Rap1A regulates generation of T regulatory cells via LFA-1-dependent and LFA-1-independent mechanisms

Cellular Immunology

Volumn 266, Issue 1, 2010, Pages 7-13

  Li, Lequn ^a   Kim, Jin sub ^a   Boussiotis, Vassiliki A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Foxp3; LFA 1; Rap1A; Regulatory T cells

Indexed keywords

LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; RAP1 PROTEIN; TRANSCRIPTION FACTOR FOXP3;

ANIMAL CELL; CELL DIFFERENTIATION; CELL FUNCTION; CELL LINE; CELL MATURATION; CONTROLLED STUDY; ENZYME ACTIVATION; MOUSE; NONHUMAN; NOTE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, CD3; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL COUNT; CELL DIFFERENTIATION; CELL PROLIFERATION; DNA-BINDING PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; LYMPH NODES; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; RAP1 GTP-BINDING PROTEINS; SPLEEN; T-LYMPHOCYTES, REGULATORY; THYMUS GLAND; TRANSFORMING GROWTH FACTOR BETA;

MUS;

EID: 77958508454     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2010.08.014     Document Type: Note

References (47)

1. Carman C.V., Springer T.A. Integrin avidity regulation: are changes in affinity and conformation underemphasized?. Curr. Opin. Cell Biol. 2003, 15:547-556.
2. Reedquist K.A., Ross E., Koop E.A., Wolthuis R.M., Zwartkruis F.J., van Kooyk Y., Salmon M., Buckley C.D., Bos J.L. The small GTPase, Rap1, mediates CD31-induced integrin adhesion. J. Cell Biol. 2000, 148:1151-1158.
3. de Bruyn K.M., Rangarajan S., Reedquist K.A., Figdor C.G., Bos J.L. The small GTPase Rap1 is required for Mn(2+)- and antibody-induced LFA-1- and VLA-4-mediated cell adhesion. J Biol Chem 2002, 277:29468-29476.
4. Katagiri K., Hattori M., Minato N., Irie S.-K., Takatsu K., Kinashi T. Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase. Mol. Cell Biol. 2000, 20:1956-1969.
5. Bertoni A., Tadokoro S., Eto K., Pampori N., Parise L.V., White G.C., Shattil S.J. Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton. J. Biol. Chem. 2002, 277:25715-25721.
6. de Bruyn K.M., Zwartkruis F.J., de Rooij J., Akkerman J.W., Bos J.L. The small GTPase Rap1 is activated by turbulence and is involved in integrin [alpha]IIb[beta]3-mediated cell adhesion in human megakaryocytes. J. Biol. Chem. 2003, 278:22412-22417.
7. Caron E., Self A.J., Hall A. The GTPase Rap1 controls functional activation of macrophage integrin alphaMbeta2 by LPS and other inflammatory mediators. Curr. Biol. 2000, 10:974-978.
8. Shattil S.J., Kashiwagi H., Pampori N. Integrin signaling: the platelet paradigm. Blood 1998, 91:2645-2657.
9. Franke B., van Triest M., de Bruijn K.M., van Willigen G., Nieuwenhuis H.K., Negrier C., Akkerman J.W., Bos J.L. Sequential regulation of the small GTPase Rap1 in human platelets. Mol. Cell Biol. 2000, 20:779-785.
10. Bachmann M.F., McKall-Faienza K., Schmits R., Bouchard D., Beach J., Speiser D.E., Mak T.W., Ohashi P.S. Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation. Immunity 1997, 7:549-557.
11. Abraham C., Miller J. Molecular mechanisms of IL-2 gene regulation following costimulation through LFA-1. J. Immunol. 2001, 167:5193-5201.
12. + T cells is required for optimal antigen-dependent activation in vivo. J. Immunol. 2004, 173:4443-4451.
13. Abraham C., Griffith J., Miller J. The dependence for leukocyte function-associated antigen-1/ICAM-1 interactions in T cell activation cannot be overcome by expression of high density TCR ligand. J. Immunol. 1999, 162:4399-4405.
14. Berlin-Rufenach C., Otto F., Mathies M., Westermann J., Owen M.J., Hamann A., Hogg N. Lymphocyte migration in lymphocyte function-associated antigen (LFA)-1-deficient mice. J. Exp. Med. 1999, 189:1467-1478.
15. Lub M., van Kooyk Y., Figdor C.G. Ins and outs of LFA-1. Immunol. Today 1995, 16:479-483.
16. Bunting M., Harris E.S., McIntyre T.M., Prescott S.M., Zimmerman G.A. Leukocyte adhesion deficiency syndromes: adhesion and tethering defects involving beta 2 integrins and selectin ligands. Curr. Opin. Hematol. 2002, 9:30-35.
17. Uzel G., Kleiner D.E., Kuhns D.B., Holland S.M. Dysfunctional LAD-1 neutrophils and colitis. Gastroenterology 2001, 121:958-964.
