollinger LA, et al. Vascularendothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1: a potential mechanism for vascular permeability in diabetic retinopathy and tumors. J Biol Chem 1999; 274 (33): 23463-7
    • (1999) J Biol Chem , vol.274 , Issue.33 , pp. 23463-23467
    • Antonetti, D.A.1    Barber, A.J.2    Hollinger, L.A.3
  • 218
    • 0037407757 scopus 로고    scopus 로고
    • VEGF164 is proin-flammatory in the diabetic retina
    • Ishida S, Usui T, Yamashiro K, et al. VEGF164 is proin-flammatory in the diabetic retina. Invest Ophthalmol Vis Sci 2003; 44 (5): 2155-62
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , Issue.5 , pp. 2155-2162
    • Ishida, S.1    Usui, T.2    Yamashiro, K.3
  • 219
    • 0031660311 scopus 로고    scopus 로고
    • In vivodemonstration of increased leukocyte entrapment in retinal microcirculation of diabetic rats
    • Miyamoto K, Hiroshiba N, Tsujikawa A, et al. In vivodemonstration of increased leukocyte entrapment in retinal microcirculation of diabetic rats. Invest Ophthalmol Vis Sci 1998; 39 (11): 2190-4
    • (1998) Invest Ophthalmol Vis Sci , vol.39 , Issue.11 , pp. 2190-2194
    • Miyamoto, K.1    Hiroshiba, N.2    Tsujikawa, A.3
  • 220
    • 7044228789 scopus 로고    scopus 로고
    • A central role forinflammation in the pathogenesis of diabetic retinopathy
    • Joussen AM, Poulaki V, Le ML, et al. A central role forinflammation in the pathogenesis of diabetic retinopathy. FASEB J 2004; 18 (12): 1450-2
    • (2004) FASEB J , vol.18 , Issue.12 , pp. 1450-1452
    • Joussen, A.M.1    Poulaki Le V, M.L.2
  • 221
    • 0037271803 scopus 로고    scopus 로고
    • Suppression of Fas-Fas L-induced endothelial cell apoptosis prevents diabetic blood-retinal barrier breakdown in a model of streptozotocin-induced diabetes
    • Joussen AM, Poulaki V, Mitsiades N, et al. Suppression ofFas-FasL-induced endothelial cell apoptosis prevents diabetic blood-retinal barrier breakdown in a model of streptozotocin-induced diabetes. FASEB J 2003; 17 (1): 76-8
    • (2003) FASEB J , vol.17 , Issue.1 , pp. 76-78
    • Joussen, A.M.1    Poulaki, V.2    Mitsiades, N.3
  • 222
    • 0025688912 scopus 로고
    • Vascular perme-ability factor: A tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration
    • Clauss M, Gerlach M, Gerlach H, et al. Vascular perme-ability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration. J Exp Med 1990; 172 (6): 1535-45
    • (1990) J Exp Med , vol.172 , Issue.6 , pp. 1535-1545
    • Clauss, M.1    Gerlach, M.2    Gerlach, H.3
  • 223
    • 0029867554 scopus 로고    scopus 로고
    • Migration of humanmonocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1
    • Barleon B, Sozzani S, Zhou D, et al. Migration of humanmonocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood 1996; 87 (8): 3336-43
    • (1996) Blood , vol.87 , Issue.8 , pp. 3336-3343
    • Barleon, B.1    Sozzani, S.2    Zhou, D.3
  • 224
    • 0043125643 scopus 로고    scopus 로고
    • VEGF164-mediatedinflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization
    • Ishida S, Usui T, Yamashiro K, et al. VEGF164-mediatedinflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization. J Exp Med 2003; 198 (3): 483-9
    • (2003) J Exp Med , vol.198 , Issue.3 , pp. 483-489
    • Ishida, S.1    Usui, T.2    Yamashiro, K.3
  • 225
    • 0028826101 scopus 로고
    • Hypoxic regulation of vascular endothelial growth factor in retinal cells
    • Aiello LP, Northrup JM, Keyt BA, et al. Hypoxic regula-tion of vascular endothelial growth factor in retinal cells. Arch Ophthalmol 1995; 113 (12): 1538-44
    • (1995) Arch Ophthalmol , vol.113 , Issue.12 , pp. 1538-1544
    • Aiello, L.P.1    Northrup, J.M.2    Keyt, B.A.3
  • 226
    • 0032863021 scopus 로고    scopus 로고
    • Preventionof leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition
    • Miyamoto K, Khosrof S, Bursell SE, et al. Preventionof leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition. Proc Natl Acad Sci \USA 1999; 96 (19): 10836-41
    • (1999) Proc Natl Acad Sci\USA , vol.96 , Issue.19 , pp. 10836-10841
    • Miyamoto, K.1    Khosrof, S.2    Bursell, S.E.3
  • 227
    • 0027942607 scopus 로고
    • Vascular endo-thelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders
    • Aiello LP, Avery RL, Arrigg PG, et al. Vascular endo-thelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 1994; 331 (22): 1480-7
    • (1994) N Engl J Med , vol.331 , Issue.22 , pp. 1480-1487
    • Aiello, L.P.1    Avery, R.L.2    Arrigg, P.G.3
  • 228
    • 0028123090 scopus 로고
    • Increased vas-cular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy
    • Adamis AP, Miller JW, Bernal MT, et al. Increased vas-cular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am J Oph-thalmol 1994; 118 (4): 445-50
    • (1994) Am J Ophthalmol , vol.118 , Issue.4 , pp. 445-450
    • Adamis, A.P.1    Miller, J.W.2    Bernal, M.T.3
  • 230
    • 0036179104 scopus 로고    scopus 로고
    • Pathologicfeatures of vascular endothelial growth factor-induced retinopathy in the nonhuman primate
    • Tolentino MJ, McLeod DS, Taomoto M, et al. Pathologicfeatures of vascular endothelial growth factor-induced retinopathy in the nonhuman primate. Am J Ophthalmol 2002; 133 (3): 373-85
    • (2002) Am J Ophthalmol , vol.133 , Issue.3 , pp. 373-385
    • Tolentino, M.J.1    McLeod, D.S.2    Taomoto, M.3
  • 231
    • 0029803087 scopus 로고    scopus 로고
