Akt deficiency attenuates muscle size and function but not the response to ActRIIB inhibition

PLoS ONE

Volumn 5, Issue 9, 2010, Pages 1-12

  Goncalves, Marcus D ^a   Pistilli, Emidio E ^a   Balduzzi, Anthony ^a   Birnbaum, Morris J ^a   Lachey, Jennifer ^b   Khurana, Tejvir S ^a   Ahima, Rexford S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Acceleron Pharma   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN RECEPTOR 2; ACTIVIN RECEPTOR 2B; HYBRID PROTEIN; PROTEIN AKT1; PROTEIN KINASE B; PROTEIN KINASE B BETA; UNCLASSIFIED DRUG; ACTIVIN RECEPTOR TYPE II B; ACTIVIN RECEPTOR TYPE II-B; AKT1 PROTEIN, MOUSE; AKT2 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY COMPOSITION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEFICIENCY; GRIP STRENGTH; IN VIVO STUDY; INHIBITION KINETICS; KNOCKOUT MOUSE; MALE; MOUSE; MUSCLE CELL; MUSCLE CONTRACTILE FORCE; MUSCLE FUNCTION; MUSCLE HYPERTROPHY; MUSCLE MASS; MUSCLE STRENGTH; MUSCULOSKELETAL SYSTEM PARAMETERS; NONHUMAN; SIGNAL TRANSDUCTION; WILD TYPE; ANIMAL; C57BL MOUSE; DOWN REGULATION; DRUG ANTAGONISM; ENZYMOLOGY; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; METABOLISM; MOUSE MUTANT; MUSCLE ATROPHY; MUSCLE CONTRACTION; PATHOPHYSIOLOGY; SKELETAL MUSCLE;

MUS;

ACTIVIN RECEPTORS, TYPE II; ANIMALS; DOWN-REGULATION; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE CONTRACTION; MUSCLE, SKELETAL; MUSCULAR ATROPHY; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 77958537905     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0012707     Document Type: Article

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