18. Scharffetter-Kochanek K., Lu H., Norman K., van Nood N., Munoz F., Grabbe S., McArthur M., Lorenzo I., Kaplan S., Ley K., Smith C.W., Montgomery C.A., Rich S., Beaudet A.L. Spontaneous skin ulceration and defective T cell function in CD18 null mice. J. Exp. Med. 1998, 188:119-131.
19. Ding Z.M., Babensee J.E., Simon S.I., Lu H., Perrard J.L., Bullard D.C., Dai X.Y., Bromley S.K., Dustin M.L., Entman M.L., Smith C.W., Ballantyne C.M. Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration. J. Immunol. 1999, 163:5029-5038.
20. + T regulatory cells. J. Immunol. 2005, 175:7889-7897.
21. Wohler J., Bullard D., Schoeb T., Barnum S. LFA-1 is critical for regulatory T cell homeostasis and function. Mol. Immunol. 2009, 46:2424-2428.
22. + regulatory T cells in vivo. J. Immunol. 2005, 175:3133-3139.
23. + T cells in mice. Eur J Immunol 2003, 33:2449-2458.
24. + regulatory T cells controls wasting disease, IL-10 secretion and T cell homeostasis. Eur. J. Immunol. 2003, 33:2419-2428.
25. Bettelli E., Carrier Y., Gao W., Korn T., Strom T.B., Oukka M., Weiner H.L., Kuchroo V.K. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006, 441:235-238.
26. Josefowicz S.Z., Rudensky A. Control of regulatory T cell lineage commitment and maintenance. Immunity 2009, 30:616-625.
27. + T cells in the thymic cortex. Proc. Natl. Acad. Sci. USA 2008, 105:11903-11908.
28. Fontenot J.D., Rasmussen J.P., Williams L.M., Dooley J.L., Farr A.G., Rudensky A.Y. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 2005, 22:329-341.
29. Suga K., Katagiri K., Kinashi T., Harazaki M., Iizuka T., Hattori M., Minato N. CD98 induces LFA-1-mediated cell adhesion in lymphoid cells via activation of Rap1. FEBS lett. 2001, 489:249-253.
30. + regulatory T cells induced by an agonist self-peptide. Nat Immunol 2001, 2:301-306.
31. Shevach E.M., Davidson T.S., Huter E.N., Dipaolo R.A., Andersson J. Role of TGF-Beta in the induction of Foxp3 expression and T regulatory cell function. J. Clin. Immunol. 2008, 28:640-646.
32. + regulatory T cells. J. Exp. Med. 2005, 201:1061-1067.
33. + regulatory T cells. Nat. Immunol. 2008, 9:632-640.
34. +CD25-T cells through Foxp3 induction and down-regulation of Smad7. J. Immunol. 2004, 172:5149-5153.
35. + regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 2003, 198:1875-1886.
36. Haribhai D., Lin W., Edwards B., Ziegelbauer J., Salzman N.H., Carlson M.R., Li S.H., Simpson P.M., Chatila T.A., Williams C.B. A central role for induced regulatory T cells in tolerance induction in experimental colitis. J. Immunol. 2009, 182:3461-3468.
37. + regulatory T cells by peripheral expansion. J. Immunol. 2004, 173:7259-7268.
38. - versus CD8-lineage choice. Nat. Rev. Immunol. 2008, 8:788-801.
39. + immunoregulatory T cells that control autoimmune diabetes. Immunity 2000, 12:431-440.
40. Benson M.J., Pino-Lagos K., Rosemblatt M., Noelle R.J. All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J. Exp. Med. 2007, 204:1765-1774.
41. Kim J.M., Rudensky A. The role of the transcription factor Foxp3 in the development of regulatory T cells. Immunol. Rev. 2006, 212:86-98.
42. Amsen D., Kruisbeek A., Bos J.L., Reedquist K. Activation of the Ras-related GTPase Rap1 by thymocyte TCR engagement and during selection. Eur. J. Immunol. 2000, 30:2832-2841.
43. Samon J.B., Champhekar A., Minter L.M., Telfer J.C., Miele L., Fauq A., Das P., Golde T.E., Osborne B.A. Notch1 and TGFbeta1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells. Blood 2008, 112:1813-1821.
44. Wang S.F., Aoki M., Nakashima Y., Shinozuka Y., Tanaka H., Taniwaki M., Hattori M., Minato N. Development of Notch-dependent T-cell leukemia by deregulated Rap1 signaling. Blood 2008, 111:2878-2886.
45. Sauer S., Bruno L., Hertweck A., Finlay D., Leleu M., Spivakov M., Knight Z.A., Cobb B.S., Cantrell D., O'Connor E., Shokat K.M., Fisher A.G., Merkenschlager M. T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proc. Natl. Acad. Sci. USA 2008, 105:7797-7802.
46. + cells. J. Exp. Med. 2008, 205:565-574.
47. Christian S.L., Lee R.L., McLeod S.J., Burgess A.E., Li A.H., Dang-Lawson M., Lin K.B., Gold M.R. Activation of the Rap GTPases in B lymphocytes modulates B cell antigen receptor-induced activation of Akt but has no effect on MAPK activation. J. Biol. Chem. 2003, 278:41756-41767.