    • Intravitreous injections of vascular endothelial growth factor produce retinal ischemia and microangiopathy in an adult primate
    • Tolentino MJ, Miller JW, Gragoudas ES, et al. Intravitre-ous injections of vascular endothelial growth factor produce retinal ischemia and microangiopathy in an adult primate. Ophthalmology 1996; 103 (11): 1820-8
    • (1996) Ophthalmology , vol.103 , Issue.11 , pp. 1820-1828
    • Tolentino, M.J.1    Miller, J.W.2    Gragoudas, E.S.3
  • 232
    • 33645095226 scopus 로고    scopus 로고
    • Pegaptanib, a targetedanti-VEGF aptamer for ocular vascular disease
    • Ng EW, Shima DT, Calias P, et al. Pegaptanib, a targetedanti-VEGF aptamer for ocular vascular disease. Nat Rev Drug Discov 2006; 5 (2): 123-32
    • (2006) Nat Rev Drug Discov , vol.5 , Issue.2 , pp. 123-132
    • Ng, E.W.1    Shima, D.T.2    Calias, P.3
  • 233
    • 33749632278 scopus 로고    scopus 로고
    • Development ofranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration
    • Ferrara N, Damico L, Shams N, et al. Development ofranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration. Retina 2006; 26 (8): 859-70
    • (2006) Retina , vol.26 , Issue.8 , pp. 859-870
    • Ferrara, N.1    Damico, L.2    Shams, N.3
  • 234
    • 11144239923 scopus 로고    scopus 로고
    • Pegaptanib for neovascular age-related macular degeneration
    • Gragoudas ES, Adamis AP, Cunningham Jr ET, et al.Pegaptanib for neovascular age-related macular degeneration. N Engl J Med 2004; 351 (27): 2805-16
    • (2004) N Engl J Med , vol.351 , Issue.27 , pp. 2805-2816
    • Gragoudas, E.S.1    Adamis, A.P.2    Cunningham Jr., E.T.3
  • 235
    • 33749451356 scopus 로고    scopus 로고
    • Ranibizumabversus verteporfin for neovascular age-related macular degeneration
    • Brown DM, Kaiser PK, Michels M, et al. Ranibizumabversus verteporfin for neovascular age-related macular degeneration. N Engl J Med 2006; 355 (14): 1432-44
    • (2006) N Engl J Med , vol.355 , Issue.14 , pp. 1432-1444
    • Brown, D.M.1    Kaiser, P.K.2    Michels, M.3
  • 236
    • 33749445317 scopus 로고    scopus 로고
    • Ranibizumab forneovascular age-related macular degeneration
    • Rosenfeld PJ, Brown DM, Heier JS, et al. Ranibizumab forneovascular age-related macular degeneration. N Engl J Med 2006; 355 (14): 1419-31
    • (2006) N Engl J Med , vol.355 , Issue.14 , pp. 1419-1431
    • Rosenfeld, P.J.1    Brown, D.M.2    Heier, J.S.3
  • 237
    • 34247182509 scopus 로고    scopus 로고
    • Bevacizumab for neovascular oculardiseases
    • Lynch SS, Cheng CM. Bevacizumab for neovascular oculardiseases. Ann Pharmacother 2007; 41 (4): 614-25
    • (2007) Ann Pharmacother , vol.41 , Issue.4 , pp. 614-625
    • Lynch, S.S.1    Cheng, C.M.2
  • 239
    • 0037143764 scopus 로고    scopus 로고
    • VEGF-Trap: AVEGF blocker with potent antitumor effects
    • Holash J, Davis S, Papadopoulos N, et al. VEGF-Trap: aVEGF blocker with potent antitumor effects. Proc Natl Acad Sci \USA 2002; 99 (17): 11393-8
    • (2002) Proc Natl Acad Sci \USA , vol.99 , Issue.17 , pp. 11393-11398
    • Holash, J.1    Davis, S.2    Papadopoulos, N.3
  • 240
    • 60849129118 scopus 로고    scopus 로고
    • An exploratory studyof the safety, tolerability and bioactivity of a single intra-vitreal injection of vascular endothelial growth factor Trap-Eye in patients with diabetic macular oedema
    • Do DV, Nguyen QD, Shah SM, et al. An exploratory studyof the safety, tolerability and bioactivity of a single intra-vitreal injection of vascular endothelial growth factor Trap-Eye in patients with diabetic macular oedema. Br J Ophthalmol 2009; 93 (2): 144-9
    • (2009) Br J Ophthalmol , vol.93 , Issue.2 , pp. 144-149
    • Do, D.V.1    Nguyen, Q.D.2    Shah, S.M.3
  • 242
    • 49649105189 scopus 로고    scopus 로고
    • Rapamycin reducesVEGF expression in retinal pigment epithelium (RPE) and inhibits RPE-induced sprouting angiogenesis in vitro
    • Stahl A, Paschek L, Martin G, et al. Rapamycin reducesVEGF expression in retinal pigment epithelium (RPE) and inhibits RPE-induced sprouting angiogenesis in vitro. FEBS Lett 2008; 582 (20): 3097-102
    • (2008) FEBS Lett , vol.582 , Issue.20 , pp. 3097-3102
    • Stahl, A.1    Paschek, L.2    Martin, G.3
  • 243
    • 77953642138 scopus 로고    scopus 로고
    • Rapamycin in-hibits VEGF-induced microvascular hyperpermeability
    • Kim DD, Kleinman D, Kanetaka T, et al. Rapamycin in-hibits VEGF-induced microvascular hyperpermeability. Microcirculation 2010; 17(2): 128-36
    • (2010) Microcirculation , vol.17 , Issue.2 , pp. 128-136
    • Kim, D.D.1    Kleinman, D.2    Kanetaka, T.3
  • 245
    • 25844513658 scopus 로고    scopus 로고
    • A phaseII randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema
    • Cunningham Jr ET, Adamis AP, Altaweel M, et al. A phaseII randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema. Ophthalmology 2005; 112 (10): 1747-57
    • (2005) Ophthalmology , vol.112 , Issue.10 , pp. 1747-1757
    • Cunningham Jr., E.T.1    Adamis, A.P.2    Altaweel, M.3
  • 246
    • 29644444716 scopus 로고    scopus 로고
    • Changes inretinal neovascularization after pegaptanib (Macugen) therapy in diabetic individuals
    • Adamis AP, Altaweel M, Bressler NM, et al. Changes inretinal neovascularization after pegaptanib (Macugen) therapy in diabetic individuals. Ophthalmology 2006; 113 (1): 23-8
    • (2006) Ophthalmology , vol.113 , Issue.1 , pp. 23-28
    • Adamis, A.P.1    Altaweel, M.2    Bressler, N.M.3
  • 247
    • 33748957021 scopus 로고    scopus 로고
    • A pilot study ofmultiple intravitreal injections of ranibizumab in patients with center-involving clinically significant diabetic macular edema
    • Chun DW, Heier JS, Topping TM, et al. A pilot study ofmultiple intravitreal injections of ranibizumab in patients with center-involving clinically significant diabetic macular edema. Ophthalmology 2006; 113 (10): 1706-12
    • (2006) Ophthalmology , vol.113 , Issue.10 , pp. 1706-1712
    • Chun, D.W.1    Heier, J.S.2    Topping, T.M.3
  • 248
    • 77958552448 scopus 로고    scopus 로고
    • Lucentis in thetreatment of macular edema (LIME): A phase II study evaluating the safety and efficacy of ranibizumab versus focal laser treatment in patients with diabetic macular edema [abstract]
    • E-Abstract 1431
    • Goodart R, Faber DW, Mehr DS, et al. Lucentis in thetreatment of macular edema (LIME): a phase II study evaluating the safety and efficacy of ranibizumab versus focal laser treatment in patients with diabetic macular edema [abstract]. Invest Ophthalmol Vis Sci 2007; 48: E-Abstract 1431
    • (2007) Invest Ophthalmol Vis Sci , vol.48
    • Goodart, R.1    Faber, D.W.2    Mehr, D.S.3
  • 249
    • 33845191304 scopus 로고    scopus 로고
    • Vascular en-dothelial growth factor is a critical stimulus for diabetic macular edema
    • Nguyen QD, Tatlipinar S, Shah SM, et al. Vascular en-dothelial growth factor is a critical stimulus for diabetic macular edema. Am J Ophthalmol 2006; 142 (6): 961-9
    • (2006) Am J Ophthalmol , vol.142 , Issue.6 , pp. 961-969
    • Nguyen, Q.D.1    Tatlipinar, S.2    Shah, S.M.3
  • 250
    • 77958564064 scopus 로고    scopus 로고
    • Safety and efficacy ofranibizumab treatment in patients with diabetic macular edema: 12-months results of the Resolve study [abstract]
    • E-Abstract 4331
    • Wolf S, Massin P, Bandello F, et al. Safety and efficacy ofranibizumab treatment in patients with diabetic macular edema: 12-months results of the Resolve study [abstract]. Invest Ophthalmol Vis Sci 2009; 50: E-Abstract 4331
    • (2009) Invest Ophthalmol Vis Sci , vol.50
    • Wolf, S.1    Massin, P.2    Bandello, F.3
  • 251
    • 79952118856 scopus 로고    scopus 로고
    • Intravitreal bevacizumab (Avastin®) for diabetic retinopathy at 24-months: The 200 Juan Verdaguer-Planas Lecture
    • The Pan-AmericanCollaborative Retina Study Group (PACORES) Epub 2010 Jul 1
    • Arevalo JF, Sanchez JG, Lasave AF, The Pan-AmericanCollaborative Retina Study Group (PACORES). Intravitreal bevacizumab (Avastin®) for diabetic retinopathy at 24-months: the 2008 Juan Verdaguer-Planas Lecture. Curr Diabetes Rev. Epub 2010 Jul 1
    • Curr Diabetes Rev
    • Arevalo, J.F.1    Sanchez, J.G.2    Lasave, A.F.3
  • 252
    • 47649090159 scopus 로고    scopus 로고
    • Panretinal pho-tocoagulation versus PRP plus intravitreal bevacizumab for high-risk proliferative diabetic retinopathy (IBeHi study)
    • Tonello M, Costa RA, Almeida FP, et al. Panretinal pho-tocoagulation versus PRP plus intravitreal bevacizumab for high-risk proliferative diabetic retinopathy (IBeHi study). Acta Ophthalmol 2008; 86 (4): 385-9
    • (2008) Acta Ophthalmol , vol.86 , Issue.4 , pp. 385-389
    • Tonello, M.1    Costa, R.A.2    Almeida, F.P.3
  • 253
    • 43749087641 scopus 로고    scopus 로고
    • Bevacizumab-augmented retinal laser photocoagulation in proliferative diabetic retinopathy: A randomized double-masked clinical trial
    • Mirshahi A, Roohipoor R, Lashay A, et al. Bevacizumab-augmented retinal laser photocoagulation in proliferative diabetic retinopathy: a randomized double-masked clinical trial. Eur J Ophthalmol 2008; 18 (2): 263-9
    • (2008) Eur J Ophthalmol , vol.18 , Issue.2 , pp. 263-269
    • Mirshahi, A.1    Roohipoor, R.2    Lashay, A.3
  • 254
    • 58149374861 scopus 로고    scopus 로고
    • Intravitrealbevacizumab versus combined bevacizumab-triamcinolone versus macular laser photocoagulation in diabetic macular edema
    • Faghihi H, Roohipoor R, Mohammadi SF, et al. Intravitrealbevacizumab versus combined bevacizumab-triamcinolone versus macular laser photocoagulation in diabetic macular edema. Eur J Ophthalmol 2008; 18 (6): 941-8
    • (2008) Eur J Ophthalmol , vol.18 , Issue.6 , pp. 941-948
    • Faghihi, H.1    Roohipoor, R.2    Mohammadi, S.F.3
  • 255
    • 77955657984 scopus 로고    scopus 로고
    • A review of clinical trials ofanti-VEGF agents for diabetic retinopathy
    • Nicholson BP, Schachat AP. A review of clinical trials ofanti-VEGF agents for diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol 2010; 248 (7): 915-30
    • (2010) Graefes Arch Clin Exp Ophthalmol , vol.248 , Issue.7 , pp. 915-930
    • Nicholson, B.P.1    Schachat, A.P.2
  • 256
    • 77958586930 scopus 로고    scopus 로고
    • Pegaptanib therapy for diabetic macular edema (DME): Two year follow-up
    • Macugen Diabetic Retinopathy Study Group Jun 9-15; Vienna A multi-center trial to evaluate the safety and efficacy ofpegaptanib sodium (Macugen) injected into the eye every6 weeks for up to 2 years for macular swelling associated with diabetes, with an open-label Macugen year extension [ClinicalTrials.gov identifier NCT00605280]. US National Institutes of Health, ClinicalTrials.gov [online] Accessed 2010 Aug 17
    • Ergun E, Macugen Diabetic Retinopathy Study Group. Pegaptanib therapy for diabetic macular edema (DME): two year follow-up. 16th Congress of the European Society of Ophthalmology; 2007 Jun 9-15; Vienna A multi-center trial to evaluate the safety and efficacy ofpegaptanib sodium (Macugen) injected into the eye every6 weeks for up to 2 years for macular swelling associated with diabetes, with an open-label Macugen year extension [ClinicalTrials.gov identifier NCT00605280]. US National Institutes of Health, ClinicalTrials.gov [online]. Available from URL: http://www.clinicaltrials.gov [Accessed 2010 Aug 17]
    • (2007) 16th Congress of the European Society of Ophthalmology
    • Ergun, E.1
  • 257
    • 70350469069 scopus 로고    scopus 로고
    • Intravitrealinjection of pegaptanib sodium for proliferative diabetic retinopathy
    • Gonzalez VH, Giuliari GP, Banda RM, et al. Intravitrealinjection of pegaptanib sodium for proliferative diabetic retinopathy. Br J Ophthalmol 2009; 93 (11): 1474-8
    • (2009) Br J Ophthalmol , vol.93 , Issue.11 , pp. 1474-1478
    • Gonzalez, V.H.1    Giuliari, G.P.2    Banda, R.M.3
  • 258
    • 77958608607 scopus 로고    scopus 로고
    • Pegaptanibsodium (Macugen) as an adjunct in proliferative diabetic retinopathy refractory to laser treatment [abstract]
    • E-Abstract 2761
    • Morilla Gomez Y, Giuliari GP, Guel DA, et al. Pegaptanibsodium (Macugen) as an adjunct in proliferative diabetic retinopathy refractory to laser treatment [abstract]. Invest Ophthalmol Vis Sci 2008: E-Abstract 2761
    • (2008) Invest Ophthalmol Vis Sci
    • Morilla Gomez, Y.1    Giuliari, G.P.2    Guel, D.A.3
  • 260
    • 70350567637 scopus 로고    scopus 로고
    • Primary end point(six months) results of the Ranibizumab for Edema of the Macula in Diabetes (READ-2) study
    • Nguyen QD, Shah SM, Heier JS, et al. Primary end point(six months) results of the Ranibizumab for Edema of the Macula in Diabetes (READ-2) study. Ophthalmology 2009; 116 (11): 2175-81.e1
    • (2009) Ophthalmology , vol.116 , Issue.11
    • Nguyen, Q.D.1    Shah, S.M.2    Heier, J.S.3
  • 261
    • 77952779304 scopus 로고    scopus 로고
    • Randomized trial evaluating ranibiz-umab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema
    • Diabetic Retinopathy Clinical Research Network
    • Diabetic Retinopathy Clinical Research Network, ElmanMJ, Aiello LP, et al. Randomized trial evaluating ranibiz-umab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema. Ophthalmology 2010; 117 (6): 1064-77.e35
    • (2010) Ophthalmology , vol.117 , Issue.6
    • Elman, M.J.1    Aiello, L.P.2
  • 263
  • 264
    • 66149129948 scopus 로고    scopus 로고
    • Panretinal photo-coagulation combined with intravitreal bevacizumab in high-risk proliferative diabetic retinopathy
    • Cho WB, Oh SB, Moon JW, et al. Panretinal photo-coagulation combined with intravitreal bevacizumab in high-risk proliferative diabetic retinopathy. Retina 2009; 29 (4): 516-22
    • (2009) Retina , vol.29 , Issue.4 , pp. 516-522
    • Cho, W.B.1    Oh, S.B.2    Moon, J.W.3
  • 265
    • 77952889192 scopus 로고    scopus 로고
    • A pro-spective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (BOLT study) 12-month data: Report 2
    • Michaelides M, Kaines A, Hamilton RD, et al. A pro-spective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (BOLT study) 12-month data: report 2. Ophthalmology 2010; 117 (6): 1078-86.e2
    • (2010) Ophthalmology , vol.117 , Issue.6
    • Michaelides, M.1    Kaines, A.2    Hamilton, R.D.3
  • 266
    • 67349168190 scopus 로고    scopus 로고
    • Randomizedtrial of intravitreal bevacizumab alone or combined with triamcinolone versus macular photocoagulation in diabetic macular edema
    • Soheilian M, Ramezani A, Obudi A, et al. Randomizedtrial of intravitreal bevacizumab alone or combined with triamcinolone versus macular photocoagulation in diabetic macular edema. Ophthalmology 2009; 116 (6): 1142-50
    • (2009) Ophthalmology , vol.116 , Issue.6 , pp. 1142-1150
    • Soheilian, M.1    Ramezani, A.2    Obudi, A.3
  • 267
    • 77954285140 scopus 로고    scopus 로고
    • Intravitreal triamcinoloneand bevacizumab as adjunctive treatments to panretinal photocoagulation in diabetic retinopathy
    • Cho WB, Moon JW, Kim HC. Intravitreal triamcinoloneand bevacizumab as adjunctive treatments to panretinal photocoagulation in diabetic retinopathy. Br J Ophthal-mol 2010; 94 (7): 858-63
    • (2010) Br J Ophthalmol , vol.94 , Issue.7 , pp. 858-863
    • Cho, W.B.1    Moon, J.W.2    Kim, H.C.3
  • 268
    • 67349105083 scopus 로고    scopus 로고
    • Analysis of the effect ofintravitreal bevacizumab injection on diabetic macular edema after cataract surgery
    • Takamura Y, Kubo E, Akagi Y. Analysis of the effect ofintravitreal bevacizumab injection on diabetic macular edema after cataract surgery. Ophthalmology 2009; 116 (6): 1151-7
    • (2009) Ophthalmology , vol.116 , Issue.6 , pp. 1151-1157
    • Takamura, Y.1    Kubo, E.2    Akagi, Y.3
  • 269
    • 49349103253 scopus 로고    scopus 로고
    • Intravitreous anti-VEGF for dia-betic retinopathy: Hopes and fears for a new therapeutic strategy
    • Simo R, Hernandez C. Intravitreous anti-VEGF for dia-betic retinopathy: hopes and fears for a new therapeutic strategy. Diabetologia 2008; 51 (9): 1574-80
    • (2008) Diabetologia , vol.51 , Issue.9 , pp. 1574-1580
    • Simo, R.1    Hernandez, C.2
  • 270
    • 49249129275 scopus 로고    scopus 로고
    • Is blockade of vascular en-dothelial growth factor beneficial for all types of diabetic retinopathy?
    • Sang DN, D'Amore PA. Is blockade of vascular en-dothelial growth factor beneficial for all types of diabetic retinopathy? Diabetologia 2008; 51 (9): 1570-3
    • (2008) Diabetologia , vol.51 , Issue.9 , pp. 1570-1573
    • Sang, D.N.1    D'Amore, P.A.2
  • 271
    • 4644234505 scopus 로고    scopus 로고
    • VEGF: Onceregarded as a specific angiogenic factor, now implicated in neuroprotection
    • Storkebaum E, Lambrechts D, Carmeliet P. VEGF: onceregarded as a specific angiogenic factor, now implicated in neuroprotection. Bioessays 2004; 26 (9): 943-54
    • (2004) Bioessays , vol.26 , Issue.9 , pp. 943-954
    • Storkebaum, E.1    Lambrechts, D.2    Carmeliet, P.3
  • 272
    • 34547702738 scopus 로고    scopus 로고
    • Vascular endothelialgrowth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury
    • Nishijima K, Ng YS, Zhong L, et al. Vascular endothelialgrowth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury. Am J Pathol 2007; 171 (1): 53-67
    • (2007) Am J Pathol , vol.171 , Issue.1 , pp. 53-67
    • Nishijima, K.1    Ng, Y.S.2    Zhong, L.3
  • 273
    • 56149103354 scopus 로고    scopus 로고
    • Endo-genous VEGF is required for visual function: Evidence for a survival role on Muller cells and photoreceptors
    • Saint-Geniez M, Maharaj AS, Walshe TE, et al. Endo-genous VEGF is required for visual function: evidence for a survival role on Muller cells and photoreceptors. PLoS One 2008; 3 (11): e3554
    • (2008) PLoS One , vol.3 , Issue.11
    • Saint-Geniez, M.1    Maharaj, A.S.2    Walshe, T.E.3
  • 274
    • 32944474182 scopus 로고    scopus 로고
    • VEGF-dependentplasticity of fenestrated capillaries in the normal adult microvasculature
    • Kamba T, Tam BY, HashizumeH, etal. VEGF-dependentplasticity of fenestrated capillaries in the normal adult microvasculature. Am J Physiol Heart Circ Physiol 2006; 290 (2): H560-76
    • (2006) Am J Physiol Heart Circ Physiol , vol.290 , Issue.2
    • Kamba, T.1    Tam, B.Y.2    Hashizume, H.3
  • 275
    • 0033027858 scopus 로고    scopus 로고
    • VEGF couples hy-pertrophic cartilage remodeling, ossification and angio-genesis during endochondral bone formation
    • Gerber HP, Vu TH, Ryan AM, et al. VEGF couples hy-pertrophic cartilage remodeling, ossification and angio-genesis during endochondral bone formation. Nat Med 1999; 5 (6): 623-8
    • (1999) Nat Med , vol.5 , Issue.6 , pp. 623-628
    • Gerber, H.P.1    Vu, T.H.2    Ryan, A.M.3
  • 276
    • 0037370325 scopus 로고    scopus 로고
    • Glomerular-specificalterations of VEGF-A expression lead to distinct congenital and acquired renal diseases
    • Eremina V, Sood M, Haigh J, et al. Glomerular-specificalterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J Clin Invest 2003; 111 (5): 707-16
    • (2003) J Clin Invest , vol.111 , Issue.5 , pp. 707-716
    • Eremina, V.1    Sood, M.2    Haigh, J.3
  • 277
    • 27944456516 scopus 로고    scopus 로고
    • Managing patients treatedwith bevacizumab combination therapy
    • Gordon MS, Cunningham D. Managing patients treatedwith bevacizumab combination therapy. Oncology 2005; 69 Suppl. 3: 25-33
    • (2005) Oncology , vol.69 , Issue.SUPPL. 3 , pp. 25-33
    • Gordon, M.S.1    Cunningham, D.2
  • 278
    • 34548141828 scopus 로고    scopus 로고
    • Arterialthromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab
    • Scappaticci FA, Skillings JR, Holden SN, et al. Arterialthromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab. J Natl Cancer Inst 2007; 99 (16): 1232-9
    • (2007) J Natl Cancer Inst , vol.99 , Issue.16 , pp. 1232-1239
    • Scappaticci, F.A.1    Skillings, J.R.2    Holden, S.N.3
  • 279
    • 15044349368 scopus 로고    scopus 로고
    • Inhibitors ofocular neovascularization: Promises and potential problems
    • van Wijngaarden P, Coster DJ, Williams KA. Inhibitors ofocular neovascularization: promises and potential problems. JAMA 2005; 293 (12): 1509-13
    • (2005) JAMA , vol.293 , Issue.12 , pp. 1509-1513
    • Van Wijngaarden, P.1    Coster, D.J.2    Williams, K.A.3
  • 280
    • 77956586572 scopus 로고    scopus 로고
    • Plasma levelsof vascular endothelial growth factor and pigment epithelium-derived factor before and after intravitreal injection of bevacizumab
    • Matsuyama K, Ogata N, Matsuoka M, et al. Plasma levelsof vascular endothelial growth factor and pigment epithelium-derived factor before and after intravitreal injection of bevacizumab. Br J Ophthalmol 2010; 94 (9): 1215-8
    • (2010) Br J Ophthalmol , vol.94 , Issue.9 , pp. 1215-1218
    • Matsuyama, K.1    Ogata, N.2    Matsuoka, M.3
  • 281
    • 0032807809 scopus 로고    scopus 로고
    • Polarizedvascular endothelial growth factor secretion by human retinal pigment epithelium and localization of vascular endothelial growth factor receptors on the inner cho-riocapillaris: Evidence for a trophic paracrine relation
    • Blaauwgeers HG, Holtkamp GM, Rutten H, et al. Polarizedvascular endothelial growth factor secretion by human retinal pigment epithelium and localization of vascular endothelial growth factor receptors on the inner cho-riocapillaris: evidence for a trophic paracrine relation. Am J Pathol 1999; 155 (2): 421-8
    • (1999) Am J Pathol , vol.155 , Issue.2 , pp. 421-428
    • Blaauwgeers, H.G.1    Holtkamp, G.M.2    Rutten, H.3
  • 282
    • 34548262708 scopus 로고    scopus 로고
    • Pegaptanib 1-yearsystemic safety results from a safety-pharmacokinetic trial in patients with neovascular age-related macular degeneration
    • Apte RS, Modi M, Masonson H, et al. Pegaptanib 1-yearsystemic safety results from a safety-pharmacokinetic trial in patients with neovascular age-related macular degeneration. Ophthalmology 2007; 114 (9): 1702-12
    • (2007) Ophthalmology , vol.114 , Issue.9 , pp. 1702-1712
    • Apte, R.S.1    Modi, M.2    Masonson, H.3
  • 283
    • 57149091202 scopus 로고    scopus 로고
    • Pegaptanibsodium for neovascular age-related macular degeneration: Third-year safety results of the VEGF Inhibition Study in Ocular Neovascularisation (VISION) trial
    • Singerman LJ, Masonson H, Patel M, et al. Pegaptanibsodium for neovascular age-related macular degeneration: third-year safety results of the VEGF Inhibition Study in Ocular Neovascularisation (VISION) trial. Br J Ophthalmol 2008; 92 (12): 1606-11
    • (2008) Br J Ophthalmol , vol.92 , Issue.12 , pp. 1606-1611
    • Singerman, L.J.1    Masonson, H.2    Patel, M.3
  • 284
    • 77952509691 scopus 로고    scopus 로고
    • Four-year safety of pegaptanib sodium in neovascular age-related macular degeneration (AMD): Results of the V.I.S.I.O.N. trial [abstract]
    • VEGF Inhibition Study Ocular Neovas-cularization Clinical Trial Group
    • Marcus DM, VEGF Inhibition Study Ocular Neovas-cularization Clinical Trial Group. Four-year safety of pegaptanib sodium in neovascular age-related macular degeneration (AMD): results of the V.I.S.I.O.N. trial [abstract]. Invest Ophthalmol Vis Sci 2008; 49: E-Abstract 5069
    • (2008) Invest Ophthalmol Vis Sci , vol.49
    • Marcus, D.M.1
  • 285
    • 69249222585 scopus 로고    scopus 로고
    • A Phase IIIb studyto evaluate the safety of ranibizumab in subjects with neovascular age-related macular degeneration
    • Boyer DS, Heier JS, Brown DM, et al. A Phase IIIb studyto evaluate the safety of ranibizumab in subjects with neovascular age-related macular degeneration. Ophthalmology 2009; 116 (9): 1731-9
    • (2009) Ophthalmology , vol.116 , Issue.9 , pp. 1731-1739
    • Boyer, D.S.1    Heier, J.S.2    Brown, D.M.3
  • 286
    • 58849084256 scopus 로고    scopus 로고
    • Cerebrovascular acci-dents in ranibizumab [letter]
    • Ueta T, Yanagi Y, Tamaki Y, et al. Cerebrovascular acci-dents in ranibizumab [letter]. Ophthalmology 2009; 116 (2): 362
    • (2009) Ophthalmology , vol.116 , Issue.2 , pp. 362
    • Ueta, T.1    Yanagi, Y.2    Tamaki, Y.3
  • 287
    • 33846973644 scopus 로고    scopus 로고
    • Ranibizumab for neovascular age-related macular degeneration
    • author reply 749-50
    • Gillies MC, Wong TY. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 2007; 356 (7): 748-9; author reply 749-50
    • N Engl J Med , vol.356 , Issue.7 , pp. 748-749
    • Gillies, M.C.1    Wong, T.Y.2
  • 288
    • 56049104902 scopus 로고    scopus 로고
    • Intravitrealbevacizumab in active progressive proliferative diabetic retinopathy
    • Moradian S, Ahmadich H, Malihi M, et al. Intravitrealbevacizumab in active progressive proliferative diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol 2008; 246 (12): 1699-705
    • (2008) Graefes Arch Clin Exp Ophthalmol , vol.246 , Issue.12 , pp. 1699-1705
    • Moradian, S.1    Ahmadich, H.2    Malihi, M.3
  • 289
    • 70350449697 scopus 로고    scopus 로고
    • Bevacizumab local complications [letter]
    • Gordon-Angelozzi M, Velez-Montoya R, Quiroz-MercadoH, et al. Bevacizumab local complications [letter]. Ophthalmology 2009; 116 (11): 2264.e1-3
    • (2009) Ophthalmology , vol.116 , Issue.11
    • Gordon-Angelozzi, M.1    Quiroz-Mercadoh, V.R.2
  • 290
    • 70350498941 scopus 로고    scopus 로고
    • Progression of trac-tional retinal detachment following intravitreal bev-acizumab
    • Jonas JB, Schmidbauer M, Rensch F. Progression of trac-tional retinal detachment following intravitreal bev-acizumab. Acta Ophthalmol 2009; 87 (5): 571-2
    • (2009) Acta Ophthalmol , vol.87 , Issue.5 , pp. 571-572
    • Jonas, J.B.1    Schmidbauer, M.2    Rensch, F.3
  • 291
    • 38949099070 scopus 로고    scopus 로고
    • Tractional retinaldetachment following intravitreal bevacizumab (Avastin) in patients with severe proliferative diabetic retinopathy
    • Arevalo JF, Maia M, Flynn Jr HW, et al. Tractional retinaldetachment following intravitreal bevacizumab (Avastin) in patients with severe proliferative diabetic retinopathy. Br J Ophthalmol 2008; 92 (2): 213-6
    • (2008) Br J Ophthalmol , vol.92 , Issue.2 , pp. 213-216
    • Arevalo, J.F.1    Maia, M.2    Flynn Jr., H.W.3
  • 292
    • 65949123351 scopus 로고    scopus 로고
    • Intravitrealpegaptanib in severe proliferative diabetic retinopathy leading to the progression of tractional retinal detachment
    • Krishnan R, Goverdhan S, Lochhead J. Intravitrealpegaptanib in severe proliferative diabetic retinopathy leading to the progression of tractional retinal detachment. Eye (Lond) 2009; 23 (5): 1238-9
    • (2009) Eye (Lond) , vol.23 , Issue.5 , pp. 1238-1239
    • Krishnan, R.1    Goverdhan, S.2    Lochhead, J.3
  • 293
    • 77950423342 scopus 로고    scopus 로고
    • The relation between bevacizumabinjection and the formation of subretinal fibrosis in diabetic patients with panretinal photocoagulation
    • Batman C, Ozdamar Y. The relation between bevacizumabinjection and the formation of subretinal fibrosis in diabetic patients with panretinal photocoagulation. Ophthalmic Surg Lasers Imaging 2010; 41 (2): 190-5
    • (2010) Ophthalmic Surg Lasers Imaging , vol.41 , Issue.2 , pp. 190-195
    • Batman, C.1    Ozdamar, Y.2
  • 294
    • 38549102077 scopus 로고    scopus 로고
    • TNF-mediated inflammatory disease
    • Bradley JR. TNF-mediated inflammatory disease. J Pathol2008; 214 (2): 149-60
    • (2008) J Pathol , vol.214 , Issue.2 , pp. 149-160
    • Bradley, J.R.1
  • 295
    • 63849267286 scopus 로고    scopus 로고
    • Recent progress in research on beta-cellapoptosis by cytokines
    • Kim KA, Lee MS. Recent progress in research on beta-cellapoptosis by cytokines. Front Biosci 2009; 14: 657-64
    • (2009) Front Biosci , vol.14 , pp. 657-664
    • Kim, K.A.1    Lee, M.S.2
  • 296
    • 44749083828 scopus 로고    scopus 로고
    • Induction of nuclearfactor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells
    • Ortis F, Pirot P, Naamane N, et al. Induction of nuclearfactor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells. Diabetologia 2008; 51 (7): 1213-25
    • (2008) Diabetologia , vol.51 , Issue.7 , pp. 1213-1225
    • Ortis, F.1    Pirot, P.2    Naamane, N.3
  • 297
    • 0041374029 scopus 로고    scopus 로고
    • Insulin resistance in adipose tissue:direct and indirect effects of tumor necrosis factor-alpha
    • Ruan H, Lodish HF. Insulin resistance in adipose tissue:direct and indirect effects of tumor necrosis factor-alpha. Cytokine Growth Factor Rev 2003; 14 (5): 447-55
    • (2003) Cytokine Growth Factor Rev , vol.14 , Issue.5 , pp. 447-455
    • Ruan, H.1    Lodish, H.F.2
  • 298
    • 33845546564 scopus 로고    scopus 로고
    • Determination ofvitreous interleukin-1 (IL-1) and tumour necrosis factor (TNF) levels in proliferative diabetic retinopathy
    • Demircan N, Safran BG, Soylu M, et al. Determination ofvitreous interleukin-1 (IL-1) and tumour necrosis factor (TNF) levels in proliferative diabetic retinopathy. Eye 2006; 20 (12): 1366-9
    • (2006) Eye , vol.20 , Issue.12 , pp. 1366-1369
    • Demircan, N.1    Safran, B.G.2    Soylu, M.3
  • 299
    • 75449101393 scopus 로고    scopus 로고
    • Roles of endothelin-1 and selected proinflammatory cytokines in the pathogenesis of proliferative diabetic ret-inopathy: Analysis of vitreous samples
    • Adamiec-Mroczek J, Oficjalska-Mynczak J, Misiuk-Hojo M. Roles of endothelin-1 and selected proinflammatory cytokines in the pathogenesis of proliferative diabetic ret-inopathy: analysis of vitreous samples. Cytokine 2010; 49 (3): 269-74
    • (2010) Cytokine , vol.49 , Issue.3 , pp. 269-274
    • Adamiec-Mroczek, J.1    Oficjalska-Mynczak, J.2    Misiuk-Hoj, M.3
  • 300
    • 0034876205 scopus 로고    scopus 로고
    • Inflammatory cyto-kines in vitreous fluid and serum of patients with diabetic vitreoretinopathy
    • Yuuki T, Kanda T, Kimura Y, et al. Inflammatory cyto-kines in vitreous fluid and serum of patients with diabetic vitreoretinopathy. J Diabetes Complications 2001; 15 (5): 257-9
    • (2001) J Diabetes Complications , vol.15 , Issue.5 , pp. 257-259
    • Yuuki, T.1    Kanda, T.2    Kimura, Y.3
  • 301
    • 43449109783 scopus 로고    scopus 로고
    • Diabetes-enhancedtumor necrosis factor-alpha production promotes apop-tosis and the loss of retinal microvascular cells in type 1and type 2 models of diabetic retinopathy
    • Behl Y, Krothapalli P, Desta T, et al. Diabetes-enhancedtumor necrosis factor-alpha production promotes apop-tosis and the loss of retinal microvascular cells in type 1and type 2 models of diabetic retinopathy. Am J Pathol 2008; 172 (5): 1411-8
    • (2008) Am J Pathol , vol.172 , Issue.5 , pp. 1411-1418
    • Behl, Y.1    Krothapalli, P.2    Desta, T.3
  • 302
    • 33750428239 scopus 로고    scopus 로고
    • Inhibition of TNF-alpha reduces laser-induced choroidal neovascularization
    • Shi X, Semkova I, Muther PS, et al. Inhibition of TNF-alpha reduces laser-induced choroidal neovascularization. Exp Eye Res 2006; 83 (6): 1325-34
    • (2006) Exp Eye Res , vol.83 , Issue.6 , pp. 1325-1334
    • Shi, X.1    Semkova, I.2    Muther, P.S.3
  • 303
    • 34548653580 scopus 로고    scopus 로고
    • Intravitreal in-fliximab and choroidal neovascularization in an animal model
    • Olson JL, Courtney RJ, Mandava N. Intravitreal in-fliximab and choroidal neovascularization in an animal model. Arch Ophthalmol 2007; 125 (9): 1221-4
    • (2007) Arch Ophthalmol , vol.125 , Issue.9 , pp. 1221-1224
    • Olson, J.L.1    Courtney, R.J.2    Mandava, N.3
  • 304
    • 29244486471 scopus 로고    scopus 로고
    • Sequential inductionof angiogenic growth factors by TNF-alpha in choroidal endothelial cells
    • Hangai M, He S, Hoffmann S, et al. Sequential inductionof angiogenic growth factors by TNF-alpha in choroidal endothelial cells. J Neuroimmunol 2006; 171 (1-2): 45-56
    • (2006) J Neuroimmunol , vol.171 , Issue.1-2 , pp. 45-56
    • Hangai, M.1    He, S.2    Hoffmann, S.3
  • 305
    • 12844263375 scopus 로고    scopus 로고
    • Regression of sight-threatening macular edema in type 2 diabetes following treatment with the anti-tumor necrosis factor monoclonal antibody infliximab
    • Sfikakis PP, Markomichelakis N, Theodossiadis GP, et al.Regression of sight-threatening macular edema in type 2 diabetes following treatment with the anti-tumor necrosis factor monoclonal antibody infliximab. Diabetes Care 2005; 28 (2): 445-7
    • (2005) Diabetes Care , vol.28 , Issue.2 , pp. 445-447
    • Sfikakis, P.P.1    Markomichelakis, N.2    Theodossiadis, G.P.3
  • 306
    • 15044342651 scopus 로고    scopus 로고
    • Regression of neovascular age-related macular degeneration following infliximab therapy
    • Markomichelakis NN, Theodossiadis PG, Sfikakis PP.Regression of neovascular age-related macular degeneration following infliximab therapy. Am J Ophthalmol 2005; 139 (3): 537-40
    • (2005) Am J Ophthalmol , vol.139 , Issue.3 , pp. 537-540
    • Markomichelakis, N.N.1    Theodossiadis, P.G.2    Sfikakis, P.P.3
  • 307
    • 64349100107 scopus 로고    scopus 로고
    • In-travitreal administration of the anti-tumor necrosis factor agent infliximab for neovascular age-related macular degeneration
    • Theodossiadis PG, Liarakos VS, Sfikakis PP, et al. In-travitreal administration of the anti-tumor necrosis factor agent infliximab for neovascular age-related macular degeneration. Am J Ophthalmol 2009; 147 (5): 825-30
    • (2009) Am J Ophthalmol , vol.147 , Issue.5 , pp. 825-830
    • Theodossiadis, P.G.1    Liarakos, V.S.2    Sfikakis, P.P.3
  • 308
    • 77956980190 scopus 로고    scopus 로고
    • In-fliximab for diabetic macular edema refractory to laser photocoagulation: A randomized double-blind placebo-controlled crossover 32 weeks study
    • Sfikakis PP, Grigoropoulos V, Emfietzoglou I, et al. In-fliximab for diabetic macular edema refractory to laser photocoagulation: a randomized, double-blind, placebo-controlled, crossover, 32 weeks study. Diabetes Care 2010; 33 (7): 1523-8
    • (2010) Diabetes Care , vol.33 , Issue.7 , pp. 1523-1528
    • Sfikakis, P.P.1    Grigoropoulos, V.2    Emfietzoglou, I.3
  • 309
    • 22844450941 scopus 로고    scopus 로고
    • A prospectivetrial of infliximab therapy for refractory uveitis: Preliminary safety and efficacy outcomes
    • Suhler EB, Smith JR, Wertheim MS, et al. A prospectivetrial of infliximab therapy for refractory uveitis: preliminary safety and efficacy outcomes. Arch Ophthalmol 2005; 123 (7): 903-12
    • (2005) Arch Ophthalmol , vol.123 , Issue.7 , pp. 903-912
    • Suhler, E.B.1    Smith, J.R.2    Wertheim, M.S.3
  • 310
    • 75149190168 scopus 로고    scopus 로고
    • Adverse eventsafter intravitreal infliximab (Remicade)
    • Giganti M, Beer PM, Lemanski N, et al. Adverse eventsafter intravitreal infliximab (Remicade). Retina 2010; 30 (1): 71-80
    • (2010) Retina , vol.30 , Issue.1 , pp. 71-80
    • Giganti, M.1    Beer, P.M.2    Lemanski, N.3
  • 311
    • 73149112200 scopus 로고    scopus 로고
    • Ruboxistaurin: PKC-beta inhibitionfor complications of diabetes
    • Danis RP, Sheetz MJ. Ruboxistaurin: PKC-beta inhibitionfor complications of diabetes. Expert Opin Pharmacother 2009; 10 (17): 2913-25
    • (2009) Expert Opin Pharmacother , vol.10 , Issue.17 , pp. 2913-2925
    • Danis, R.P.1    Sheetz, M.J.2
  • 312
    • 15644366961 scopus 로고    scopus 로고
    • Vascular en-dothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor
    • Aiello LP, Bursell SE, Clermont A, et al. Vascular en-dothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor. Diabetes 1997; 46 (9): 1473-80
    • (1997) Diabetes , vol.46 , Issue.9 , pp. 1473-1480
    • Aiello, L.P.1    Bursell, S.E.2    Clermont, A.3
  • 313
    • 33947313405 scopus 로고    scopus 로고
    • VEGF acti-vation of protein kinase C stimulates occludin phosphor-ylation and contributes to endothelial permeability
    • Harhaj NS, Felinski EA, Wolpert EB, et al. VEGF acti-vation of protein kinase C stimulates occludin phosphor-ylation and contributes to endothelial permeability. Invest Ophthalmol Vis Sci 2006; 47 (11): 5106-15
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , Issue.11 , pp. 5106-5115
    • Harhaj, N.S.1    Felinski, E.A.2    Wolpert, E.B.3
  • 314
    • 21344435254 scopus 로고    scopus 로고
    • The effect of ruboxistaurin onvisual loss in patients with moderately severe to very severe nonproliferative diabetic retinopathy: Initial results of the Protein Kinase C beta Inhibitor Diabetic Retinop-athy Study (PKC-DRS) multicenter randomized clinical trial
    • PKC-DMES Study Group
    • PKC-DMES Study Group. The effect of ruboxistaurin onvisual loss in patients with moderately severe to very severe nonproliferative diabetic retinopathy: initial results of the Protein Kinase C beta Inhibitor Diabetic Retinop-athy Study (PKC-DRS) multicenter randomized clinical trial. Diabetes 2005; 54 (7): 2188-97
    • (2005) Diabetes , vol.54 , Issue.7 , pp. 2188-2197
  • 315
    • 33751520614 scopus 로고    scopus 로고
    • Effect of rubox-istaurin on visual loss in patients with diabetic retinop-athy
    • Aiello LP, Davis MD, Girach A, et al. Effect of rubox-istaurin on visual loss in patients with diabetic retinop-athy. Ophthalmology 2006; 113 (12): 2221-30
    • (2006) Ophthalmology , vol.113 , Issue.12 , pp. 2221-2230
    • Aiello, L.P.1    Davis, M.D.2    Girach, A.3
  • 316
    • 33947236725 scopus 로고    scopus 로고
    • Effect of ruboxistaurin inpatients with diabetic macular edema: Thirty-month results of the randomized PKC-DMES clinical trial
    • PKC-DMES Study Group
    • PKC-DMES Study Group. Effect of ruboxistaurin inpatients with diabetic macular edema: thirty-month results of the randomized PKC-DMES clinical trial. Arch Ophthalmol 2007; 125 (3): 318-24
    • (2007) Arch Ophthalmol , vol.125 , Issue.3 , pp. 318-324


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